Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0085 | 0.0216 | 0.0371 |
Echinococcus granulosus | glutathione S transferase Mu 1 | 0.0457 | 0.3191 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 0.5635 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0762 | 0.5635 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Plasmodium vivax | aspartyl protease, putative | 0.0085 | 0.0216 | 0.0235 |
Echinococcus multilocularis | glutathione S transferase | 0.0102 | 0.0354 | 0.1633 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.182 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0195 | 0.1097 | 0.1937 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0195 | 0.1097 | 0.1097 |
Brugia malayi | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDasubunit precursor | 0.0178 | 0.0955 | 0.5249 |
Trichomonas vaginalis | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0178 | 0.0955 | 0.8694 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 0.5635 | 1 |
Echinococcus multilocularis | glutathione s transferase mu | 0.0126 | 0.0541 | 0.2703 |
Echinococcus multilocularis | dolichyl diphosphooligosaccharide protein | 0.0178 | 0.0955 | 0.5065 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0085 | 0.0216 | 0.0235 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Brugia malayi | Pepsin A precursor | 0.0085 | 0.0216 | 0.1187 |
Plasmodium falciparum | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0178 | 0.0955 | 0.8384 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 0.5635 | 1 |
Entamoeba histolytica | dolichyl-diphosphooligosaccharide-protein glycotransferase, putative | 0.0178 | 0.0955 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0195 | 0.1097 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0126 | 0.0541 | 0.2703 |
Echinococcus multilocularis | glutathione S transferase | 0.0083 | 0.0195 | 0.0725 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0085 | 0.0216 | 0.1187 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0195 | 0.1097 | 0.3425 |
Schistosoma mansoni | GST class-mu | 0.0126 | 0.0541 | 0.0541 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.0083 | 0.0195 | 0.0589 |
Echinococcus multilocularis | glutathione S transferase | 0.0102 | 0.0354 | 0.1633 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0195 | 0.1097 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.182 | 0.322 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1097 | 0.1937 |
Echinococcus granulosus | glutathione S transferase | 0.0067 | 0.0068 | 0.019 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0195 | 0.1097 | 0.5878 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0216 | 0.0371 |
Plasmodium falciparum | plasmepsin I | 0.0195 | 0.1097 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0476 | 0.3347 | 0.3347 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0085 | 0.0216 | 0.1187 |
Loa Loa (eye worm) | dolichyl-di-phosphooligosaccharide-protein glycotransferase | 0.0178 | 0.0955 | 0.1684 |
Brugia malayi | Glutathione S-transferase 4 | 0.0059 | 0.0007 | 0.004 |
Plasmodium vivax | plasmepsin V, putative | 0.0085 | 0.0216 | 0.0235 |
Onchocerca volvulus | 0.0085 | 0.0216 | 1 | |
Schistosoma mansoni | glutathione-S-transferase | 0.0126 | 0.0541 | 0.0541 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0476 | 0.3347 | 0.3347 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.1487 | 0.2628 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Plasmodium vivax | aspartyl protease, putative | 0.0085 | 0.0216 | 0.0235 |
Plasmodium vivax | aspartyl protease, putative | 0.0085 | 0.0216 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0216 | 0.0371 |
Echinococcus granulosus | glutathione s transferase mu | 0.0126 | 0.0541 | 0.1678 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Brugia malayi | hypothetical protein | 0.0286 | 0.182 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Plasmodium falciparum | glutathione S-transferase | 0.0126 | 0.0541 | 0.3692 |
Plasmodium falciparum | plasmepsin VI | 0.0195 | 0.1097 | 1 |
Echinococcus multilocularis | glutathione S-transferase | 0.0126 | 0.0541 | 0.2703 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0195 | 0.1097 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0085 | 0.0216 | 0.0371 |
Toxoplasma gondii | hypothetical protein | 0.0762 | 0.5635 | 1 |
Plasmodium vivax | dolichyl-diphosphooligosaccharide--protein glycosyltransferase, putative | 0.0178 | 0.0955 | 0.8422 |
Schistosoma mansoni | dolichyl-diphosphooligosaccharide-protein glycosyltransferase | 0.0178 | 0.0955 | 0.0955 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Onchocerca volvulus | 0.0085 | 0.0216 | 1 | |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0195 | 0.1097 | 1 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0083 | 0.0195 | 0.0725 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0195 | 0.1097 | 0.1627 |
Plasmodium vivax | plasmepsin IV, putative | 0.0195 | 0.1097 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0126 | 0.0541 | 0.2703 |
Toxoplasma gondii | dolichyl-diphosphooligosaccharide--protein glycosyltransferase | 0.0178 | 0.0955 | 0.1364 |
Onchocerca volvulus | 0.0059 | 0.0007 | 0.0339 | |
Echinococcus granulosus | glutathione S transferase | 0.0126 | 0.0541 | 0.1678 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0216 | 0.1187 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0085 | 0.0216 | 0.1187 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Echinococcus granulosus | dolichyl diphosphooligosaccharide protein | 0.0178 | 0.0955 | 0.2977 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0216 | 0.0216 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0083 | 0.0195 | 0.0195 |
Brugia malayi | glutathione transferase | 0.0244 | 0.1487 | 0.817 |
Plasmodium falciparum | plasmepsin IV | 0.0195 | 0.1097 | 1 |
Echinococcus granulosus | glutathione S transferase | 0.0067 | 0.0068 | 0.019 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.182 | 0.5693 |
Entamoeba histolytica | dolichyl-di-phosphooligosaccharide-protein glycotransferase, putative | 0.0178 | 0.0955 | 1 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0216 | 0.1187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.