Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0275 | 0.3658 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0082 | 0.1287 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0192 | 0.3001 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0192 | 0.2769 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0283 | 0.4427 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.0447 | 0.6458 |
Treponema pallidum | polypeptide deformylase (def) | 0.072 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0255 | 0.05 |
Plasmodium falciparum | peptide deformylase | 0.072 | 1 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.0447 | 0.6458 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0049 | 0.0447 | 0.7 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0082 | 0.1287 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0283 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.0508 | 0.7949 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.0692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0804 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0447 | 0.1535 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0175 | 0.2743 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0639 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0082 | 0.1188 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0283 | 0.4437 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0275 | 0.3658 | 1 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0318 | 0.0731 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.2861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0383 | 0.1312 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0283 | 0.4094 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.0508 | 0.0322 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0275 | 0.3658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0491 | 0.169 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0255 | 0.0862 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0054 | 0.0156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0508 | 0.7334 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0275 | 0.3658 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.0508 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0283 | 0.4427 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0275 | 0.3658 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0275 | 0.3658 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0249 | 0.3292 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.0508 | 0.7949 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0283 | 0.4437 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.072 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.072 | 1 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0192 | 0.2769 |
Mycobacterium ulcerans | peptide deformylase | 0.072 | 1 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0038 | 0.0592 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0255 | 0.3683 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0054 | 0.0774 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0508 | 0.1422 |
Toxoplasma gondii | hypothetical protein | 0.072 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0491 | 0.169 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0355 | 0.1211 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0319 | 0.1087 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0491 | 0.1361 |
Plasmodium vivax | peptide deformylase, putative | 0.072 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0192 | 0.027 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0491 | 0.1361 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0508 | 0.1748 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0275 | 0.3658 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.2861 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0038 | 0.0546 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.0868 | 0.2734 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0049 | 0.0447 | 0.7 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0283 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.0508 | 0.7949 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0038 | 0.0592 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0283 | 0.4094 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0283 | 0.0604 |
Onchocerca volvulus | 0.0249 | 0.3292 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0283 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.0508 | 0.7949 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.072 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0283 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.