TDR Targets

Basic information

Technical information

TDR Targets ID: 877765
Name: 3-(2-ethylsulfanylethyl)-2-(3,4,5-trimethoxyp henyl)-1,3-thiazolidin-4-one
MW: 357.488 | Formula: C16H23NO4S2
H donors: 0 H acceptors: 1 LogP: 2.73 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCSCCN1C(=O)CSC1c1cc(OC)c(c(c1)OC)OC
InChi: 1S/C16H23NO4S2/c1-5-22-7-6-17-14(18)10-23-16(17)11-8-12(19-2)15(21-4)13(9-11)20-3/h8-9,16H,5-7,10H2,1-4H3
InChiKey: NMYFEISSQPXSEM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-ethylsulfanylethyl)-2-(3,4,5-trimethoxyphenyl)thiazolidin-4-one
3-[2-(ethylthio)ethyl]-2-(3,4,5-trimethoxyphenyl)-4-thiazolidinone
3-[2-(ethylthio)ethyl]-2-(3,4,5-trimethoxyphenyl)thiazolidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	axis inhibition protein axin	0.0057	0.0039	0.0056
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.0015	0.0021
Echinococcus granulosus	axis inhibition protein axin	0.0057	0.0039	0.0098
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0015	0.0037
Echinococcus granulosus	regulator of G protein signaling 7	0.0057	0.0039	0.0098
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.0015	0.0021
Trichomonas vaginalis	CMGC family protein kinase	0.0308	0.0363	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Trypanosoma brucei	cdc2-related kinase 3	0.006	0.0042	0.1168
Giardia lamblia	G2/mitotic-specific cyclin B	0.0101	0.0095	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.0015	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0039	0.0056
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.007	0.01
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.0015	0.0037
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	cyclin dependent kinase 5	0.006	0.0042	0.0107
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0161	0.0172	0.0435
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.007	0.0176
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.0015	0.0037
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0095	0.0136
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0014	0.0389
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.0015	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0042	0.0061
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0057	0.0039	0.0056
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0308	0.0363	0.0914
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.0064	0.0092
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0308	0.0363	0.0522
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0161	0.0172	0.0172
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	sulfakinin receptor protein	0.0039	0.0015	0.0015
Echinococcus multilocularis	serine threonine protein kinase	0.0071	0.0056	0.0141
Echinococcus granulosus	serotonin receptor	0.0039	0.0015	0.0037
Echinococcus granulosus	protein kinase shaggy	0.0308	0.0363	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	serine/threonine protein kinase	0.541	0.6953	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0042	0.1168
Schistosoma mansoni	amine GPCR	0.0039	0.0015	0.0021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.3099	0.3967	0.5706
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.0015	0.0037
Brugia malayi	Serotonin receptor	0.0039	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0039	0.0056
Echinococcus granulosus	cyclins	0.0052	0.0032	0.0081
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.0015	0.0021
Entamoeba histolytica	protein kinase domain containing protein	0.0308	0.0363	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1029	0.1293	0.186
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	amine GPCR	0.0039	0.0015	0.0021
Brugia malayi	Protein kinase domain containing protein	0.006	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.0039
Echinococcus granulosus	regulator of G protein signaling 3	0.0129	0.0132	0.0332
Schistosoma mansoni	axis inhibition protein axin	0.0057	0.0039	0.0056
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.0015	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0015	0.0021
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.007	0.007
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.0015	0.0015
Trichomonas vaginalis	cyclin B, putative	0.0101	0.0095	0.261
Trichomonas vaginalis	CMGC family protein kinase	0.0308	0.0363	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0057	0.0039	0.0098
Brugia malayi	Melatonin receptor type 1A	0.0039	0.0015	0.0015
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.0015	0.0037
Schistosoma mansoni	opsin-like receptor	0.0039	0.0015	0.0021
Entamoeba histolytica	cyclin family protein	0.0052	0.0032	0.0882
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Echinococcus multilocularis	protein kinase c iota type	0.0034	0.0008	0.0021
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0015	0.0037
Echinococcus granulosus	expressed protein	0.0763	0.0951	0.2397
Trichomonas vaginalis	cyclin D, putative	0.0052	0.0032	0.0882
Brugia malayi	regulator of G-protein signaling rgs-7	0.0129	0.0132	0.0132
Echinococcus multilocularis	cyclin dependent kinase 1	0.006	0.0042	0.0107
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0019	0.0047
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.0015	0.0037
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.0015	0.0021
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	adenoreceptor	0.0039	0.0015	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0042	0.1168
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0076	0.0063	0.0063
Echinococcus granulosus	fmrfamide receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0057	0.0039	0.0098
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Giardia lamblia	Kinase, CMGC GSK	0.0308	0.0363	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.0015	0.0021
Echinococcus granulosus	allatostatin A receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0308	0.0363	0.0914
Trypanosoma brucei	cdc2-related kinase 1	0.006	0.0042	0.1168
Trichomonas vaginalis	cyclins, putative	0.0052	0.0032	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.0015	0.0037
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.0015	0.0021
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	cyclins	0.0052	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.0015	0.0037
Brugia malayi	Dopamine receptor	0.0039	0.0015	0.0015
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.0015	0.0037
Brugia malayi	putative neuropeptide receptor	0.0039	0.0015	0.0015
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.0148	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	cyclins	0.0052	0.0032	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.0015	0.0015
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.0015	0.0037
Brugia malayi	Protein kinase c protein 2	0.0068	0.0053	0.0053
Trichomonas vaginalis	cyclins, putative	0.0101	0.0095	0.261
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.0015	0.0015
Plasmodium falciparum	protein kinase 5	0.006	0.0042	0.0811
Giardia lamblia	Hypothetical protein	0.0052	0.0032	0.0513
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0161	0.0172	0.0435
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0057	0.0039	0.0098
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0015	0.0037
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Schistosoma mansoni	opsin-like receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	axis inhibition protein axin	0.0057	0.0039	0.0098
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0063	0.009
Schistosoma mansoni	amine GPCR	0.0039	0.0015	0.0021
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.3099	0.3967	1
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	hypothetical protein	0.0039	0.0015	0.0037
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.0015	0.0037
Giardia lamblia	Kinase, CMGC GSK	0.0308	0.0363	1
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0015	0.0021
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.0015	0.0037
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0101	0.0095	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.0015	0.0021
Trichomonas vaginalis	cyclin D, putative	0.0052	0.0032	0.0882
Schistosoma mansoni	cyclin B	0.0101	0.0095	0.0136
Echinococcus granulosus	orexin receptor type 2	0.0039	0.0015	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Echinococcus granulosus	sex peptide receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0039	0.0056
Schistosoma mansoni	opsin-like receptor	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	histamine h1 receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.0015	0.0037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.0015	0.0021
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0308	0.0363	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.0015	0.0037
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	RNA directed DNA polymerase	0.0042	0.0019	0.0048
Loa Loa (eye worm)	PXA domain-containing protein	0.0057	0.0039	0.0056
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.0015	0.0021
Schistosoma mansoni	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trypanosoma brucei	protein kinase, putative	0.0308	0.0363	1
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Plasmodium vivax	protein kinase Crk2	0.006	0.0042	0.0691
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	Cyclin dependent kinase 2 associated protein	0.2374	0.3032	0.7642
Echinococcus granulosus	neuropeptide receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0081	0.007	0.01
Echinococcus multilocularis	cyclin dependent kinase	0.006	0.0042	0.0107
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.0143	0.0359
Loa Loa (eye worm)	cyclin domain-containing protein	0.0161	0.0172	0.0248
Echinococcus multilocularis	serotonin receptor	0.1029	0.1293	0.326
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0015	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	cyclin dependent kinase 1	0.006	0.0042	0.0107
Echinococcus multilocularis	protein kinase c epsilon type	0.0035	0.001	0.0025
Trypanosoma cruzi	cyclin, putative	0.0101	0.0095	0.1633
Echinococcus granulosus	cyclin dependent kinase 1	0.006	0.0042	0.0107
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0035	0.001	0.0014
Toxoplasma gondii	hypothetical protein	0.0039	0.0016	0.0435
Schistosoma mansoni	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	larval opioid receptor	0.0039	0.0015	0.0015
Brugia malayi	A-kinase anchor protein 10, precursor	0.0057	0.0039	0.0039
Brugia malayi	PXA domain containing protein	0.0057	0.0039	0.0039
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Entamoeba histolytica	cyclin family protein	0.0052	0.0032	0.0882
Echinococcus granulosus	cyclin B3 1	0.0052	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.0015	0.0021
Brugia malayi	RE15519p	0.0039	0.0015	0.0015
Brugia malayi	neuropeptide F receptor	0.0039	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0057	0.0039	0.1074
Schistosoma mansoni	regulator of G protein signaling	0.0057	0.0039	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0039	0.0056
Echinococcus granulosus	cyclin dependent kinase 5	0.006	0.0042	0.0107
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0308	0.0363	0.0522
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.0015	0.0037
Echinococcus granulosus	neuropeptide receptor	0.0039	0.0015	0.0037
Echinococcus granulosus	cyclin b3	0.0052	0.0032	0.0081
Echinococcus multilocularis	regulator of G protein signaling	0.0129	0.0132	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trichomonas vaginalis	cyclins, putative	0.0101	0.0095	0.261
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0019	0.0027
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0015	0.0037
Entamoeba histolytica	cyclin, putative	0.0052	0.0032	0.0882
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0057	0.0039	0.0056
Echinococcus multilocularis	expressed protein	0.0763	0.0951	0.2397
Entamoeba histolytica	cell division protein kinase 2, putative	0.006	0.0042	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0042	0.1168
Echinococcus granulosus	regulator of G protein signaling 7	0.0057	0.0039	0.0098
Schistosoma mansoni	amine GPCR	0.0039	0.0015	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.0015	0.0021
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	regulator of G protein signaling 7	0.0057	0.0039	0.0098
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.0015	0.0021
Trypanosoma cruzi	cyclin 6, putative	0.0101	0.0095	0.1633
Brugia malayi	Protein kinase domain containing protein	0.541	0.6953	0.6953
Onchocerca volvulus		0.0101	0.0095	0.0265
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0019	0.0513
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.541	0.6953	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.0015	0.0037
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.0015	0.0037
Brugia malayi	G protein-coupled receptor	0.0039	0.0015	0.0015
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0057	0.0039	0.0039
Schistosoma mansoni	z-protein (S1r protein)	0.0057	0.0039	0.0056
Schistosoma mansoni	amine GPCR	0.0039	0.0015	0.0021
Echinococcus granulosus	cyclin dependent kinase	0.006	0.0042	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Echinococcus multilocularis	protein kinase shaggy	0.0308	0.0363	0.0914
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0032	0.0882
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.0015	0.0015
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0015	0.0021
Giardia lamblia	Kinase, CMGC CDK	0.006	0.0042	0.0811
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.006	0.0042	0.0107
Brugia malayi	G-protein coupled receptor	0.0039	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0019	0.0027
Echinococcus granulosus	Regulator of G protein signaling 20	0.0057	0.0039	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.1029	0.1293	0.186
Entamoeba histolytica	protein kinase, putative	0.0308	0.0363	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0129	0.0132	0.0332
Schistosoma mansoni	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	protein kinase C gamma type	0.0071	0.0056	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0095	0.0136
Echinococcus granulosus	protein kinase c iota type	0.0034	0.0008	0.0021
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0057	0.0039	0.0098
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0057	0.0039	0.0056
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0015	0.0037
Echinococcus granulosus	Protein kinase C brain isozyme	0.0077	0.0064	0.0162
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0019	0.0513
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0019	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	protein kinase C II.	0.0035	0.001	0.001
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0308	0.0363	0.0522
Echinococcus multilocularis	cyclin B3 1	0.0052	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.0132	0.0189
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0308	0.0363	1
Echinococcus granulosus	cyclins	0.0052	0.0032	0.0081
Onchocerca volvulus		0.0081	0.007	0.0182
Trichomonas vaginalis	cyclin B, putative	0.0101	0.0095	0.261
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0063	0.009
Echinococcus multilocularis	cyclin b3	0.0052	0.0032	0.0081
Trichomonas vaginalis	cyclins, putative	0.0101	0.0095	0.261
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.0015	0.0037
Entamoeba histolytica	cyclin, putative	0.0101	0.0095	0.261
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0076	0.0063	0.009
Schistosoma mansoni	cyclin B3	0.0161	0.0172	0.0248
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.0015	0.0037
Leishmania major	cyclin	0.0101	0.0095	0.1633
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0063	0.009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Echinococcus granulosus	RNA directed DNA polymerase	0.0042	0.0019	0.0048
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.0015	0.0037
Brugia malayi	Serotonin receptor	0.0039	0.0015	0.0015
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.0015	0.0037
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.006	0.0042	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0042	0.0061
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.0015	0.0037
Brugia malayi	intracellular kinase	0.0308	0.0363	0.0363
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0057	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Echinococcus granulosus	protein kinase c epsilon type	0.0035	0.001	0.0025
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0042	0.0019	0.0048
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.0015	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.0015	0.0037
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0101	0.0095	0.0095
Brugia malayi	AKH receptor	0.0039	0.0015	0.0015
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.0132	0.0189
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0076	0.0063	0.009
Trypanosoma brucei	mitotic cyclin 6	0.0101	0.0095	0.261
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.0015	0.0021
Echinococcus granulosus	biogenic amine 5HT receptor	0.3099	0.3967	1
Brugia malayi	ORL1-like opioid receptor	0.0039	0.0015	0.0015
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.0015	0.0037
Schistosoma mansoni	atypical protein kinase C	0.0034	0.0008	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0039	0.1074
Plasmodium falciparum	glycogen synthase kinase 3	0.0308	0.0363	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0077	0.0064	0.0162
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.0015	0.0015
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.0015	0.0037
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0027	0.004
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.0015	0.0021
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0101	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Trypanosoma cruzi	cyclin, putative	0.0101	0.0095	0.1633
Brugia malayi	regulator of G-protein signaling egl-10	0.0057	0.0039	0.0039
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0015	0.0037
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0015	0.0021
Loa Loa (eye worm)	acetyltransferase	0.0142	0.0148	0.0212
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.0015	0.0037
Trichomonas vaginalis	cyclin A, putative	0.0101	0.0095	0.261
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0057	0.0039	0.1074
Brugia malayi	neuropeptide F receptor	0.0039	0.0015	0.0015
Echinococcus granulosus	cyclins	0.0052	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	biogenic amine 5HT receptor	0.1029	0.1293	0.326
Trichomonas vaginalis	cyclin B, putative	0.0052	0.0032	0.0882
Brugia malayi	GnHR receptor homolog	0.0039	0.0015	0.0015
Echinococcus multilocularis	regulator of G protein signaling 3	0.0129	0.0132	0.0332
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0015	0.0021
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.0015	0.0037
Giardia lamblia	Cyclin A	0.0052	0.0032	0.0513
Echinococcus granulosus	axis inhibition protein axin	0.0057	0.0039	0.0098
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	deleted in oral cancer 1/cdk2-associated protein-like	0.2374	0.3032	0.436
Schistosoma mansoni	regulator of G protein signaling	0.0057	0.0039	0.0056
Brugia malayi	Dopamine receptor protein 2	0.0039	0.0015	0.0015
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.006	0.0042	0.1168
Onchocerca volvulus	Diphthamide biosynthesis protein 7 homolog	0.2374	0.3032	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0076	0.0063	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus multilocularis	somatostatin receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.0015	0.0037
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.0015	0.0015
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0015	0.0037
Echinococcus multilocularis	axis inhibition protein axin	0.0057	0.0039	0.0098
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0057	0.0039	0.1074
Echinococcus multilocularis	regulator of G protein signaling 3	0.0129	0.0132	0.0332
Brugia malayi	cell division control protein 2 homolog	0.006	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.2374	0.3032	0.436
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Brugia malayi	PXA domain containing protein	0.0057	0.0039	0.0039
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.006	0.0042	0.0061
Brugia malayi	G-protein coupled receptor	0.0039	0.0015	0.0015
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0015	0.0037
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0308	0.0363	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0039	0.0056
Trichomonas vaginalis	cyclin B, putative	0.0101	0.0095	0.261
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0132	0.0189
Brugia malayi	hypothetical protein	0.0057	0.0039	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0077	0.0064	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Echinococcus granulosus	somatostatin receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.0148	0.0148
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.0015	0.0021
Echinococcus granulosus	cyclin B	0.0101	0.0095	0.0239
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0076	0.0063	0.0158
Trichomonas vaginalis	cyclin B3, putative	0.0052	0.0032	0.0882
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.0015	0.0015
Entamoeba histolytica	protein kinase domain containing protein	0.0308	0.0363	1
Onchocerca volvulus		0.0308	0.0363	0.1153
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.0015	0.0021
Brugia malayi	hypothetical protein	0.0039	0.0015	0.0015
Schistosoma mansoni	myosin xvIII	0.0039	0.0015	0.0021
Echinococcus granulosus	Cyclin dependent kinase 2 associated protein	0.2374	0.3032	0.7642
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0015	0.0021
Echinococcus multilocularis	cyclin B	0.0101	0.0095	0.0239
Giardia lamblia	Kinase, CMGC CDK	0.006	0.0042	0.0811
Echinococcus multilocularis	serotonin receptor	0.1029	0.1293	0.326
Entamoeba histolytica	hypothetical protein	0.0057	0.0039	0.1074
Echinococcus granulosus	cyclins	0.0052	0.0032	0.0081
Entamoeba histolytica	cell division protein kinase 2, putative	0.006	0.0042	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Loa Loa (eye worm)	RGS-3 protein	0.0057	0.0039	0.0056
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.0015	0.0037
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.006	0.0042	0.0061
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0062	0.0044	0.0064
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0015	0.0021
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0015	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0015	0.0021
Echinococcus granulosus	cyclins	0.0052	0.0032	0.0081
Trichomonas vaginalis	cyclin B, putative	0.0101	0.0095	0.261
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.0015	0.0037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Schistosoma mansoni	regulator of G protein signaling	0.0057	0.0039	0.0056
Trichomonas vaginalis	cyclins, putative	0.0061	0.0044	0.1204
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.0015	0.0037
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0015	0.0037
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.0015	0.0021
Trichomonas vaginalis	cyclins, putative	0.0101	0.0095	0.261
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0019	0.0513
Brugia malayi	Dopamine receptor protein 1	0.0039	0.0015	0.0015
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.0015	0.0015
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.007	0.0176
Loa Loa (eye worm)	hypothetical protein	0.1029	0.1293	0.186
Brugia malayi	hypothetical protein	0.0057	0.0039	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.001	0.0014
Echinococcus multilocularis	sex peptide receptor	0.0039	0.0015	0.0037
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0308	0.0363	1
Plasmodium falciparum	cyclin	0.0052	0.0032	0.0513
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0101	0.0095	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0015	0.0021
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.0148	0.0212
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0057	0.0039	0.0056

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 877765