TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.502 | Formula: C19H19N3O4S2
H donors: 3 H acceptors: 4 LogP: -0.77 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(c1cccc2c1scc2C)N)NC1C(=O)N2C1SCC(=C2C(=O)O)C
InChi: 1S/C19H19N3O4S2/c1-8-6-27-15-10(8)4-3-5-11(15)12(20)16(23)21-13-17(24)22-14(19(25)26)9(2)7-28-18(13)22/h3-6,12-13,18H,7,20H2,1-2H3,(H,21,23)(H,25,26)
InChiKey: ZFEKBHICBSNETQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ran, putative	0.0021	0.0283	0.129
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0581	0.084
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0514	0.0934
Echinococcus granulosus	thioredoxin glutathione reductase	0.0098	0.2047	0.272
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0564	0.125
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0514	0.0683
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0539	0.2451
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0.0026	0.0058
Onchocerca volvulus		0.0009	0.001	0.0179
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0484	0.0643
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.1257	0.1671
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0051	0.0067
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0131	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0539	0.2451
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	General substrate transporter	0.0089	0.186	0.2471
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0223	0.4934	0.8958
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0564	0.075
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0331	0.0478
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0131	0.0174
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0131	0.029
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0564	0.125
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0009	0.001	0.0013
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0329	0.5743
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Loa Loa (eye worm)	hypothetical protein	0.005	0.0945	0.1368
Onchocerca volvulus		0.0015	0.0131	0.232
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0009	0.001	0.0179
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0333	0.1517
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0329	0.0598
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0539	0.1193
Trypanosoma cruzi	hexose transporter	0.0032	0.0539	0.1193
Echinococcus granulosus	solute carrier family 22	0.0015	0.0131	0.0174
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0564	1
Leishmania major	protein kinase, putative	0.0032	0.0529	0.1172
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0089	0.0129
Plasmodium falciparum	importin beta, putative	0.0029	0.0459	0.0459
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0564	0.4443
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0459	0.0665
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0009	0.001	0.0013
Onchocerca volvulus		0.0009	0.001	0.0179
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0514	0.0683
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.053	0.0804
Brugia malayi	RNA, U transporter 1	0.0082	0.1689	0.3742
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0564	0.1024
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.494
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0564	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0514	0.1139
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0157	0.0209
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0204	0.4513	0.5998
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0168	0.3679	0.5585
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0564	0.9832
Schistosoma mansoni	ran	0.0021	0.0283	0.0377
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0529	0.0703
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.053	0.053
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0574	0.1271
Plasmodium vivax	glutathione reductase, putative	0.0098	0.2047	0.2047
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.0762
Brugia malayi	enteropeptidase precursor	0.0009	0.001	0.0022
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0329	0.0438
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0131	0.0199
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.0762
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.0283
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.4086	0.543
Onchocerca volvulus		0.0015	0.0131	0.232
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.1257	0.1671
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.1257	0.1671
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2198	0.3336
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0204	0.4513	1
Schistosoma mansoni	sugar transporter	0.0015	0.0131	0.0174
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0634	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0333	0.1517
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0204	0.4513	0.5998
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0539	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0157	0.0228
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.0628
Loa Loa (eye worm)	glutathione reductase	0.0098	0.2047	0.2961
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0204	0.4513	1
Echinococcus granulosus	pyruvate kinase	0.0017	0.0189	0.0251
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.127	0.1687
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0331	0.0733
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0329	0.073
Leishmania major	GTP-binding protein, putative	0.0021	0.0283	0.0628
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.0574	0.0871
Entamoeba histolytica	hypothetical protein	0.0023	0.0333	0.0739
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Schistosoma mansoni	importin beta-1	0.0029	0.0459	0.0611
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0564	0.125
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0539	0.1193
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0157	0.0209
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0157	0.0228
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0308	0.6911	1
Echinococcus granulosus	transcription factor Dp 1	0.0118	0.2525	0.3356
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Plasmodium falciparum	glutathione reductase	0.0098	0.2047	0.2047
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0009	0.001	0.0013
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0131	0.1031
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0131	0.0199
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0529	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Leishmania major	trypanothione reductase	0.0098	0.2047	0.4534
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0009	0.001	0.0013
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.0574	0.1271
Brugia malayi	Cam kinase protein 1	0.0032	0.0529	0.1172
Echinococcus granulosus	Low density lipoprotein receptor class A cysteine rich	0.0009	0.001	0.0013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0015
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0574	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	Thioredoxin reductase	0.0098	0.2047	0.4534
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0539	0.2451
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.1271
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0634	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0574	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0514	0.0744
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0189	0.0251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.4086	0.543
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0539	0.2451
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0514	0.8963
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.0628
Entamoeba histolytica	protein kinase, putative	0.0032	0.0529	0.1172
Loa Loa (eye worm)	sugar transporter	0.0104	0.2198	0.318
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0131	0.0595
Echinococcus multilocularis	transcription factor Dp 1	0.0118	0.2525	0.3356
Schistosoma mansoni	hypothetical protein	0.0335	0.7525	1
Echinococcus granulosus	snurportin 1	0.0308	0.6911	0.9184
Brugia malayi	Sugar transporter family protein	0.0104	0.2198	0.4869
Schistosoma mansoni	sugar transporter	0.0015	0.0131	0.0174
Schistosoma mansoni	hypothetical protein	0.0016	0.0157	0.0209
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0131	0.0189
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0539	0.2451
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0634	0.0634
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0025	0.0368	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Schistosoma mansoni	glucose transport protein	0.0104	0.2198	0.292
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0329	0.1499
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0529	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Onchocerca volvulus		0.0015	0.0131	0.232
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.0574	0.0574
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0064	0.127	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0634	0.0962
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0333	0.0739
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0131	0.0174
Loa Loa (eye worm)	sugar transporter	0.0015	0.0131	0.0189
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.127	0.1687
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0634	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0574	0.4519
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0204	0.4513	1
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.1257	0.2786
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0204	0.4513	0.5998
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0368	0.0368
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.053	0.0804
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0064	0.127	0.2813
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0131	0.0174
Onchocerca volvulus	Terribly reduced optic lobes homolog	0.0009	0.001	0.0179
Leishmania major	glucose transporter, lmgt2	0.0032	0.0539	0.1193
Schistosoma mansoni	hypothetical protein	0.0308	0.6911	0.9184
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0131	0.0199
Echinococcus granulosus	GPCR family 2	0.0016	0.0157	0.0209
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.1271
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0263	0.1198
Schistosoma mansoni	hypothetical protein	0.0016	0.0157	0.0209
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0131	0.1031
Schistosoma mansoni	hypothetical protein	0.0009	0.001	0.0013
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0329	0.05
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2198	0.292
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0131	0.0131
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0131	0.0238
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.1257	0.1671
Echinococcus granulosus	General substrate transporter	0.0089	0.186	0.2471
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0329	0.073
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0329	0.073
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0564	0.1024
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0131	0.029
Plasmodium vivax	hexose transporter	0.0104	0.2198	0.2198
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0204	0.4513	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.053	0.053
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0945	0.1368
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0131	0.029
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0539	0.1193
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0459	0.0611
Toxoplasma gondii	protein kinase, putative	0.0294	0.6588	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.4086	0.543
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0574	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0329	0.0477
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0009	0.001	0.0013
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0574	0.2611
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0157	0.0209
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.0628
Onchocerca volvulus		0.0015	0.0131	0.232
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.1257	0.1671
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0368	0.0815
Onchocerca volvulus		0.0009	0.001	0.0179
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0529	0.2408
Onchocerca volvulus	Arrow homolog	0.0009	0.001	0.0179
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0249	0.0451
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0064	0.127	0.2813
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.4086	0.543
Echinococcus multilocularis	low density lipoprotein receptor protein	0.0009	0.001	0.0013
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0283	0.0377
Giardia lamblia	Hexose transporter	0.0015	0.0131	0.2281
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0539	0.1193
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0368	0.0368
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0223	0.4934	0.8958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Echinococcus granulosus	geminin	0.0335	0.7525	1
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0131	0.0199
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0186	0.4086	0.9054
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.001	0.0022
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Schistosoma mansoni	protein kinase	0.0032	0.0529	0.0703
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0131	0.0595
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0459	0.0697
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0564	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0131	0.0595
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0009	0.001	0.0013
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0048	0.0829
Onchocerca volvulus		0.0009	0.001	0.0179
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0329	0.0329
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0189	0.0251
Mycobacterium tuberculosis	Probable reductase	0.0223	0.4934	0.8958
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0574	0.1271
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.0574	0.1042
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0131	0.029
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.0574	0.0574
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0204	0.4513	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0574	0.4519
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0283	0.0377
Echinococcus granulosus	5'partial\|Low density lipoprotein receptor class A cysteine rich	0.0009	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0564	0.2567
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0204	0.4513	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.2047	0.3716
Brugia malayi	Importin beta-1 subunit	0.0029	0.0459	0.1018
Entamoeba histolytica	Ran family GTPase	0.0021	0.0283	0.0628
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0131	0.029
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0168	0.3679	0.3679
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0048	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Brugia malayi	hypothetical protein	0.0015	0.0131	0.029
Schistosoma mansoni	hypothetical protein	0.0009	0.001	0.0013
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0131	0.0174
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0329	0.073
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.117	0.1693
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0574	0.2611
Leishmania major	glucose transporter, lmgt3	0.0032	0.0539	0.1193
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.4519
Plasmodium vivax	sugar transporter, putative	0.0015	0.0131	0.0131
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0564	0.125
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0064	0.127	0.1687
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0539	0.1193
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0009	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Brugia malayi	CUB domain containing protein	0.0009	0.001	0.0022
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0009	0.001	0.0013
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0574	0.1271
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0634	0.0634
Schistosoma mansoni	hypothetical protein	0.0011	0.0051	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Brugia malayi	TAR-binding protein	0.0063	0.1257	0.2786
Onchocerca volvulus		0.0015	0.0131	0.232
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.041
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0131	0.0174
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0574	0.1271
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.0574	1
Brugia malayi	Sugar transporter family protein	0.0015	0.0131	0.029
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0574	0.0762
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0945	0.2095
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0333	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0368	0.0532
Echinococcus granulosus	solute carrier family 22	0.0015	0.0131	0.0174
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0131	0.1031
Brugia malayi	major facilitator superfamily protein	0.0015	0.0131	0.029
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0529	0.1172
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.0574	0.1271
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0514	0.1139
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0529	0.0766
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0131	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0168	0.3679	0.3679
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0634	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0331	0.0478
Schistosoma mansoni	hypothetical protein	0.0104	0.2198	0.292
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0564	0.0816
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0574	0.0574
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0539	0.2451
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0131	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0366	0.0812
Schistosoma mansoni	protein kinase	0.0032	0.0529	0.0703
Schistosoma mansoni	glucose transport protein	0.0104	0.2198	0.292
Onchocerca volvulus		0.0015	0.0131	0.232
Entamoeba histolytica	hypothetical protein	0.0023	0.0329	0.073
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0459	0.0459
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0484	0.0643
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0015
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0945	0.2095
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.2047	0.2047
Loa Loa (eye worm)	RNA binding protein	0.0063	0.1257	0.182
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0368	0.0815
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0189	0.0251
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0564	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Mycobacterium ulcerans	sugar transporter	0.0015	0.0131	0.1031
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0157	0.0349
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.1257	0.182
Onchocerca volvulus		0.0015	0.0131	0.232
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Onchocerca volvulus		0.0009	0.001	0.0179
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0368	0.0558
Mycobacterium tuberculosis	Probable dehydrogenase	0.0223	0.4934	0.8958
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0223	0.4934	0.8958
Plasmodium falciparum	glutathione reductase	0.0034	0.0574	0.0574
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0009	0.001	0.0022
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0634	0.1404
Onchocerca volvulus		0.0015	0.0131	0.232
Brugia malayi	hypothetical protein	0.0015	0.0131	0.029
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0249	0.0451
Leishmania major	pyruvate kinase	0.0033	0.0564	0.125
Onchocerca volvulus		0.0015	0.0131	0.232
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0368	0.0368
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0015
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.1257	0.1671
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0514	0.1139
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0247	0.5508	1
Toxoplasma gondii	thioredoxin reductase	0.0098	0.2047	0.3107
Schistosoma mansoni	ran	0.0021	0.0283	0.0377
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0009	0.001	0.0013
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.0574	0.0574
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0009	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0368	0.0815
Schistosoma mansoni	hypothetical protein	0.0034	0.0581	0.0772
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.053	0.053
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0247	0.5508	1
Onchocerca volvulus		0.0015	0.0131	0.232
Echinococcus granulosus	tar DNA binding protein	0.0063	0.1257	0.1671
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0009	0.001	0.0015
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0009	0.001	0.0013
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0131	0.0174
Schistosoma mansoni	glucose transport protein	0.0104	0.2198	0.292
Leishmania major	hypothetical protein, conserved	0.0015	0.0131	0.029
Onchocerca volvulus	Putative transporter	0.0015	0.0131	0.232
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0514	0.0683
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.053	0.053
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0131	0.029
Mycobacterium tuberculosis	Probable oxidoreductase	0.0247	0.5508	1
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0009	0.001	0.0013
Echinococcus granulosus	pyruvate kinase	0.0017	0.0189	0.0251
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0514	0.234
Giardia lamblia	Pyruvate kinase	0.0033	0.0564	0.9832
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0131	0.0595
Leishmania major	glucose transporter, lmgt1	0.0032	0.0539	0.1193
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0402	0.0534
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	basement membrane proteoglycan precursor	0.0009	0.001	0.0022
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.4086	0.543
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0157	0.0209
Giardia lamblia	Pyruvate kinase	0.0017	0.0189	0.3287
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0329	0.0438
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0131	0.029
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0329	0.0438
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.4086	0.543
Brugia malayi	glutathione reductase	0.0098	0.2047	0.4534
Echinococcus multilocularis	snurportin 1	0.0308	0.6911	0.9184
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0223	0.4934	0.8958
Schistosoma mansoni	protein kinase	0.0032	0.0529	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0131	0.0595
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0283	0.043
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0131	0.0174
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0574	1
Onchocerca volvulus		0.0015	0.0131	0.232
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.053	0.053
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.0628
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.053	0.053
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0131	0.2281
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0564	0.125
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.0574	0.0574
Schistosoma mansoni	pyruvate kinase	0.0033	0.0564	0.075
Plasmodium falciparum	hexose transporter	0.0104	0.2198	0.2198
Schistosoma mansoni	glucose transporter	0.0015	0.0131	0.0174
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0529	0.1172
Leishmania major	pyruvate kinase	0.0033	0.0564	0.125
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.2047	0.4534
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0009	0.001	0.0013
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0564	0.2567
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0329	0.5743
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0064	0.127	0.2305
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.1257	0.182
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0529	0.0766
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0131	0.0595
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0131	0.0595
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	hypothetical protein	0.0016	0.0164	0.0363
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0459	0.0611
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0564	0.125
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0564	0.075
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Echinococcus granulosus	solute carrier family 22	0.0015	0.0131	0.0174
Echinococcus granulosus	solute carrier family 22	0.0015	0.0131	0.0174
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0131	0.029
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0329	0.0329
Echinococcus granulosus	pyruvate kinase	0.0033	0.0564	0.075
Schistosoma mansoni	hypothetical protein	0.0016	0.0157	0.0209
Entamoeba histolytica	protein kinase, putative	0.0032	0.0529	0.1172
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.053	0.053
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0009	0.001	0.0015
Onchocerca volvulus		0.0009	0.001	0.0179
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0539	0.1193
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0223	0.4934	0.8958
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0329	0.0438
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0564	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0379	0.0548
Echinococcus granulosus	pyruvate kinase	0.0017	0.0189	0.0251
Trypanosoma brucei	trypanothione reductase	0.0098	0.2047	0.4534
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0539	0.2451
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0204	0.4513	0.6531
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0564	0.0856
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0442	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Onchocerca volvulus		0.0015	0.0131	0.232
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0539	0.1193
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0247	0.5508	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0368	0.0815
Treponema pallidum	NADH oxidase	0.0034	0.0574	1
Schistosoma mansoni	sugar transporter	0.0015	0.0131	0.0174
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.053	0.0804
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0157	0.0349
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0539	0.1193
Schistosoma mansoni	sugar transporter	0.0015	0.0131	0.0174
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0514	0.0683
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.0189	0.0286
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2198	0.292
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.4086	0.543
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.0574	0.0871
Brugia malayi	hypothetical protein	0.0015	0.0131	0.029
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0048	0.0375
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Schistosoma mansoni	hypothetical protein	0.0016	0.0157	0.0209
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0186	0.4086	0.5913
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0459	0.1018
Brugia malayi	major facilitator superfamily protein	0.0015	0.0131	0.029
Plasmodium falciparum	pyruvate kinase	0.0033	0.0564	0.0564
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus granulosus	pyruvate kinase	0.0033	0.0564	0.075
Schistosoma mansoni	hypothetical protein	0.0335	0.7525	1
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2198	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0009	0.001	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0514	0.0744
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0574	0.1271
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0564	0.0564
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0051	0.0067
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.2047	0.2961
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0131	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0366	0.0812
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0459	0.1018
Plasmodium falciparum	thioredoxin reductase	0.0098	0.2047	0.2047
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0157	0.0209
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0009	0.001	0.0022
Plasmodium falciparum	pyruvate kinase 2	0.0017	0.0189	0.0189
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0064	0.127	1
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.02	0.0444
Schistosoma mansoni	pyruvate kinase	0.0017	0.0189	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0131	0.0595
Echinococcus granulosus	low density lipoprotein receptor protein	0.0009	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0574	0.1271
Brugia malayi	Sugar transporter family protein	0.0015	0.0131	0.029
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0131	0.029
Giardia lamblia	Sugar-proton symporter	0.0015	0.0131	0.2281
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0098	0.2047	0.272
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0249	0.0451
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0009	0.001	0.0013
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0539	0.1193
Onchocerca volvulus		0.0015	0.0131	0.232
Onchocerca volvulus		0.0015	0.0131	0.232
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0009	0.001	0.0013
Onchocerca volvulus		0.0015	0.0131	0.232
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0131	0.0189
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0329	0.2595
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0581	0.1287
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0529	0.0703
Onchocerca volvulus		0.0015	0.0131	0.232
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0333	0.1517
Schistosoma mansoni	pyruvate kinase	0.0033	0.0564	0.075
Plasmodium falciparum	protein kinase 7	0.0294	0.6588	0.6588
Brugia malayi	RNA binding protein	0.0063	0.1257	0.2786
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0329	0.2595
Echinococcus multilocularis	geminin	0.0335	0.7525	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0564	0.0816

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 1 ug ml-1	The compound was tested for antibacterial activity against Streptococcus pyogenes C203.	ChEMBL.	3877809
MIC (functional)	= 1 ug ml-1	The compound was tested for antibacterial activity against resistant Haemophilus influenzae 76.	ChEMBL.	3877809
MIC (functional)	= 2 ug ml-1	Antibacterial activity against penicillin G sensitive Staphylococcus aureus X1.1	ChEMBL.	3877809
MIC (functional)	= 2 ug ml-1	The compound was tested for antibacterial activity against Streptococcus pneumoniae Park.	ChEMBL.	3877809
MIC (functional)	= 8 ug ml-1	The compound was tested for antibacterial activity against Staphylococcus epidermidis EP11.	ChEMBL.	3877809
MIC (functional)	= 8 ug ml-1	The compound was tested for antibacterial activity against sensitive Haemophilus influenzae C.L.	ChEMBL.	3877809
MIC (functional)	= 16 ug ml-1	Antibacterial activity against penicillin G resistant Staphylococcus aureus V41.	ChEMBL.	3877809
MIC (functional)	= 64 ug ml-1	Aantibacterial activity against methicillin resistant Staphylococcus aureus S13E.	ChEMBL.	3877809
MIC (functional)	= 64 ug ml-1	Antibacterial activity against methicillin resistant Staphylococcus aureus X400.	ChEMBL.	3877809
MIC (functional)	= 64 ug ml-1	The compound was tested for antibacterial activity against Streptococcus group D X66.	ChEMBL.	3877809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL294872

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 86554