Detailed information for compound 876193

Basic information

Technical information
  • TDR Targets ID: 876193
  • Name: 1-[(5-bromo-2-fluorophenyl)methyl]-3-(4-methy lsulfanylphenyl)urea
  • MW: 369.252 | Formula: C15H14BrFN2OS
  • H donors: 2 H acceptors: 1 LogP: 3.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)NC(=O)NCc1cc(Br)ccc1F
  • InChi: 1S/C15H14BrFN2OS/c1-21-13-5-3-12(4-6-13)19-15(20)18-9-10-8-11(16)2-7-14(10)17/h2-8H,9H2,1H3,(H2,18,19,20)
  • InChiKey: LIIXXNBNBLRGDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(5-bromo-2-fluoro-phenyl)methyl]-3-(4-methylsulfanylphenyl)urea
  • 1-[(5-bromo-2-fluorophenyl)methyl]-3-[4-(methylthio)phenyl]urea
  • 1-(5-bromo-2-fluoro-benzyl)-3-[4-(methylthio)phenyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0041 0.0117
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.051 0.1516 0.1793
Brugia malayi intermediate filament protein 0.0027 0.0051 0.0061
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0108 0.0127
Echinococcus granulosus intermediate filament protein 0.0027 0.0051 0.0049
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.2041 0.2039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0066
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0068 0.0066
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.331 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.051 0.1516 0.17
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Echinococcus multilocularis tumor protein p63 0.0335 0.0984 0.0982
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0031 0.0029
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0031 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.0021
Plasmodium vivax phosphodiesterase gamma, putative 0.051 0.1516 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0031 0.0029
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.051 0.1516 0.1514
Trypanosoma brucei cAMP-specific phosphodiesterase 0.051 0.1516 0.17
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0018
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0068 1
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0031 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.2404 0.2402
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0023 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0018
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0031 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0041 0.3996
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.051 0.1516 0.17
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0015
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0068 0.0048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0041 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0108 0.0105
Brugia malayi nuclear hormone receptor 0.002 0.0031 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus granulosus pyruvate kinase 0.0032 0.0068 0.0066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0007
Schistosoma mansoni lamin 0.0027 0.0051 0.0049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.051 0.1516 0.1514
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi hypothetical protein 0.0234 0.068 0.0804
Trypanosoma brucei cAMP-specific phosphodiesterase 0.051 0.1516 0.17
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.051 0.1516 0.1793
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0003
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0068 0.032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0014 0.0011
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0041 0.0049
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.051 0.1516 0.1793
Schistosoma mansoni hypothetical protein 0.0048 0.0115 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0031 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0051 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0029
Echinococcus granulosus FTZ F1 alpha 0.002 0.0031 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0031 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0041 0.3996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0005
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0068 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0068 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.012 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0003
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.051 0.1516 0.1514
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1516 1
Brugia malayi HSF-type DNA-binding domain containing protein 0.0098 0.0268 0.0317
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.331 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0018
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.0268 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.051 0.1516 0.1514
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0015
Onchocerca volvulus 0.0023 0.0041 0.0434
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.051 0.1516 0.1514
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.331 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.2041 0.2039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.012 0.0142
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0041 0.3996
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.051 0.1516 0.1514
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0041 0.3996
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.2843 0.8583 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0014 0.0016
Giardia lamblia Pyruvate kinase 0.0032 0.0068 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0031 0.0037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0023 0.0606
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0031 0.0029
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.2843 0.8583 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.331 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.331 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0031 0.0029
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0029
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.051 0.1516 0.17
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0041 0.0049
Echinococcus granulosus lamin 0.0027 0.0051 0.0049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.0015
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0068 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0108 0.0105
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.051 0.1516 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0031 0.0029
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0051 0.0049
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi ecdysteroid receptor 0.002 0.0031 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.051 0.1516 0.1514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.012 0.0142
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.051 0.1516 0.1514
Echinococcus granulosus lamin dm0 0.0027 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0234 0.068 0.0678
Plasmodium falciparum cGMP-specific phosphodiesterase 0.051 0.1516 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Mycobacterium ulcerans hypothetical protein 0.0023 0.0041 0.3996
Plasmodium falciparum phosphodiesterase gamma, putative 0.051 0.1516 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.331 1 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.051 0.1516 0.1514
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0068 0.1576
Leishmania major pyruvate kinase 0.0032 0.0068 0.0032
Echinococcus granulosus tumor protein p63 0.0335 0.0984 0.0982
Onchocerca volvulus 0.0027 0.0051 0.0847
Schistosoma mansoni lamin 0.0027 0.0051 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1516 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.0021
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 0.17
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0041 0.436
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.0015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0015
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.051 0.1516 0.1793
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Chlamydia trachomatis pyruvate kinase 0.0032 0.0068 1
Onchocerca volvulus 0.0027 0.0051 0.0847
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.051 0.1516 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0041 0.3996
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.051 0.1516 0.17
Plasmodium falciparum phosphodiesterase delta, putative 0.051 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0108 0.0105
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.0268 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0021
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.051 0.1516 0.1727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0037
Echinococcus multilocularis pyruvate kinase 0.0032 0.0068 0.0066
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Onchocerca volvulus 0.0048 0.0115 0.3544
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.051 0.1516 0.1514
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.051 0.1516 0.17
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0115 0.0136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0015
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0108 0.0105
Schistosoma mansoni pyruvate kinase 0.0032 0.0068 0.0066
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.28 0.8454 0.8454
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.28 0.8454 0.8454
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0031 0.0037
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.051 0.1516 0.1514
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0037
Loa Loa (eye worm) PDE1B protein 0.051 0.1516 0.1514
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0108 0.0105
Leishmania major pyruvate kinase 0.0032 0.0068 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0108 0.0105
Loa Loa (eye worm) hypothetical protein 0.051 0.1516 0.1514
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0041 0.3996
Schistosoma mansoni nuclear hormone receptor 0.002 0.0031 0.0029
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0007
Leishmania major hypothetical protein, conserved 0.051 0.1516 0.1727
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0068 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.012 0.0117
Plasmodium falciparum cGMP-specific phosphodiesterase 0.051 0.1516 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.051 0.1516 0.17
Leishmania major cAMP-specific phosphodiesterase, putative 0.051 0.1516 0.1727
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.28 0.8454 0.8454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0041 0.436
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.068 0.0678
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Loa Loa (eye worm) hypothetical protein 0.0034 0.0073 0.007
Onchocerca volvulus 0.0049 0.0119 0.3699
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Schistosoma mansoni pyruvate kinase 0.0032 0.0068 0.0066
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.051 0.1516 0.17
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.28 0.8454 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0108 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.051 0.1516 0.17
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0037
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0073 0.0086
Echinococcus multilocularis lamin 0.0027 0.0051 0.0049
Echinococcus granulosus pyruvate kinase 0.0032 0.0068 0.0066
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi steroid hormone receptor 0.002 0.0031 0.0037
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0015
Echinococcus multilocularis musashi 0.0027 0.0051 0.0049
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.051 0.1516 0.1514
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0268 0.0265
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.051 0.1516 0.1514
Plasmodium falciparum pyruvate kinase 0.0032 0.0068 0.032
Schistosoma mansoni pyruvate kinase 0.0017 0.0021 0.0018
Echinococcus granulosus microtubule associated protein 2 0.0684 0.2041 0.2039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0068 0.0066
Leishmania major hypothetical protein, conserved 0.2843 0.8583 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0039 0.0036
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.051 0.1516 0.1514
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0023 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0029
Giardia lamblia Hypothetical protein 0.051 0.1516 0.1499
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0018
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1516 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0115 0.0113
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0068 0.1576
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.051 0.1516 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0037
Schistosoma mansoni intermediate filament proteins 0.0027 0.0051 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.068 0.0678
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.051 0.1516 0.1514
Brugia malayi nuclear receptor RXR 0.0011 0.0002 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Echinococcus multilocularis pyruvate kinase 0.0032 0.0068 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0119 0.0116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0031 0.0029
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.051 0.1516 0.1793
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0039
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.051 0.1516 0.1514
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0041 0.0117
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.051 0.1516 0.1793
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0098 0.0268 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0031 0.0029
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0068 0.0081
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Trypanosoma cruzi hypothetical protein, conserved 0.051 0.1516 0.17
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.051 0.1516 0.17
Echinococcus multilocularis pyruvate kinase 0.0026 0.0048 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0051 0.0061
Schistosoma mansoni coup transcription factor 0.002 0.0031 0.0029
Giardia lamblia hypothetical protein 0.051 0.1516 0.1499
Brugia malayi nuclear receptor NHR-88 0.002 0.0031 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0652 0.065
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.331 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.051 0.1516 0.1514
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.051 0.1516 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.051 0.1516 0.1514
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0041 0.3996
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0031 0.0029
Echinococcus multilocularis lamin dm0 0.0027 0.0051 0.0049
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.051 0.1516 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0031 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0652 0.0771
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0108 0.0105
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0031 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.051 0.1516 0.1499
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.051 0.1516 0.17

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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