Detailed information for compound 848642

Basic information

Technical information
  • TDR Targets ID: 848642
  • Name: N-(5-chloro-2-methylphenyl)-1,3,3-trimethyl-2 -oxoindole-5-sulfonamide
  • MW: 378.873 | Formula: C18H19ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)NS(=O)(=O)c1ccc2c(c1)C(C)(C)C(=O)N2C)C
  • InChi: 1S/C18H19ClN2O3S/c1-11-5-6-12(19)9-15(11)20-25(23,24)13-7-8-16-14(10-13)18(2,3)17(22)21(16)4/h5-10,20H,1-4H3
  • InChiKey: UACNWNXAMDATCU-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(5-chloro-2-methyl-phenyl)-1,3,3-trimethyl-2-oxo-indoline-5-sulfonamide
  • N-(5-chloro-2-methylphenyl)-1,3,3-trimethyl-2-oxo-5-indolinesulfonamide
  • N-(5-chloro-2-methyl-phenyl)-2-keto-1,3,3-trimethyl-indoline-5-sulfonamide
  • N-(5-chloro-2-methyl-phenyl)-1,3,3-trimethyl-2-oxo-indole-5-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni survival motor neuron protein 0.0047 0.1311 0.2342
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.5596 1
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0322 0.0576
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0383 0.2454
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0322 0.2065
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0322 0.0576
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0322 0.0576
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0814 0.1455
Giardia lamblia Cathepsin B precursor 0.0048 0.1377 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0814 0.0814
Echinococcus multilocularis cathepsin b 0.0137 0.5596 0.5652
Schistosoma mansoni hypothetical protein 0.0047 0.1311 0.2342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Onchocerca volvulus 0.0052 0.1561 0.2179
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0383 0.0387
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0814 0.1455
Loa Loa (eye worm) cathepsin B 0.0048 0.1377 0.1391
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0322 0.0576
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0322 0.0326
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0322 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.1561 0.1576
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0322 0.0326
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0322 0.2065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0814 0.0822
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.1561 0.1576
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0814 0.5914
Giardia lamblia Cathepsin B precursor 0.0048 0.1377 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0814 0.0814
Echinococcus granulosus laminin 0.0027 0.0383 0.0387
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0383 0.0387
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0322 0.0326
Mycobacterium ulcerans lipase LipD 0.0036 0.0814 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0814 0.1455
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0814 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Toxoplasma gondii ABC1 family protein 0.0036 0.0814 0.5217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1339 0.1352
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0814 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0814 0.5
Plasmodium vivax vivapain-2 0.0026 0.0322 0.2065
Onchocerca volvulus 0.0047 0.1311 0.1739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Toxoplasma gondii cathepsin B 0.0048 0.1377 0.8822
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0048 0.1377 0.8822
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0814 0.5914
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0322 0.2341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1339 0.1352
Brugia malayi beta-lactamase family protein 0.0036 0.0814 0.0822
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Mycobacterium tuberculosis Conserved protein 0.0036 0.0814 0.0814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0322 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0814 0.0822
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0322 0.0326
Onchocerca volvulus Arrow homolog 0.0027 0.0383 0.0107
Loa Loa (eye worm) hypothetical protein 0.0052 0.1561 0.1576
Onchocerca volvulus 0.0036 0.0814 0.0866
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0387
Mycobacterium ulcerans hypothetical protein 0.0036 0.0814 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0814 0.0814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Schistosoma mansoni hypothetical protein 0.0052 0.1561 0.2789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Trypanosoma brucei cysteine peptidase C (CPC) 0.0048 0.1377 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.5596 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0322 0.0326
Plasmodium vivax vivapain-2 0.0026 0.0322 0.2065
Brugia malayi Fibulin-1 precursor 0.0027 0.0383 0.0387
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0814 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0322 0.0576
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0814 0.1455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Loa Loa (eye worm) hypothetical protein 0.0228 0.99 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.99 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.1561 1
Brugia malayi hypothetical protein 0.0228 0.99 1
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Loa Loa (eye worm) hypothetical protein 0.0146 0.6005 0.6066
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0322 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Echinococcus multilocularis fibrillin 1 0.0027 0.0383 0.0387
Leishmania major hypothetical protein, conserved 0.0036 0.0814 0.5217
Echinococcus multilocularis cysteine protease 0.0026 0.0322 0.0326
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.1561 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1339 0.1352
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.1377 1
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.1561 0.2789
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.0383 0.0387
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0326
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0383 0.0387
Brugia malayi Kringle domain containing protein 0.0052 0.1561 0.1576
Mycobacterium tuberculosis Conserved protein 0.0036 0.0814 0.0814
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.5596 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1339 0.1352
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0027 0.0383 0.0387
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1339 0.1352
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0814 0.0822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Brugia malayi Protein kinase domain containing protein 0.0052 0.1561 0.1576
Loa Loa (eye worm) hypothetical protein 0.0137 0.5596 0.5652
Loa Loa (eye worm) ctsf protein 0.0026 0.0322 0.0326
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.1377 0.246
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.1377 0.246
Loa Loa (eye worm) fibroinase 0.0026 0.0322 0.0326
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0322 0.0326
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0137 0.5596 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1311 0.1324
Brugia malayi beta-lactamase 0.0036 0.0814 0.0822
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0322 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0814 0.0822
Brugia malayi beta-lactamase family protein 0.0036 0.0814 0.0822
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Schistosoma mansoni egf-like domain protein 0.0027 0.0383 0.0684
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1339 0.2392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Entamoeba histolytica cysteine protease, putative 0.0026 0.0322 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0383 0.2454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Mycobacterium tuberculosis Conserved protein 0.0036 0.0814 0.0814
Echinococcus granulosus cathepsin b 0.0137 0.5596 0.5652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0322 0.2341
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Toxoplasma gondii kringle domain-containing protein 0.0052 0.1561 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0027 0.0383 0.0684
Toxoplasma gondii cathepsin CPL 0.0026 0.0322 0.2065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0814 0.0822
Echinococcus granulosus cathepsin l1 0.0026 0.0322 0.0326
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0137 0.5596 1
Loa Loa (eye worm) cysteine protease 0.0026 0.0322 0.0326
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0322 0.2065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0387
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0814 0.5914
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0322 0.0326
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0814 0.5914
Echinococcus multilocularis laminin 0.0027 0.0383 0.0387
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0387
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0814 0.5914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Loa Loa (eye worm) beta-lactamase 0.0036 0.0814 0.0822
Echinococcus multilocularis cysteine protease 0.0026 0.0322 0.0326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0387
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1339 0.2392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Echinococcus granulosus cathepsin b 0.0137 0.5596 0.5652
Trichomonas vaginalis esterase, putative 0.0036 0.0814 0.5914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1339 0.1352
Mycobacterium ulcerans beta-lactamase 0.0036 0.0814 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1339 0.2392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0322 0.2341
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.1561 0.1576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0814 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0814 0.0814
Echinococcus multilocularis Tolloid protein 1 0.0027 0.0383 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0814 0.5914
Brugia malayi hypothetical protein 0.0146 0.6005 0.6066
Echinococcus granulosus Tolloid protein 1 0.0027 0.0383 0.0387
Leishmania major hypothetical protein, conserved 0.0052 0.1561 1
Giardia lamblia Cathepsin B precursor 0.0048 0.1377 1
Onchocerca volvulus 0.0036 0.0814 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0322 0.2065
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0814 0.0814
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0322 0.0576
Onchocerca volvulus 0.0146 0.6005 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0814 0.0814
Leishmania major cathepsin L-like protease 0.0026 0.0322 0.2065
Echinococcus multilocularis cathepsin b 0.0137 0.5596 0.5652
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.99 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Onchocerca volvulus 0.0036 0.0814 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0322 0.2341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0322 0.2341
Brugia malayi Cathepsin L-like precursor 0.0026 0.0322 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0814 0.5217
Brugia malayi cathepsin B-like cysteine proteinase 0.0137 0.5596 0.5652
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0322 0.0326

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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