TDR Targets

Basic information

Technical information

TDR Targets ID: 865471
Name: N-(4-diethylaminophenyl)-2-[4-(4-fluorophenyl )piperazin-1-yl]acetamide
MW: 384.49 | Formula: C22H29FN4O
H donors: 1 H acceptors: 1 LogP: 3.72 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cc1)NC(=O)CN1CCN(CC1)c1ccc(cc1)F)CC
InChi: 1S/C22H29FN4O/c1-3-26(4-2)20-11-7-19(8-12-20)24-22(28)17-25-13-15-27(16-14-25)21-9-5-18(23)6-10-21/h5-12H,3-4,13-17H2,1-2H3,(H,24,28)
InChiKey: GOFPRKSEATUYNL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-diethylaminophenyl)-2-[4-(4-fluorophenyl)-1-piperazinyl]acetamide
N-(4-diethylaminophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]ethanamide
MLS000057977
SMR000063024
T0520-4763

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	tyrosyl-DNA phosphodiesterase 1	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania braziliensis	tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210	Get druggable targets OG5_129037	All targets in OG5_129037
Cryptosporidium parvum	tyrosyl-DNA phodphodiesterase 1 (tdp1)	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania donovani	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania major	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma congolense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania mexicana	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania infantum	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei gambiense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_129037	All targets in OG5_129037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0383	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0214	0.1722	0.1754
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0021	0.0098	0.9428
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0221	0.0271
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0022	0.0103	1
Trichomonas vaginalis	glutaminase, putative	0.033	0.2699	1
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0098	0.035
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0021	0.0098	0.035
Trypanosoma cruzi	fatty acid desaturase, putative	0.1175	0.9819	0.9818
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0589	0.0496
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0251	0.2032	0.1953
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0221	1
Schistosoma mansoni	apoferritin-2	0.001	0.0003	0.0013
Echinococcus granulosus	Sphingolipid delta4 desaturase DES1	0.0021	0.0098	0.0481
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0589	0.0496
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0383	0.0468
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.0589	0.06
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0074	0.0541	0.1992
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0383	0.1418
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.0589	0.2182
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0078	0.0383
Schistosoma mansoni	ferritin light chain	0.001	0.0003	0.0013
Schistosoma mansoni	glutaminase	0.033	0.2699	1
Loa Loa (eye worm)	fatty acid desaturase	0.0021	0.0098	0.01
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0251	0.2032	0.1953
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0022	0.0103	0.0006
Loa Loa (eye worm)	FAT-3 protein	0.0214	0.1722	0.1754
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0383	0.1418
Schistosoma mansoni	ferritin	0.001	0.0003	0.0013
Schistosoma mansoni	apoferritin-2	0.001	0.0003	0.0013
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0264	0.0269
Echinococcus multilocularis	ferritin	0.001	0.0003	0.0004
Loa Loa (eye worm)	fatty acid desaturase	0.0021	0.0098	0.01
Brugia malayi	Fatty acid desaturase family protein	0.0021	0.0098	0.01
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0306	0.0375
Echinococcus granulosus	dnaJ subfamily C 6	0.0074	0.0541	0.266
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0021	0.0098	0.012
Brugia malayi	Pre-SET motif family protein	0.0251	0.2035	0.2074
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0021	0.0098	0.035
Mycobacterium ulcerans	glutaminase	0.033	0.2699	1
Giardia lamblia	Kinase, STE STE20	0.0251	0.2032	0.5
Echinococcus granulosus	Fatty acid desaturase type 1	0.0021	0.0098	0.0481
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.001	0.0003	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0221	0.0271
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0221	0.1087
Leishmania major	delta-6 fatty acid desaturase	0.0022	0.0103	0.0006
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.8168	1
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0074	0.0541	0.0551
Schistosoma mansoni	hypothetical protein	0.0019	0.0078	0.0288
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0221	0.0819
Brugia malayi	glutaminase DH11.1	0.033	0.2699	0.275
Schistosoma mansoni	ferritin	0.001	0.0003	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1541	0.1571
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0021	0.0098	0.035
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0078	0.0095
Schistosoma mansoni	ferritin	0.001	0.0003	0.0013
Plasmodium falciparum	stearoyl-CoA desaturase	0.1175	0.9814	0.5
Brugia malayi	Fatty acid desaturase family protein	0.0021	0.0098	0.01
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0078	0.0095
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0078	0.0383
Leishmania major	delta-5 fatty acid desaturase	0.0214	0.1722	0.164
Echinococcus multilocularis	Fatty acid desaturase, type 1	0.0021	0.0098	0.012
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.0589	0.06
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0221	0.0819
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0251	0.2032	0.2071
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0264	0.0269
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0022	0.0103	0.0006
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.2327	0.8623
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.0589	0.5
Brugia malayi	Pre-SET motif family protein	0.0036	0.0221	0.0225
Echinococcus multilocularis	expressed protein	0.001	0.0003	0.0004
Echinococcus granulosus	ferritin	0.001	0.0003	0.0017
Loa Loa (eye worm)	acyl-CoA desaturase	0.1175	0.9814	1
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0251	0.2032	0.1953
Loa Loa (eye worm)	glutaminase	0.033	0.2699	0.275
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.0589	0.0496
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0251	0.2032	0.2071
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0103	0.0371
Schistosoma mansoni	hypothetical protein	0.0019	0.0078	0.0288
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0078	0.0095
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.1175	0.9814	1
Trypanosoma brucei	fatty acid desaturase, putative	0.1197	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0424	0.0433
Onchocerca volvulus		0.1196	0.9994	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0078	0.0288
Schistosoma mansoni	hypothetical protein	0.0019	0.0078	0.0288
Echinococcus granulosus	expressed protein	0.001	0.0003	0.0017
Trypanosoma cruzi	fatty acid desaturase, putative	0.1175	0.9819	0.9818
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0021	0.0098	0.012
Loa Loa (eye worm)	glutaminase 2	0.033	0.2699	0.275
Onchocerca volvulus		0.1196	0.9994	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0589	0.0496
Schistosoma mansoni	fatty acid desaturase	0.0215	0.1728	0.6401
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0221	0.0819
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0021	0.0098	0.9428
Loa Loa (eye worm)	hypothetical protein	0.006	0.0424	0.0433
Schistosoma mansoni	hypothetical protein	0.0074	0.0541	0.2003
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2035	0.2074
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0221	0.0819
Leishmania major	fatty-acid desaturase, putative	0.1197	1	1
Onchocerca volvulus		0.0215	0.1728	0.1541
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.021	0.1032
Echinococcus granulosus	dual specificity mitogen activated protein	0.0251	0.2032	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1132	0.1153
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0078	0.0079
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0251	0.2032	0.2488
Echinococcus granulosus	GPCR family 2	0.0019	0.0078	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0221	0.0225
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1132	0.1153
Mycobacterium ulcerans	electron transfer protein FdxB	0.0021	0.0098	0.035
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0306	0.1506
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0383	0.1418
Schistosoma mansoni	hypothetical protein	0.0041	0.0264	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0078	0.0079
Treponema pallidum	bacterioferrin (TpF1)	0.001	0.0003	0.5
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0021	0.0098	0.035
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0078	0.0079
Trichomonas vaginalis	STE family protein kinase	0.0251	0.2032	0.7526
Schistosoma mansoni	ferritin	0.001	0.0003	0.0013
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.001	0.0003	0.5
Brugia malayi	acyl-CoA desaturase	0.1175	0.9814	1
Schistosoma mansoni	ferritin light chain	0.001	0.0003	0.0013
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0078	0.0079
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0383	0.039
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0424	0.0433
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0424	0.0433
Brugia malayi	DnaJ domain containing protein	0.0074	0.0541	0.0551
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0383	0.039
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0383	0.0468
Trichomonas vaginalis	STE family protein kinase	0.0251	0.2032	0.7526
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.0589	0.0721
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.0589	0.2898
Onchocerca volvulus		0.0286	0.2327	0.2155
Echinococcus multilocularis	dnaJ subfamily C 6	0.0074	0.0541	0.0662
Trypanosoma cruzi	fatty acid desaturase, putative	0.1197	1	1
Brugia malayi	Delta5 fatty acid desaturase	0.0214	0.1722	0.1754
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0383	0.1883
Schistosoma mansoni	protein kinase	0.0251	0.2032	0.753
Brugia malayi	MH2 domain containing protein	0.0144	0.1132	0.1153
Trichomonas vaginalis	STE family protein kinase	0.0251	0.2032	0.7526

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.7783 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1470401
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 865471