TDR Targets

Basic information

Technical information

TDR Targets ID: 869786
Name: N-(2,5-difluorophenyl)-2-ethyl-2,3-dihydro-1, 4-benzoxazine-4-carboxamide
MW: 318.318 | Formula: C17H16F2N2O2
H donors: 1 H acceptors: 1 LogP: 3.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccccc2N(C1)C(=O)Nc1cc(F)ccc1F
InChi: 1S/C17H16F2N2O2/c1-2-12-10-21(15-5-3-4-6-16(15)23-12)17(22)20-14-9-11(18)7-8-13(14)19/h3-9,12H,2,10H2,1H3,(H,20,22)
InChiKey: HGABXHHCUMUASF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0357	0.8881
Loa Loa (eye worm)	animal heme peroxidase	0.0278	0.3814	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.009	0.1044	0.0679
Brugia malayi	Blistered cuticle protein 3	0.0278	0.3814	1
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.0391	1
Brugia malayi	Calcium binding EGF domain containing protein	0.009	0.1044	0.2272
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0464	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0122	0.1267
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Echinococcus granulosus	neurogenic locus notch protein	0.009	0.1044	0.0713
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Echinococcus multilocularis	protein jagged 2	0.009	0.1044	0.0679
Echinococcus multilocularis	neurogenic locus protein delta	0.009	0.1044	0.0679
Onchocerca volvulus		0.009	0.1044	0.1745
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0118	0.1138
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0039	0.0985
Onchocerca volvulus	Slit protein homolog	0.009	0.1044	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Echinococcus multilocularis	neurogenic locus protein delta	0.009	0.1044	0.0679
Onchocerca volvulus		0.009	0.1044	0.1745
Loa Loa (eye worm)	Notch2	0.009	0.1044	0.2272
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Echinococcus granulosus	notch	0.009	0.1044	0.0713
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Echinococcus granulosus	protein jagged 1	0.009	0.1044	0.0713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0083	0.0018
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0357	0.1662
Loa Loa (eye worm)	animal heme peroxidase	0.0278	0.3814	1
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Schistosoma mansoni	laminin gamma-3 chain	0.009	0.1044	0.0834
Onchocerca volvulus		0.0278	0.3814	1
Schistosoma mansoni	cell polarity protein	0.009	0.1044	0.0834
Giardia lamblia	High cysteine protein	0.009	0.1044	1
Brugia malayi	Peroxidasin	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Brugia malayi	Cadherin domain containing protein	0.009	0.1044	0.2272
Echinococcus multilocularis	peroxidasin	0.0278	0.3814	0.3562
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.0391	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1973	0.4863
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0464	0.0655
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.009	0.1044	0.1745
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Brugia malayi	Muscle positioning protein 4	0.009	0.1044	0.2272
Echinococcus granulosus	fibropellin Ia	0.009	0.1044	0.0713
Onchocerca volvulus		0.009	0.1044	0.1745
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0157	0.2387
Brugia malayi	Animal haem peroxidase family protein	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0254	0.556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0171	0.2856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0254	0.556
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0357	0.8881
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Loa Loa (eye worm)	hypothetical protein	0.005	0.0459	0.0639
Onchocerca volvulus		0.009	0.1044	0.1745
Brugia malayi	Cadherin domain containing protein	0.009	0.1044	0.2272
Onchocerca volvulus		0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Brugia malayi	Delta serrate ligand family protein	0.009	0.1044	0.2272
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Brugia malayi	GCC2 and GCC3 family protein	0.009	0.1044	0.2272
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.1881	0.169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Giardia lamblia	GTOR	0.0046	0.0391	0.1181
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.0391	1
Echinococcus granulosus	protein jagged 1	0.009	0.1044	0.0713
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.009	0.1044	0.0834
Brugia malayi	hypothetical protein	0.0278	0.3814	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.009	0.1044	0.1745
Echinococcus multilocularis	microtubule associated protein 2	0.0699	1	1
Echinococcus granulosus	peroxidasin	0.0278	0.3814	0.3585
Brugia malayi	Animal haem peroxidase family protein	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0459	0.0234
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Echinococcus multilocularis	slit 2 protein	0.009	0.1044	0.0679
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Brugia malayi	Calcium binding EGF domain containing protein	0.009	0.1044	0.2272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0293	0.6827
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0122	0.1267
Echinococcus granulosus	neurogenic locus notch protein	0.009	0.1044	0.0713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0122	0.1267
Onchocerca volvulus		0.009	0.1044	0.1745
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.009	0.1044	0.2272
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.182	0.1518
Onchocerca volvulus	Peroxidase homolog	0.0278	0.3814	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0046	0.0391	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0254	0.556
Schistosoma mansoni	microtubule-associated protein tau	0.0699	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Echinococcus granulosus	neural cadherin	0.009	0.1044	0.0713
Schistosoma mansoni	septate junction protein	0.009	0.1044	0.0834
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Echinococcus granulosus	delta-like protein 1	0.009	0.1044	0.0713
Brugia malayi	Animal haem peroxidase family protein	0.0278	0.3814	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0391	1
Echinococcus granulosus	neurogenic locus protein delta	0.009	0.1044	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0254	0.556
Loa Loa (eye worm)	acetyltransferase	0.0147	0.1881	0.4606
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Echinococcus granulosus	protein jagged 2	0.009	0.1044	0.0713
Echinococcus multilocularis	notch	0.009	0.1044	0.0679
Loa Loa (eye worm)	notch protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.0391	0.0451
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Onchocerca volvulus		0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Schistosoma mansoni	peroxidasin	0.0278	0.3814	0.3669
Toxoplasma gondii	EGF family domain-containing protein	0.009	0.1044	1
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Onchocerca volvulus	Putative cubilin	0.009	0.1044	0.1745
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0118	0.1138
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Echinococcus multilocularis	neurogenic locus notch protein	0.009	0.1044	0.0679
Loa Loa (eye worm)	hypothetical protein	0.005	0.0464	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Echinococcus multilocularis	fibropellin Ia	0.009	0.1044	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.0391	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.0391	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0391	1
Schistosoma mansoni	peroxidasin	0.0278	0.3814	0.3669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0083	0.0018
Echinococcus granulosus	tumor protein p63	0.0342	0.4755	0.4561
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	blistered cuticle protein 3	0.0278	0.3814	1
Onchocerca volvulus	Dual oxidase homolog	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.1881	0.155
Brugia malayi	Calcium binding EGF domain containing protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	animal heme peroxidase	0.0278	0.3814	1
Brugia malayi	hypothetical protein	0.0153	0.1973	0.4863
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Onchocerca volvulus	Peroxidasin homolog	0.0278	0.3814	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.1881	0.4606
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0046	0.0391	1
Echinococcus granulosus	protein jagged 2	0.009	0.1044	0.0713
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Onchocerca volvulus	Peroxidase homolog	0.0278	0.3814	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.0391	1
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Echinococcus multilocularis	protein jagged 1	0.009	0.1044	0.0679
Echinococcus multilocularis	neural cadherin	0.009	0.1044	0.0679
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0083	0.0018
Echinococcus multilocularis	protein jagged 1	0.009	0.1044	0.0679
Schistosoma mansoni	hypothetical protein	0.009	0.1044	0.0834
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0391	1
Brugia malayi	Animal haem peroxidase family protein	0.0278	0.3814	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0357	0.5
Brugia malayi	notch-like transmembrane receptor	0.009	0.1044	0.2272
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0357	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.022	0.444
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0255	0.6514
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Echinococcus multilocularis	neurogenic locus notch protein	0.009	0.1044	0.0679
Schistosoma mansoni	notch	0.009	0.1044	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.0391	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Loa Loa (eye worm)	animal heme peroxidase	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.0391	0.0036
Schistosoma mansoni	slit	0.009	0.1044	0.0834
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0254	0.556
Onchocerca volvulus	Chorion peroxidase homolog	0.0278	0.3814	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.009	0.1044	0.0679
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0304	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0278	0.3814	1
Echinococcus multilocularis	tumor protein p63	0.0342	0.4755	0.4541
Echinococcus granulosus	neurogenic locus notch protein 4	0.009	0.1044	0.0713
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0464	0.0655
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Loa Loa (eye worm)	hypothetical protein	0.0278	0.3814	1
Onchocerca volvulus	Peroxidasin homolog	0.0278	0.3814	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.1044	0.2272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0083	0.0018
Echinococcus granulosus	slit 2 protein	0.009	0.1044	0.0713
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.0391	1
Brugia malayi	EGF-like domain containing protein	0.009	0.1044	0.2272
Onchocerca volvulus		0.0153	0.1973	0.4512

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869786