TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.383 | Formula: C20H18N4O2
H donors: 1 H acceptors: 4 LogP: 3.05 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccccc1N(C(=O)Cn1ncc2c(c1O)nc1c2cccc1)C
InChi: 1S/C20H18N4O2/c1-13-7-3-6-10-17(13)23(2)18(25)12-24-20(26)19-15(11-21-24)14-8-4-5-9-16(14)22-19/h3-11,26H,12H2,1-2H3
InChiKey: IYCJZOZUCUVUCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0625	0.0725
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0165	0.0733
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0407	0.0399
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0001
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0072	0.0072
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0111	0.0102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0407	0.0473
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0407	0.0399
Brugia malayi	Hsp90 protein	0.0017	0.0029	0.0022
Schistosoma mansoni	hypothetical protein	0.0336	0.4765	0.476
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0407	0.0462
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.033	0.4682	0.4677
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0076	0.0067
Echinococcus multilocularis	dual specificity	0.0089	0.1101	0.1093
Onchocerca volvulus		0.0091	0.1128	0.4007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0407	0.0462
Brugia malayi	nuclear hormone receptor	0.0042	0.0407	0.0462
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0165	0.1418
Schistosoma mansoni	ap endonuclease	0.002	0.0072	0.0062
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0076	0.0067
Brugia malayi	ecdysone receptor	0.002	0.0076	0.0076
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0076	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0359
Schistosoma mansoni	ap endonuclease	0.002	0.0072	0.0062
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0072	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0165	0.0733
Schistosoma mansoni	nuclear receptor	0.002	0.0076	0.0066
Echinococcus granulosus	GPCR family 2	0.0048	0.0491	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0488	0.0567
Mycobacterium ulcerans	hydrolase	0.0111	0.1421	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0488	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0255	0.0296
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0089	0.1101	0.1278
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0309	0.5
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0072	0.0304
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0407	0.0398
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0407	0.0399
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.203	0.2348
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0488	0.3296
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.1101	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0491	0.056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0407	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0488	0.0556
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0034	0.0039
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0488	0.3388
Schistosoma mansoni	hypothetical protein	0.0048	0.0491	0.0482
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0072	0.0063
Brugia malayi	tailless protein	0.002	0.0076	0.0076
Brugia malayi	conserved hypotetical protein	0.002	0.0076	0.0076
Onchocerca volvulus	Matrilysin homolog	0.0091	0.1128	0.4007
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0488	0.3296
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0407	0.0399
Echinococcus granulosus	dual specificity	0.0089	0.1101	0.1093
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0072	0.0083
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0488	0.3296
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.203	0.2348
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.028	0.1913
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0407	0.0399
Schistosoma mansoni	hypothetical protein	0.0104	0.1318	0.1309
Brugia malayi	nuclear hormone receptor	0.002	0.0076	0.0076
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0076	0.0067
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0001
Trypanosoma cruzi	heat shock protein, putative	0.0017	0.0029	0.0177
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0089	0.1101	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1128	0.1309
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0076	0.0066
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0488	0.3296
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0491	0.0483
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0165	0.0733
Plasmodium vivax	heat shock protein 90, putative	0.0017	0.0029	0.0092
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0407	0.0399
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0076	0.0067
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0407	0.0398
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0072	0.0395
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0488	0.4383
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0129
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0488	0.4282
Echinococcus multilocularis	jun protein	0.0184	0.252	0.2513
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0001
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0089	0.1101	1
Toxoplasma gondii	exonuclease III APE	0.002	0.0072	0.0292
Loa Loa (eye worm)	heat shock protein 75	0.0017	0.0029	0.0034
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0017	0.0029	0.0021
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0184	0.252	0.2513
Brugia malayi	hypothetical protein	0.0017	0.0028	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0407	0.0473
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0407	0.0462
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0072	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0076	0.0067
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0407	0.0399
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0072	0.0565
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0043	0.0419	0.041
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0111	0.0101
Echinococcus multilocularis	lamin dm0	0.0032	0.0255	0.0246
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0184	0.252	0.2513
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0488	0.3296
Loa Loa (eye worm)	hypothetical protein	0.0151	0.203	0.2357
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0407	0.0399
Brugia malayi	Protein kinase domain containing protein	0.0089	0.1101	0.1268
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0043	0.0419	0.0475
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0076	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0129
Onchocerca volvulus		0.002	0.0076	0.0168
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Loa Loa (eye worm)	matrix metalloproteinase	0.0091	0.1128	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0165	0.0191
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0407	0.0399
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.028	0.1913
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0165	0.0733
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0255	0.0245
Entamoeba histolytica	protein kinase, putative	0.0089	0.1101	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1128	0.1309
Brugia malayi	hypothetical protein	0.0026	0.0165	0.018
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.1318	0.152
Loa Loa (eye worm)	hypothetical protein	0.0595	0.8615	1
Brugia malayi	Matrixin family protein	0.0219	0.3039	0.3521
Brugia malayi	Matrixin family protein	0.0091	0.1128	0.1299
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0072	1
Echinococcus granulosus	lamin	0.0032	0.0255	0.0246
Trypanosoma brucei	heat shock protein 84, putative	0.0017	0.0029	0.0177
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0091	0.1128	0.1119
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0165	0.1418
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0491	0.0483
Brugia malayi	Matrixin family protein	0.0091	0.1128	0.1299
Echinococcus granulosus	endoplasmin	0.0017	0.0029	0.0021
Brugia malayi	hypothetical protein	0.0022	0.0111	0.0117
Plasmodium falciparum	heat shock protein 90, putative	0.0158	0.2122	1
Onchocerca volvulus		0.0032	0.0255	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Schistosoma mansoni	hypothetical protein	0.0336	0.4765	0.476
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0201	0.277	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Loa Loa (eye worm)	DR-78	0.002	0.0076	0.0088
Echinococcus granulosus	lamin dm0	0.0032	0.0255	0.0246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0407	0.0473
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0407	0.0462
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0407	0.0398
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0407	0.138
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0407	0.0398
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0111	0.0117
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.1101	1
Onchocerca volvulus		0.005	0.0517	0.1779
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0309	0.2009
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0072	0.0565
Onchocerca volvulus		0.0145	0.1931	0.6939
Toxoplasma gondii	Hsp90 domain-containing protein	0.0158	0.2122	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0491	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0359
Onchocerca volvulus		0.0032	0.0255	0.0822
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0488	0.3296
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0309	0.1416
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus multilocularis	geminin	0.0336	0.4765	0.476
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0017	0.0029	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0407	0.0473
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0491	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0359
Onchocerca volvulus		0.0048	0.0488	0.1675
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0111	0.0129
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0377	1
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Onchocerca volvulus	Matrilysin homolog	0.0201	0.277	1
Onchocerca volvulus		0.0042	0.0407	0.138
Brugia malayi	nuclear receptor NHR-67	0.002	0.0076	0.0076
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.001	0.0001
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0488	0.3296
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0488	0.4383
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.002	0.0076	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0388
Brugia malayi	nuclear receptor RXR	0.002	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0072	0.0292
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0255	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0407	0.0462
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0076	0.0088
Schistosoma mansoni	hypothetical protein	0.0048	0.0491	0.0482
Schistosoma mansoni	hypothetical protein	0.015	0.2006	0.1998
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0407	0.0399
Schistosoma mansoni	survival motor neuron protein	0.005	0.0517	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0179	0.2444	0.2838
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0072	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3396	0.3943
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0072	0.0565
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0407	0.0399
Brugia malayi	ecdysteroid receptor	0.0042	0.0407	0.0462
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0407	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0129
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0407	0.0399
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0407	0.0462
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0111	0.1421	0.164
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0488	0.0556
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0517	0.0589
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0407	0.0399
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0407	0.138
Echinococcus granulosus	geminin	0.0336	0.4765	0.476
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.001	0.0001
Echinococcus granulosus	intermediate filament protein	0.0032	0.0255	0.0246
Brugia malayi	steroid hormone receptor	0.0042	0.0407	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0407	0.0462
Schistosoma mansoni	zinc finger protein	0.002	0.0076	0.0066
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0407	0.0398
Schistosoma mansoni	heat shock protein	0.0017	0.0029	0.0019
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0076	0.0076
Brugia malayi	small heat shock protein	0.0595	0.8615	1
Brugia malayi	hypothetical protein	0.002	0.0076	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0407	0.0462
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0407	0.0462
Brugia malayi	intermediate filament protein	0.0032	0.0255	0.0284
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0076	0.0076
Brugia malayi	Matrixin family protein	0.0091	0.1128	0.1299
Schistosoma mansoni	hypothetical protein	0.005	0.0517	0.0507
Schistosoma mansoni	coup transcription factor	0.0042	0.0407	0.0398
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.3396	0.3391
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0488	0.4383
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0377	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0407	0.0398
Brugia malayi	hypothetical protein	0.0022	0.0111	0.0117
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0076	0.0066
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0407	0.0473
Loa Loa (eye worm)	matrixin family protein	0.0201	0.277	0.3215
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0407	0.0462
Echinococcus granulosus	jun protein	0.0184	0.252	0.2513
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0407	0.0473
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0072	0.0565
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0076	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1318	0.153
Echinococcus multilocularis	lamin	0.0032	0.0255	0.0246
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0407	0.0399
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0407	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0407	0.0462
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0072	0.0437
Brugia malayi	hypothetical protein	0.0145	0.1931	0.2233
Echinococcus multilocularis	musashi	0.0032	0.0255	0.0246
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0407	0.0462
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.203	0.2357
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0076	0.0067
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0111	0.0101
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0309	0.2118
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0491	0.0571
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0491	0.056
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0407	0.0462
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.001	0.0012
Loa Loa (eye worm)	matrixin family protein	0.0219	0.3039	0.3528
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0407	0.0399
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0076	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0111	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Brugia malayi	Matrixin family protein	0.0091	0.1128	0.1299
Leishmania major	heat shock protein, putative	0.0017	0.0029	0.0177
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0407	0.0473
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0111	0.1421	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.028	0.1913
Brugia malayi	nuclear receptor RXR	0.0022	0.0111	0.0117
Onchocerca volvulus		0.0129	0.1691	0.6064
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0488	0.4282
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0488	0.0567
Entamoeba histolytica	protein kinase, putative	0.0089	0.1101	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0491	0.0482
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0072	0.0063
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.002	0.0076	0.0067
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.028	0.1913
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0072	0.0292
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0076	0.0076
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0407	0.0398
Plasmodium vivax	heat shock protein, putative	0.0158	0.2122	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0072	0.1218
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0488	0.3296
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0096	0.1202	0.1194
Toxoplasma gondii	heat shock protein 75, putative	0.0017	0.0029	0.0092
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0017	0.0029	0.0021
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0491	0.0483
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.002	0.0076	0.0168
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0407	0.0399
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0076	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1094	0.127
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0076	0.0076
Schistosoma mansoni	nuclear receptor	0.002	0.0076	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0129
Schistosoma mansoni	lamin	0.0032	0.0255	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.3396	0.3391
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0359
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0407	0.0398
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0255	0.0284
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0076	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1128	0.1309
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0407	0.0398
Schistosoma mansoni	hypothetical protein	0.0113	0.1456	0.1448
Schistosoma mansoni	hypothetical protein	0.0129	0.1691	0.1683
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0488	0.3296
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0407	0.0398
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0076	0.0066
Leishmania major	hypothetical protein, conserved	0.0026	0.0165	0.1418
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.1101	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0407	0.0473
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0477	0.0468
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.1101	0.1092
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.033	0.4682	0.4677
Schistosoma mansoni	microtubule-associated protein tau	0.0688	1	1
Brugia malayi	nuclear receptor NHR-88	0.002	0.0076	0.0076
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0309	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1094	0.127
Brugia malayi	Hemopexin family protein	0.0129	0.1691	0.1954
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0111	0.0117
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0491	0.0571
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0407	0.138
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0407	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0246	0.0286
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0076	0.0067
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0076	0.0088
Mycobacterium leprae	PROBABLE HYDROLASE	0.0111	0.1421	1
Schistosoma mansoni	jun-related protein	0.015	0.2006	0.1998
Entamoeba histolytica	hypothetical protein	0.0089	0.1101	1
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0407	0.0462
Schistosoma mansoni	lamin	0.0032	0.0255	0.0245
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0255	0.0296
Brugia malayi	hypothetical protein	0.0243	0.3396	0.3936
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0017	0.0029	0.0137
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0407	0.0398
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0034	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1421	0.165
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0488	0.0556
Loa Loa (eye worm)	hypothetical protein	0.002	0.0076	0.0088
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.0419	0.0486
Loa Loa (eye worm)	nuclear hormone receptor	0.002	0.0076	0.0088
Brugia malayi	bZIP transcription factor family protein	0.0184	0.252	0.2916
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0165	0.1418
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0477	0.0468
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0407	0.0462
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0407	0.0399
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0043	0.0419	0.041
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0309	0.0359
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0488	0.3296
Echinococcus multilocularis	microtubule associated protein 2	0.0688	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0488	0.4282
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0488	0.3388
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0129
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0407	0.0398
Onchocerca volvulus		0.002	0.0076	0.0168
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0625	0.0714
Brugia malayi	hypothetical protein	0.002	0.0076	0.0076
Echinococcus multilocularis	endoplasmin	0.0017	0.0029	0.0021
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0491	0.0483

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 863259