Detailed information for compound 841337

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.507 | Formula: C21H25N3O3S
  • H donors: 3 H acceptors: 0 LogP: 3.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)NC(=S)NCCc1c(C)[nH]c2c1cc(OC)cc2)OC
  • InChi: 1S/C21H25N3O3S/c1-13-16(17-11-14(25-2)5-7-18(17)23-13)9-10-22-21(28)24-19-12-15(26-3)6-8-20(19)27-4/h5-8,11-12,23H,9-10H2,1-4H3,(H2,22,24,28)
  • InChiKey: YOJZQVAEIUIPOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase HCK 0.0093 0.0866 0.0852
Brugia malayi Protein kinase domain containing protein 0.0177 0.2295 0.3263
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Brugia malayi P38 map kinase family protein 2 0.014 0.1676 0.2377
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0105 0.0155
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0065 0.039 0.2069
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0136 0.1601 0.2026
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0452 0.7 0.9008
Brugia malayi Sema domain containing protein 0.007 0.0475 0.0658
Loa Loa (eye worm) TK protein kinase 0.0093 0.0866 0.1097
Loa Loa (eye worm) hypothetical protein 0.0082 0.0684 0.0862
Echinococcus multilocularis semaphorin 5B 0.007 0.0475 0.0587
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0136 0.1601 0.2026
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Echinococcus multilocularis tyrosine kinase 0.0054 0.0205 0.0243
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1096 0.5979
Brugia malayi hypothetical protein 0.0054 0.0205 0.0272
Loa Loa (eye worm) hypothetical protein 0.0082 0.0684 0.0862
Brugia malayi Protein kinase domain containing protein 0.0177 0.2295 0.3264
Echinococcus granulosus insulin receptor 0.0258 0.369 0.368
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Loa Loa (eye worm) hypothetical protein 0.0497 0.7769 1
Brugia malayi Protein kinase domain containing protein 0.0054 0.0205 0.0272
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Schistosoma mansoni tyrosine kinase 0.0379 0.5748 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.1906 0.2438
Echinococcus multilocularis ephrin type A receptor 4 A 0.0103 0.1038 0.1306
Brugia malayi Protein kinase domain containing protein 0.0054 0.0205 0.0272
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1676 0.2121
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.2678 0.4644
Echinococcus multilocularis roundabout 2 0.0046 0.0074 0.0075
Echinococcus multilocularis Immunoglobulin 0.0064 0.0371 0.0454
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0522 0.0647
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0235 0.0283
Onchocerca volvulus 0.007 0.0475 0.1589
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0078 0.0609 0.0595
Trichomonas vaginalis AGC family protein kinase 0.0065 0.039 0.1992
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0177 0.2295 0.7677
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0235 0.0283
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0177 0.2295 0.2939
Echinococcus granulosus twitchin 0.0082 0.0687 0.0672
Onchocerca volvulus 0.0054 0.0205 0.0687
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.014 0.1676 1
Brugia malayi Protein kinase domain containing protein 0.0258 0.369 0.526
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Schistosoma mansoni nephrin 0.0096 0.0926 0.1587
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0277 0.4002 0.3993
Entamoeba histolytica protein kinase, putative 0.0093 0.0866 0.7419
Echinococcus granulosus Immunoglobulin 0.0064 0.0371 0.0356
Onchocerca volvulus 0.0154 0.1906 0.6377
Schistosoma mansoni tyrosine kinase 0.0198 0.2659 0.4612
Echinococcus granulosus tyrosine kinase 0.0054 0.0205 0.019
Loa Loa (eye worm) AUR protein kinase 0.0065 0.039 0.0483
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0074 0.0075
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0502 0.7843 1
Onchocerca volvulus 0.0056 0.0242 0.0809
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Schistosoma mansoni cell adhesion molecule 0.0046 0.0074 0.0102
Schistosoma mansoni tyrosine kinase 0.0274 0.3965 0.6889
Brugia malayi hypothetical protein 0.0082 0.0684 0.0957
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0074 0.0058
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0065 0.039 0.2069
Schistosoma mansoni vesicular amine transporter 0.0064 0.0371 0.062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0684 0.0957
Brugia malayi ephrin receptor 1 precursor 0.0058 0.0263 0.0355
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.1096 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0054 0.0205 0.0245
Trichomonas vaginalis AGC family protein kinase 0.0065 0.039 0.1992
Echinococcus granulosus tyrosine protein kinase Src64B 0.0136 0.1601 0.1588
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.039 0.0375
Schistosoma mansoni tyrosine kinase 0.0258 0.369 0.6409
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0136 0.1601 0.2026
Toxoplasma gondii aurora kinase 0.0065 0.039 1
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0199 0.2678 0.3401
Loa Loa (eye worm) AUR protein kinase 0.0065 0.039 0.0483
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0199 0.2678 0.3433
Loa Loa (eye worm) hypothetical protein 0.0064 0.0375 0.0464
Echinococcus multilocularis tyrosine protein kinase Srms 0.0117 0.1284 0.1621
Giardia lamblia Aurora kinase 0.0065 0.039 0.1796
Echinococcus multilocularis epidermal growth factor receptor 0.0379 0.5748 0.7324
Entamoeba histolytica protein kinase, putative 0.0056 0.0235 0.0333
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.039 0.1074
Echinococcus granulosus contactin 0.007 0.048 0.0465
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.1096 0.1381
Schistosoma mansoni tyrosine kinase 0.0136 0.1601 0.2766
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.014 0.1676 1
Echinococcus multilocularis hemicentin 1 0.0052 0.0167 0.0194
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0044 0.0029 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.1601 0.1588
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.039 0.0536
Schistosoma mansoni tyrosine kinase 0.0304 0.4472 0.7773
Echinococcus granulosus mitogen activated protein kinase 14 0.014 0.1676 0.1663
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.0235 0.0281
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.1096 0.3669
Brugia malayi intracellular kinase 0.0056 0.0235 0.0314
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0065 0.039 0.2069
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0054 0.0205 0.0243
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.1096 0.1548
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.039 1
Onchocerca volvulus 0.0054 0.0205 0.0687
Echinococcus granulosus semaphorin 5B 0.007 0.0475 0.046
Echinococcus multilocularis insulin receptor 0.0258 0.369 0.4694
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.039 0.0653
Echinococcus multilocularis neuroglian 0.0046 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0684 0.0862
Schistosoma mansoni tyrosine kinase 0.0073 0.0522 0.0884
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.039 1
Onchocerca volvulus Tyrosine kinase homolog 0.0217 0.2989 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0199 0.2678 0.2666
Entamoeba histolytica protein kinase, putative 0.0065 0.039 0.2069
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0054 0.0205 0.019
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0074 0.0084
Echinococcus granulosus protein kinase shaggy 0.0056 0.0235 0.022
Echinococcus granulosus tyrosine protein kinase Srms 0.0054 0.0205 0.019
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Brugia malayi Protein kinase domain containing protein 0.0054 0.0205 0.0272
Loa Loa (eye worm) sema domain-containing protein 0.007 0.0475 0.0592
Echinococcus granulosus neuroglian 0.0046 0.0074 0.0058
Echinococcus multilocularis tyrosine protein kinase Blk 0.0117 0.1284 0.1621
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1676 0.2121
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0235 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Echinococcus multilocularis aurora kinase A 0.0065 0.039 0.0478
Loa Loa (eye worm) TK/INSR protein kinase 0.0258 0.369 0.4739
Loa Loa (eye worm) AUR protein kinase 0.0065 0.039 0.0483
Echinococcus multilocularis roundabout 2 0.0046 0.0074 0.0075
Schistosoma mansoni protein kinase 0.0177 0.2295 0.3977
Echinococcus multilocularis Immunoglobulin 0.0064 0.0371 0.0454
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0177 0.2295 0.2912
Loa Loa (eye worm) TK protein kinase 0.0044 0.0029 0.0018
Echinococcus granulosus semaphorin 1A 0.007 0.0475 0.046
Onchocerca volvulus 0.015 0.1834 0.6136
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0136 0.1601 0.1588
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Brugia malayi Fibronectin type III domain containing protein 0.0082 0.0684 0.0957
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0217 0.2976 0.2965
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.1601 0.2026
Entamoeba histolytica tyrosin kinase, putative 0.006 0.0311 0.1183
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.1096 0.5979
Onchocerca volvulus 0.0054 0.0205 0.0687
Trypanosoma brucei polo-like protein kinase 0.0106 0.1096 0.5979
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.1601 0.1588
Brugia malayi serine/threonine kinase 12 0.0065 0.039 0.0536
Schistosoma mansoni tyrosine kinase 0.0258 0.369 0.6409
Loa Loa (eye worm) hypothetical protein 0.0077 0.0601 0.0756
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0136 0.1601 0.2026
Brugia malayi plexin A 0.0184 0.2429 0.3456
Brugia malayi Immunoglobulin I-set domain containing protein 0.0257 0.3669 0.5231
Echinococcus granulosus roundabout 2 0.011 0.1164 0.115
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0029 0.002
Brugia malayi SRC-1 0.0136 0.1601 0.227
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0522 0.0508
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0277 0.4002 0.5093
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0522 0.0726
Echinococcus multilocularis neuroglian 0.0078 0.0613 0.0763
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0235 0.0333
Leishmania major protein kinase, putative 0.0065 0.039 0.1074
Schistosoma mansoni plexin 0.0084 0.0712 0.1215
Loa Loa (eye worm) TK/EGFR protein kinase 0.0379 0.5748 0.7393
Loa Loa (eye worm) hypothetical protein 0.0084 0.0712 0.0898
Schistosoma mansoni plexin 0.0154 0.1906 0.3298
Schistosoma mansoni ephrin receptor 0.0089 0.0797 0.1364
Schistosoma mansoni cell adhesion molecule 0.0046 0.0074 0.0102
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0136 0.1601 0.2026
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0051 0.0148 0.0171
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0069
Schistosoma mansoni neuroglian 0.0046 0.0074 0.0102
Loa Loa (eye worm) hypothetical protein 0.0064 0.0371 0.0458
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.014 0.1675 0.1662
Brugia malayi Protein kinase domain containing protein 0.0107 0.1108 0.1565
Brugia malayi SH2 domain containing protein 0.0054 0.0205 0.0272
Brugia malayi protein-tyrosine kinase 0.0117 0.1284 0.1816
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Onchocerca volvulus 0.0059 0.029 0.0971
Echinococcus granulosus mitogen activated protein kinase 11 0.014 0.1676 0.1663
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0046 0.0074 0.0075
Echinococcus granulosus plexin a4 0.0184 0.2429 0.2417
Echinococcus granulosus tyrosine protein kinase Blk 0.0117 0.1284 0.1271
Echinococcus granulosus roundabout 2 0.0046 0.0074 0.0058
Echinococcus multilocularis hypothetical protein 0.007 0.0475 0.0587
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0074 0.0084
Brugia malayi Plexin repeat family protein 0.0154 0.1906 0.2707
Echinococcus granulosus aurora kinase A 0.0065 0.039 0.0375
Echinococcus granulosus tyrosine protein kinase Src42A 0.0136 0.1601 0.1588
Brugia malayi Protein kinase domain containing protein 0.0452 0.7 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0136 0.1601 0.2026
Schistosoma mansoni hypothetical protein 0.0056 0.0242 0.0395
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.1601 0.1588
Echinococcus multilocularis tyrosine protein kinase shark 0.0054 0.0205 0.0243
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0177 0.2295 0.294
Echinococcus multilocularis protein kinase shaggy 0.0056 0.0235 0.0281
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0205 0.0245
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1676 0.2121
Schistosoma mansoni tyrosine kinase 0.0054 0.0205 0.0331
Onchocerca volvulus 0.0056 0.0235 0.0787
Onchocerca volvulus 0.0054 0.0205 0.0687
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Loa Loa (eye worm) TK/EPH protein kinase 0.0105 0.1074 0.1365
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0064 0.0371 0.0454
Schistosoma mansoni nephrin 0.0046 0.0074 0.0102
Giardia lamblia Kinase, PLK 0.0106 0.1096 1
Echinococcus multilocularis 0.0194 0.2586 0.3284
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0117 0.1284 0.1271
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0522 0.0884
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0117 0.1284 0.1621
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0064 0.0371 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.2295 0.3976
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.0235 0.0383
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1096 1
Echinococcus multilocularis roundabout 2 0.011 0.1164 0.1467
Echinococcus multilocularis tyrosine protein kinase HCK 0.0093 0.0866 0.1087
Echinococcus multilocularis plexin a4 0.0184 0.2429 0.3083
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0235 0.0239
Schistosoma mansoni hypothetical protein 0.007 0.0475 0.0801
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0304 0.4472 0.4463
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0235 0.0239
Echinococcus granulosus roundabout 2 0.0046 0.0074 0.0058
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0217 0.2976 0.3782
Entamoeba histolytica protein kinase , putative 0.0065 0.039 0.2069
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.1601 0.2026
Loa Loa (eye worm) plexin A 0.0184 0.2429 0.3113
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1096 0.5979
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.1096 0.1394
Onchocerca volvulus 0.0054 0.0205 0.0687
Schistosoma mansoni cell adhesion molecule 0.0096 0.0922 0.1582
Trichomonas vaginalis AGC family protein kinase 0.0065 0.039 0.1992
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.0235 0.022
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0054 0.0205 0.0243
Brugia malayi serine/threonine protein kinase 6 0.0065 0.039 0.0536
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.1601 0.2026
Loa Loa (eye worm) TK/FER protein kinase 0.0054 0.0205 0.0245
Echinococcus granulosus tyrosine protein kinase shark 0.0054 0.0205 0.019
Schistosoma mansoni tyrosine kinase 0.0274 0.3965 0.6889
Schistosoma mansoni tyrosine kinase 0.0058 0.0268 0.044
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.039 0.0478
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.039 0.2069
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0257 0.3669 0.4712
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0074 0.0075
Echinococcus granulosus epidermal growth factor receptor 0.0304 0.4472 0.4463
Brugia malayi SH2 domain containing protein 0.0054 0.0205 0.0272
Brugia malayi Sema domain containing protein 0.007 0.0475 0.0658
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1096 0.1886
Echinococcus granulosus ephrin type A receptor 4 A 0.0103 0.1038 0.1024
Schistosoma mansoni tyrosine kinase 0.0073 0.0522 0.0884
Loa Loa (eye worm) TK/ROR protein kinase 0.0044 0.0029 0.0018
Brugia malayi Furin-like cysteine rich region family protein 0.0379 0.5748 0.8208
Loa Loa (eye worm) hypothetical protein 0.0064 0.0371 0.0458
Schistosoma mansoni tyrosine kinase 0.0274 0.3965 0.6889
Brugia malayi Protein kinase domain containing protein 0.0054 0.0205 0.0272
Loa Loa (eye worm) hypothetical protein 0.0059 0.029 0.0354
Schistosoma mansoni tyrosine kinase 0.0136 0.1601 0.2766
Brugia malayi hypothetical protein 0.007 0.0475 0.0658
Loa Loa (eye worm) TK protein kinase 0.0117 0.1284 0.1636
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0044 0.0029 0.0014
Schistosoma mansoni semaphorin 5-related 0.007 0.0475 0.0801
Schistosoma mansoni hypothetical protein 0.0084 0.0712 0.1215
Schistosoma mansoni tyrosine kinase 0.0304 0.4472 0.7773
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0088 0.0777 0.0973
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0177 0.2295 0.2283
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0136 0.1601 0.1588
Brugia malayi map kinase activated protein kinase protein 2 0.0199 0.2678 0.3811
Loa Loa (eye worm) sema domain-containing protein 0.007 0.0475 0.0592
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0177 0.2295 0.2939
Schistosoma mansoni kinase 0.0056 0.0237 0.0387
Schistosoma mansoni hypothetical protein 0.007 0.0475 0.0801
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0075
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0074 0.0075
Echinococcus multilocularis epidermal growth factor receptor 0.0304 0.4472 0.5693
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.014 0.1676 0.2141
Onchocerca volvulus 0.0054 0.0205 0.0687
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0046 0.0074 0.0075
Echinococcus granulosus tyrosine protein kinase Src42A 0.0088 0.0777 0.0763
Echinococcus granulosus tyrosine kinase 0.0117 0.1284 0.1271
Echinococcus granulosus hemicentin 1 0.0052 0.0167 0.0152
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0502 0.7843 0.784
Echinococcus granulosus tyrosine protein kinase ABL1 0.0054 0.0205 0.019
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0522 0.0647
Loa Loa (eye worm) hypothetical protein 0.0092 0.0851 0.1078
Loa Loa (eye worm) hypothetical protein 0.0078 0.0609 0.0766
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1676 0.2121
Brugia malayi Protein kinase domain containing protein 0.0054 0.0205 0.0272
Brugia malayi hypothetical protein 0.007 0.0475 0.0658
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0177 0.2295 0.3263
Schistosoma mansoni titin 0.0052 0.0167 0.0265
Loa Loa (eye worm) hypothetical protein 0.0116 0.1258 0.1602
Echinococcus granulosus epidermal growth factor receptor 0.0379 0.5748 0.5742
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.0592
Schistosoma mansoni ephrin receptor 0.0048 0.0101 0.0148
Trypanosoma brucei aurora B kinase 0.0065 0.039 0.1074
Entamoeba histolytica protein kinase, putative 0.0065 0.039 0.2069
Loa Loa (eye worm) SRC-1 0.0136 0.1601 0.2045
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1676 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0074 0.0102
Schistosoma mansoni protein kinase 0.0065 0.039 0.0653
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0064 0.0371 0.062
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0052 0.0167 0.056
Echinococcus granulosus neuroglian 0.0078 0.0613 0.0598
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0311 0.1183
Echinococcus granulosus defective proboscis extension response 0.0064 0.0371 0.0356
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.1096 0.1083
Trichomonas vaginalis AGC family protein kinase 0.0065 0.039 0.1992
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0074 0.0084

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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