TDR Targets

Basic information

Technical information

TDR Targets ID: 868035
Name: 3-acetamido-N-(3-fluorophenyl)-1-benzofuran-2 -carboxamide
MW: 312.295 | Formula: C17H13FN2O3
H donors: 2 H acceptors: 2 LogP: 3.32 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)NC(=O)c1oc2c(c1NC(=O)C)cccc2
InChi: 1S/C17H13FN2O3/c1-10(21)19-15-13-7-2-3-8-14(13)23-16(15)17(22)20-12-6-4-5-11(18)9-12/h2-9H,1H3,(H,19,21)(H,20,22)
InChiKey: VBLMMUZRPIBVOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-acetamido-N-(3-fluorophenyl)benzofuran-2-carboxamide
3-acetamido-N-(3-fluorophenyl)-2-benzofurancarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1165	0.2652
Schistosoma mansoni	hypothetical protein	0.0017	0.007	0.0167
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0767	0.1688
Echinococcus granulosus	GPCR family 2	0.0017	0.007	0.007
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0179	0.0179
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0348	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0114	0.1971	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0767	0.1688
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Echinococcus multilocularis	geminin	0.0178	0.3214	0.3214
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1971	1
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0179	0.0179
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.006	0.0912	0.2039
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2112	0.4945
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0311	0.0736
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Brugia malayi	6-phosphofructokinase	0.0114	0.1971	0.4603
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Schistosoma mansoni	hypothetical protein	0.0178	0.3214	0.7652
Echinococcus granulosus	6 phosphofructokinase	0.0114	0.1971	0.1971
Brugia malayi	RhoGAP domain containing protein	0.0073	0.1165	0.2652
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Loa Loa (eye worm)	phosphofructokinase	0.0114	0.1971	0.4603
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1971	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0311	0.138
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0179	0.0695
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0084	0.139	0.139
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0348	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.1971	0.4603
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.1971	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0311	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0228	0.42	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0348	0.2692
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1971	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Leishmania major	DNA polymerase eta, putative	0.0051	0.0748	0.3175
Echinococcus multilocularis	6 phosphofructokinase	0.0114	0.1971	0.1971
Schistosoma mansoni	DNA polymerase eta	0.0051	0.0748	0.178
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0179	0.0179
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0348	0.0946
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.1971	1
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0228	0.42	1
Echinococcus granulosus	Rac GTPase activating protein 1	0.0084	0.139	0.139
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0311	0.0736
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.1971	0.4693
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0179	0.0425
Schistosoma mansoni	peptidylglycine monooxygenase	0.0121	0.2112	0.5029
Schistosoma mansoni	hypothetical protein	0.0178	0.3214	0.7652
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0179	0.0695
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0121	0.2112	0.5029
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0061	0.0947	0.2124
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.007	0.007
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0348	0.1719
Echinococcus multilocularis	GPCR, family 2	0.0017	0.007	0.007
Echinococcus granulosus	dna polymerase eta	0.0051	0.0748	0.0748
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0228	0.42	0.42
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0228	0.42	0.42
Echinococcus granulosus	geminin	0.0178	0.3214	0.3214
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0767	0.1688
Leishmania major	ATP-dependent phosphofructokinase	0.0114	0.1971	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0051	0.0748	0.3175
Brugia malayi	hypothetical protein	0.0029	0.0311	0.0582
Brugia malayi	MH2 domain containing protein	0.0137	0.2414	0.5677
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0311	0.0582
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0348	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.007	0.007
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1971	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0121	0.2112	0.4945
Schistosoma mansoni	hypothetical protein	0.0017	0.007	0.0167
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0348	0.0946
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.1971	0.4693
Trypanosoma brucei	unspecified product	0.0022	0.0179	0.0695
Schistosoma mansoni	hypothetical protein	0.0036	0.0445	0.1058
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0348	0.5
Trypanosoma brucei	DNA polymerase eta, putative	0.0051	0.0748	0.3649
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0348	0.0946
Schistosoma mansoni	rac gtpase activating protein	0.0084	0.139	0.331
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0348	0.2692
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0179	0.0179
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1971	1
Brugia malayi	hypothetical protein	0.0019	0.0111	0.0099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0114	0.1971	1
Brugia malayi	phosphofructokinase	0.0114	0.1971	0.4603
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0348	0.5
Loa Loa (eye worm)	hypothetical protein	0.0084	0.139	0.3197
Brugia malayi	6-phosphofructokinase	0.0114	0.1971	0.4603
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0348	0.2692
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0036	0.045	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0767	0.1688
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0114	0.1971	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0525	1	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.1971	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0179	0.0425
Schistosoma mansoni	hypothetical protein	0.0017	0.007	0.0167
Echinococcus multilocularis	dna polymerase eta	0.0051	0.0748	0.0748
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.1971	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.007	0.007
Brugia malayi	RhoGAP domain containing protein	0.0084	0.139	0.3197
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0179	0.0695
Giardia lamblia	Rho GAP, putative	0.0073	0.1165	1
Leishmania major	DNA polymerase eta, putative	0.0036	0.045	0.1516
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0114	0.1971	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.2414	0.5677
Trypanosoma cruzi	DNA polymerase eta, putative	0.0036	0.045	0.1516
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0179	0.0263
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0179	0.0695
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.1971	0.4603
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0748	0.1641
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0445	0.0907
Brugia malayi	ImpB/MucB/SamB family protein	0.0051	0.0748	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0445	0.0907
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.2414	0.5677
Schistosoma mansoni	hypothetical protein	0.0017	0.007	0.0167
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0228	0.42	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0348	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0179	0.0263

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 868035