TDR Targets

Basic information

Technical information

TDR Targets ID: 837143
Name: N-(2-methoxyphenyl)-2-oxo-1-(phenylmethoxy)py ridine-3-carboxamide
MW: 350.368 | Formula: C20H18N2O4
H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)c1cccn(c1=O)OCc1ccccc1
InChi: 1S/C20H18N2O4/c1-25-18-12-6-5-11-17(18)21-19(23)16-10-7-13-22(20(16)24)26-14-15-8-3-2-4-9-15/h2-13H,14H2,1H3,(H,21,23)
InChiKey: QRXRIUDEOKSPNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methoxyphenyl)-2-oxo-1-(phenylmethoxy)-3-pyridinecarboxamide
1-(benzyloxy)-2-keto-N-(2-methoxyphenyl)nicotinamide
IFLab1_002900
IDI1_009359

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	peptidase family M48 containing protein	0.0071	0.1424	0.2002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0065	0.0153
Mycobacterium ulcerans	hypothetical protein	0.004	0.0698	0.5139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0065	0.0153
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0277	0.0277
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.0613	0.8785
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1301	0.274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0203	0.0482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Echinococcus multilocularis	CAAX prenyl protease 2	0.0192	0.4211	0.4211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Leishmania major	hypothetical protein, conserved	0.0036	0.0613	0.1024
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.0613	0.1456
Brugia malayi	cathepsin L-like precursor	0.0012	0.0065	0.0091
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.569	0.569
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0065	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0203	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0082
Loa Loa (eye worm)	cysteine protease	0.0018	0.0203	0.0277
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.0613	0.8785
Treponema pallidum	hypothetical protein	0.004	0.0698	0.5
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.004	0.0698	0.5139
Loa Loa (eye worm)	fibroinase	0.0018	0.0203	0.0277
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0203	0.0197
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.124	0.2944
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Brugia malayi	Peptidase family M48 containing protein	0.0071	0.1424	0.201
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0277	0.0277
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1301	0.8995
Echinococcus granulosus	RUN	0.0021	0.0277	0.0277
Schistosoma mansoni	rab6-interacting	0.0021	0.0277	0.0277
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0012	0.006	0.0143
Schistosoma mansoni	hypothetical protein	0.0052	0.0989	0.0989
Loa Loa (eye worm)	hepatopoietin HPO2	0.0036	0.0613	0.0857
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Schistosoma mansoni	rab6-interacting	0.0021	0.0277	0.0277
Toxoplasma gondii	hypothetical protein	0.004	0.0698	0.4056
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0203	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Entamoeba histolytica	CAAX prenyl protease, putative	0.0071	0.1424	0.3381
Schistosoma mansoni	cpg binding protein	0.0031	0.0502	0.0502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0192	0.4211	1
Brugia malayi	hypothetical protein	0.0021	0.0277	0.0391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Brugia malayi	Augmenter of liver regeneration	0.0036	0.0613	0.0866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0203	0.0482
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0128	0.273	0.273
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.1378	0.3272
Onchocerca volvulus		0.0018	0.0203	0.0197
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0203	0.0482
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1301	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Plasmodium vivax	protease, putative	0.004	0.0698	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Toxoplasma gondii	hypothetical protein	0.004	0.0698	0.4056
Entamoeba histolytica	CAAX amino terminal protease family	0.004	0.0698	0.1657
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0192	0.4211	1
Leishmania major	cathepsin L-like protease	0.0069	0.1378	0.2932
Echinococcus granulosus	cpg binding protein	0.0033	0.0543	0.0543
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0071	0.1424	0.3381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0192	0.4211	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.0613	0.1456
Schistosoma mansoni	hypothetical protein	0.0178	0.3877	0.3877
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0036	0.0613	0.0613
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0277	0.0277
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1143	0.7704
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Onchocerca volvulus		0.0018	0.0203	0.0197
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1378	0.3272
Schistosoma mansoni	cpg binding protein	0.0033	0.0543	0.0543
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0203	0.0277
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Plasmodium vivax	vivapain-2	0.0018	0.0203	0.2905
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Onchocerca volvulus		0.0018	0.0203	0.0197
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0277	0.3969
Echinococcus multilocularis	cpg binding protein	0.0033	0.0543	0.0543
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0203	0.0277
Trypanosoma brucei	metallo- peptidase, Clan M- Family M48	0.0071	0.1424	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0082
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0698	0.5139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Onchocerca volvulus		0.0018	0.0203	0.0197
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0989	0.0989
Onchocerca volvulus		0.0018	0.0203	0.0197
Schistosoma mansoni	lipoxygenase	0.0128	0.273	0.273
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0502	0.07
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0192	0.4211	1
Schistosoma mansoni	loxhd1	0.0021	0.0277	0.0277
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0036	0.0613	0.0613
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0203	0.0203
Onchocerca volvulus		0.0021	0.0277	0.0303
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0203	0.2905
Schistosoma mansoni	hypothetical protein	0.0021	0.0277	0.0277
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0192	0.4211	0.4211
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0203	0.0203
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0203	0.2905
Entamoeba histolytica	CAAX amino terminal protease family	0.004	0.0698	0.1657
Leishmania major	CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48	0.0071	0.1424	0.3046
Schistosoma mansoni	cpg binding protein	0.0033	0.0543	0.0543
Mycobacterium ulcerans	hypothetical protein	0.004	0.0698	0.5139
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0203	0.0482
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0203	0.0482
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0326	0.0774
Echinococcus multilocularis	RUN	0.0021	0.0277	0.0277
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.006	0.0143
Wolbachia endosymbiont of Brugia malayi	TPR repeat-containing Zn-dependent protease	0.0012	0.006	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0203	0.0197
Loa Loa (eye worm)	ctsf protein	0.0018	0.0203	0.0277
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Schistosoma mansoni	hypothetical protein	0.0178	0.3877	0.3877
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.004	0.0698	0.5139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Brugia malayi	hypothetical protein	0.0021	0.0277	0.0391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0128	0.273	0.273
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0192	0.4211	0.4211
Brugia malayi	CAAX amino terminal protease family protein	0.0192	0.4211	0.5944
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0203	0.2905
Toxoplasma gondii	CAAX amino terminal protease family protein	0.004	0.0698	0.4056
Onchocerca volvulus		0.0018	0.0203	0.0197
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0192	0.4211	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Onchocerca volvulus		0.0052	0.0989	0.1317
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0277	0.0277
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1378	0.3272
Echinococcus multilocularis	cysteine protease	0.0018	0.0203	0.0203
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0203	0.0203
Toxoplasma gondii	CAAX metallo endopeptidase	0.0071	0.1424	1
Plasmodium falciparum	protease, putative	0.004	0.0698	1
Onchocerca volvulus		0.0317	0.7084	1
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0071	0.1424	0.3381
Chlamydia trachomatis	hypothetical protein	0.004	0.0698	0.5
Echinococcus multilocularis	geminin	0.0178	0.3877	0.3877
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Echinococcus multilocularis	caax prenyl protease 1	0.0071	0.1424	0.1424
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.1378	0.3272
Brugia malayi	hypothetical protein	0.0317	0.7084	1
Mycobacterium tuberculosis	Probable integral membrane protein	0.004	0.0698	0.5139
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0203	0.0286
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.0613	0.1456
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1301	0.1301
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0277	0.0382
Schistosoma mansoni	polycystin 1-related	0.0021	0.0277	0.0277
Brugia malayi	hypothetical protein	0.0257	0.569	0.8033
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.0613	0.1456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Giardia lamblia	Hypothetical protein	0.0192	0.4211	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0065	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0257	0.569	0.8031
Schistosoma mansoni	hypothetical protein	0.0444	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1301	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0317	0.7084	1
Echinococcus granulosus	cathepsin l1	0.0018	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0326	0.0774
Echinococcus multilocularis	cysteine protease	0.0018	0.0203	0.0203
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.0613	0.3361
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0277	0.0277
Schistosoma mansoni	farnesylated-protein converting enzyme 1 (M48 family)	0.0071	0.1424	0.1424
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1301	1
Echinococcus granulosus	cathepsin l1	0.0012	0.0065	0.0065
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0989	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0277	0.0382
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0203	0.0203
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Brugia malayi	Doublecortin family protein	0.0021	0.0277	0.0391
Trypanosoma cruzi	metallo- peptidase, Clan M- Family M48	0.0071	0.1424	0.3381
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.0613	0.3361
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.1037	0.2462
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0203	0.0482
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0203	0.0286
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0502	0.0708
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0065	0.0153
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0004	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0203	0.0482
Onchocerca volvulus		0.0031	0.0502	0.0623
Schistosoma mansoni	lipoxygenase	0.0089	0.1844	0.1844
Mycobacterium ulcerans	integral membrane protein	0.004	0.0698	0.5139
Leishmania major	cathepsin L-like protease	0.0069	0.1378	0.2932
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0203	0.0203
Echinococcus multilocularis	dnaJ subfamily B	0.0444	1	1
Trypanosoma cruzi	CAAX prenyl protease 1, putative	0.0071	0.1424	0.3381
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0065	0.0091
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1301	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4211	0.5941
Echinococcus granulosus	CAAX prenyl protease 2	0.0192	0.4211	0.4211
Onchocerca volvulus		0.0018	0.0203	0.0197
Echinococcus granulosus	caax prenyl protease 1	0.0071	0.1424	0.1424
Mycobacterium leprae	CONSERVED HYPOTHETICAL TRANSMEMBRANE PROTEIN	0.0012	0.006	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0006
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1301	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Echinococcus granulosus	geminin	0.0178	0.3877	0.3877
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1306	0.1306
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0203	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Entamoeba histolytica	CAAX prenyl protease family	0.0192	0.4211	1
Mycobacterium leprae	PROBABLE PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX	0.0012	0.006	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0203	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0277	0.0382
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1301	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.1378	0.3272
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1301	0.1301
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0065	0.0091
Leishmania major	cathepsin L-like protease	0.0069	0.1378	0.2932
Onchocerca volvulus		0.0021	0.0277	0.0303
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0277	0.0277
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.569	0.569
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0203	0.0203
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0277	0.3969
Plasmodium vivax	vivapain-2	0.0018	0.0203	0.2905

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837143