TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.444 | Formula: C24H23NO3
H donors: 1 H acceptors: 2 LogP: 3.29 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=C1C(=NC2=C(C1c1ccccc1)C(=O)CC(C2)c1ccccc1)C)O
InChi: 1S/C24H23NO3/c1-15-21(24(27)28-2)22(17-11-7-4-8-12-17)23-19(25-15)13-18(14-20(23)26)16-9-5-3-6-10-16/h3-12,18,22,27H,13-14H2,1-2H3
InChiKey: CXZKCDOKELPGGO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0047	0.0119	0.6522
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0035	0.0006
Mycobacterium ulcerans	hypothetical protein	0.0035	0.007	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0035	0.007	0.0101
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0116	0.0392	0.0753
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0035	0.007	0.0171
Echinococcus granulosus	microtubule associated protein 2	0.0547	0.2111	0.4258
Loa Loa (eye worm)	hypothetical protein	0.003	0.005	0.0061
Brugia malayi	beta-lactamase family protein	0.0059	0.0165	0.0293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0113	0.038	0.0767
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0026	0.0035	0.0219
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0086	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.002	0.002
Echinococcus granulosus	expressed conserved protein	0.0066	0.0193	0.0389
Schistosoma mansoni	hypothetical protein	0.0082	0.0256	0.0516
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0377	0.1431	0.6758
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0026	0.0035	0.003
Trichomonas vaginalis	set domain proteins, putative	0.0376	0.1428	0.2835
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0026	0.0035	0.0071
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.002	0.002
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.007	0.0101
Onchocerca volvulus		0.0059	0.0165	0.0293
Echinococcus multilocularis	survival motor neuron protein 1	0.0524	0.2019	0.2019
Mycobacterium tuberculosis	Conserved protein	0.0059	0.0165	0.0655
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0035	0.007	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0119	0.0239
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0119	0.0239
Echinococcus granulosus	Niemann Pick C1 protein	0.007	0.021	0.0424
Mycobacterium tuberculosis	Conserved protein	0.0059	0.0165	0.0655
Loa Loa (eye worm)	MH2 domain-containing protein	0.0186	0.0672	0.1321
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.002	0.004
Mycobacterium ulcerans	esterase/lipase LipP	0.0059	0.0165	0.063
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0113	0.038	0.073
Brugia malayi	Latrophilin receptor protein 2	0.0037	0.0076	0.0113
Echinococcus granulosus	GPCR family 2	0.0037	0.0076	0.0153
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.4103
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0047	0.0119	0.0119
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0046	0.0112	0.0225
Echinococcus multilocularis	tumor protein p63	0.0241	0.0892	0.0892
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.002	0.004
Mycobacterium tuberculosis	Probable hydrolase	0.0059	0.0165	0.0655
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0026	0.0035	0.0071
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.007	0.021	0.0361
Schistosoma mansoni	tar DNA-binding protein	0.005	0.0129	0.0261
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0071	0.0102
Schistosoma mansoni	hypothetical protein	0.0029	0.0046	0.0092
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0035	0.007	0.0076
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0545	0.2103	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.1262	0.4957	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0059	0.0165	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0035	0.007	0.0198
Mycobacterium leprae	conserved hypothetical protein	0.0059	0.0165	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0037	0.0076	0.0153
Trichomonas vaginalis	D-aminoacylase, putative	0.0059	0.0165	0.0269
Loa Loa (eye worm)	transcription factor SMAD2	0.0186	0.0672	0.1321
Schistosoma mansoni	glycogen phosphorylase	0.0545	0.2103	0.4243
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.002	0.002
Echinococcus multilocularis	muscleblind protein	0.0221	0.0812	0.0812
Echinococcus multilocularis	microtubule associated protein 2	0.0547	0.2111	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0029
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0059	0.0165	0.0332
Chlamydia trachomatis	glycogen phosphorylase	0.1262	0.4957	1
Echinococcus granulosus	Glycosyl transferase family 35	0.1262	0.4957	1
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0545	0.2103	1
Echinococcus multilocularis	protein dispatched 1	0.0034	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0035	0.003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0119	0.02
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0059	0.0165	0.0655
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.002	0.002
Echinococcus granulosus	transcription factor btf3	0.0026	0.0032	0.0065
Entamoeba histolytica	glycogen phosphorylase, putative	0.0545	0.2103	0.4206
Echinococcus multilocularis	expressed conserved protein	0.0066	0.0193	0.0193
Onchocerca volvulus	Glycogen phosphorylase homolog	0.1262	0.4957	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0392	0.0753
Brugia malayi	beta-lactamase	0.0059	0.0165	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0812	0.1604
Loa Loa (eye worm)	hypothetical protein	0.007	0.021	0.0385
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.007	0.0101
Onchocerca volvulus		0.0107	0.0356	0.068
Schistosoma mansoni	tar DNA-binding protein	0.005	0.0129	0.0261
Brugia malayi	TAR-binding protein	0.005	0.0129	0.0221
Schistosoma mansoni	hypothetical protein	0.0037	0.0076	0.0153
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.002	0.004
Schistosoma mansoni	hypothetical protein	0.0037	0.0076	0.0153
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0035	0.007	0.0171
Brugia malayi	Pre-SET motif family protein	0.0047	0.0119	0.02
Toxoplasma gondii	LsmAD domain-containing protein	0.0039	0.0086	0.4103
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.002	0.004
Toxoplasma gondii	ABC1 family protein	0.0059	0.0165	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0119	0.0239
Loa Loa (eye worm)	glycogen phosphorylase	0.1262	0.4957	1
Schistosoma mansoni	tar DNA-binding protein	0.005	0.0129	0.0261
Schistosoma mansoni	hypothetical protein	0.0029	0.0046	0.0092
Onchocerca volvulus		0.0059	0.0165	0.0293
Brugia malayi	beta-lactamase family protein	0.0059	0.0165	0.0293
Schistosoma mansoni	hypothetical protein	0.0079	0.0245	0.0495
Schistosoma mansoni	hypothetical protein	0.0037	0.0076	0.0153
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.002	0.004
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.002	0.004
Echinococcus multilocularis	geminin	0.0134	0.0465	0.0465
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0026	0.0035	0.0006
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.007	0.0171
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.002	0.002
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0059	0.0165	0.0293
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.007	0.0171
Schistosoma mansoni	transcription factor LCR-F1	0.0082	0.0256	0.0516
Trypanosoma cruzi	hypothetical protein, conserved	0.0059	0.0165	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0059	0.0165	0.0269
Brugia malayi	Muscleblind-like protein	0.0221	0.0812	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0035	0.007	0.0101
Echinococcus granulosus	ubiquitin specific protease 41	0.0026	0.0035	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0029
Onchocerca volvulus		0.0035	0.007	0.0101
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.002	0.004
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.033	0.1246	0.2484
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0029
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0047	0.0119	0.0119
Mycobacterium ulcerans	lipase LipD	0.0059	0.0165	0.063
Schistosoma mansoni	glycogen phosphorylase	0.1262	0.4957	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0086	1
Plasmodium vivax	SET domain protein, putative	0.0047	0.0119	0.6522
Trichomonas vaginalis	esterase, putative	0.0059	0.0165	0.0269
Echinococcus multilocularis	protein patched	0.003	0.005	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.005	0.0036
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.002	0.004
Mycobacterium tuberculosis	Probable lipase LipD	0.0059	0.0165	0.0655
Echinococcus multilocularis	muscleblind protein 1	0.0221	0.0812	0.0812
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.007	0.0171
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.002	0.002
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.002	0.004
Leishmania major	hypothetical protein, conserved	0.0059	0.0165	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0059	0.0165	0.0655
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0037	0.0076	0.0076
Brugia malayi	CHE-14 protein	0.003	0.005	0.0061
Onchocerca volvulus		0.0376	0.1428	0.2852
Echinococcus multilocularis	glycogen phosphorylase	0.1262	0.4957	0.4957
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0116	0.0392	0.0753
Schistosoma mansoni	survival motor neuron protein	0.0107	0.0356	0.0718
Trichomonas vaginalis	penicillin-binding protein, putative	0.0059	0.0165	0.0269
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0082	0.0256	0.0256
Plasmodium falciparum	acyl-CoA synthetase	0.0026	0.0034	0.0411
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0059	0.0165	0.063
Plasmodium vivax	acyl-CoA synthetase, putative	0.0026	0.0034	0.0168
Schistosoma mansoni	patched 1	0.003	0.005	0.0101
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.002	0.004
Onchocerca volvulus		0.0059	0.0165	0.0293
Plasmodium vivax	hypothetical protein, conserved	0.0059	0.0165	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.002	0.004
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0037	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0524	0.2019	0.405
Echinococcus granulosus	sterol regulatory element binding protein	0.003	0.005	0.0101
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.002	0.004
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0026	0.0035	0.0071
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.033	0.0667
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0116	0.0392	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0035	0.007	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0221	0.0812	0.1604
Brugia malayi	hypothetical protein	0.0025	0.0031	0.0022
Echinococcus granulosus	muscleblind protein	0.0221	0.0812	0.1638
Mycobacterium ulcerans	hypothetical protein	0.0059	0.0165	0.063
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0035	0.007	0.0171
Echinococcus granulosus	beta LACTamase domain containing family member	0.0059	0.0165	0.0332
Entamoeba histolytica	hypothetical protein	0.0082	0.0256	0.0454
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.002	0.004
Schistosoma mansoni	hypothetical protein	0.0107	0.0356	0.0718
Entamoeba histolytica	acyl-coA synthetase, putative	0.0035	0.007	0.0076
Trichomonas vaginalis	penicillin-binding protein, putative	0.0059	0.0165	0.0269
Brugia malayi	MH2 domain containing protein	0.0186	0.0672	0.1321
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0082	0.0256	0.0516
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.007	0.0171
Loa Loa (eye worm)	TAR-binding protein	0.005	0.0129	0.0221
Echinococcus multilocularis	tar DNA binding protein	0.005	0.0129	0.0129
Schistosoma mansoni	microtubule-associated protein tau	0.0547	0.2111	0.4258
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0059	0.0165	0.0655
Brugia malayi	hypothetical protein	0.0524	0.2019	0.405
Onchocerca volvulus		0.0035	0.0071	0.0102
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0113	0.038	0.0767
Brugia malayi	latrophilin 2 splice variant baaae	0.0079	0.0245	0.0457
Echinococcus granulosus	Protein patched homolog 1	0.003	0.005	0.0101
Entamoeba histolytica	hypothetical protein	0.0082	0.0256	0.0454
Trichomonas vaginalis	glycogen phosphorylase, putative	0.1262	0.4957	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.007	0.021	0.0385
Echinococcus multilocularis	sterol regulatory element binding protein	0.003	0.005	0.005
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.002	0.004
Entamoeba histolytica	glycogen phosphorylase, putative	0.1262	0.4957	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0026	0.0035	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0076	0.0113
Plasmodium vivax	ataxin-2 like protein, putative	0.0039	0.0086	0.4103
Schistosoma mansoni	coup transcription factor	0.0023	0.002	0.004
Loa Loa (eye worm)	RNA binding protein	0.005	0.0129	0.0221
Trypanosoma brucei	hypothetical protein, conserved	0.0059	0.0165	1
Echinococcus granulosus	tar DNA binding protein	0.005	0.0129	0.0261
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0086	0.4103
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0029
Brugia malayi	RNA binding protein	0.005	0.0129	0.0221
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0113	0.038	0.0767
Mycobacterium tuberculosis	Conserved protein	0.0059	0.0165	0.0655
Echinococcus granulosus	histone lysine methyltransferase setb	0.0047	0.0119	0.0239
Echinococcus multilocularis	Glycosyl transferase, family 35	0.1262	0.4957	0.4957
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.007	0.0198
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0059	0.0165	0.0293
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0026	0.0035	0.0006
Onchocerca volvulus		0.0047	0.0119	0.02
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.002	0.004
Schistosoma mansoni	hypothetical protein	0.0134	0.0465	0.0939
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0113	0.038	0.038
Trypanosoma brucei	PAB1-binding protein , putative	0.0039	0.0086	0.4103
Echinococcus multilocularis	ubiquitin specific protease 41	0.0026	0.0035	0.0035
Echinococcus multilocularis	Niemann Pick C1 protein	0.007	0.021	0.021
Loa Loa (eye worm)	beta-lactamase	0.0059	0.0165	0.0293
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.007	0.0101
Echinococcus granulosus	tumor protein p63	0.0241	0.0892	0.1799
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.002	0.004
Brugia malayi	Pre-SET motif family protein	0.033	0.1246	0.2484
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.002	0.002
Trichomonas vaginalis	glycogen phosphorylase, putative	0.1262	0.4957	1
Brugia malayi	carbohydrate phosphorylase	0.1262	0.4957	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0135
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.002	0.002
Leishmania major	4-coumarate:coa ligase-like protein	0.0035	0.007	0.284
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0071	0.0214	0.0433
Entamoeba histolytica	glycogenphosphorylase, putative	0.0545	0.2103	0.4206
Echinococcus granulosus	geminin	0.0134	0.0465	0.0939
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0026	0.0035	0.0071
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0037	0.0076	0.0113
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0059	0.0165	0.0332
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Brugia malayi	hypothetical protein	0.0082	0.0256	0.0478
Schistosoma mansoni	cellular tumor antigen P53	0.0035	0.0071	0.0142
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0059	0.0165	0.0165
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0037	0.0076	0.0153
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.003	0.005	0.0061
Echinococcus multilocularis	transcription factor btf3	0.0026	0.0032	0.0032
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.033	0.033
Schistosoma mansoni	transcription factor btf3	0.0026	0.0032	0.0065
Entamoeba histolytica	hypothetical protein	0.0082	0.0256	0.0454
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0026	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0245	0.0457
Schistosoma mansoni	hypothetical protein	0.0134	0.0465	0.0939
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0086	0.4103
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0107	0.0356	0.068
Schistosoma mansoni	tar DNA-binding protein	0.005	0.0129	0.0261
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0026	0.0034	0.0028
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0026	0.0035	0.0035
Echinococcus multilocularis	GPCR, family 2	0.0037	0.0076	0.0076
Schistosoma mansoni	hypothetical protein	0.0029	0.0046	0.0092
Leishmania major	4-coumarate:coa ligase-like protein	0.0035	0.007	0.284
Echinococcus multilocularis	glycogen phosphorylase	0.1262	0.4957	0.4957
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0113	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0165	0.0293
Entamoeba histolytica	hypothetical protein	0.0082	0.0256	0.0454
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.002	0.004
Schistosoma mansoni	glycogen phosphorylase	0.1262	0.4957	1
Echinococcus granulosus	survival motor neuron protein 1	0.0524	0.2019	0.4074
Schistosoma mansoni	tar DNA-binding protein	0.005	0.0129	0.0261
Trichomonas vaginalis	D-aminoacylase, putative	0.0059	0.0165	0.0269
Leishmania major	4-coumarate:coa ligase-like protein	0.0035	0.007	0.284
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.005	0.0129	0.0221
Mycobacterium tuberculosis	Probable esterase LipL	0.0059	0.0165	0.0655
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0113	0.038	0.0767
Echinococcus granulosus	glycogen phosphorylase	0.1262	0.4957	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0076	0.0153
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0026	0.0035	0.0006
Mycobacterium leprae	Probable lipase LipE	0.0059	0.0165	1
Brugia malayi	beta-NAC-like protein	0.0026	0.0032	0.0024
Entamoeba histolytica	glycogen phosphorylase, putative	0.0545	0.2103	0.4206
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0113	0.038	0.0767
Brugia malayi	RNA recognition motif domain containing protein	0.005	0.0129	0.0221
Loa Loa (eye worm)	ICD-1 protein	0.0026	0.0032	0.0024
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0113	0.038	0.073
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0026	0.0035	0.0219
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0037	0.0076	0.0113
Brugia malayi	hypothetical protein	0.0039	0.0086	0.0135
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0026	0.0035	0.0219
Schistosoma mansoni	hypothetical protein	0.0029	0.0046	0.0092
Echinococcus granulosus	glycogen phosphorylase	0.1262	0.4957	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0077	0.0116
Mycobacterium ulcerans	beta-lactamase	0.0059	0.0165	0.063
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0059	0.0165	0.0655
Giardia lamblia	Glycogen phosphorylase	0.1262	0.4957	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.0119	0.0239
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.002	0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 838187