Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0218 | 0.0218 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0218 | 0.0611 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0721 | 1 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.3574 | 1 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0721 | 1 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1106 | 1 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0182 | 0.2041 | 0.379 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.3574 | 1 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0649 | 0.8936 | 0.5 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1106 | 0.3094 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0721 | 1 | 0.5 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0182 | 0.2041 | 0.5712 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1106 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0206 | 0.2399 | 0.524 |
Brugia malayi | hypothetical protein | 0.0286 | 0.3574 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2041 | 0.379 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3574 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.0721 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0721 | 1 | 0.5 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.0649 | 0.8936 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0218 | 0.0218 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0721 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.