TDR Targets

Basic information

Technical information

TDR Targets ID: 875276
Name: N-[3-(2-methylphenyl)-[1,2,4]triazolo[4,5-d][ 1,3,4]thiadiazol-6-yl]propanamide
MW: 287.34 | Formula: C13H13N5OS
H donors: 1 H acceptors: 4 LogP: 2.27 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)Nc1nn2c(s1)nnc2c1ccccc1C
InChi: 1S/C13H13N5OS/c1-3-10(19)14-12-17-18-11(15-16-13(18)20-12)9-7-5-4-6-8(9)2/h4-7H,3H2,1-2H3,(H,14,17,19)
InChiKey: BABSMDCOMDHPDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(2-methylphenyl)-[1,2,4]triazolo[4,5-d][1,3,4]thiadiazol-6-yl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Beta tubulin	0.0239	0.1401	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0125	0.0443	0.1989
Trichomonas vaginalis	tubulin beta chain, putative	0.0239	0.1401	0.6287
Leishmania major	beta tubulin	0.0239	0.1401	1
Echinococcus multilocularis	voltage gated potassium channel	0.0105	0.0278	0.0278
Brugia malayi	Tubulin beta-1 chain	0.0239	0.1401	0.5771
Trichomonas vaginalis	tubulin alpha chain, putative	0.0073	0.0014	0.0064
Entamoeba histolytica	tubulin family protein	0.0239	0.1401	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Echinococcus multilocularis	tubulin alpha chain	0.0181	0.0914	0.0914
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus granulosus	tubulin alpha chain	0.0181	0.0914	0.0914
Trypanosoma brucei	epsilon tubulin	0.013	0.0485	0.3392
Trichomonas vaginalis	tubulin, putative	0.0239	0.1401	0.6287
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0108	0.0301	0.1349
Giardia lamblia	Alpha-tubulin	0.0181	0.0914	0.4682
Echinococcus granulosus	beta tubulin	0.0239	0.1401	0.1401
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0362	0.2428	0.2428
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0105	0.0278	0.1145
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Echinococcus multilocularis	tubulin alpha chain	0.0181	0.0914	0.0914
Leishmania major	beta tubulin	0.0239	0.1401	1
Schistosoma mansoni	tubulin subunit alpha	0.0181	0.0914	0.106
Toxoplasma gondii	alpha-tubulin I, putative	0.0181	0.0914	0.4682
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Schistosoma mansoni	tubulin subunit alpha	0.0181	0.0914	0.106
Echinococcus granulosus	tubulin gamma 1 chain	0.013	0.0485	0.0485
Leishmania major	beta tubulin	0.0239	0.1401	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0073	0.0014	0.0064
Echinococcus multilocularis	tubulin alpha	0.013	0.0485	0.0485
Echinococcus granulosus	tubulin alpha chain	0.0181	0.0914	0.0914
Trypanosoma brucei	alpha tubulin	0.0181	0.0914	0.6486
Leishmania major	beta tubulin	0.0239	0.1401	1
Leishmania major	beta tubulin	0.0239	0.1401	1
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Plasmodium vivax	tubulin alpha chain, putative	0.0181	0.0914	0.4682
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0165	0.0778	0.3205
Entamoeba histolytica	tubulin alpha-1 chain	0.0181	0.0914	0.4682
Echinococcus multilocularis	tubulin subunit beta	0.0239	0.1401	0.1401
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0914	0.3764
Trichomonas vaginalis	tubulin gamma chain, putative	0.013	0.0485	0.2175
Echinococcus granulosus	beta tubulin	0.0239	0.1401	0.1401
Brugia malayi	Kinesin motor domain containing protein	0.0165	0.0778	0.3205
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0108	0.0301	0.1239
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus granulosus	tubulin beta 1 chain	0.0239	0.1401	0.1401
Giardia lamblia	Beta tubulin	0.0239	0.1401	1
Trypanosoma brucei	alpha tubulin	0.0181	0.0914	0.6486
Plasmodium vivax	kinesin-5	0.0165	0.0778	0.3202
Leishmania major	beta tubulin	0.0239	0.1401	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0239	0.1401	0.6287
Echinococcus granulosus	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Leishmania major	beta tubulin	0.0239	0.1401	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.013	0.0485	0.2175
Trypanosoma brucei	beta tubulin	0.0239	0.1401	1
Toxoplasma gondii	kinesin motor domain-containing protein	0.0165	0.0778	0.3202
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus granulosus	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Echinococcus multilocularis	tubulin alpha 1C chain	0.0181	0.0914	0.0914
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Echinococcus granulosus	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0278	0.1145
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0105	0.0278	0.0278
Echinococcus multilocularis	tubulin epsilon chain	0.013	0.0485	0.0485
Echinococcus multilocularis	tubulin gamma 1 chain	0.013	0.0485	0.0485
Loa Loa (eye worm)	tubulin beta-2A chain	0.0239	0.1401	0.5771
Leishmania major	beta tubulin	0.0239	0.1401	1
Trypanosoma brucei	epsilon tubulin	0.013	0.0485	0.3392
Schistosoma mansoni	alpha tubulin	0.0181	0.0914	0.106
Echinococcus multilocularis	tubulin alpha 3 chain	0.0181	0.0914	0.0914
Echinococcus granulosus	tubulin epsilon chain	0.013	0.0485	0.0485
Schistosoma mansoni	voltage-gated potassium channel	0.0105	0.0278	0.0322
Brugia malayi	beta-tubulin, identical	0.0239	0.1401	0.5771
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0239	0.1401	0.6287
Brugia malayi	Tubulin beta chain	0.0073	0.0014	0.0059
Brugia malayi	tubulin alpha chain - mouse	0.0181	0.0914	0.3764
Echinococcus granulosus	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Leishmania major	beta tubulin	0.0239	0.1401	1
Plasmodium vivax	tubulin alpha chain, putative	0.0181	0.0914	0.4682
Echinococcus multilocularis	beta tubulin	0.0239	0.1401	0.1401
Loa Loa (eye worm)	tubulin alpha chain	0.0181	0.0914	0.3764
Brugia malayi	tubulin alpha-2 chain	0.0181	0.0914	0.3764
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0181	0.0914	0.41
Loa Loa (eye worm)	hypothetical protein	0.0314	0.2028	0.8354
Schistosoma mansoni	alpha tubulin	0.0181	0.0914	0.106
Loa Loa (eye worm)	tubulin alpha chain	0.0181	0.0914	0.3764
Brugia malayi	Tubulin alpha-2 chain	0.0181	0.0914	0.3764
Echinococcus multilocularis	tubulin subunit TubB	0.0181	0.0914	0.0914
Loa Loa (eye worm)	tubulin alpha 2	0.0125	0.0443	0.1826
Schistosoma mansoni	tubulin subunit epsilon	0.013	0.0485	0.0562
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus multilocularis	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Giardia lamblia	Alpha-tubulin	0.0181	0.0914	0.4682
Trichomonas vaginalis	tubulin alpha chain, putative	0.013	0.0485	0.2175
Giardia lamblia	Kinesin-5	0.0165	0.0778	0.3202
Trypanosoma cruzi	alpha tubulin, putative	0.0181	0.0914	0.4682
Echinococcus granulosus	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Trypanosoma brucei	alpha tubulin	0.0181	0.0914	0.6486
Leishmania major	beta tubulin	0.0239	0.1401	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0181	0.0914	0.0914
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Schistosoma mansoni	kinesin eg-5	0.0165	0.0778	0.0902
Trichomonas vaginalis	tubulin alpha chain, putative	0.0073	0.0014	0.0064
Brugia malayi	Tubulin gamma chain	0.013	0.0485	0.1997
Trichomonas vaginalis	tubulin, putative	0.0073	0.0014	0.0064
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0125	0.0443	0.1826
Echinococcus multilocularis	tubulin alpha 1C chain	0.0181	0.0914	0.0914
Trypanosoma brucei	tubulin gamma chain	0.013	0.0485	0.3392
Loa Loa (eye worm)	tubulin alpha 2	0.0125	0.0443	0.1826
Echinococcus granulosus	tubulin alpha chain	0.0181	0.0914	0.0914
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Trichomonas vaginalis	tubulin alpha chain, putative	0.0239	0.1401	0.6287
Trichomonas vaginalis	tubulin alpha chain, putative	0.0073	0.0014	0.0064
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Trypanosoma brucei	epsilon tubulin	0.013	0.0485	0.3392
Trichomonas vaginalis	tubulin gamma chain, putative	0.0239	0.1401	0.6287
Toxoplasma gondii	alpha tubulin TUBA1	0.0181	0.0914	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0301	0.1239
Brugia malayi	alpha-tubulin	0.0181	0.0914	0.3764
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0338	0.2228	1
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Schistosoma mansoni	tubulin subunit alpha	0.0181	0.0914	0.106
Giardia lamblia	Beta tubulin	0.0239	0.1401	1
Leishmania major	beta tubulin	0.0239	0.1401	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0239	0.1401	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	0.0914	0.41
Trypanosoma brucei	alpha tubulin	0.0181	0.0914	0.6486
Schistosoma mansoni	tubulin subunit beta	0.0239	0.1401	0.1625
Plasmodium falciparum	alpha tubulin 1	0.0181	0.0914	0.4682
Loa Loa (eye worm)	beta-tubulin	0.0239	0.1401	0.5771
Schistosoma mansoni	voltage-gated potassium channel	0.0395	0.2706	0.3138
Echinococcus multilocularis	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Echinococcus multilocularis	tubulin beta 1 chain	0.0239	0.1401	0.1401
Echinococcus granulosus	tubulin alpha chain	0.0181	0.0914	0.0914
Echinococcus multilocularis	tubulin alpha chain	0.0181	0.0914	0.0914
Entamoeba histolytica	kinesin, putative	0.0165	0.0778	0.3202
Plasmodium vivax	tubulin beta chain, putative	0.0239	0.1401	1
Loa Loa (eye worm)	tubulin gamma chain	0.013	0.0485	0.1997
Leishmania major	beta tubulin	0.0239	0.1401	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0181	0.0914	0.41
Loa Loa (eye worm)	BEN-1 protein	0.0239	0.1401	0.5771
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0362	0.2428	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0239	0.1401	0.1401
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0181	0.0914	0.0914
Toxoplasma gondii	beta tubulin	0.0239	0.1401	1
Onchocerca volvulus		0.0073	0.0014	0.5
Echinococcus granulosus	tubulin alpha chain	0.0181	0.0914	0.0914
Echinococcus multilocularis	peroxisome assembly protein 26	0.0181	0.0914	0.0914
Echinococcus granulosus	tubulin alpha 1C chain	0.0181	0.0914	0.0914
Echinococcus multilocularis	tubulin alpha chain	0.0181	0.0914	0.0914
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0338	0.2228	1
Schistosoma mansoni	voltage-gated potassium channel	0.0105	0.0278	0.0322
Brugia malayi	Tubulin alpha chain	0.0181	0.0914	0.3764
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Schistosoma mansoni	hypothetical protein	0.1103	0.8623	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0362	0.2428	0.2428
Echinococcus granulosus	voltage gated potassium channel	0.0105	0.0278	0.0278
Echinococcus granulosus	tubulin alpha 1C chain	0.0181	0.0914	0.0914
Schistosoma mansoni	voltage-gated potassium channel	0.0395	0.2706	0.3138
Leishmania major	beta tubulin	0.0239	0.1401	1
Entamoeba histolytica	tubulin family protein	0.0239	0.1401	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0181	0.0914	0.41
Loa Loa (eye worm)	alpha-tubulin	0.0181	0.0914	0.3764
Echinococcus granulosus	tubulin alpha 3 chain	0.0181	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0443	0.1826
Trypanosoma brucei	beta tubulin	0.0239	0.1401	1
Leishmania major	beta tubulin	0.0239	0.1401	1
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Echinococcus multilocularis	tubulin alpha chain	0.0181	0.0914	0.0914
Plasmodium falciparum	alpha tubulin 2	0.0181	0.0914	0.4682
Echinococcus granulosus	tubulin alpha	0.013	0.0485	0.0485
Trypanosoma brucei	beta tubulin	0.013	0.0485	0.3392
Leishmania major	beta tubulin	0.0239	0.1401	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Loa Loa (eye worm)	alpha-tubulin	0.0181	0.0914	0.3764
Plasmodium falciparum	kinesin-5	0.0165	0.0778	0.3202
Echinococcus granulosus	tubulin beta 4A class IVa	0.0239	0.1401	0.1401
Plasmodium falciparum	tubulin beta chain	0.0239	0.1401	1
Echinococcus multilocularis	hypothetical protein	0.0181	0.0914	0.0914
Trypanosoma cruzi	beta tubulin, putative	0.0239	0.1401	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Schistosoma mansoni	alpha tubulin	0.0181	0.0914	0.106
Echinococcus granulosus	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Trichomonas vaginalis	tubulin, putative	0.0073	0.0014	0.0064
Echinococcus multilocularis	beta tubulin	0.0239	0.1401	0.1401
Toxoplasma gondii	beta-tubulin, putative	0.0239	0.1401	1
Loa Loa (eye worm)	BEN-1 protein	0.0239	0.1401	0.5771
Echinococcus multilocularis	kinesin family 1	0.1267	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0181	0.0914	0.0914
Echinococcus granulosus	tubulin subunit beta	0.0239	0.1401	0.1401
Trypanosoma brucei	beta tubulin	0.0239	0.1401	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0239	0.1401	0.5771
Echinococcus granulosus	tubulin alpha 3 chain	0.0181	0.0914	0.0914
Trichomonas vaginalis	tubulin beta chain, putative	0.0073	0.0014	0.0064
Echinococcus granulosus	Tubulin beta 2C chain	0.0239	0.1401	0.1401
Loa Loa (eye worm)	tubulin beta-1 chain	0.0239	0.1401	0.5771
Brugia malayi	Tubulin alpha-2 chain	0.0181	0.0914	0.3764
Leishmania major	beta tubulin	0.0239	0.1401	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0105	0.0278	0.0278
Leishmania major	beta tubulin	0.0239	0.1401	1
Leishmania major	beta tubulin	0.0239	0.1401	1
Loa Loa (eye worm)	tubulin beta chain	0.0239	0.1401	0.5771
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0181	0.0914	0.3764
Trypanosoma brucei	beta tubulin	0.0239	0.1401	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0181	0.0914	0.0914
Schistosoma mansoni	tubulin subunit gamma	0.013	0.0485	0.0562
Echinococcus granulosus	alpha tubulin	0.0181	0.0914	0.0914
Entamoeba histolytica	tubulin alpha chain, putative	0.0181	0.0914	0.4682
Leishmania major	alpha tubulin	0.0181	0.0914	0.4682
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0362	0.2428	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875276