TDR Targets

Basic information

Technical information

TDR Targets ID: 841688
Name: ethyl 2-[[1-(4-ethoxyphenyl)-4-oxopyridazine- 3-carbonyl]amino]-4,5,6,7-tetrahydro-1-benzot hiophene-3-carboxylate
MW: 467.537 | Formula: C24H25N3O5S
H donors: 1 H acceptors: 3 LogP: 5.18 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)n1ccc(=O)c(n1)C(=O)Nc1sc2c(c1C(=O)OCC)CCCC2
InChi: 1S/C24H25N3O5S/c1-3-31-16-11-9-15(10-12-16)27-14-13-18(28)21(26-27)22(29)25-23-20(24(30)32-4-2)17-7-5-6-8-19(17)33-23/h9-14H,3-8H2,1-2H3,(H,25,29)
InChiKey: TUEFUWRRNARZQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[[1-(4-ethoxyphenyl)-4-oxo-pyridazine-3-carbonyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
2-[[[1-(4-ethoxyphenyl)-4-oxo-3-pyridazinyl]-oxomethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
2-[[1-(4-ethoxyphenyl)-4-keto-pyridazine-3-carbonyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
ethyl 2-[[1-(4-ethoxyphenyl)-4-oxo-pyridazin-3-yl]carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0131	0.0181
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.0049	0.0031
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0295	0.0444
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.0049	0.0031
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0295	0.0444
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0095	0.1182	0.1864
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0295	0.0903
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0131	0.0181
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0049	0.0079
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0295	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Schistosoma mansoni	hypothetical protein	0.003	0.0211	0.0193
Loa Loa (eye worm)	calpain family protein 1	0.0045	0.0433	0.0664
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0024	0.0526
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0701	0.0684
Trichomonas vaginalis	esterase, putative	0.0036	0.0295	1
Echinococcus multilocularis	hypothetical protein	0.0019	0.0046	0.0028
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.003	0.0211	0.0193
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0113	0.0326
Onchocerca volvulus		0.0036	0.0295	0.0681
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0741	0.1183
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0328	0.0311
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0017	0.0018	0.5
Brugia malayi	beta-lactamase family protein	0.0036	0.0295	0.0472
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.0086	0.0068
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0295	0.0472
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0295	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0295	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0295	0.0903
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0295	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0152
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.003	0.0211	0.0193
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0701	0.0684
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.018
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0295	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0295	0.0444
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.0049	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.0049	0.005
Toxoplasma gondii	ABC1 family protein	0.0036	0.0295	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.001
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.0049	0.0031
Schistosoma mansoni	hypothetical protein	0.003	0.0211	0.0193
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0295	1
Brugia malayi	hypothetical protein	0.0025	0.0131	0.0209
Brugia malayi	steroid hormone receptor	0.0019	0.0049	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Echinococcus granulosus	calpain 5	0.0019	0.0046	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.0049	0.005
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0435	0.6263	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.0049	0.0079
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0046	0.0044
Brugia malayi	TAR-binding protein	0.0063	0.0701	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.0049	0.0079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.0049	0.005
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0049	0.0079
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Leishmania major	C-8 sterol isomerase-like protein	0.0435	0.6263	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0295	0.0278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.0049	0.0031
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0049	0.0031
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.0049	0.0031
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0067	0.0766	0.0749
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0295	0.0903
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0067	0.0766	0.0749
Brugia malayi	calpain family protein 1	0.0064	0.0717	0.1145
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0024	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0433	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0717	0.1119
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Brugia malayi	calpain family protein 1	0.0064	0.0717	0.1145
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.0049	0.0031
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0152
Trypanosoma brucei	kinesin, putative	0.0019	0.0046	0.0044
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0152
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0095	0.1182	0.1887
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1182	0.1864
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0113	0.3421
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.001
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0295	0.0903
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0017	0.0018	0.0027
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0701	0.0684
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0019	0.0046	0.0381
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0295	0.0903
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0701	0.1094
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0049	0.0079
Echinococcus granulosus	GPCR family 2	0.003	0.0211	0.0193
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0295	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.0049	0.0031
Onchocerca volvulus		0.0024	0.0113	0.0176
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0113	0.3421
Echinococcus multilocularis	calpain family protein 1, d	0.0045	0.0433	0.0415
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0131	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0131	0.4071
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0741	0.0724
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0435	0.6263	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0019	0.0046	0.0044
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0046	0.0028
Echinococcus multilocularis	calpain	0.0019	0.0046	0.0028
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0131	0.4071
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0701	0.0684
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.0049	0.0031
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0295	0.0278
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0741	0.1157
Schistosoma mansoni	hypothetical protein	0.0065	0.0732	0.0716
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0295	0.0278
Echinococcus multilocularis	GPCR, family 2	0.003	0.0211	0.0193
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.018
Onchocerca volvulus		0.0036	0.0295	0.0681
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.0049	0.0031
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0095	0.1182	0.1887
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0131	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.0049	0.0079
Plasmodium vivax	calpain, putative	0.0019	0.0046	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0049	0.0031
Trypanosoma cruzi	kinesin, putative	0.0019	0.0046	0.0044
Onchocerca volvulus		0.0045	0.0433	0.106
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Leishmania major	kinesin, putative	0.0019	0.0046	0.0044
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0049	0.0031
Echinococcus multilocularis	calpain A	0.0067	0.0766	0.0749
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.003	0.0211	0.0193
Loa Loa (eye worm)	calpain family protein 1	0.0064	0.0717	0.1119
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0261	0.3665	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0295	0.0903
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0046	0.0044
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.003	0.0211	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0131	0.0181
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0295	0.0444
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0024	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.3421
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.0049	0.005
Loa Loa (eye worm)	calpain	0.0019	0.0046	0.0044
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.003	0.0211	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0152
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0046	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0295	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0046	0.0028
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0261	0.3665	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0049	0.0031
Brugia malayi	Latrophilin receptor protein 2	0.003	0.0211	0.0337
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0701	0.0684
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0049	0.0079
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0741	1
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.0049	0.005
Echinococcus granulosus	calpain	0.0019	0.0046	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0113	0.3421
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0701	0.0684
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.0049	0.0079
Brugia malayi	calpain 5	0.0019	0.0046	0.0073
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0295	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0295	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0741	0.1157
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0113	0.1313
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0113	0.0326
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0295	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0295	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0067	0.0766	0.0749
Brugia malayi	ecdysteroid receptor	0.0019	0.0049	0.0079
Trypanosoma cruzi	kinesin, putative	0.0019	0.0046	0.0044
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0049	0.0031
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.003	0.0211	0.0193
Brugia malayi	beta-lactamase	0.0036	0.0295	0.0472
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0741	0.1157
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0113	0.1313
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.0049	0.0031
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.3174	1
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0261	0.3665	0.5852
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.3421
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0046	0.0028
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0152
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0046	0.0044
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0295	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.3421
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0295	0.0278
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0295	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.001
Schistosoma mansoni	hypothetical protein	0.003	0.0211	0.0193
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0064	0.0717	0.07
Brugia malayi	beta-lactamase family protein	0.0036	0.0295	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0049	0.0079
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.0049	0.0031
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0261	0.3665	0.584
Schistosoma mansoni	microtubule-associated protein tau	0.0685	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.0049	0.0031
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0328	0.0311
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0741	0.0724
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.0049	0.005
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0701	0.1094
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0017	0.0018	0.5
Leishmania major	hypothetical protein, conserved	0.0025	0.0131	0.0181
Brugia malayi	RNA binding protein	0.0063	0.0701	0.112
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.0049	0.0031
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0067	0.0766	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0732	0.1144
Brugia malayi	calpain 7	0.0019	0.0046	0.0073
Mycobacterium ulcerans	lipase LipD	0.0036	0.0295	1
Entamoeba histolytica	protein kinase, putative	0.0019	0.0046	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0717	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0435	0.6263	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0295	0.0903
Leishmania major	hypothetical protein, conserved	0.0036	0.0295	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0433	0.0664
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0741	0.1157
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0113	0.3421
Echinococcus granulosus	calpain A	0.0067	0.0766	0.0749
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.0049	0.0031
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0049	0.0079
Trypanosoma brucei	antigen, putative	0.0019	0.0046	0.0044
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0741	0.0724
Echinococcus granulosus	vesicular acetylcholine transporter	0.0261	0.3665	0.3653
Schistosoma mansoni	coup transcription factor	0.0019	0.0049	0.0031
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0435	0.6263	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0046	0.0044
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.0049	0.0031
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0024	0.0214
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0701	0.112
Brugia malayi	exodeoxyribonuclease III family protein	0.0017	0.0018	0.0029
Brugia malayi	latrophilin 2 splice variant baaae	0.0065	0.0732	0.1169
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0046	0.0028
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0701	0.0684
Schistosoma mansoni	vesicular acetylcholine transporter	0.0261	0.3665	0.3653
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0024	0.0045
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0701	0.1094
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.0086	0.0068
Loa Loa (eye worm)	calpain 5	0.0019	0.0046	0.0044
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.0049	0.0079
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.0049	0.0031
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.0049	0.0079
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0295	0.0903
Echinococcus multilocularis	microtubule associated protein 2	0.0685	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0049	0.0079
Loa Loa (eye worm)	latrophilin receptor protein 2	0.003	0.0211	0.0308
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.0049	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0049	0.005
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0131	1
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.0049	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0049	0.0031
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0049	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0049	0.0079
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.0049	0.005
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0741	0.1157
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.0049	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.0049	0.0079
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0046	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.0049	0.0079
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0019	0.0046	0.0044
Brugia malayi	nuclear hormone receptor	0.0019	0.0049	0.0079
Echinococcus granulosus	calpain A	0.0019	0.0046	0.0028
Echinococcus multilocularis	calpain 5	0.0019	0.0046	0.0028
Onchocerca volvulus		0.0036	0.0295	0.0681
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0295	1
Schistosoma mansoni	hypothetical protein	0.003	0.0211	0.0193
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0017	0.0018	0.5
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0113	0.3421
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.0049	0.0031
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0113	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3084	0.491

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 841688