TDR Targets

Basic information

Technical information

TDR Targets ID: 869418
Name: 2-[(2-chlorophenyl)methyl]-N-(3-ethoxypropyl) -8-methyl-4,5-dihydrofuro[5,4-g]indazole-7-ca rboxamide
MW: 427.924 | Formula: C23H26ClN3O3
H donors: 1 H acceptors: 2 LogP: 4.06 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCCNC(=O)c1oc2c(c1C)c1nn(cc1CC2)Cc1ccccc1Cl
InChi: 1S/C23H26ClN3O3/c1-3-29-12-6-11-25-23(28)22-15(2)20-19(30-22)10-9-17-14-27(26-21(17)20)13-16-7-4-5-8-18(16)24/h4-5,7-8,14H,3,6,9-13H2,1-2H3,(H,25,28)
InChiKey: FIYDSDPBOCSUSH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-chlorobenzyl)-N-(3-ethoxypropyl)-8-methyl-4,5-dihydrofuro[5,4-g]indazole-7-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.1592	0.1595
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0969	0.6233
Brugia malayi	beta-lactamase family protein	0.0037	0.0969	0.0971
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0147	0.0045
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0969	1
Echinococcus granulosus	survival motor neuron protein 1	0.0242	0.9982	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.1592	0.1595
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0883	0.0884
Echinococcus multilocularis	lamin	0.0028	0.0563	0.0507
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0969	0.0903
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0693	0.4337
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0969	0.0903
Plasmodium vivax	SET domain protein, putative	0.0031	0.0693	0.0653
Mycobacterium ulcerans	lipase LipD	0.0037	0.0969	1
Onchocerca volvulus		0.0037	0.0969	0.0577
Onchocerca volvulus		0.0037	0.0969	0.0577
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0416	0.0417
Echinococcus granulosus	intermediate filament protein	0.0028	0.0563	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Echinococcus multilocularis	musashi	0.0028	0.0563	0.0507
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0693	0.0638
Echinococcus multilocularis	lamin dm0	0.0028	0.0563	0.0507
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0969	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1592	0.1595
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0969	1
Brugia malayi	beta-lactamase	0.0037	0.0969	0.0971
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.006	0.006
Schistosoma mansoni	lamin	0.0028	0.0563	0.3449
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0693	0.4337
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0416	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0416	0.0417
Leishmania major	hypothetical protein, conserved	0.0037	0.0969	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.8707	0.8723
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0693	0.0694
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1407	0.9233
Schistosoma mansoni	hypothetical protein	0.0035	0.0883	0.5639
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0969	0.0971
Schistosoma mansoni	lamin	0.0028	0.0563	0.3449
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0969	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.9982	1
Toxoplasma gondii	60S ribosomal protein L27, putative	0.0208	0.8503	1
Schistosoma mansoni	survival motor neuron protein	0.0049	0.1519	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0969	0.0903
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0416	0.3277
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0563	0.0564
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0969	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0416	0.0417
Onchocerca volvulus		0.0028	0.0563	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0147	0.0147
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0693	0.0638
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0969	0.0984
Brugia malayi	Pre-SET motif family protein	0.0031	0.0693	0.0694
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0969	0.0903
Schistosoma mansoni	hypothetical protein	0.0049	0.1519	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1407	0.141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Brugia malayi	intermediate filament protein	0.0028	0.0563	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Trichomonas vaginalis	set domain proteins, putative	0.0242	1	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0969	0.0917
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0693	0.0638
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0563	0.0564
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0969	0.6233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1407	0.1358
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1407	0.9233
Onchocerca volvulus		0.0031	0.0693	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0969	0.0903
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0563	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0969	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0416	0.0417
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1407	0.1358
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1407	0.141
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0416	0.0417
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0693	0.4337
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0969	0.0903
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0693	0.4337
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.1519	0.1522
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.006	0.006
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0969	0.0903
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0969	0.5
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0416	0.0326
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0416	0.3277
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0416	0.3277
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.006
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0969	0.0903
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0416	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0969	0.0917
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0416	0.3277
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0147	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0242	0.9982	1
Onchocerca volvulus		0.0037	0.0969	0.0577
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1407	0.1358
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0563	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0541	0.0542
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0643	0.0588
Brugia malayi	beta-lactamase family protein	0.0037	0.0969	0.0971
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0416	0.3277
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.9692	1
Echinococcus granulosus	lamin dm0	0.0028	0.0563	0.0507
Brugia malayi	hypothetical protein	0.0242	0.9982	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0969	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0883	0.0884
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0416	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0563	0.0564
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0416	0.3277
Onchocerca volvulus		0.0028	0.0563	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0147	0.0147
Plasmodium falciparum	mitochondrial ribosomal protein L41, putative	0.0208	0.8503	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0416	0.5
Onchocerca volvulus		0.0049	0.1519	0.115
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1407	0.9233
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0969	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0147	0.0147
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0969	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.006	0.006
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0969	0.0971
Echinococcus granulosus	lamin	0.0028	0.0563	0.0507
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1407	0.1358
Brugia malayi	Pre-SET motif family protein	0.0213	0.8707	0.8723
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0416	0.3277
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.1592	0.1595
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0416	0.0417
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0969	1
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0969	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0969	0.0354
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0969	0.0903
Plasmodium vivax	mitochondrial ribosomal protein L41, putative	0.0208	0.8503	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0416	0.3277

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869418