Detailed information for compound 867078

Basic information

Technical information
  • TDR Targets ID: 867078
  • Name: N-(4-acetylphenyl)-2-[methyl-[(2-phenyl-3H-be nzimidazol-5-yl)sulfonyl]amino]acetamide
  • MW: 462.521 | Formula: C24H22N4O4S
  • H donors: 2 H acceptors: 5 LogP: 2.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc2c(c1)nc([nH]2)c1ccccc1)C)Nc1ccc(cc1)C(=O)C
  • InChi: 1S/C24H22N4O4S/c1-16(29)17-8-10-19(11-9-17)25-23(30)15-28(2)33(31,32)20-12-13-21-22(14-20)27-24(26-21)18-6-4-3-5-7-18/h3-14H,15H2,1-2H3,(H,25,30)(H,26,27)
  • InChiKey: FXDKROLSUGFFAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-ethanoylphenyl)-2-[methyl-[(2-phenyl-3H-benzimidazol-5-yl)sulfonyl]amino]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.006 0.0283 0.0992
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.004 0.021
Schistosoma mansoni glycogen phosphorylase 0.0048 0.012 0.0139
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.006 0.0283 0.7635
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.017 0.1737 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.2084 0.2402
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0553 0.2991
Brugia malayi prolyl oligopeptidase family protein 0.006 0.0283 0.1529
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0949 1
Onchocerca volvulus 0.006 0.0277 0.1498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Echinococcus multilocularis peroxidasin 0.0081 0.0553 0.0553
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0361 0.4257 1
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0553 0.2994
Echinococcus multilocularis Dipeptidyl peptidase 9 0.006 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.017 0.1737 0.6398
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.012 0.127
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0148 0.0801
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Brugia malayi hypothetical protein 0.0081 0.0553 0.2994
Brugia malayi Blistered cuticle protein 3 0.0081 0.0553 0.2994
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.0949 0.0949
Onchocerca volvulus Peroxidase homolog 0.0081 0.0553 0.2991
Echinococcus granulosus chromobox protein 1 0.0069 0.0401 0.0463
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0028 0.0149
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0239 0.1294
Trichomonas vaginalis aldehyde oxidase, putative 0.0361 0.4257 1
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0277 0.1501
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.006 0.0283 0.7635
Brugia malayi carbohydrate phosphorylase 0.0111 0.0949 0.5134
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.0949 0.1093
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0553 0.2994
Brugia malayi hypothetical protein 0.0046 0.0096 0.0517
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0179 0.1848 0.213
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0148 0.0148
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0234 0.2468
Treponema pallidum quinoline 2-oxidoreductase 0.0057 0.0247 0.8682
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0234 0.055
Schistosoma mansoni hypothetical protein 0.0303 0.3491 0.4024
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0401 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Treponema pallidum hypothetical protein 0.0059 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0239 0.1294
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.006 0.0277 0.0277
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0234 0.6327
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0107 0.0903 0.3096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Loa Loa (eye worm) sodium-independent organic anion transporter 0.006 0.0277 0.1501
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.012 0.127
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0149
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0553 0.2994
Schistosoma mansoni organic anion transporter 0.006 0.0277 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.037 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0239 0.2648 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0234 0.6327
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0001 0.0002
Echinococcus multilocularis agrin 0.0041 0.0028 0.0028
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0028 0.0149
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.037 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0234 0.6327
Onchocerca volvulus 0.0081 0.0553 0.2991
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0239 0.0239
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.0949 0.5134
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0148 0.0171
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0179 0.1848 0.213
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0949 0.1093
Onchocerca volvulus 0.006 0.0277 0.1498
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0234 0.027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0149
Onchocerca volvulus 0.005 0.0148 0.0797
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0553 0.2994
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.037 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.006 0.0277 0.0277
Schistosoma mansoni agrin 0.0041 0.0028 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0081 0.0553 0.2994
Echinococcus multilocularis neuropeptide receptor A26 0.0514 0.6279 0.6279
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.037 1
Onchocerca volvulus Peroxidase homolog 0.0081 0.0553 0.2991
Brugia malayi mbt repeat family protein 0.005 0.0148 0.0801
Loa Loa (eye worm) hypothetical protein 0.0046 0.0096 0.0517
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0069 0.04 0.1106
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1052 0.5693
Brugia malayi prostaglandin transporter 0.006 0.0277 0.1501
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0148 0.0797
Echinococcus multilocularis neuropeptide s receptor 0.0514 0.6279 0.6279
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0234 0.6327
Echinococcus multilocularis follistatin 0.0041 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Onchocerca volvulus 0.0081 0.0553 0.2991
Onchocerca volvulus Putative organic anion transporter 0.006 0.0277 0.1498
Echinococcus granulosus peroxidasin 0.0081 0.0553 0.0638
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Brugia malayi prolyl oligopeptidase family protein 0.0179 0.1848 1
Chlamydia trachomatis glycogen phosphorylase 0.0111 0.0949 0.5
Loa Loa (eye worm) agrin synaptic family protein 0.0041 0.0028 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0149
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0361 0.4257 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0234 0.6327
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0234 0.6327
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0239 0.0276
Schistosoma mansoni chromobox protein 0.0069 0.0401 0.0463
Echinococcus granulosus Dipeptidyl peptidase 9 0.006 0.0283 0.0326
Onchocerca volvulus 0.0081 0.0553 0.2991
Brugia malayi secreted modular calcium-binding protein 1 0.0041 0.0028 0.0149
Onchocerca volvulus 0.006 0.0277 0.1498
Echinococcus multilocularis geminin 0.0696 0.8677 0.8677
Schistosoma mansoni chromobox protein 0.0069 0.0401 0.0463
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Echinococcus granulosus neuropeptide receptor A26 0.0514 0.6279 0.7237
Echinococcus granulosus chromobox protein 1 0.0069 0.0401 0.0463
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0182 0.4908
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0234 0.0234
Brugia malayi hypothetical protein 0.006 0.0277 0.1501
Loa Loa (eye worm) MBCTL1 0.0057 0.0239 0.1294
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.006 0.0283 0.7635
Schistosoma mansoni follistatin 0.0041 0.0028 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Onchocerca volvulus Dual oxidase homolog 0.0081 0.0553 0.2991
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0179 0.1848 0.1848
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0234 0.027
Onchocerca volvulus 0.0041 0.0028 0.0145
Echinococcus multilocularis expressed protein 0.0041 0.0028 0.0028
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0028 0.0149
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0234 0.0804
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Onchocerca volvulus 0.006 0.0277 0.1498
Brugia malayi SPARC precursor 0.0041 0.0028 0.0149
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0148 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0234 0.055
Schistosoma mansoni peroxidasin 0.0081 0.0553 0.0638
Leishmania major cathepsin L-like protease 0.0067 0.037 1
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0949 0.1093
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1052 0.5693
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0553 0.2994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0949 0.1093
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0236 0.2598 1
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0553 0.2994
Brugia malayi hypothetical protein 0.006 0.0277 0.1501
Leishmania major cathepsin L-like protease 0.0067 0.037 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0001 0.0002
Echinococcus granulosus agrin 0.0041 0.0028 0.0032
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0949 0.1093
Brugia malayi chromobox protein homolog 3 0.0039 0.0001 0.0004
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0069 0.04 0.1728
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0149
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma cruzi MFS transporter, putative 0.006 0.0277 0.7498
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0122 0.1099 0.3873
Trichomonas vaginalis chromobox protein, putative 0.0042 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.005 0.0148 0.0801
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0234 0.055
Brugia malayi MH2 domain containing protein 0.0118 0.1052 0.5693
Brugia malayi Heterochromatin protein 1 0.0069 0.0401 0.2172
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0148 0.0171
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0949 1
Onchocerca volvulus Chorion peroxidase homolog 0.0081 0.0553 0.2991
Giardia lamblia Glycogen phosphorylase 0.0111 0.0949 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0234 0.6327
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0277 0.0972
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0401 0.0943
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0949 0.0949
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0069 0.04 0.1106
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Brugia malayi mbt repeat family protein 0.005 0.0148 0.0801
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.012 0.127
Schistosoma mansoni organic anion transporter 0.006 0.0277 0.032
Echinococcus multilocularis chromobox protein 1 0.0069 0.0401 0.0401
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0553 0.2994
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0179 0.1848 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0294 0.7936
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0553 0.2994
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Onchocerca volvulus 0.006 0.0277 0.1498
Trypanosoma brucei protein kinase, putative 0.0056 0.0234 0.6327
Onchocerca volvulus Putative organic anion transporter 0.006 0.0277 0.1498
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0234 0.1267
Schistosoma mansoni peroxidasin 0.0081 0.0553 0.0638
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.1501
Echinococcus multilocularis chromobox protein 1 0.0069 0.0401 0.0401
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0949 0.0949
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0949 0.2228
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0148 0.0171
Mycobacterium ulcerans hypothetical protein 0.0059 0.0265 0.057
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0277 0.1501
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0122 0.1099 0.6053
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0239 0.0276
Echinococcus granulosus follistatin 0.0041 0.0028 0.0032
Brugia malayi Peroxidasin 0.0081 0.0553 0.2994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0553 0.2991
Leishmania major cathepsin L-like protease 0.0067 0.037 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.017 0.1737 0.6398
Echinococcus granulosus geminin 0.0696 0.8677 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0148 0.0171
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0028 0.0149
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0028 0.0149
Loa Loa (eye worm) hypothetical protein 0.0081 0.0553 0.2994
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.006 0.0283 0.7635
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0553 0.2994
Brugia malayi MAP kinase sur-1 0.0056 0.0234 0.1267
Schistosoma mansoni hypothetical protein 0.0696 0.8677 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.006 0.0283 0.0326
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0239 0.0276
Trichomonas vaginalis chromobox protein, putative 0.0042 0.004 0.0093
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0234 0.055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0001 0.0004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.2084 0.2084
Loa Loa (eye worm) prolyl oligopeptidase 0.0179 0.1848 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Onchocerca volvulus Putative organic anion transporter 0.006 0.0277 0.1498
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0239 0.0239
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0122 0.1099 0.3873
Echinococcus granulosus Solute carrier organic anion transporter family 0.006 0.0277 0.032
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.0949 0.5132
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0401 0.2172
Echinococcus granulosus organic anion transporting polypeptide 30B 0.006 0.0277 0.032
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0949 0.2228
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0234 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.037 1
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0277 0.1501
Echinococcus granulosus neuropeptide s receptor 0.0514 0.6279 0.7237
Schistosoma mansoni hypothetical protein 0.0696 0.8677 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.006 0.0283 0.7635

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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