Detailed information for compound 845174

Basic information

Technical information
  • TDR Targets ID: 845174
  • Name: 5-chloro-2-ethylsulfanyl-N-[5-[(4-fluoropheny l)methylsulfanyl]-1,3,4-thiadiazol-2-yl]pyrim idine-4-carboxamide
  • MW: 441.954 | Formula: C16H13ClFN5OS3
  • H donors: 1 H acceptors: 5 LogP: 4.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1ncc(c(n1)C(=O)Nc1nnc(s1)SCc1ccc(cc1)F)Cl
  • InChi: 1S/C16H13ClFN5OS3/c1-2-25-14-19-7-11(17)12(20-14)13(24)21-15-22-23-16(27-15)26-8-9-3-5-10(18)6-4-9/h3-7H,2,8H2,1H3,(H,21,22,24)
  • InChiKey: FWRSRPPLCTYMGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-2-(ethylthio)-N-[5-[(4-fluorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]-4-pyrimidinecarboxamide
  • 5-chloro-2-(ethylthio)-N-[5-[(4-fluorobenzyl)thio]-1,3,4-thiadiazol-2-yl]pyrimidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2173 0.449
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0021 0.0021
Trichomonas vaginalis esterase, putative 0.0035 0.0398 0.2982
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1562 0.1562
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0072 0.1074
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0398 0.0786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0398 0.2982
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0021 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0072 0.0105
Brugia malayi beta-lactamase family protein 0.0035 0.0398 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0398 0.1048
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0232 0.3769 0.7821
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.1285 0.1285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0607 0.0597
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0584 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.2377 0.2377
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0021 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0216 0.06
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0398 0.0388
Brugia malayi Patched family protein 0.0012 0.001 0.001
Plasmodium falciparum heat shock protein 90 0.0013 0.0021 0.0193
Leishmania major hypothetical protein, conserved 0.0026 0.0245 0.0467
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0216 0.11
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1786 0.4904
Brugia malayi Patched family protein 0.0012 0.001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0132 0.0132
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0132 0.0342
Brugia malayi Patched family protein 0.0012 0.001 0.001
Plasmodium falciparum thioredoxin reductase 0.0016 0.0072 0.1074
Brugia malayi Patched family protein 0.0012 0.001 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0245 0.0467
Plasmodium vivax glutathione reductase, putative 0.0046 0.0584 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0584 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0216 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0072
Echinococcus multilocularis expressed conserved protein 0.019 0.3049 0.3049
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0398 0.0786
Entamoeba histolytica hypothetical protein 0.0037 0.043 0.1263
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0216 0.0216
Mycobacterium ulcerans hypothetical protein 0.0154 0.2441 1
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0235 0.0235
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0117 0.0296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0398 0.0398
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0216 0.0802
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0072 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0607 0.0607
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0232 0.3769 0.3769
Schistosoma mansoni hypothetical protein 0.0048 0.0616 0.1634
Brugia malayi hypothetical protein 0.0026 0.0245 0.0245
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0111 0.175
Mycobacterium tuberculosis Probable reductase 0.0104 0.1586 0.4351
Mycobacterium ulcerans beta-lactamase 0.0035 0.0398 0.1557
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0216 0.0216
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0235 0.0235
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0117 0.0117
Echinococcus multilocularis muscleblind protein 0.0597 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0235
Schistosoma mansoni pyruvate dehydrogenase 0.0219 0.3548 0.9414
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0235 0.1609
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0232 0.3769 0.3769
Brugia malayi beta-lactamase family protein 0.0035 0.0398 0.0398
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0117 0.0117
Brugia malayi protein C24B5.3 0.0012 0.001 0.001
Brugia malayi heat shock protein 90 0.0013 0.0021 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0117 0.0107
Echinococcus granulosus heat shock protein 90 0.0013 0.0021 0.0021
Plasmodium falciparum endoplasmin, putative 0.0013 0.0021 0.0193
Loa Loa (eye worm) glutathione reductase 0.0046 0.0584 0.0574
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.2173 0.449
Onchocerca volvulus 0.0035 0.0398 0.1305
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0118 0.0201
Mycobacterium leprae Probable lipase LipE 0.0035 0.0398 0.2136
Schistosoma mansoni heat shock protein 0.0013 0.0021 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0235 0.1693
Mycobacterium ulcerans hypothetical protein 0.0035 0.0398 0.1557
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0117 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0398 0.2982
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0111 0.0369
Leishmania major developmentally regulated phosphoprotein-like protein 0.0232 0.3769 0.7821
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.3259 0.3259
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0021 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.066 0.1332
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0132 0.0231
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0072 0.044
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0245 0.1678
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0398 0.1557
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0021 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0132 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0245 0.0467
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0072 0.5659
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0216 0.11
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.4813 1
Brugia malayi Patched related family protein 4 0.0012 0.001 0.001
Loa Loa (eye worm) beta-lactamase 0.0035 0.0398 0.0388
Mycobacterium tuberculosis Conserved protein 0.0035 0.0398 0.1048
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0616 0.0616
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0232 0.3769 0.3769
Schistosoma mansoni hypothetical protein 0.0037 0.043 0.1141
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0072 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0607 0.1611
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1786 0.4904
Brugia malayi beta-lactamase 0.0035 0.0398 0.0398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0191
Treponema pallidum NADH oxidase 0.0016 0.0072 0.4558
Brugia malayi glutathione reductase 0.0046 0.0584 0.0584
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0117 0.02
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0081 0.1188 0.2435
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0877
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0235 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0616 0.0606
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0584 0.1563
Echinococcus granulosus muscleblind protein 0.0597 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0216 0.0405
Toxoplasma gondii thioredoxin reductase 0.0046 0.0584 0.4098
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.043 0.1141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Entamoeba histolytica hypothetical protein 0.0037 0.043 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0398 0.1557
Schistosoma mansoni heat shock protein 0.0013 0.0021 0.0057
Brugia malayi Endoplasmin precursor 0.0013 0.0021 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0398 0.2982
Trypanosoma brucei trypanothione reductase 0.0046 0.0584 0.1173
Loa Loa (eye worm) hypothetical protein 0.0151 0.2377 0.2369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Loa Loa (eye worm) heat shock protein 90 0.0013 0.0021 0.0011
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0081 0.1188 0.8421
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0021 0.0193
Loa Loa (eye worm) hypothetical protein 0.0232 0.3769 0.3763
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0021 0.0193
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0216 0.0216
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0132 0.0231
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0398 0.0398
Schistosoma mansoni hypothetical protein 0.0084 0.1231 0.3267
Loa Loa (eye worm) hypothetical protein 0.0186 0.2983 0.2976
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1786 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0021 0.0193
Schistosoma mansoni endoplasmin 0.0013 0.0021 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0094 0.0201
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0072 0.0105
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0398 0.1048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.2377 0.2369
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0616 0.0616
Brugia malayi hypothetical protein 0.0012 0.001 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0398 0.1048
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.2377 0.2377
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1586 0.4351
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0216 0.054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0094 0.0201
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0216 0.06
Leishmania major hypothetical protein, conserved 0.0035 0.0398 0.0786
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.4743 0.4743
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0245 0.4095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0132 0.0231
Brugia malayi hypothetical protein 0.0012 0.001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0597 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0216 0.06
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.4813 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.1285 0.1285
Entamoeba histolytica hypothetical protein 0.0037 0.043 0.1263
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0506 0.101
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.1285 1
Brugia malayi Myosin head containing protein 0.0012 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0132 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0506 0.101
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0072
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1586 0.4351
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.01
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.3259 0.3259
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0245 0.4095
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0132 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0132 0.2126
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0216 0.0802
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0351
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.01
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0117 0.0311
Brugia malayi hypothetical protein 0.0012 0.001 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0132 0.0458
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0081 0.1188 0.2435
Brugia malayi protein C24B5.3 0.0012 0.001 0.001
Toxoplasma gondii heat shock protein HSP90 0.0013 0.0021 0.0079
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0118 0.0201
Mycobacterium ulcerans lipase LipD 0.0035 0.0398 0.1557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0021 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Schistosoma mansoni pyruvate dehydrogenase 0.0219 0.3548 0.9414
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0105
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0011
Echinococcus multilocularis heat shock protein 0.0013 0.0021 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0072 0.1074
Schistosoma mansoni hypothetical protein 0.0084 0.1231 0.3267
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0117 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0021 0.0021
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.3313 0.8789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0607 0.1611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3618 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0117 0.02
Plasmodium vivax endoplasmin, putative 0.0013 0.0021 0.0193
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0117 0.02
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.043 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0094 0.0201
Brugia malayi Patched family protein 0.0012 0.001 0.001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0117 0.02
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0072 0.014
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0398 0.1048
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0072 0.4558
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.01
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1786 0.4904
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0398 0.0398
Brugia malayi N-terminal motif family protein 0.0186 0.2983 0.2983
Loa Loa (eye worm) hypothetical protein 0.0024 0.0216 0.0205
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0506 0.101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0094 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Brugia malayi Patched family protein 0.0012 0.001 0.001
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.1285 0.1276
Entamoeba histolytica hypothetical protein 0.0037 0.043 0.1263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0616 0.0616
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1586 0.4351
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0117 0.02
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.01
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0235 0.0235
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0072 0.0209
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0398 0.1048
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0607 0.1611
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0117 0.02
Brugia malayi Patched family protein 0.0012 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0351
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1586 0.4351
Schistosoma mansoni hypothetical protein 0.0048 0.0616 0.1634
Brugia malayi CHE-14 protein 0.0087 0.1285 0.1285
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0072 0.04
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0072 0.4558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0245 0.4095
Echinococcus granulosus Protein patched homolog 1 0.0087 0.1285 0.1285
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0584 0.0583
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0506 0.101
Loa Loa (eye worm) hypothetical protein 0.0202 0.3259 0.3252
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0398 0.1048
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0235 0.0446
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0117 0.0311
Schistosoma mansoni hypothetical protein 0.0084 0.1231 0.3267
Loa Loa (eye worm) hypothetical protein 0.0024 0.0216 0.0205
Brugia malayi Thioredoxin reductase 0.0046 0.0584 0.0584
Onchocerca volvulus 0.0024 0.0216 0.069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2173 0.449
Brugia malayi Patched family protein 0.0012 0.001 0.001
Plasmodium falciparum glutathione reductase 0.0046 0.0584 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0616 0.0606
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0209
Echinococcus multilocularis heat shock protein 90 0.0013 0.0021 0.0021
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0117 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0616 0.0616
Plasmodium vivax heat shock protein 86, putative 0.0013 0.0021 0.0193
Echinococcus multilocularis GPCR, family 2 0.0048 0.0616 0.0616
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0072 0.0209
Leishmania major trypanothione reductase 0.0046 0.0584 0.1173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Schistosoma mansoni hypothetical protein 0.0103 0.1562 0.4144
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0117 0.02
Schistosoma mansoni hypothetical protein 0.0084 0.1231 0.3267
Brugia malayi Patched protein homolog 1 0.0012 0.001 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.4743 0.4743
Brugia malayi Patched family protein 0.0012 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0398 0.1057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0072 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.4813 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0398 0.6768
Onchocerca volvulus 0.0035 0.0398 0.1305
Brugia malayi Patched family protein 0.0012 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0072 0.04
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0132 0.0231
Brugia malayi hypothetical protein 0.0017 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0081 0.1188 0.2435
Echinococcus granulosus heat shock protein 0.0013 0.0021 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0132 0.0122
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0117 0.0296
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0117 0.0763
Mycobacterium ulcerans hypothetical protein 0.0024 0.0216 0.0802
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0132 0.2126
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0117 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0072 0.0105
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0117 0.02
Onchocerca volvulus 0.0035 0.0398 0.1305
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0072 0.044
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0117 0.0107
Toxoplasma gondii ABC1 family protein 0.0035 0.0398 0.2773
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0216 0.0802
Schistosoma mansoni endoplasmin 0.0013 0.0021 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Schistosoma mansoni hypothetical protein 0.0048 0.0616 0.1634
Loa Loa (eye worm) hypothetical protein 0.0024 0.0216 0.0205
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0398 0.0786
Plasmodium falciparum thioredoxin reductase 0.0046 0.0584 1
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0021 0.0011
Brugia malayi Patched family protein 0.0012 0.001 0.001
Plasmodium falciparum glutathione reductase 0.0016 0.0072 0.1074
Loa Loa (eye worm) hypothetical protein 0.0597 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0216 0.0802
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0072 0.0105
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0235 0.0624
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0584 0.1173
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.2983 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0216 0.054
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0117 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0216 0.0405
Toxoplasma gondii exonuclease III APE 0.0019 0.0132 0.0871
Echinococcus granulosus GPCR family 2 0.0048 0.0616 0.0616
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0616 0.0616
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0398 0.2982
Trypanosoma brucei developmentally regulated phosphoprotein 0.0232 0.3769 0.7821
Mycobacterium tuberculosis Conserved protein 0.0035 0.0398 0.1048
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0117 0.0117
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0072 0.0105
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0132 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0021 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0216 0.0802
Schistosoma mansoni hypothetical protein 0.0048 0.0616 0.1634
Schistosoma mansoni patched 1 0.0087 0.1285 0.3409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Brugia malayi Patched related family protein 10 0.0012 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0245 0.0467
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0398 0.2982
Mycobacterium tuberculosis Conserved protein 0.0035 0.0398 0.1048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0388
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0398 0.2136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0175 0.0319
Toxoplasma gondii hypothetical protein 0.0047 0.0609 0.4281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0021 0.0037
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0216 0.0802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0607 0.0607
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.3259 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2441 0.6726
Brugia malayi Patched family protein 0.0012 0.001 0.001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0117 0.02
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0021 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0398 0.1048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0132 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.3259 0.3259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Brugia malayi Patched family protein 0.0012 0.001 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0072 0.4558
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.1409 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0072 0.1074
Loa Loa (eye worm) hypothetical protein 0.0103 0.1562 0.1553
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0164
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0021 0.0021
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0111 0.0248
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1586 0.887
Toxoplasma gondii heat shock protein 90, putative 0.0013 0.0021 0.0079
Brugia malayi hypothetical protein 0.0012 0.001 0.001
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0111 0.175
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0117 0.02
Loa Loa (eye worm) endoplasmin 0.0013 0.0021 0.0011
Brugia malayi Patched related family protein 12 0.0012 0.001 0.001
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.4813 1
Brugia malayi kinase, mitochondrial precursor 0.0232 0.3769 0.3769
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0072 0.0105
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0021 0.0193
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0072 0.1074
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0117 0.02
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0117 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0877
Brugia malayi hypothetical protein 0.0037 0.043 0.043
Brugia malayi Patched family protein 0.0012 0.001 0.001
Echinococcus multilocularis protein patched 0.0087 0.1285 0.1285
Entamoeba histolytica hypothetical protein 0.0025 0.0235 0.0661
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0021 0.0057
Echinococcus granulosus expressed conserved protein 0.019 0.3049 0.3049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0584 0.0583
Schistosoma mansoni pyruvate dehydrogenase 0.0232 0.3769 1
Echinococcus multilocularis muscleblind protein 1 0.0597 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Loa Loa (eye worm) hypothetical protein 0.0106 0.1619 0.161
Loa Loa (eye worm) hypothetical protein 0.0087 0.1285 0.1276
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1586 0.4351
Giardia lamblia GTOR 0.0019 0.0117 0.8638
Brugia malayi Patched family protein 0.0012 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0216 0.0405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0398 0.1057
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0021 0.0193
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0111 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0117 0.0758
Echinococcus multilocularis protein dispatched 1 0.0099 0.1495 0.1495

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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