Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1311 | 0.2342 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0137 | 0.5596 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0026 | 0.0322 | 0.0576 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0027 | 0.0383 | 0.2454 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0026 | 0.0322 | 0.2065 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0322 | 0.0576 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0322 | 0.0576 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0814 | 0.1455 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.1377 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0814 | 0.0814 |
Echinococcus multilocularis | cathepsin b | 0.0137 | 0.5596 | 0.5652 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1311 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Onchocerca volvulus | 0.0052 | 0.1561 | 0.2179 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0027 | 0.0383 | 0.0387 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0814 | 0.1455 |
Loa Loa (eye worm) | cathepsin B | 0.0048 | 0.1377 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0383 | 0.0387 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0322 | 0.0576 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0026 | 0.0322 | 0.0326 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0322 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0052 | 0.1561 | 0.1576 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0026 | 0.0322 | 0.0326 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0026 | 0.0322 | 0.2065 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0814 | 0.0822 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0052 | 0.1561 | 0.1576 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0814 | 0.5914 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.1377 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0814 | 0.0814 |
Echinococcus granulosus | laminin | 0.0027 | 0.0383 | 0.0387 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.0383 | 0.0387 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0026 | 0.0322 | 0.0326 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0814 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0814 | 0.1455 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0814 | 0.0814 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0814 | 0.5217 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1339 | 0.1352 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0814 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0814 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.0322 | 0.2065 |
Onchocerca volvulus | 0.0047 | 0.1311 | 0.1739 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Toxoplasma gondii | cathepsin B | 0.0048 | 0.1377 | 0.8822 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0048 | 0.1377 | 0.8822 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0814 | 0.5914 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1339 | 0.1352 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0814 | 0.0822 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0814 | 0.0814 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0322 | 0.0576 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0814 | 0.0822 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.0322 | 0.0326 |
Onchocerca volvulus | Arrow homolog | 0.0027 | 0.0383 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1561 | 0.1576 |
Onchocerca volvulus | 0.0036 | 0.0814 | 0.0866 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0383 | 0.0387 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0814 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0814 | 0.0814 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1561 | 0.2789 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0048 | 0.1377 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0137 | 0.5596 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0026 | 0.0322 | 0.0326 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.0322 | 0.2065 |
Brugia malayi | Fibulin-1 precursor | 0.0027 | 0.0383 | 0.0387 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0814 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0322 | 0.0576 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0814 | 0.1455 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.99 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.99 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0052 | 0.1561 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.99 | 1 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6005 | 0.6066 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.0322 | 0.0326 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Echinococcus multilocularis | fibrillin 1 | 0.0027 | 0.0383 | 0.0387 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0814 | 0.5217 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.0322 | 0.0326 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0052 | 0.1561 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1339 | 0.1352 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0048 | 0.1377 | 1 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0052 | 0.1561 | 0.2789 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0027 | 0.0383 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0322 | 0.0326 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.0383 | 0.0387 |
Brugia malayi | Kringle domain containing protein | 0.0052 | 0.1561 | 0.1576 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0814 | 0.0814 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0137 | 0.5596 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1339 | 0.1352 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0027 | 0.0383 | 0.0387 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1339 | 0.1352 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0814 | 0.0822 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.1561 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.5596 | 0.5652 |
Loa Loa (eye worm) | ctsf protein | 0.0026 | 0.0322 | 0.0326 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0048 | 0.1377 | 0.246 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0048 | 0.1377 | 0.246 |
Loa Loa (eye worm) | fibroinase | 0.0026 | 0.0322 | 0.0326 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.0322 | 0.0326 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0137 | 0.5596 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1311 | 0.1324 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0814 | 0.0822 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0322 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0814 | 0.0822 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0814 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Schistosoma mansoni | egf-like domain protein | 0.0027 | 0.0383 | 0.0684 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1339 | 0.2392 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Entamoeba histolytica | cysteine protease, putative | 0.0026 | 0.0322 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0027 | 0.0383 | 0.2454 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0814 | 0.0814 |
Echinococcus granulosus | cathepsin b | 0.0137 | 0.5596 | 0.5652 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Toxoplasma gondii | kringle domain-containing protein | 0.0052 | 0.1561 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0027 | 0.0383 | 0.0684 |
Toxoplasma gondii | cathepsin CPL | 0.0026 | 0.0322 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0814 | 0.0822 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.0322 | 0.0326 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0137 | 0.5596 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0026 | 0.0322 | 0.0326 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0026 | 0.0322 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0383 | 0.0387 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0814 | 0.5914 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.0322 | 0.0326 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0814 | 0.5914 |
Echinococcus multilocularis | laminin | 0.0027 | 0.0383 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0383 | 0.0387 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0814 | 0.5914 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0814 | 0.0822 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.0322 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0383 | 0.0387 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1339 | 0.2392 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0137 | 0.5596 | 0.5652 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0814 | 0.5914 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1339 | 0.1352 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0814 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1339 | 0.2392 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0052 | 0.1561 | 0.1576 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0814 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0814 | 0.0814 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0027 | 0.0383 | 0.0387 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0814 | 0.5914 |
Brugia malayi | hypothetical protein | 0.0146 | 0.6005 | 0.6066 |
Echinococcus granulosus | Tolloid protein 1 | 0.0027 | 0.0383 | 0.0387 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.1561 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.1377 | 1 |
Onchocerca volvulus | 0.0036 | 0.0814 | 0.0866 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Leishmania major | cysteine peptidase A (CPA) | 0.0026 | 0.0322 | 0.2065 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0814 | 0.0814 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0322 | 0.0576 |
Onchocerca volvulus | 0.0146 | 0.6005 | 1 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0814 | 0.0814 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.0322 | 0.2065 |
Echinococcus multilocularis | cathepsin b | 0.0137 | 0.5596 | 0.5652 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.99 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Onchocerca volvulus | 0.0036 | 0.0814 | 0.0866 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0322 | 0.2341 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0322 | 0.2341 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0322 | 0.0326 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0814 | 0.5217 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0137 | 0.5596 | 0.5652 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0026 | 0.0322 | 0.0326 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.