TDR Targets

Basic information

Technical information

TDR Targets ID: 865206
Name: N-(3,4-difluorophenyl)-2-(3-oxo-1H-isoindol-2 -yl)-3-phenylpropanamide
MW: 392.398 | Formula: C23H18F2N2O2
H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(N1Cc2c(C1=O)cccc2)Cc1ccccc1)Nc1ccc(c(c1)F)F
InChi: 1S/C23H18F2N2O2/c24-19-11-10-17(13-20(19)25)26-22(28)21(12-15-6-2-1-3-7-15)27-14-16-8-4-5-9-18(16)23(27)29/h1-11,13,21H,12,14H2,(H,26,28)
InChiKey: VSYPYNBKPWAFET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,4-difluorophenyl)-2-(1-oxoisoindolin-2-yl)-3-phenyl-propanamide
N-(3,4-difluorophenyl)-2-(1-oxo-2-isoindolinyl)-3-phenylpropanamide
N-(3,4-difluorophenyl)-2-(1-ketoisoindolin-2-yl)-3-phenyl-propionamide
N-(3,4-difluorophenyl)-2-(3-oxo-1H-isoindol-2-yl)-3-phenyl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus granulosus	solute carrier family 5	0.0045	0.0016	0.0016
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.0362	0.0362
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1175	0.5248	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	Sodium:solute symporter family protein	0.0045	0.0016	0.0016
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0028	0.0028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0045	0.0016	0.0016
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1175	0.5248	0.5248
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0079	0.0178	0.0211
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus multilocularis		0.0056	0.0068	0.0068
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1175	0.5248	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.0178	0.0178
Trypanosoma cruzi	hypothetical protein, conserved	0.0362	0.1486	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.0178	0.0178
Onchocerca volvulus		0.0515	0.2195	0.4164
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.2201	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0119	0.0362	0.0362
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Echinococcus multilocularis	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0045	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0056	0.0068	0.0068
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0056	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0134	0.0134
Schistosoma mansoni	lozenge	0.0065	0.0109	0.0109
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0056	0.0068	0.0068
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0813	0.3572	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0016	0.0016
Schistosoma mansoni	inositol transporter	0.0045	0.0016	0.0016
Brugia malayi	jmjC domain containing protein	0.0111	0.0324	0.0324
Onchocerca volvulus		0.0056	0.0068	0.0099
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1175	0.5248	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0045	0.0016	0.0016
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Trypanosoma cruzi	hypothetical protein, conserved	0.0362	0.1486	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1175	0.5248	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.2201	1	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.1486	0.2738
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.1486	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Schistosoma mansoni	inositol transporter	0.0045	0.0016	0.0016
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0045	0.0016	0.0016
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0028	0.0028
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1175	0.5248	0.5248
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Onchocerca volvulus		0.0056	0.0068	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0056	0.0068	0.0068
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Schistosoma mansoni	protein tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	GH02984p	0.0404	0.1682	0.1682
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1175	0.5248	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.1486	0.2738
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0119	0.0362	0.0362
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	runx1	0.0065	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Leishmania major	hypothetical protein, conserved	0.0362	0.1486	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0515	0.2195	0.2195
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0079	0.0079
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0056	0.0068	0.0068
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0045	0.0016	0.0016
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0056	0.0068	0.0068
Schistosoma mansoni	pcd6 interacting protein-related	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Schistosoma mansoni	jumonji domain containing protein	0.0088	0.0218	0.0218
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.2201	1	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0056	0.0068	0.0068
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Onchocerca volvulus		0.1175	0.5248	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0111	0.0324	0.0324
Schistosoma mansoni	sodium/solute symporter	0.0045	0.0016	0.0016
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1175	0.5248	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0045	0.0016	0.0016
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.2201	1	1
Brugia malayi	hypothetical protein	0.0056	0.0068	0.0068
Toxoplasma gondii	melibiase subfamily protein	0.0119	0.0362	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1175	0.5248	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0056	0.0068	0.0068
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0119	0.0362	0.0362
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0056	0.0068	0.0068
Echinococcus multilocularis	high affinity choline transporter 1	0.0404	0.1682	0.1682
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0056	0.0068	0.0068
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0056	0.0068	0.0068
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Schistosoma mansoni	microtubule-associated protein tau	0.0803	0.3526	0.3526
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Brugia malayi	hypothetical protein	0.0515	0.2195	0.2195
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0515	0.2195	0.2195
Onchocerca volvulus		0.0056	0.0068	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0056	0.0068	0.0068
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.0362	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1682	0.1682
Brugia malayi	Protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Schistosoma mansoni	high-affinity choline transporter	0.0404	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Brugia malayi	hypothetical protein	0.0056	0.0068	0.0068
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	microtubule associated protein 2	0.0803	0.3526	0.3526
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase 1	0.0056	0.0068	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0056	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0056	0.0068	0.0068
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0056	0.0068	0.0068
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1175	0.5248	1
Echinococcus multilocularis	solute carrier family 5	0.0045	0.0016	0.0016
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Schistosoma mansoni	protein tyrosine phosphatase	0.0056	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0056	0.0068	0.0068
Echinococcus granulosus	sodium:glucose cotransporter	0.0045	0.0016	0.0016
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.0362	0.0362
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0056	0.0068	0.0068
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.0362	0.0362
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	microtubule associated protein 2	0.0803	0.3526	0.3526
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0111	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0068	0.0068
Echinococcus granulosus	high affinity choline transporter 1	0.0404	0.1682	0.1682
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Brugia malayi	Melibiase family protein	0.0079	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0056	0.0068	0.0068
Onchocerca volvulus		0.0056	0.0068	0.0099
Echinococcus multilocularis	Protein lozenge	0.0065	0.0109	0.0109
Onchocerca volvulus	4.1 G protein, putative homolog	0.0056	0.0068	0.0099
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1175	0.5248	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1175	0.5248	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0056	0.0068	0.0068
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0056	0.0068	0.0068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 865206