Detailed information for compound 836561

Basic information

Technical information
  • TDR Targets ID: 836561
  • Name: 2-[3-(4-fluorophenyl)-2-oxo-1,4-diazaspiro[4. 5]dec-3-en-1-yl]-N-(3-methylphenyl)acetamide
  • MW: 393.454 | Formula: C23H24FN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)C(=NC21CCCCC2)c1ccc(cc1)F)Nc1cccc(c1)C
  • InChi: 1S/C23H24FN3O2/c1-16-6-5-7-19(14-16)25-20(28)15-27-22(29)21(17-8-10-18(24)11-9-17)26-23(27)12-3-2-4-13-23/h5-11,14H,2-4,12-13,15H2,1H3,(H,25,28)
  • InChiKey: UQKLBMUHOWMGNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[3-(4-fluorophenyl)-2-keto-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-(3-methylphenyl)acetamide
  • 2-[3-(4-fluorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]-N-(3-methylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.0728 0.0964
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0221 0.0254 0.0253
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0547 0.0758 0.101
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0097 0.0063 0.0061
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0547 0.0758 0.2198
Echinococcus granulosus tyrosine protein kinase Src64B 0.0221 0.0254 0.0253
Leishmania major phosphatidylinositol 4-kinase, putative 0.0268 0.0327 0.0339
Brugia malayi Immunoglobulin I-set domain containing protein 0.0487 0.0665 0.1007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0217 0.0248 0.0224
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.4319 0.6592 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Schistosoma mansoni hypothetical protein 0.0217 0.0248 0.0248
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.148 0.2202 0.2202
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.148 0.2202 0.3338
Loa Loa (eye worm) phosphatidylinositol 3 0.0217 0.0248 0.0281
Loa Loa (eye worm) phosphatidylinositol 3 0.0217 0.0248 0.0281
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.012 0.0098 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.148 0.2202 0.3338
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.148 0.2202 1
Loa Loa (eye worm) SRC-1 0.0221 0.0254 0.0288
Echinococcus multilocularis growth factor receptor bound protein 2 0.008 0.0036 0.0035
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0221 0.0254 0.0253
Entamoeba histolytica protein kinase rad3, putative 0.034 0.0438 0.0662
Toxoplasma gondii FATC domain-containing protein 0.034 0.0438 0.2414
Loa Loa (eye worm) hypothetical protein 0.1604 0.2394 0.2733
Echinococcus granulosus epidermal growth factor receptor 0.0329 0.0422 0.042
Schistosoma mansoni hypothetical protein 0.0144 0.0136 0.0136
Schistosoma mansoni tyrosine kinase 0.0221 0.0254 0.0254
Echinococcus multilocularis tyrosine protein kinase HCK 0.0141 0.013 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0906
Echinococcus granulosus tyrosine kinase 0.0181 0.0193 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.0248 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0484 0.0661 0.2115
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.0197 0.0196
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0547 0.0758 0.0757
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.4319 0.6592 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0484 0.0661 0.0661
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.0197 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0547 0.0758 0.2198
Echinococcus granulosus serine:threonine protein kinase SMG1 0.034 0.0438 0.0436
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0144 0.0136 0.0134
Echinococcus multilocularis epidermal growth factor receptor 0.0329 0.0422 0.042
Loa Loa (eye worm) TK/EPH protein kinase 0.0163 0.0165 0.0187
Entamoeba histolytica hypothetical protein 0.0217 0.0248 0.0374
Schistosoma mansoni growth factor receptor-bound protein 0.008 0.0036 0.0036
Echinococcus granulosus c src tyrosine kinase 0.0097 0.0063 0.0061
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0547 0.0758 0.1148
Schistosoma mansoni tyrosine kinase 0.0167 0.0171 0.0171
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0484 0.0661 0.066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.0248 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0661 0.086
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.148 0.2202 0.3235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.0728 0.0964
Trichomonas vaginalis conserved hypothetical protein 0.0361 0.0471 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0907
Leishmania major phosphatidylinositol 3-kinase, putative 0.0675 0.0957 0.3053
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0528 0.0728 0.246
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0255 0.0308 0.0306
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0675 0.0957 0.9
Brugia malayi SRC-1 0.0221 0.0254 0.0383
Schistosoma mansoni tyrosine kinase 0.0893 0.1293 0.1293
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.191 0.2866 0.4346
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0217 0.0248 0.0248
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0221 0.0254 0.0253
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0097 0.0063 0.0063
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.2203 0.332 0.5035
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0675 0.0957 0.1316
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0438 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0661 0.086
Loa Loa (eye worm) hypothetical protein 0.0144 0.0136 0.0153
Echinococcus granulosus tyrosine protein kinase Src42A 0.0164 0.0167 0.0165
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0547 0.0758 0.2612
Loa Loa (eye worm) hypothetical protein 0.034 0.0438 0.0498
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.0327 0.0371
Echinococcus multilocularis tyrosine protein kinase Abl 0.0432 0.058 0.0579
Brugia malayi Furin-like cysteine rich region family protein 0.0329 0.0422 0.0638
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.4452 0.6799 0.6798
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0361 0.0471 0.2832
Echinococcus granulosus tyrosine protein kinase Lyn 0.0221 0.0254 0.0253
Brugia malayi Variant SH3 domain containing protein 0.008 0.0036 0.0053
Giardia lamblia GTOR 0.0547 0.0758 0.16
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0675 0.0957 0.1316
Schistosoma mansoni tyrosine kinase 0.0116 0.0091 0.0091
Onchocerca volvulus 0.0431 0.0579 0.9385
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0726 0.1035 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0221 0.0254 0.0253
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.034 0.0438 0.0662
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.148 0.2202 0.3235
Schistosoma mansoni tyrosine kinase 0.0058 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0268 0.0327 0.0345
Echinococcus multilocularis tyrosine protein kinase Blk 0.0181 0.0193 0.0191
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.034 0.0438 0.0436
Loa Loa (eye worm) hypothetical protein 0.0217 0.0248 0.0281
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0097 0.0063 0.0061
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0675 0.0957 0.1316
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0164 0.0167 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0484 0.0661 0.0753
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0675 0.0957 0.0955
Loa Loa (eye worm) hypothetical protein 0.0115 0.009 0.0101
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.4319 0.6592 1
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.0136 0.0051
Loa Loa (eye worm) phosphatidylinositol 3 0.5717 0.8755 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0484 0.0661 0.086
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0217 0.0248 0.0246
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.6522 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0181 0.0193 0.0191
Schistosoma mansoni tyrosine kinase 0.0116 0.0091 0.0091
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0675 0.0957 0.0955
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1263 0.1867 0.2718
Loa Loa (eye worm) phosphatidylinositol kinase 0.0217 0.0248 0.0281
Brugia malayi Tyrosine-protein kinase abl-1 0.0432 0.058 0.0878
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.3084 0.4683 0.7058
Onchocerca volvulus Tyrosine kinase homolog 0.0456 0.0617 1
Leishmania major hypothetical protein, conserved 0.1718 0.257 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.034 0.0438 0.0438
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0675 0.0957 1
Brugia malayi protein-tyrosine kinase 0.0181 0.0193 0.029
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0484 0.0661 0.086
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0675 0.0957 0.0957
Loa Loa (eye worm) TK protein kinase 0.0141 0.013 0.0147
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.034 0.0438 0.0662
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0675 0.0957 0.1449
Schistosoma mansoni tyrosine kinase 0.0097 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0236 0.0278 0.027
Brugia malayi Tyrosine-protein kinase abl-1 0.0541 0.0749 0.1134
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0221 0.0254 0.0253
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.2279 0.3438 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.0728 0.0964
Schistosoma mansoni tyrosine kinase 0.0221 0.0254 0.0254
Echinococcus multilocularis insulin receptor 0.0116 0.0091 0.009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0217 0.0248 0.0224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0484 0.0661 0.1001
Loa Loa (eye worm) hypothetical protein 0.0352 0.0457 0.052
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0217 0.0248 0.0246
Echinococcus multilocularis 0.0097 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0123 0.0103 0.0115
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.034 0.0438 0.0973
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.2715 0.4111 0.411
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.4319 0.6592 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.0248 0.0374
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0484 0.0661 0.066
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.034 0.0438 0.0438
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0484 0.0661 0.1779
Echinococcus granulosus tyrosine protein kinase HCK 0.0141 0.013 0.0129
Giardia lamblia Phosphatidylinositol 4-kinase 0.0268 0.0327 0.0247
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.4102 0.6257 0.9491
Schistosoma mansoni growth factor receptor-bound protein 0.008 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.148 0.2202 0.3235
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0217 0.0248 0.0224
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Loa Loa (eye worm) hypothetical protein 0.2715 0.4111 0.4695
Entamoeba histolytica hypothetical protein 0.0217 0.0248 0.0374
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0528 0.0728 0.207
Echinococcus granulosus insulin growth factor 1 receptor beta 0.012 0.0098 0.0096
Schistosoma mansoni ephrin receptor 0.0132 0.0117 0.0117
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0675 0.0957 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.148 0.2202 0.3338
Loa Loa (eye worm) TK/EGFR protein kinase 0.0329 0.0422 0.048
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0675 0.0957 0.1449
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.038 0.0501 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.0728 0.0964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0498 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.3514 0.5347 0.8111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0327 0.0493
Loa Loa (eye worm) phosphatidylinositol 3 0.0547 0.0758 0.0864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0268 0.0327 0.0327
Schistosoma mansoni tyrosine kinase 0.0167 0.0171 0.0171
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0217 0.0248 0.0224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2715 0.4111 0.6235
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0268 0.0327 0.0403
Echinococcus multilocularis Zinc finger, PHD finger 0.0675 0.0957 0.0955
Entamoeba histolytica protein kinase, putative 0.0141 0.013 0.0195
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.034 0.0438 0.0662
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0675 0.0957 0.1316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0403 0.0535 0.0667
Onchocerca volvulus 0.0115 0.009 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0438 0.0517
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.6522 1 1
Brugia malayi Variant SH3 domain containing protein 0.008 0.0036 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0498 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.4319 0.6592 1
Schistosoma mansoni tyrosine kinase 0.0167 0.0171 0.0171
Echinococcus granulosus growth factor receptor bound protein 2 0.008 0.0036 0.0035
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0675 0.0957 0.1316
Schistosoma mansoni tyrosine kinase 0.0058 0.0002 0.0002
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0268 0.0327 0.1111
Schistosoma mansoni tyrosine kinase 0.0184 0.0197 0.0197
Loa Loa (eye worm) variant SH3 domain-containing protein 0.008 0.0036 0.004
Mycobacterium leprae conserved hypothetical protein 0.0217 0.0248 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0907
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0221 0.0254 0.0253
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0217 0.0248 0.0246
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0217 0.0248 0.0248
Brugia malayi Sex muscle abnormal protein 5 0.008 0.0036 0.0053
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.034 0.0438 0.0517
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0675 0.0957 0.1449
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0221 0.0254 0.0253
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0547 0.0758 0.101
Echinococcus multilocularis 0.0268 0.0327 0.0325
Schistosoma mansoni adapter molecule crk 0.008 0.0036 0.0036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.4319 0.6592 1
Schistosoma mansoni tyrosine kinase 0.0097 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0508 0.0698 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0498 0.0609
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0675 0.0957 0.3053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.4319 0.6592 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.0471 0.0536
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.034 0.0438 0.0517
Entamoeba histolytica hypothetical protein 0.034 0.0438 0.0662
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0221 0.0254 0.0253
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0217 0.0248 0.0374
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.3084 0.4683 0.7058
Echinococcus granulosus serine protein kinase ATM 0.034 0.0438 0.0436
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0268 0.0327 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0661 0.086
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0547 0.0758 0.2612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0508 0.0698 0.0918
Trypanosoma cruzi hypothetical protein, conserved 0.1502 0.2235 0.3286
Echinococcus granulosus tyrosine protein kinase ABL1 0.0933 0.1356 0.1354
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0217 0.0248 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.0728 0.0964
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0438 0.0517
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.2715 0.4111 0.411
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.1022 0.1493 0.3903
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0547 0.0758 0.1148
Echinococcus multilocularis NCK adaptor protein 0.008 0.0036 0.0035
Echinococcus multilocularis c src tyrosine kinase 0.0097 0.0063 0.0061
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0217 0.0248 0.0224
Toxoplasma gondii target of rapamycin (TOR), putative 0.0523 0.0721 0.6005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0547 0.0758 0.101
Echinococcus multilocularis ephrin type A receptor 4 A 0.0159 0.0159 0.0157
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0484 0.0661 0.2115
Loa Loa (eye worm) hypothetical protein 0.008 0.0036 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0217 0.0248 0.0281
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.008 0.0036 0.0036
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0547 0.0758 0.0757
Echinococcus granulosus NCK adaptor protein 0.008 0.0036 0.0035
Brugia malayi ephrin receptor 1 precursor 0.0071 0.0023 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.0505 0.062
Schistosoma mansoni tyrosine kinase 0.0329 0.0422 0.0422
Leishmania major phosphatidylinositol 3-kinase, putative 0.0484 0.0661 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0248 0.0224
Echinococcus granulosus insulin receptor 0.0116 0.0091 0.009
Echinococcus granulosus ephrin type A receptor 4 A 0.0159 0.0159 0.0157
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0181 0.0193 0.0191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0547 0.0758 0.101
Brugia malayi Protein kinase domain containing protein 0.0116 0.0091 0.0136
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0675 0.0957 0.3628
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0675 0.0957 0.0957
Schistosoma mansoni tyrosine kinase 0.0184 0.0197 0.0197
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0547 0.0758 0.1148
Brugia malayi FAT domain containing protein 0.0144 0.0136 0.0203
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0547 0.0758 0.0758
Loa Loa (eye worm) TK protein kinase 0.0181 0.0193 0.0219
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4452 0.6799 0.6798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0547 0.0758 0.101
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0675 0.0957 0.1091
Echinococcus granulosus tyrosine protein kinase Fyn 0.0221 0.0254 0.0253
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0268 0.0327 0.0345
Schistosoma mansoni nck2/grb4 0.008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0058 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Echinococcus granulosus tyrosine protein kinase Src42A 0.0221 0.0254 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0248 0.0224
Echinococcus multilocularis tyrosine protein kinase Srms 0.0181 0.0193 0.0191
Loa Loa (eye worm) TK/INSR protein kinase 0.0116 0.0091 0.0103
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0144 0.0136 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0661 0.086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0906
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0933 0.1356 0.1354
Trypanosoma cruzi target of rapamycin kinase 3 0.0528 0.0728 0.0964
Entamoeba histolytica hypothetical protein 0.3514 0.5347 0.8111
Echinococcus granulosus tyrosine protein kinase Blk 0.0181 0.0193 0.0191
Onchocerca volvulus 0.0217 0.0248 0.4001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.148 0.2202 0.3235
Loa Loa (eye worm) TK/ABL protein kinase 0.0933 0.1356 0.1547
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0268 0.0327 0.0325
Entamoeba histolytica hypothetical protein 0.0217 0.0248 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0538 0.0671
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0184 0.0197 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0503 0.0691 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0484 0.0661 0.086
Onchocerca volvulus 0.0217 0.0248 0.4001
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0675 0.0957 0.0955
Echinococcus multilocularis serine protein kinase ATM 0.034 0.0438 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Loa Loa (eye worm) phosphatidylinositol 3 0.1263 0.1867 0.2131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.0721 0.0952
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0487 0.0665 0.0758
Loa Loa (eye worm) sex muscle abnormal protein 5 0.008 0.0036 0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.