TDR Targets

Basic information

Technical information

TDR Targets ID: 879088
Name: 2-butanoyl-N-[2-(1-cyclohexenyl)ethyl]pyrazol idine-1-carbothioamide
MW: 309.47 | Formula: C16H27N3OS
H donors: 1 H acceptors: 1 LogP: 2.85 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)N1CCCN1C(=S)NCCC1=CCCCC1
InChi: 1S/C16H27N3OS/c1-2-7-15(20)18-12-6-13-19(18)16(21)17-11-10-14-8-4-3-5-9-14/h8H,2-7,9-13H2,1H3,(H,17,21)
InChiKey: IOPYUZRKKGIMDP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(1-cyclohexenyl)ethyl]-2-(1-oxobutyl)-1-pyrazolidinecarbothioamide
2-butyryl-N-[2-(1-cyclohexenyl)ethyl]pyrazolidine-1-carbothioamide
Oprea1_314710

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0135	0.0481	0.2213
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Brugia malayi	hypothetical protein	0.0062	0.0137	0.0649
Entamoeba histolytica	hypothetical protein	0.0076	0.0204	0.3124
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0135	0.0481	0.0534
Toxoplasma gondii	sugar transporter ST1	0.0062	0.0137	0.0091
Brugia malayi	lysyl-tRNA synthetase	0.0098	0.0308	0.1465
Toxoplasma gondii	lysine-tRNA ligase	0.0098	0.0308	0.0396
Onchocerca volvulus		0.0062	0.0137	0.2436
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0062	0.0137	0.406
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0062	0.0137	0.0136
Brugia malayi	major facilitator superfamily protein	0.0062	0.0137	0.0649
Loa Loa (eye worm)	hypothetical protein	0.005	0.0079	0.0284
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0135	0.0481	0.2284
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0308	0.0234
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0085	0.0076
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0489	0.1973
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0571	1
Entamoeba histolytica	hypothetical protein	0.0076	0.0204	0.3124
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0054	0.01	0.0389
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0098	0.0308	0.0961
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0135	0.0481	0.0703
Echinococcus granulosus	synaptic vesicle 2 protein	0.0062	0.0137	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0132	0.0468	0.0394
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0308	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0481	0.2213
Onchocerca volvulus		0.0062	0.0137	0.2436
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0135	0.0481	0.0534
Entamoeba histolytica	hypothetical protein	0.0098	0.0308	0.5712
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0135	0.0481	0.0534
Schistosoma mansoni	hypothetical protein	0.0441	0.1923	0.186
Plasmodium vivax	proline--tRNA ligase, putative	0.0154	0.0571	0.0638
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0132	0.0468	0.0394
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0062	0.0137	0.1055
Trypanosoma brucei	glucose transporter 1E	0.0137	0.0489	0.8307
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0137	0.0649
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0098	0.0308	0.5901
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0308	0.1386
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0062	0.0137	0.0061
Entamoeba histolytica	hypothetical protein	0.0076	0.0204	0.3124
Entamoeba histolytica	hypothetical protein	0.0076	0.0204	0.3124
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0079	0.0373
Loa Loa (eye worm)	sugar transporter	0.0062	0.0137	0.0563
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.005	0.0079	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Loa Loa (eye worm)	hypothetical protein	0.01	0.0317	0.1428
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Leishmania major	hypothetical protein, conserved	0.0051	0.0085	0.0139
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0085	0.0076
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0062	0.0137	0.5549
Echinococcus granulosus	solute carrier family 22	0.0062	0.0137	0.0061
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0062	0.0137	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0079	0.0373
Echinococcus granulosus	solute carrier family 22	0.0062	0.0137	0.0061
Echinococcus multilocularis	General substrate transporter	0.0379	0.1631	0.1566
Loa Loa (eye worm)	hypothetical protein	0.005	0.0079	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0351	0.159
Echinococcus granulosus	calcium dependent protein kinase	0.0127	0.0441	0.0368
Mycobacterium ulcerans	hypothetical protein	0.005	0.0079	0.2048
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0132	0.0468	0.968
Onchocerca volvulus		0.0062	0.0137	0.2436
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0489	0.8307
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0489	0.8307
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0578	0.2679
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0468	0.2151
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0062	0.0137	0.0061
Onchocerca volvulus		0.0062	0.0137	0.2436
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0077	0.0274
Leishmania major	hypothetical protein, conserved	0.0062	0.0137	0.118
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0137	0.0489	0.833
Trichomonas vaginalis	conserved hypothetical protein	0.0441	0.1923	1
Entamoeba histolytica	protein kinase, putative	0.0135	0.0481	1
Schistosoma mansoni	protein kinase	0.0135	0.0481	0.0407
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0441	0.1923	0.186
Echinococcus granulosus	solute carrier family 22	0.0062	0.0137	0.0061
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0137	0.0563
Onchocerca volvulus		0.0062	0.0137	0.2436
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0308	1
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0489	0.1973
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0132	0.0468	0.2223
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0135	0.0481	0.0534
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0135	0.0481	0.0703
Schistosoma mansoni	protein kinase	0.0135	0.0481	0.0407
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0135	0.0481	0.0703
Leishmania major	protein kinase, putative	0.0135	0.0481	0.8165
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0135	0.0481	0.0534
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0712	0.3203	0.3682
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0154	0.0571	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0085	0.0317
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0137	0.0061
Trypanosoma cruzi	hexose transporter, putative	0.0062	0.0137	0.1055
Treponema pallidum	prolyl-tRNA synthetase	0.0047	0.0065	0.5
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.0468	0.0394
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0135	0.0481	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.005	0.0079	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Schistosoma mansoni	glucose transport protein	0.0441	0.1923	0.186
Brugia malayi	Sugar transporter family protein	0.0441	0.1923	0.9135
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0571	1
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0084	0.0238	0.4106
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0132	0.0468	0.2223
Schistosoma mansoni	protein kinase	0.0135	0.0481	0.0407
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0489	0.1973
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0086	0.0251	0.0641
Schistosoma mansoni	sugar transporter	0.0062	0.0137	0.0061
Chlamydia trachomatis	lysine--tRNA ligase	0.0098	0.0308	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0479	0.2105	0.2044
Schistosoma mansoni	cellular tumor antigen P53	0.01	0.0317	0.0243
Schistosoma mansoni	sugar transporter	0.0062	0.0137	0.0061
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0062	0.0137	0.0061
Leishmania major	glucose transporter, lmgt3	0.0137	0.0489	0.833
Brugia malayi	Sugar transporter family protein	0.0062	0.0137	0.0649
Plasmodium vivax	lysine--tRNA ligase, putative	0.0098	0.0308	0.0334
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Giardia lamblia	Prolyl-tRNA synthetase	0.0132	0.0468	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0098	0.0308	0.0234
Toxoplasma gondii	transporter, major facilitator family protein	0.0062	0.0137	0.0091
Leishmania major	myo-inositol/proton symporter (MIT)	0.0062	0.0137	0.118
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Brugia malayi	hypothetical protein	0.0479	0.2105	1
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0489	0.8307
Onchocerca volvulus		0.0062	0.0137	0.2436
Onchocerca volvulus		0.0062	0.0137	0.2436
Trypanosoma brucei	glucose transporter 2A	0.0137	0.0489	0.8307
Plasmodium falciparum	proline--tRNA ligase	0.0154	0.0571	0.0638
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0712	0.3203	0.5536
Schistosoma mansoni	microtubule-associated protein tau	0.2153	1	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0571	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0079	0.0284
Onchocerca volvulus		0.0062	0.0137	0.2436
Loa Loa (eye worm)	transcription factor SMAD2	0.0242	0.0986	0.4633
Brugia malayi	hypothetical protein	0.0051	0.0085	0.0406
Trypanosoma cruzi	hexose transporter	0.0137	0.0489	0.8307
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.0578	0.2746
Plasmodium vivax	hexose transporter	0.0441	0.1923	0.2201
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0712	0.3203	0.3682
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0079	0.0373
Onchocerca volvulus		0.0062	0.0137	0.2436
Toxoplasma gondii	sugar transporter ST2	0.0062	0.0137	0.0091
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0077	0.0274
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0098	0.0306	0.1451
Echinococcus granulosus	General substrate transporter	0.0379	0.1631	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0479	0.2105	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0135	0.0481	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0489	0.1973
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0135	0.0481	0.0407
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.0468	0.0394
Schistosoma mansoni	sugar transporter	0.0062	0.0137	0.0061
Mycobacterium ulcerans	integral membrane transport protein	0.0062	0.0137	0.406
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0137	0.0061
Leishmania major	glucose transporter, lmgt1	0.0137	0.0489	0.833
Echinococcus multilocularis	calcium dependent protein kinase	0.0127	0.0441	0.0368
Onchocerca volvulus		0.0062	0.0137	0.2436
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0137	0.0061
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Schistosoma mansoni	survival motor neuron protein	0.0098	0.0306	0.0231
Trypanosoma cruzi	hexose transporter, putative	0.0137	0.0489	0.8307
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0571	1
Trypanosoma cruzi	hexose transporter, putative	0.0075	0.0197	0.2292
Leishmania major	lysyl-tRNA synthetase, putative	0.0098	0.0308	0.4664
Onchocerca volvulus		0.0062	0.0137	0.2436
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0132	0.0468	1
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0137	0.0649
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0135	0.0481	0.0534
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0137	0.0061
Brugia malayi	hypothetical protein	0.0062	0.0137	0.0649
Schistosoma mansoni	glucose transport protein	0.0441	0.1923	0.186
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0037	0.0019	0.0418
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0079	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.0204	0.0129
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0135	0.0481	0.2213
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Plasmodium falciparum	lysine--tRNA ligase	0.0098	0.0308	0.0334
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Brugia malayi	major facilitator superfamily protein	0.0062	0.0137	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Entamoeba histolytica	protein kinase, putative	0.0135	0.0481	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0135	0.0481	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Trichomonas vaginalis	CAMK family protein kinase	0.0135	0.0481	0.1927
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0077	0.0364
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Trichomonas vaginalis	glucose transporter, putative	0.0137	0.0489	0.1973
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.0204	0.0129
Trypanosoma cruzi	sugar transporter, putative	0.0062	0.0137	0.1055
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Onchocerca volvulus		0.0062	0.0137	0.2436
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0062	0.0137	0.5549
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0084	0.0238	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0084	0.0238	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0062	0.0137	0.5
Schistosoma mansoni	glucose transporter	0.0062	0.0137	0.0061
Echinococcus multilocularis	lysyl tRNA synthetase	0.0098	0.0308	0.0234
Schistosoma mansoni	sugar transporter	0.0062	0.0137	0.0061
Plasmodium falciparum	protein kinase 7	0.1245	0.5717	0.6589
Plasmodium vivax	sugar transporter, putative	0.0062	0.0137	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0079	0.2048
Toxoplasma gondii	sugar transporter ST3	0.0062	0.0137	0.0091
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.005	0.0079	0.2048
Echinococcus granulosus	tumor protein p63	0.0685	0.3075	0.3021
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.0346	0.1644
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0135	0.0481	0.8139
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0062	0.0137	0.406
Echinococcus multilocularis	microtubule associated protein 2	0.2153	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Schistosoma mansoni	glucose transport protein	0.0441	0.1923	0.186
Trypanosoma cruzi	glucose transporter, putative	0.0062	0.0137	0.1055
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0137	0.0649
Echinococcus granulosus	survival motor neuron protein 1	0.0479	0.2105	0.2044
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Onchocerca volvulus		0.0062	0.0137	0.2436
Loa Loa (eye worm)	sugar transporter	0.0441	0.1923	0.9127
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0489	0.8307
Brugia malayi	hypothetical protein	0.0062	0.0137	0.0649
Brugia malayi	hypothetical protein	0.0076	0.0204	0.097
Schistosoma mansoni	hypothetical protein	0.0076	0.0204	0.0129
Brugia malayi	Cam kinase protein 1	0.0135	0.0481	0.2284
Plasmodium falciparum	hexose transporter	0.0441	0.1923	0.2201
Chlamydia trachomatis	proline--tRNA ligase	0.0047	0.0065	0.1569
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.005	0.0079	0.3006
Schistosoma mansoni	hypothetical protein	0.0106	0.0346	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0468	0.2151
Brugia malayi	MH2 domain containing protein	0.0242	0.0986	0.4683
Trypanosoma brucei	glucose transporter, putative	0.0137	0.0489	0.8307
Onchocerca volvulus		0.01	0.0317	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0242	0.0986	0.4633
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0077	0.0364
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Schistosoma mansoni	hypothetical protein	0.0098	0.0306	0.0231
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0047	0.0065	0.1569
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0079	0.3006
Trichomonas vaginalis	sugar transporter, putative	0.0137	0.0489	0.1973
Brugia malayi	Sugar transporter family protein	0.0062	0.0137	0.0649
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0085	0.0076
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0098	0.0308	0.4588
Onchocerca volvulus		0.0062	0.0137	0.2436
Leishmania major	glucose transporter, lmgt2	0.0137	0.0489	0.833
Plasmodium falciparum	protein kinase 6	0.187	0.8666	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0571	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.0578	0.2679
Schistosoma mansoni	serine/threonine protein kinase	0.0135	0.0481	0.0407
Echinococcus granulosus	solute carrier family 22	0.0062	0.0137	0.0061
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.005	0.0079	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0137	0.0489	0.8307
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.0578	0.2746
Onchocerca volvulus		0.0062	0.0137	0.2436
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0137	0.0563
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0098	0.0308	0.4588
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Plasmodium vivax	CDK-related protein kinase 6, putative	0.187	0.8666	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0481	0.0407
Trichomonas vaginalis	glucose transporter, putative	0.0137	0.0489	0.1973
Toxoplasma gondii	protein kinase, putative	0.1245	0.5717	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0079	0.2048
Onchocerca volvulus		0.0062	0.0137	0.2436
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0441	0.1923	0.186
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0308	0.0234
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.0204	0.0129
Echinococcus multilocularis	tumor protein p63	0.0685	0.3075	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0137	0.0563
Onchocerca volvulus		0.0098	0.0306	0.9509
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0346	0.1566
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0132	0.0468	0.1855
Onchocerca volvulus	Putative transporter	0.0062	0.0137	0.2436
Mycobacterium ulcerans	sugar transporter	0.0062	0.0137	0.406
Toxoplasma gondii	facilitative glucose transporter GT1	0.0441	0.1923	0.3263
Giardia lamblia	Lysyl-tRNA synthetase	0.0098	0.0308	0.5182
Trypanosoma brucei	sugar transporter, putative	0.0062	0.0137	0.1055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879088