Detailed information for compound 85020

Basic information

Technical information
  • TDR Targets ID: 85020
  • Name: 2-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl ]-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]o xazin-3-one
  • MW: 374.409 | Formula: C19H23FN4O3
  • H donors: 0 H acceptors: 2 LogP: 1.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1nc2n(c1=O)CCOC2
  • InChi: 1S/C19H23FN4O3/c20-16-3-1-14(2-4-16)18(25)15-5-7-22(8-6-15)9-10-24-19(26)23-11-12-27-13-17(23)21-24/h1-4,15H,5-13H2
  • InChiKey: DNHGOVVFIRYXSL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-one
  • 2-[2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperidinyl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-one
  • 2-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-one
  • 2-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-one
  • 2-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[5,4-c][1,4]oxazin-3-one
  • 2-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[5,4-c][1,4]oxazin-3-one
  • 2-[2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperidinyl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[5,4-c][1,4]oxazin-3-one
  • 2-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-6,8-dihydro-5H-[1,2,4]triazolo[5,4-c][1,4]oxazin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References
Rattus norvegicus Serotonin 2 (5-HT2) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis g protein coupled receptor Serotonin 2 (5-HT2) receptor   460 aa 409 aa 21.5 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 2 (5-HT2) receptor   460 aa 408 aa 20.8 %
Loa Loa (eye worm) hypothetical protein Serotonin 2 (5-HT2) receptor   460 aa 417 aa 21.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 2 (5-HT2) receptor   460 aa 427 aa 28.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 2 (5-HT2) receptor   460 aa 412 aa 19.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 2 (5-HT2) receptor   460 aa 405 aa 31.1 %
Echinococcus granulosus g protein coupled receptor Serotonin 2 (5-HT2) receptor   460 aa 409 aa 21.8 %
Echinococcus granulosus g protein coupled receptor Serotonin 2 (5-HT2) receptor   460 aa 412 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0016 0.0163 0.2874
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.049 0.8651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0221 0.0221
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Plasmodium vivax sugar transporter, putative 0.0016 0.0163 0.0201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0482 0.0482
Brugia malayi sulfakinin receptor protein 0.0019 0.0221 0.1214
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0221 0.0221
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0566 1
Echinococcus granulosus somatostatin receptor 0.0019 0.0221 0.0221
Brugia malayi AKH receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0566 0.106
Trichomonas vaginalis sugar transporter, putative 0.0035 0.049 0.269
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.047 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.049 0.8651
Echinococcus granulosus solute carrier family 22 0.0016 0.0163 0.0163
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0322 0.1769
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0163 0.0894
Brugia malayi G protein-coupled receptor 0.0019 0.0221 0.1214
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.047 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.047 0.2583
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.047 0.2583
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0184 0.301 0.3724
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0096 0.2978
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0221 0.0221
Onchocerca volvulus 0.0019 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0163 0.0894
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0221 0.0221
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0322 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.047 0.047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0221 0.1214
Brugia malayi Sugar transporter family protein 0.0016 0.0163 0.0894
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0221 0.1214
Brugia malayi neuropeptide F receptor 0.0019 0.0221 0.1214
Schistosoma mansoni amine GPCR 0.0019 0.0221 0.1214
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0221 0.1214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.1821 0.3408
Echinococcus granulosus fmrfamide receptor 0.0019 0.0221 0.0221
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0221 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1821 1
Schistosoma mansoni opsin-like receptor 0.0019 0.0221 0.1214
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0322 0.1769
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0221 0.1214
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0483 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0034 0.047 0.2583
Leishmania major protein kinase, putative 0.0035 0.0482 0.8517
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Echinococcus multilocularis sex peptide receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis solute carrier family 22 0.0016 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi GnHR receptor homolog 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni sugar transporter 0.0016 0.0163 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0163 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0221 0.0221
Trichomonas vaginalis glucose transporter, putative 0.0035 0.049 0.269
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0322 0.6849
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0163 0.2874
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0163 0.0305
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0096 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0483 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0221 0.0221
Schistosoma mansoni glucose transport protein 0.0114 0.1821 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0483 0.0597
Leishmania major glucose transporter, lmgt3 0.0035 0.049 0.8651
Echinococcus multilocularis solute carrier family 22 0.0016 0.0163 0.0163
Schistosoma mansoni amine GPCR 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni biogenic amine receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0221 0.1214
Schistosoma mansoni protein kinase 0.0035 0.0482 0.2648
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0483 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0483 0.0903
Plasmodium falciparum protein kinase 6 0.0483 0.8083 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0184 0.301 0.5632
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Echinococcus granulosus g protein coupled receptor 0.0019 0.0221 0.0221
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0221 0.0221
Brugia malayi Serotonin receptor 0.0019 0.0221 0.1214
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Schistosoma mansoni hypothetical protein 0.0114 0.1821 1
Brugia malayi Sugar transporter family protein 0.0114 0.1821 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Leishmania major glucose transporter, lmgt2 0.0035 0.049 0.8651
Schistosoma mansoni protein kinase 0.0035 0.0482 0.2648
Onchocerca volvulus 0.0019 0.0221 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0221 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Trypanosoma brucei sugar transporter, putative 0.0016 0.0163 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus neuropeptide receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0566 1
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0163 0.0894
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0221 0.1214
Schistosoma mansoni sugar transporter 0.0016 0.0163 0.0894
Plasmodium vivax hexose transporter 0.0114 0.1821 0.2253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.047 0.2583
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0482 0.2648
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0221 0.1214
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0483 0.0597
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0221 0.0221
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0163 0.6328
Schistosoma mansoni hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0034 0.047 0.2583
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0221 1
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0221 0.0221
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Brugia malayi major facilitator superfamily protein 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0221 0.0221
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0221 0.0221
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0221 0.0221
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0129 0.0709
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0221 0.0221
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0163 0.0894
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0163 0.2874
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.047 0.047
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0221 0.1214
Schistosoma mansoni opsin-like receptor 0.0019 0.0221 0.1214
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.049 0.8651
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0163 0.0163
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Echinococcus multilocularis serotonin receptor 0.0019 0.0221 0.0221
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0163 0.0894
Schistosoma mansoni biogenic amine receptor 0.0019 0.0221 0.1214
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0257 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.047 0.2583
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0163 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0269 0.1477
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0322 0.5689
Echinococcus granulosus orexin receptor type 2 0.0019 0.0221 0.0221
Echinococcus multilocularis solute carrier family 22 0.0016 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0035 0.049 0.269
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.047 0.2583
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0221 0.1214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0446 0.0446
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Toxoplasma gondii sugar transporter ST3 0.0016 0.0163 0.0305
Schistosoma mansoni glucose transport protein 0.0114 0.1821 1
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0482 0.2648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0482 0.2648
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0221 0.1214
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0322 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0482 0.8517
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0221 0.0221
Trypanosoma cruzi hexose transporter, putative 0.0035 0.049 0.8651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0221 0.0221
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0257 0.5469
Brugia malayi Serotonin receptor 0.0019 0.0221 0.1214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Onchocerca volvulus 0.0019 0.0221 1
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0163 0.5052
Onchocerca volvulus 0.0019 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Schistosoma mansoni amine GPCR 0.0019 0.0221 0.1214
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0322 0.5689
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0483 0.0597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0221 0.1214
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0163 0.0894
Echinococcus granulosus g protein coupled receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Schistosoma mansoni biogenic amine receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Brugia malayi Sugar transporter family protein 0.0016 0.0163 0.0894
Schistosoma mansoni adenoreceptor 0.0019 0.0221 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0566 0.0701
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0221 0.0221
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0322 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Schistosoma mansoni myosin xvIII 0.0019 0.0221 0.1214
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0221 0.0221
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0322 0.1769
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0221 0.1214
Schistosoma mansoni histamine h1 receptor 0.0019 0.0221 0.1214
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0322 0.5689
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0221 0.0221
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0483 0.0597
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0221 0.1214
Schistosoma mansoni protein kinase 0.0035 0.0482 0.2648
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0322 0.1769
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0163 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0221 0.0221
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0163 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Onchocerca volvulus 0.0019 0.0221 1
Brugia malayi Dopamine receptor 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.049 0.269
Brugia malayi ORL1-like opioid receptor 0.0019 0.0221 0.1214
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0221 0.0221
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0566 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0221 0.1214
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0322 0.0322
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0322 0.0603
Brugia malayi major facilitator superfamily protein 0.0016 0.0163 0.0894
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0221 0.0221
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0221 0.1214
Echinococcus granulosus solute carrier family 22 0.0016 0.0163 0.0163
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0566 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0163 0.5052
Trypanosoma brucei glucose transporter 1E 0.0035 0.049 0.8651
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0257 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0221 0.0221
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.1821 0.1821
Schistosoma mansoni amine GPCR 0.0019 0.0221 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus granulosus allatostatin A receptor 0.0019 0.0221 0.0221
Schistosoma mansoni amine GPCR 0.0019 0.0221 0.1214
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0221 0.0221
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Schistosoma mansoni glucose transporter 0.0016 0.0163 0.0894
Entamoeba histolytica protein kinase, putative 0.0035 0.0482 1
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0221 0.1214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Plasmodium falciparum protein kinase 7 0.0321 0.5345 0.6612
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0219 0.386
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0221 0.0221
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.049 0.8651
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0482 0.2648
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0483 0.0597
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0163 0.0163
Schistosoma mansoni neuropeptide receptor 0.0019 0.0221 0.1214
Brugia malayi RE15519p 0.0019 0.0221 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0221 0.1214
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0483 0.0597
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis serotonin receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) sugar transporter 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.2648
Brugia malayi putative neuropeptide receptor 0.0019 0.0221 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Plasmodium vivax CDK-related protein kinase 6, putative 0.0483 0.8083 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Trypanosoma cruzi hexose transporter 0.0035 0.049 0.8651
Plasmodium falciparum proline--tRNA ligase 0.004 0.0566 0.0701
Toxoplasma gondii protein kinase, putative 0.0321 0.5345 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0221 0.1214
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Schistosoma mansoni opsin-like receptor 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Plasmodium falciparum hexose transporter 0.0114 0.1821 0.2253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Schistosoma mansoni neuropeptide receptor 0.0019 0.0221 0.1214
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0163 0.0163
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0322 0.6849
Echinococcus multilocularis solute carrier family 22 0.0016 0.0163 0.0163
Brugia malayi hypothetical protein 0.0016 0.0163 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0322 0.0399
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0221 0.0221
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0221 0.1214
Schistosoma mansoni glucose transport protein 0.0114 0.1821 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0221 0.0221
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0221 0.0221
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0221 0.0221
Brugia malayi Dopamine receptor protein 2 0.0019 0.0221 0.1214
Toxoplasma gondii sugar transporter ST1 0.0016 0.0163 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Brugia malayi larval opioid receptor 0.0019 0.0221 0.1214
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0028 0.0362 0.1987
Trypanosoma brucei glucose transporter, putative 0.0035 0.049 0.8651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0221 0.1214
Schistosoma mansoni sugar transporter 0.0016 0.0163 0.0894
Onchocerca volvulus 0.0019 0.0221 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0221 0.0221
Mycobacterium ulcerans sugar transporter 0.0016 0.0163 0.5052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0163 0.0894
Leishmania major glucose transporter, lmgt1 0.0035 0.049 0.8651
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0322 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus solute carrier family 22 0.0016 0.0163 0.0163
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0221 0.0221
Brugia malayi Melatonin receptor type 1A 0.0019 0.0221 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0482 0.2648
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0221 0.0221
Onchocerca volvulus 0.0019 0.0221 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0221 0.0221
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0483 0.0597
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0483 0.0597
Echinococcus granulosus g protein coupled receptor 0.0019 0.0221 0.0221
Brugia malayi Dopamine receptor protein 1 0.0019 0.0221 0.1214
Giardia lamblia Sugar-proton symporter 0.0016 0.0163 0.346
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0322 0.1769
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Schistosoma mansoni hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0035 0.049 0.269
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis somatostatin receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis General substrate transporter 0.0098 0.155 0.155
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0221 0.1214
Trichomonas vaginalis glucose transporter, putative 0.0035 0.049 0.269
Onchocerca volvulus 0.0019 0.0221 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi hypothetical protein 0.0016 0.0163 0.0894
Echinococcus granulosus General substrate transporter 0.0098 0.155 0.155
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Brugia malayi hypothetical protein 0.0016 0.0163 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0035 0.049 0.8651
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0221 0.0221
Echinococcus granulosus solute carrier family 22 0.0016 0.0163 0.0163
Toxoplasma gondii sugar transporter ST2 0.0016 0.0163 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0221 0.0221
Onchocerca volvulus 0.0019 0.0221 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Trypanosoma brucei glucose transporter 2A 0.0035 0.049 0.8651
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0446 0.0446
Brugia malayi Cam kinase protein 1 0.0035 0.0482 0.2648
Brugia malayi neuropeptide F receptor 0.0019 0.0221 0.1214
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0163 0.2874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Trypanosoma cruzi hexose transporter, putative 0.0035 0.049 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.049 0.269
Echinococcus granulosus serotonin receptor 0.0019 0.0221 0.0221
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0221 0.1214
Entamoeba histolytica protein kinase, putative 0.0035 0.0482 1
Schistosoma mansoni neuropeptide receptor 0.0019 0.0221 0.1214
Onchocerca volvulus 0.0019 0.0221 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0096 0.2978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni neuropeptide receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) sugar transporter 0.0114 0.1821 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni hypothetical protein 0.0019 0.0221 0.1214
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0221 0.1214
Echinococcus granulosus neuropeptide receptor 0.0019 0.0221 0.0221
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0221 0.0221
Brugia malayi G-protein coupled receptor 0.0019 0.0221 0.1214
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0163 0.2874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0221 0.0221
Plasmodium falciparum mitogen-activated protein kinase 2 0.0184 0.301 0.3724
Echinococcus granulosus hypothetical protein 0.0019 0.0221 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0163 0.0894
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Schistosoma mansoni hypothetical protein 0.0019 0.0221 0.1214
Giardia lamblia Hexose transporter 0.0016 0.0163 0.346
Echinococcus granulosus sex peptide receptor 0.0019 0.0221 0.0221
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0221 0.1214
Brugia malayi G-protein coupled receptor 0.0019 0.0221 0.1214
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0221 0.1214
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0163 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Entamoeba histolytica hypothetical protein 0.0025 0.0322 0.6679
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.047 0.9752
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0221 0.0221
Schistosoma mansoni sugar transporter 0.0016 0.0163 0.0894
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0595 1 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0163 0.0894
Onchocerca volvulus 0.0019 0.0221 1
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0221 0.0221
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0163 0.6328
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0221 0.0221
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0566 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Loa Loa (eye worm) hypothetical protein 0.0019 0.0221 0.1214
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0221 0.1214
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0163 1
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1821 0.1821
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0482 0.0482
Brugia malayi hypothetical protein 0.0019 0.0221 0.1214
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0221 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0163 0.0894

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 36 % In vivo inhibitory activity in rats against elevation of blood pressure caused by phenylephrine (30 microg/kg,iv) through Alpha-1 adrenergic receptor, after 1 hr oral administration at dose of 10 mg/kg ChEMBL. 1732528
Inhibition (functional) = 36 % In vivo inhibitory activity in rats against elevation of blood pressure caused by phenylephrine (30 microg/kg,iv) through Alpha-1 adrenergic receptor, after 1 hr oral administration at dose of 10 mg/kg ChEMBL. 1732528
Inhibition (functional) = 62 % In vivo inhibitory activity of 10 mg/kg compound in rats against elevation of BP caused by 5-HT (300 ug/kg,iv) through 5-hydroxytryptamine 2 receptor 1 hr after oral administration ChEMBL. 1732528
Inhibition (functional) = 62 % In vivo inhibitory activity of 10 mg/kg compound in rats against elevation of BP caused by 5-HT (300 ug/kg,iv) through 5-hydroxytryptamine 2 receptor 1 hr after oral administration ChEMBL. 1732528
Kd (functional) = 6.3 In vitro antagonistic activity tested against the contraction induced by phenylephrine through Alpha-1 adrenergic receptor in rat thoracic aortic strips ChEMBL. 1732528
Kd (functional) = 7.4 In vitro antagonistic activity tested against the contraction induced by 5-HT through 5-hydroxytryptamine 2 receptor in rat thoracic aortic strips ChEMBL. 1732528
pA2 (functional) = 6.3 In vitro antagonistic activity tested against the contraction induced by phenylephrine through Alpha-1 adrenergic receptor in rat thoracic aortic strips ChEMBL. 1732528
pA2 (functional) = 7.4 In vitro antagonistic activity tested against the contraction induced by 5-HT through 5-hydroxytryptamine 2 receptor in rat thoracic aortic strips ChEMBL. 1732528

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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