Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Brugia malayi | Sushi domain | 0.0025 | 0.209 | 0.209 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0068 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0034 | 0.3756 | 0.8887 | |
Onchocerca volvulus | Peroxidase homolog | 0.0034 | 0.3756 | 0.8887 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Plasmodium falciparum | thioredoxin reductase | 0.0068 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0013 | 0.0016 | 0.0016 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0025 | 0.209 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0068 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0036 | 0.4225 | 0.4225 |
Echinococcus granulosus | protein jagged 1 | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | Peroxidasin homolog | 0.0036 | 0.4225 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0034 | 0.3756 | 0.3756 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | fibropellin Ia | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0024 | 0.1875 | 0.1862 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0017 | 0.0732 | 0.0732 |
Plasmodium falciparum | apical sushi protein | 0.0025 | 0.209 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0025 | 0.209 | 0.209 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0025 | 0.209 | 0.209 |
Plasmodium vivax | glutathione reductase, putative | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4823 | 0.4823 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0034 | 0.3756 | 0.3756 |
Echinococcus granulosus | protein jagged 1 | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Plasmodium falciparum | glutathione reductase | 0.0068 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | delta-like protein 1 | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | Notch2 | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Echinococcus granulosus | protein jagged 2 | 0.0013 | 0.0016 | 0.0016 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | notch protein | 0.0013 | 0.0016 | 0.0016 |
Treponema pallidum | NADH oxidase | 0.0024 | 0.1875 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0024 | 0.1875 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0034 | 0.3756 | 0.8887 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Peroxidasin | 0.004 | 0.4823 | 0.4823 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0013 | 0.0016 | 0.0016 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0469 | 0.0453 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1862 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0025 | 0.209 | 0.209 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0025 | 0.209 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Brugia malayi | Delta serrate ligand family protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Cadherin domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4539 | 0.4539 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0024 | 0.1875 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0038 | 0.4539 | 0.4539 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0068 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0017 | 0.0732 | 0.0732 |
Brugia malayi | Animal haem peroxidase family protein | 0.0034 | 0.3756 | 0.3756 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | notch-like transmembrane receptor | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0034 | 0.3756 | 0.8887 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | slit 2 protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Thioredoxin reductase | 0.0068 | 1 | 1 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0025 | 0.209 | 0.2077 |
Schistosoma mansoni | peroxidasin | 0.0037 | 0.4354 | 0.4354 |
Toxoplasma gondii | thioredoxin reductase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0025 | 0.209 | 0.209 |
Echinococcus granulosus | peroxidasin | 0.004 | 0.4823 | 0.4823 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus multilocularis | peroxidasin | 0.004 | 0.4823 | 0.4815 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0024 | 0.1875 | 0.1862 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | Peroxidase homolog | 0.0034 | 0.3756 | 0.8887 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | protein jagged 2 | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0034 | 0.3756 | 0.8887 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Onchocerca volvulus | Peroxidasin homolog | 0.0036 | 0.4225 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | septate junction protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Leishmania major | trypanothione reductase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0034 | 0.3756 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0025 | 0.209 | 0.2077 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0068 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0036 | 0.4225 | 0.4225 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0024 | 0.1875 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0068 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0024 | 0.1875 | 0.1875 |
Brugia malayi | Animal haem peroxidase family protein | 0.0034 | 0.3756 | 0.3756 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0034 | 0.3756 | 0.3756 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Animal haem peroxidase family protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0068 | 1 | 1 |
Echinococcus granulosus | notch | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | neural cadherin | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0034 | 0.3756 | 0.3756 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 | |
Plasmodium vivax | apical sushi protein, putative | 0.0025 | 0.209 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | notch | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0469 | 0.0469 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | EGF-like domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.209 | 0.209 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1875 |
Onchocerca volvulus | 0.0034 | 0.3756 | 0.8887 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2597 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | slit | 0.0013 | 0.0016 | 0.0016 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0025 | 0.209 | 0.2077 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1875 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3756 | 0.3756 |
Brugia malayi | Muscle positioning protein 4 | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | peroxidasin | 0.0034 | 0.3756 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0025 | 0.209 | 0.4927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.