TDR Targets

Basic information

Technical information

TDR Targets ID: 877696
Name: 4-chloro-N-[2-(2,4-dimethylphenyl)ethyl]benze nesulfonamide
MW: 323.838 | Formula: C16H18ClNO2S
H donors: 1 H acceptors: 2 LogP: 4.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)S(=O)(=O)NCCc1ccc(cc1C)C
InChi: 1S/C16H18ClNO2S/c1-12-3-4-14(13(2)11-12)9-10-18-21(19,20)16-7-5-15(17)6-8-16/h3-8,11,18H,9-10H2,1-2H3
InChiKey: WHXRMWAJFDGNNW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0623	0.9081	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0387	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0387	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Echinococcus multilocularis	lamin	0.003	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0062	0.07	0.0476
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0062	0.07	0.5
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0235	0.0235
Echinococcus granulosus	geminin	0.0191	0.2632	0.2632
Onchocerca volvulus		0.0041	0.0387	0.0172
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0387	0.5
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0062	0.07	1
Echinococcus multilocularis	musashi	0.003	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Brugia malayi	beta-lactamase family protein	0.0041	0.0387	0.0364
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0235	0.0211
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0387	0.5
Trypanosoma cruzi	protein arginine n-methyltransferase 7	0.0062	0.07	1
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0062	0.07	0.07
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0062	0.07	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0387	0.0364
Schistosoma mansoni	protein arginine n-methyltransferase	0.0685	1	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0387	0.0387
Leishmania major	arginine N-methyltransferase, type I	0.0062	0.07	1
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0387	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0235	0.0235
Mycobacterium ulcerans	lipase LipD	0.0041	0.0387	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0235	0.0235
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0062	0.07	0.07
Brugia malayi	Protein arginine N-methyltransferase	0.0062	0.07	0.0677
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0062	0.07	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0024	0.0024
Echinococcus multilocularis	lamin dm0	0.003	0.0235	0.0235
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0387	0.5
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0062	0.07	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0062	0.07	0.07
Brugia malayi	intermediate filament protein	0.003	0.0235	0.0211
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0387	0.5
Schistosoma mansoni	hypothetical protein	0.0191	0.2632	0.2455
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0685	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0685	1	1
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0062	0.07	0.07
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0062	0.07	1
Onchocerca volvulus		0.0041	0.0387	0.0172
Echinococcus granulosus	methyltransferase protein 5	0.0062	0.07	0.07
Schistosoma mansoni	hypothetical protein	0.0191	0.2632	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0062	0.07	1
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0387	0.5
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0062	0.07	0.0326
Loa Loa (eye worm)	Carm1-pending protein	0.0685	1	1
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0685	1	1
Trypanosoma brucei	protein arginine n-methyltransferase 7	0.0062	0.07	1
Trypanosoma cruzi	arginine N-methyltransferase, type III	0.0062	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0226	0.0226
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0387	0.5
Echinococcus granulosus	lamin	0.003	0.0235	0.0235
Brugia malayi	beta-lactamase	0.0041	0.0387	0.0364
Leishmania major	arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490	0.0062	0.07	1
Onchocerca volvulus		0.0041	0.0387	0.0172
Echinococcus granulosus	intermediate filament protein	0.003	0.0235	0.0235
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0062	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0387	0.0387
Entamoeba histolytica	hypothetical protein	0.0062	0.07	0.5
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0062	0.07	1
Echinococcus multilocularis	geminin	0.0191	0.2632	0.2632
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0387	0.0387
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0387	0.0387
Entamoeba histolytica	arginine N-methyltransferase 1, putative	0.0062	0.07	0.5
Brugia malayi	hypothetical protein	0.0062	0.07	0.0677
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0259	0.3652	1
Echinococcus granulosus	lamin dm0	0.003	0.0235	0.0235
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0387	0.0364
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0387	0.0387
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0062	0.07	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 877696