Detailed information for compound 871573

Basic information

Technical information
  • TDR Targets ID: 871573
  • Name: N-(5-methyl-1,2-oxazol-3-yl)-2-nitrobenzenesu lfonamide
  • MW: 283.261 | Formula: C10H9N3O5S
  • H donors: 1 H acceptors: 5 LogP: 1.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1onc(c1)NS(=O)(=O)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C10H9N3O5S/c1-7-6-10(11-18-7)12-19(16,17)9-5-3-2-4-8(9)13(14)15/h2-6H,1H3,(H,11,12)
  • InChiKey: QFEDDNGWUIKTEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-methylisoxazol-3-yl)-2-nitro-benzenesulfonamide
  • N-(5-methyl-3-isoxazolyl)-2-nitrobenzenesulfonamide
  • N-(5-methyl-1,2-oxazol-3-yl)-2-nitro-benzenesulfonamide
  • ZINC00068337
  • AG-690/33051058
  • BIM-0047400.P001
  • MixCom6_002589
  • CBMicro_047645
  • IVK/8094975
  • EU-0073204

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.1875 0.5
Echinococcus multilocularis C type lectin domian containing protein 0.0025 0.209 0.2077
Echinococcus granulosus thioredoxin glutathione reductase 0.0068 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.1875 0.1862
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Onchocerca volvulus Dual oxidase homolog 0.0034 0.3756 0.8887
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Schistosoma mansoni peroxidasin 0.0037 0.4354 0.4354
Treponema pallidum NADH oxidase 0.0024 0.1875 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Toxoplasma gondii rhoptry neck protein RON9 0.0025 0.209 0.2077
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Echinococcus granulosus notch 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Echinococcus granulosus neurogenic locus notch protein 4 0.0013 0.0016 0.0016
Echinococcus granulosus neural cadherin 0.0013 0.0016 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Echinococcus granulosus protein jagged 2 0.0013 0.0016 0.0016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.1875 0.1875
Trypanosoma brucei trypanothione reductase 0.0068 1 1
Plasmodium vivax glutathione reductase, putative 0.0068 1 1
Schistosoma mansoni peroxidasin 0.0034 0.3756 0.3756
Onchocerca volvulus 0.0034 0.3756 0.8887
Onchocerca volvulus Peroxidase homolog 0.0034 0.3756 0.8887
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0024 0.1875 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.2597 0.2597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Onchocerca volvulus Peroxidase homolog 0.0034 0.3756 0.8887
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Trypanosoma cruzi trypanothione reductase, putative 0.0068 1 1
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi Muscle positioning protein 4 0.0013 0.0016 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.1875 0.5
Echinococcus multilocularis c4b binding protein beta chain 0.0025 0.209 0.2077
Onchocerca volvulus 0.0025 0.209 0.4927
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Onchocerca volvulus Peroxidasin homolog 0.0036 0.4225 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Plasmodium falciparum thioredoxin reductase 0.0068 1 1
Schistosoma mansoni septate junction protein 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0025 0.209 0.4927
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Brugia malayi Animal haem peroxidase family protein 0.0034 0.3756 0.3756
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.1875 1
Onchocerca volvulus 0.0025 0.209 0.4927
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.1875 0.1862
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.3756 0.3756
Onchocerca volvulus Peroxidasin homolog 0.0036 0.4225 1
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Echinococcus granulosus neurogenic locus notch protein 0.0013 0.0016 0.0016
Schistosoma mansoni slit 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Schistosoma mansoni c4b-binding protein beta chain 0.0025 0.209 0.209
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0013 0.0016 0.0016
Plasmodium vivax apical sushi protein, putative 0.0025 0.209 0.0264
Brugia malayi Animal haem peroxidase family protein 0.0036 0.4225 0.4225
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Onchocerca volvulus 0.0025 0.209 0.4927
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Brugia malayi Animal haem peroxidase family protein 0.0034 0.3756 0.3756
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Leishmania major trypanothione reductase 0.0068 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.1875 0.5
Loa Loa (eye worm) Notch2 0.0013 0.0016 0.0016
Plasmodium falciparum glutathione reductase 0.0068 1 1
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.1875 0.5
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.1875 0.5
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0025 0.209 0.4927
Loa Loa (eye worm) hypothetical protein 0.004 0.4823 0.4823
Echinococcus granulosus delta-like protein 1 0.0013 0.0016 0.0016
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0016 0.0016
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.1875 0.1862
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.1875 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Echinococcus granulosus fibropellin Ia 0.0013 0.0016 0.0016
Schistosoma mansoni laminin gamma-3 chain 0.0013 0.0016 0.0016
Echinococcus granulosus roundabout 2 0.0016 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0025 0.209 0.209
Plasmodium falciparum apical sushi protein 0.0025 0.209 0.0264
Brugia malayi Blistered cuticle protein 3 0.0034 0.3756 0.3756
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0068 1 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0034 0.3756 0.3756
Echinococcus granulosus protein jagged 2 0.0013 0.0016 0.0016
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Echinococcus granulosus neurogenic locus protein delta 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0025 0.209 0.4927
Onchocerca volvulus 0.0025 0.209 0.4927
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Plasmodium vivax thioredoxin reductase, putative 0.0068 1 1
Echinococcus granulosus peroxidasin 0.004 0.4823 0.4823
Brugia malayi Animal haem peroxidase family protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0016 0.0469 0.0469
Brugia malayi hypothetical protein 0.0025 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Onchocerca volvulus 0.0025 0.209 0.4927
Brugia malayi Animal haem peroxidase family protein 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Echinococcus multilocularis roundabout 2 0.0016 0.0469 0.0453
Brugia malayi Cadherin domain containing protein 0.0013 0.0016 0.0016
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.1875 0.1875
Onchocerca volvulus 0.0034 0.3756 0.8887
Schistosoma mansoni cell polarity protein 0.0013 0.0016 0.0016
Brugia malayi Delta serrate ligand family protein 0.0013 0.0016 0.0016
Schistosoma mansoni notch 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0469 0.0469
Brugia malayi Thioredoxin reductase 0.0068 1 1
Onchocerca volvulus 0.0025 0.209 0.4927
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.4539 0.4539
Loa Loa (eye worm) thioredoxin reductase 0.0068 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.1875 0.5
Toxoplasma gondii rhoptry neck protein RON1 0.0025 0.209 0.2077
Loa Loa (eye worm) glutathione reductase 0.0068 1 1
Brugia malayi EGF-like domain containing protein 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi Cadherin domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0034 0.3756 0.3756
Toxoplasma gondii thioredoxin reductase 0.0068 1 1
Echinococcus granulosus c4b binding protein beta chain 0.0025 0.209 0.209
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0013 0.0016 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.0036 0.4225 0.4225
Echinococcus granulosus protein jagged 1 0.0013 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.1875 0.5
Brugia malayi Sushi domain 0.0025 0.209 0.209
Onchocerca volvulus 0.0025 0.209 0.4927
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.0034 0.3756 0.3756
Onchocerca volvulus Chorion peroxidase homolog 0.0034 0.3756 0.8887
Loa Loa (eye worm) notch protein 0.0013 0.0016 0.0016
Echinococcus granulosus slit 2 protein 0.0013 0.0016 0.0016
Brugia malayi notch-like transmembrane receptor 0.0013 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi GCC2 and GCC3 family protein 0.0038 0.4539 0.4539
Echinococcus granulosus neurogenic locus notch protein 0.0013 0.0016 0.0016
Brugia malayi pregnancy-associated plasma protein-A 0.0025 0.209 0.209
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0732 0.0732
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0016
Echinococcus granulosus C type lectin domian containing protein 0.0025 0.209 0.209
Brugia malayi Peroxidasin 0.004 0.4823 0.4823
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0025 0.209 0.209
Onchocerca volvulus 0.0034 0.3756 0.8887
Echinococcus multilocularis peroxidasin 0.004 0.4823 0.4815
Brugia malayi hypothetical protein 0.0034 0.3756 0.3756
Echinococcus granulosus protein jagged 1 0.0013 0.0016 0.0016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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