TDR Targets

Basic information

Technical information

TDR Targets ID: 843024
Name: ethyl 2-[(7-chloro-5,5-dioxo4H-thieno[4,5-c]t hiochromene-2-carbonyl)amino]benzoate
MW: 461.938 | Formula: C21H16ClNO5S2
H donors: 1 H acceptors: 4 LogP: 4.64 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccccc1NC(=O)c1cc2c(s1)c1ccc(cc1S(=O)(=O)C2)Cl
InChi: 1S/C21H16ClNO5S2/c1-2-28-21(25)14-5-3-4-6-16(14)23-20(24)17-9-12-11-30(26,27)18-10-13(22)7-8-15(18)19(12)29-17/h3-10H,2,11H2,1H3,(H,23,24)
InChiKey: IMXZSFYRBJNAMF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[(7-chloro-5,5-dioxo-4H-thieno[4,5-c]thiochromene-2-carbonyl)amino]benzoate
2-[[(7-chloro-5,5-dioxo-4H-thieno[4,5-c]thiochromen-2-yl)-oxomethyl]amino]benzoic acid ethyl ester
2-[(7-chloro-5,5-diketo-4H-thieno[4,5-c]thiochromene-2-carbonyl)amino]benzoic acid ethyl ester
ethyl 2-[(7-chloro-5,5-dioxo-4H-thieno[4,5-c]thiochromen-2-yl)carbonylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0487	0.0903
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0171	0.0171
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0264	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0444	0.1684
Schistosoma mansoni	protein kinase	0.0031	0.0487	0.0639
Brugia malayi	Cam kinase protein 1	0.0031	0.0487	0.1846
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1064	0.4034
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0475	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0444	0.1684
Echinococcus granulosus	solute carrier family 22	0.0014	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0475	0.1801
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0072	0.1257	0.1649
Brugia malayi	jmjC domain containing protein	0.007	0.1226	0.4648
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0451	0.0451
Leishmania major	hypothetical protein, conserved	0.003	0.0469	0.8205
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.0255	0.0335
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0006	0.001	0.0036
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0487	0.0597
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1064	0.1064
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Brugia malayi	hypothetical protein	0.0042	0.0688	0.2608
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0104	0.2978
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0171	0.0171
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0475	0.2583
Echinococcus multilocularis	glycyl tRNA synthetase	0.0006	0.001	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0494	0.269
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0688	0.0688
Entamoeba histolytica	hypothetical protein	0.0042	0.0688	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0328	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.057	0.0701
Plasmodium vivax	hexose transporter	0.0101	0.1812	0.2253
Brugia malayi	glycyl-tRNA synthetase	0.0006	0.001	0.0036
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Echinococcus granulosus	solute carrier family 22	0.0014	0.0171	0.0171
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0328	1
Schistosoma mansoni	glucose transport protein	0.0101	0.1812	0.2378
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0639	1
Onchocerca volvulus		0.0029	0.0444	0.4113
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0171	0.0647
Entamoeba histolytica	hypothetical protein	0.0042	0.0688	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0475	0.1801
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0475	0.7391
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0171	0.0224
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0255	0.0967
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Schistosoma mansoni	hypothetical protein	0.0408	0.7621	1
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0019	0.0255	0.0307
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0487	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0171	0.6328
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0328	0.0603
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0255	0.0967
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0171	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0328	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.0255	0.0255
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0171	0.0171
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0475	0.0623
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0171	0.0647
Plasmodium falciparum	protein kinase 7	0.0285	0.5298	0.6612
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0706	0.1318
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0639	0.9288
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0255	0.0967
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1064	0.4034
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0006	0.001	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0494	0.8651
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0171	0.0171
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0706	0.0706
Brugia malayi	major facilitator superfamily protein	0.0014	0.0171	0.0647
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1052	0.138
Loa Loa (eye worm)	sugar transporter	0.0101	0.1812	0.6871
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0328	0.0328
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0104	0.2978
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0286	0.0286
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0037	0.0037
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0328	0.0399
Schistosoma mansoni	hypothetical protein	0.0101	0.1812	0.2378
Echinococcus granulosus	neuropeptide receptor A26	0.0534	1	1
Brugia malayi	hypothetical protein	0.003	0.0469	0.178
Echinococcus granulosus	solute carrier family 22	0.0014	0.0171	0.0171
Echinococcus granulosus	geminin	0.0397	0.7416	0.7416
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.0255	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0255	0.0967
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0494	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0494	0.269
Schistosoma mansoni	hypothetical protein	0.0013	0.0157	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0016	0.02	0.0757
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Brugia malayi	jmjC domain containing protein	0.0019	0.0255	0.0967
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0328	0.6849
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.0255	0.0255
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.02	0.02
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0171	0.0894
Schistosoma mansoni	hypothetical protein	0.0397	0.7416	0.9731
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1064	0.1064
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0171	0.0647
Brugia malayi	Sugar transporter family protein	0.0101	0.1812	0.6871
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0494	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0171	0.0647
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0639	0.0787
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0012	0.0137	0.0521
Echinococcus granulosus	GPCR family 2	0.0016	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Trypanosoma cruzi	hexose transporter	0.0031	0.0494	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0328	0.1245
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0487	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Plasmodium falciparum	protein kinase 6	0.0429	0.8008	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0328	0.5689
Plasmodium falciparum	hexose transporter	0.0101	0.1812	0.2253
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.007	0.1226	0.1226
Entamoeba histolytica	hypothetical protein	0.0042	0.0688	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0487	0.0597
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0255	0.4381
Onchocerca volvulus		0.0049	0.0835	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus granulosus	cpg binding protein	0.003	0.0475	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0171	1
Loa Loa (eye worm)	sugar transporter	0.0014	0.0171	0.0647
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0276	0.1477
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0706	0.3866
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0163	0.2988	0.3724
Schistosoma mansoni	sugar transporter	0.0014	0.0171	0.0224
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0487	0.1846
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0171	0.5052
Echinococcus multilocularis	neuropeptide s receptor	0.0534	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0688	0.0688
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Plasmodium vivax	JmjC domain containing protein	0.0019	0.0255	0.0307
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0487	0.0903
Schistosoma mansoni	cpg binding protein	0.003	0.0475	0.0623
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Schistosoma mansoni	hypothetical protein	0.0016	0.02	0.0262
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0469	0.8205
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0835	0.3168
Brugia malayi	hypothetical protein	0.0014	0.0171	0.0647
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0328	0.5689
Loa Loa (eye worm)	acetyltransferase	0.0145	0.2637	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0171	0.0171
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0286	0.0286
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0494	0.8651
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0487	0.0597
Brugia malayi	hypothetical protein	0.0014	0.0171	0.0647
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.007	0.0265
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0328	0.0431
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0494	0.269
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0487	0.0597
Schistosoma mansoni	sugar transporter	0.0014	0.0171	0.0224
Leishmania major	glucose transporter, lmgt1	0.0031	0.0494	0.8651
Schistosoma mansoni	glucose transport protein	0.0101	0.1812	0.2378
Schistosoma mansoni	hypothetical protein	0.0397	0.7416	0.9731
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0469	0.0575
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0171	0.0171
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0429	0.8008	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0843	0.3196
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.057	0.106
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.02	0.02
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0475	0.0623
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1064	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0036
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0226	0.386
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0487	0.0903
Schistosoma mansoni	sugar transporter	0.0014	0.0171	0.0224
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0171	0.0647
Brugia malayi	jmjC domain containing protein	0.0019	0.0255	0.0967
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0469	0.8205
Echinococcus multilocularis	General substrate transporter	0.0087	0.1543	0.1543
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0328	0.5689
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0157	0.0157
Schistosoma mansoni	cpg binding protein	0.0029	0.0444	0.0583
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0545	0.2067
Trichomonas vaginalis	helicase, putative	0.0006	0.0025	0.0085
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.02	0.0757
Schistosoma mansoni	hypothetical protein	0.0034	0.0545	0.0715
Mycobacterium ulcerans	sugar transporter	0.0014	0.0171	0.5052
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.178
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0368	0.1394
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0494	0.8651
Leishmania major	glucose transporter, lmgt2	0.0031	0.0494	0.8651
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0264	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.0255	0.0335
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0163	0.2988	0.5632
Schistosoma mansoni	hypothetical protein	0.0042	0.0688	0.0902
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0706	0.0871
Brugia malayi	Sugar transporter family protein	0.0014	0.0171	0.0647
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0487	0.1846
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0006	0.001	0.0036
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0469	0.0575
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.057	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Entamoeba histolytica	protein kinase, putative	0.0031	0.0487	0.7039
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0157	0.0157
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.007	0.007
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0171	0.0305
Giardia lamblia	Sugar-proton symporter	0.0014	0.0171	0.2558
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Schistosoma mansoni	protein kinase	0.0031	0.0487	0.0639
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0171	0.6328
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0487	0.0597
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0171	0.2874
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0006	0.001	0.0036
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.0255	0.0335
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0019	0.0255	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0545	0.2067
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1064	0.4034
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0475	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0019	0.0255	0.0464
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0006	0.001	0.001
Schistosoma mansoni	sugar transporter	0.0014	0.0171	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0328	1
Brugia malayi	major facilitator superfamily protein	0.0014	0.0171	0.0647
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0255	0.0967
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0171	0.5052
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0475	0.0475
Leishmania major	hypothetical protein, conserved	0.0019	0.0255	0.4381
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0255	0.4381
Schistosoma mansoni	jumonji domain containing protein	0.007	0.1226	0.1609
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0328	0.5062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.02	0.0757
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0487	0.8517
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0706	0.3866
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.0255	0.0255
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0487	0.0639
Leishmania major	glucose transporter, lmgt3	0.0031	0.0494	0.8651
Echinococcus granulosus	General substrate transporter	0.0087	0.1543	0.1543
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.2561	0.2561
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.007	0.1226	0.1226
Loa Loa (eye worm)	hypothetical protein	0.003	0.0475	0.1801
Echinococcus multilocularis	lysine specific demethylase 5A	0.007	0.1226	0.1226
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0171	0.0171
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0494	0.269
Brugia malayi	jmjC domain containing protein	0.0019	0.0255	0.0967
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0171	0.0305
Loa Loa (eye worm)	hypothetical protein	0.003	0.0475	0.1801
Entamoeba histolytica	hypothetical protein	0.0023	0.0328	0.4702
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1812	1
Echinococcus granulosus	phd:f box containing protein	0.0019	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0068	0.0256
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0494	0.269
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1064	0.1396
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0843	0.3196
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0451	0.0451
Giardia lamblia	Hexose transporter	0.0014	0.0171	0.2558
Leishmania major	hypothetical protein, conserved	0.0014	0.0171	0.2874
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Schistosoma mansoni	hypothetical protein	0.0016	0.02	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0171	0.0171
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.02	0.0757
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.0255	0.0335
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.1812	0.1812
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0487	0.2648
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.057	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.057	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0706	0.1318
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.057	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0487	0.1846
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.1812	0.3408
Brugia malayi	TAR-binding protein	0.0061	0.1064	0.4034
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0171	0.2874
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0328	0.1245
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0469	0.087
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.0255	0.0335
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0145	0.2637	0.3461
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0171	0.0894
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0843	0.3196
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0171	0.0171
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0025	0.0085
Entamoeba histolytica	hypothetical protein	0.0042	0.0688	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0688	0.0902
Echinococcus granulosus	glycyl tRNA synthetase	0.0006	0.001	0.001
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0163	0.2988	0.3724
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0171	0.0305
Brugia malayi	acetyltransferase, GNAT family protein	0.0145	0.2637	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0171	0.2874
Brugia malayi	Sugar transporter family protein	0.0014	0.0171	0.0647
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0487	0.0487
Leishmania major	protein kinase, putative	0.0031	0.0487	0.8517
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0072	0.1257	0.1649
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0487	0.1846
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0171	0.0894
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0469	0.0575
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0171	0.0894
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0171	0.2874
Schistosoma mansoni	hypothetical protein	0.0016	0.02	0.0262
Brugia malayi	jmjC domain containing protein	0.0019	0.0255	0.0967
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0006	0.001	0.0036
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.0255	0.0255
Echinococcus multilocularis	cpg binding protein	0.003	0.0475	0.0475
Schistosoma mansoni	glucose transporter	0.0014	0.0171	0.0224
Loa Loa (eye worm)	jmjC domain-containing protein	0.0072	0.1257	0.4765
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.7621	0.7621
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.057	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0171	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.02	0.02
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1064	0.1396
Echinococcus multilocularis	tumor protein p63	0.0337	0.6279	0.6279
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0843	0.3196
Schistosoma mansoni	glycyl-tRNA synthetase	0.0006	0.001	0.0013
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0171	0.0305
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0835	0.1096
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0171	0.0647
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0328	0.0399
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0487	0.0597
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0019	0.0255	0.4381
Brugia malayi	hypothetical protein	0.0019	0.0268	0.1018
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0487	0.0597
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0494	0.269
Toxoplasma gondii	protein kinase, putative	0.0285	0.5298	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0494	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0025	0.0085
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.007	0.007
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.0255	0.0255
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0475	0.6865
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0996	0.1865
Entamoeba histolytica	protein kinase, putative	0.0031	0.0487	0.7039
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1064	0.4034
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0025	0.0085
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.057	1
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.0255	0.0255
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0104	1
Schistosoma mansoni	protein kinase	0.0031	0.0487	0.0639
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0037	0.0048
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0255	0.0967
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1064	0.1396
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0487	0.0487
Echinococcus granulosus	tumor protein p63	0.0337	0.6279	0.6279
Schistosoma mansoni	cpg binding protein	0.003	0.0475	0.0623
Plasmodium vivax	sugar transporter, putative	0.0014	0.0171	0.0201
Schistosoma mansoni	hypothetical protein	0.0016	0.02	0.0262
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0494	0.8651
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0171	0.5052
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0264	0.5469
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	GPCR, family 2	0.0016	0.02	0.02
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0171	0.0894
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0145	0.2637	0.2637
Echinococcus multilocularis	geminin	0.0397	0.7416	0.7416
Schistosoma mansoni	glucose transport protein	0.0101	0.1812	0.2378
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1064	0.1396
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0171	0.2874
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0469	0.8205
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1812	0.1812
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.02	0.02
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0171	0.2874
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0328	0.0328
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0328	0.0431
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0171	0.0201
Brugia malayi	jmjC domain containing protein	0.0072	0.1257	0.4765
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.7621	0.7621
Echinococcus multilocularis	neuropeptide receptor A26	0.0534	1	1
Brugia malayi	hypothetical protein	0.0014	0.0171	0.0647
Echinococcus granulosus	lysine specific demethylase 5A	0.0072	0.1257	0.1257
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0025	0.0085
Brugia malayi	RNA binding protein	0.0061	0.1064	0.4034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 843024