TDR Targets

Basic information

Technical information

TDR Targets ID: 843791
Name: 3-(4-fluorophenyl)-1-propyl-1-(thiophen-2-ylm ethyl)urea
MW: 292.372 | Formula: C15H17FN2OS
H donors: 1 H acceptors: 1 LogP: 3.31 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(C(=O)Nc1ccc(cc1)F)Cc1cccs1
InChi: 1S/C15H17FN2OS/c1-2-9-18(11-14-4-3-10-20-14)15(19)17-13-7-5-12(16)6-8-13/h3-8,10H,2,9,11H2,1H3,(H,17,19)
InChiKey: DGTNAKOGDBUITM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(4-fluorophenyl)-1-propyl-1-(2-thienylmethyl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0068	0.0583	0.0583
Echinococcus granulosus	titin	0.0069	0.0624	0.0624
Echinococcus multilocularis	roundabout 2	0.0153	1	1
Echinococcus granulosus	peroxidasin	0.0089	0.2929	0.2929
Echinococcus multilocularis	roundabout 2	0.0089	0.2929	0.2929
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0068	0.0583	0.0583
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0583	0.0783
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0068	0.0583	0.0583
Echinococcus granulosus	hemicentin 1	0.0089	0.2929	0.2929
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0068	0.0583	0.0583
Schistosoma mansoni	septate junction protein	0.0089	0.2929	0.3629
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0583	0.0783
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Echinococcus granulosus	nephrin	0.0069	0.0624	0.0624
Echinococcus granulosus	tyrosine kinase	0.0068	0.0583	0.0583
Echinococcus multilocularis	titin	0.0069	0.0624	0.0624
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.2929	0.2929
Onchocerca volvulus		0.0069	0.0624	0.0078
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0069	0.0624	0.0773
Brugia malayi	Prion-like-	0.0089	0.2929	0.3932
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0583	0.0583
Loa Loa (eye worm)	TK protein kinase	0.0115	0.5766	0.5766
Schistosoma mansoni	roundabout	0.0089	0.2929	0.3629
Echinococcus granulosus	tyrosine protein kinase otk	0.0089	0.2929	0.2929
Schistosoma mansoni	cell adhesion molecule	0.0069	0.0624	0.0773
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0069	0.0624	0.0624
Echinococcus multilocularis	twitchin	0.0069	0.0624	0.0624
Onchocerca volvulus		0.0069	0.0624	0.0078
Echinococcus multilocularis	titin	0.0069	0.0624	0.0624
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0068	0.0583	0.0583
Brugia malayi	Prion-like-	0.0069	0.0624	0.0837
Brugia malayi	kettin	0.0069	0.0624	0.0837
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0068	0.0583	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0115	0.5766	0.5766
Echinococcus granulosus	neuroglian	0.0132	0.7695	0.7695
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0068	0.0583	0.0583
Onchocerca volvulus		0.0069	0.0624	0.0078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Schistosoma mansoni	myosin-binding protein-related	0.0069	0.0624	0.0773
Echinococcus granulosus	roundabout 2	0.0089	0.2929	0.2929
Loa Loa (eye worm)	hypothetical protein	0.0153	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0068	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0583	0.0583
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Loa Loa (eye worm)	animal heme peroxidase	0.0069	0.0624	0.0624
Loa Loa (eye worm)	CAMK protein kinase	0.0069	0.0624	0.0624
Onchocerca volvulus		0.0069	0.0624	0.0078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0115	0.5766	0.7742
Onchocerca volvulus		0.0069	0.0624	0.0078
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Schistosoma mansoni	neuroglian	0.0089	0.2929	0.3629
Echinococcus multilocularis	titin	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Schistosoma mansoni	cell adhesion molecule	0.0089	0.2929	0.3629
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Echinococcus multilocularis	c src tyrosine kinase	0.0068	0.0583	0.0583
Echinococcus multilocularis	hemicentin 1	0.0089	0.2929	0.2929
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0089	0.2929	0.4526
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0089	0.2929	0.3629
Brugia malayi	Animal haem peroxidase family protein	0.0069	0.0624	0.0837
Echinococcus multilocularis	peroxidasin	0.0089	0.2929	0.2929
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0068	0.0583	0.0583
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0068	0.0583	0.0583
Schistosoma mansoni	hemicentin	0.0069	0.0624	0.0773
Onchocerca volvulus	Netrin receptor homolog	0.0069	0.0624	0.0078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Onchocerca volvulus		0.0069	0.0624	0.0078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Brugia malayi	SH2 domain containing protein	0.0068	0.0583	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Echinococcus granulosus	neuroglian	0.0089	0.2929	0.2929
Echinococcus multilocularis		0.0069	0.0624	0.0624
Echinococcus granulosus	lachesin	0.0089	0.2929	0.2929
Loa Loa (eye worm)	disorganized muscle protein 1	0.0069	0.0624	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Echinococcus granulosus	tyrosine protein kinase Blk	0.0068	0.0583	0.0583
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Leucine Rich Repeat family protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2305	0.2305
Onchocerca volvulus	Peroxidasin homolog	0.0069	0.0624	0.0078
Loa Loa (eye worm)	projectin	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.7448	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Brugia malayi	protein unc-22	0.0069	0.0624	0.0837
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0069	0.0624	0.0624
Echinococcus granulosus	titin	0.0069	0.0624	0.0624
Schistosoma mansoni	cell adhesion molecule	0.0069	0.0624	0.0773
Echinococcus granulosus	tyrosine kinase	0.0068	0.0583	0.0583
Echinococcus granulosus	tyrosine protein kinase Srms	0.0068	0.0583	0.0583
Brugia malayi	protein-tyrosine kinase	0.0068	0.0583	0.0783
Onchocerca volvulus		0.0069	0.0624	0.0078
Echinococcus granulosus	titin	0.0069	0.0624	0.0624
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0068	0.0583	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Schistosoma mansoni	cell adhesion molecule	0.0089	0.2929	0.3629
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0069	0.0624	0.0624
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0068	0.0583	0.0583
Schistosoma mansoni	nephrin	0.0089	0.2929	0.3629
Schistosoma mansoni	cell adhesion molecule	0.0084	0.2305	0.2856
Loa Loa (eye worm)	one IG domain family member	0.0069	0.0624	0.0624
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Prion-like-	0.0069	0.0624	0.0837
Schistosoma mansoni	septate junction protein	0.0089	0.2929	0.3629
Loa Loa (eye worm)	hypothetical protein	0.0153	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0068	0.0583	0.0583
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Schistosoma mansoni	titin	0.0089	0.2929	0.3629
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0068	0.0583	0.0583
Brugia malayi	SRC-1	0.0068	0.0583	0.0783
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0089	0.2929	0.2929
Schistosoma mansoni	nephrin	0.0132	0.7695	0.9533
Onchocerca volvulus		0.0069	0.0624	0.0078
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Onchocerca volvulus		0.0069	0.0624	0.0078
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0069	0.0624	0.0624
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0583	0.0783
Echinococcus granulosus	down syndrome cell adhesion	0.0069	0.0624	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0068	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Onchocerca volvulus	Tyrosine kinase homolog	0.0115	0.5766	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0068	0.0583	0.0583
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Echinococcus multilocularis	neuroglian	0.0132	0.7695	0.7695
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0081	0.1945	0.2611
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	SRC-1	0.0068	0.0583	0.0583
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Echinococcus multilocularis	insulin growth factor binding	0.0069	0.0624	0.0624
Brugia malayi	Prion-like-	0.0069	0.0624	0.0837
Brugia malayi	hypothetical protein	0.0068	0.0583	0.0783
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0624	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0069	0.0624	0.0624
Brugia malayi	Peroxidasin	0.0089	0.2929	0.3932
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Echinococcus multilocularis	tyrosine protein kinase otk	0.0089	0.2929	0.2929
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Schistosoma mansoni	vesicular amine transporter	0.0068	0.0593	0.0735
Onchocerca volvulus		0.0069	0.0624	0.0078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Loa Loa (eye worm)	hypothetical protein	0.007	0.0754	0.0754
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.1352	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.2929	0.2929
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.1352	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0068	0.0583	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0069	0.0624	0.0624
Schistosoma mansoni	voltage-gated potassium channel	0.0088	0.2773	0.3436
Onchocerca volvulus	Peroxidasin homolog	0.0069	0.0624	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0583	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0081	0.1945	0.1945
Echinococcus granulosus	tyrosine protein kinase shark	0.0068	0.0583	0.0583
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0069	0.0624	0.0624
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0068	0.0583	0.0583
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0089	0.2929	0.2929
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0089	0.2929	0.2929
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0115	0.5766	0.5766
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0084	0.2305	0.2305
Schistosoma mansoni	voltage-gated potassium channel	0.0088	0.2773	0.3436
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0081	0.1945	0.1945
Brugia malayi	Disorganized muscle protein 1	0.0069	0.0624	0.0837
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0068	0.0583	0.0583
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0069	0.0624	0.0624
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0068	0.0583	0.0583
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Echinococcus multilocularis	transfer RNA-Phe	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0583	0.0783
Echinococcus granulosus	c src tyrosine kinase	0.0068	0.0583	0.0583
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Schistosoma mansoni	cell adhesion molecule	0.0069	0.0624	0.0773
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0089	0.2929	0.3629
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0068	0.0583	0.0583
Echinococcus multilocularis	neuroglian	0.0089	0.2929	0.2929
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0089	0.2929	0.2929
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0068	0.0583	0.0583
Brugia malayi	SH2 domain containing protein	0.0068	0.0583	0.0783
Loa Loa (eye worm)	TK/ROR protein kinase	0.0115	0.5766	0.5766
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0624	0.0773
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0081	0.1945	0.1945
Schistosoma mansoni	hypothetical protein	0.0069	0.0624	0.0773
Echinococcus granulosus	insulin growth factor binding	0.0069	0.0624	0.0624
Schistosoma mansoni	titin	0.0069	0.0624	0.0773
Onchocerca volvulus	Putative titin	0.0069	0.0624	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Echinococcus multilocularis	titin	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0068	0.0583	0.0583
Echinococcus granulosus	titin	0.0069	0.0624	0.0624
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0068	0.0583	0.0583
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0089	0.2929	0.2929
Echinococcus multilocularis	tyrosine kinase	0.0068	0.0583	0.0583
Schistosoma mansoni	slit	0.0069	0.0624	0.0773
Echinococcus multilocularis	lachesin	0.0089	0.2929	0.2929
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0089	0.2929	0.2929
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2929	0.2929
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Echinococcus multilocularis	hemicentin 1	0.0089	0.2929	0.2929
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Echinococcus granulosus	roundabout 2	0.0089	0.2929	0.2929
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0583	0.0583
Schistosoma mansoni	tyrosine kinase	0.0135	0.8072	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0068	0.0583	0.0583
Echinococcus granulosus	twitchin	0.0132	0.7695	0.7695
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.013	0.7448	0.7448
Echinococcus granulosus	contactin	0.0089	0.2929	0.2929
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0624	0.0837
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Schistosoma mansoni	nephrin related	0.0069	0.0624	0.0773
Echinococcus multilocularis	roundabout 2	0.0089	0.2929	0.2929
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0069	0.0624	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0624	0.0624
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0089	0.2929	0.2929
Echinococcus granulosus	titin	0.0069	0.0624	0.0624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2929	0.3932
Schistosoma mansoni	tyrosine kinase	0.0068	0.0583	0.0722
Onchocerca volvulus		0.0069	0.0624	0.0078
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0069	0.0624	0.0624
Schistosoma mansoni	cell adhesion molecule	0.0089	0.2929	0.3629
Echinococcus multilocularis	down syndrome cell adhesion	0.0069	0.0624	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0583	0.0583
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.2929	0.2929

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 843791