Detailed information for compound 883710

Basic information

Technical information
  • TDR Targets ID: 883710
  • Name: 2-(2,6-dimethoxypyridine-3-carbonyl)-N-methyl pyrazolidine-1-carbothioamide
  • MW: 310.372 | Formula: C13H18N4O3S
  • H donors: 1 H acceptors: 2 LogP: 1.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=S)N1CCCN1C(=O)c1ccc(nc1OC)OC
  • InChi: 1S/C13H18N4O3S/c1-14-13(21)17-8-4-7-16(17)12(18)9-5-6-10(19-2)15-11(9)20-3/h5-6H,4,7-8H2,1-3H3,(H,14,21)
  • InChiKey: BYOULDLFELJEMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,6-dimethoxypyridine-3-carbonyl)-N-methyl-pyrazolidine-1-carbothioamide
  • 2-[(2,6-dimethoxy-3-pyridyl)-oxomethyl]-N-methyl-1-pyrazolidinecarbothioamide
  • 2-(2,6-dimethoxypyridin-3-yl)carbonyl-N-methyl-pyrazolidine-1-carbothioamide
  • Oprea1_737210

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclin B3, putative 0.0804 0.3508 0.6708
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0051 0.0079 0.0065
Echinococcus granulosus Immunoglobulin 0.0049 0.0071 0.0057
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0059 0.0113
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0097 0.0291 0.0556
Echinococcus multilocularis cyclin 0.0194 0.073 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0092 0.0092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.01 0.0304 0.0582
Brugia malayi hypothetical protein 0.0049 0.0071 0.0071
Trichomonas vaginalis cyclin B, putative 0.1182 0.5229 1
Schistosoma mansoni cyclin d 0.223 1 1
Entamoeba histolytica cyclin, domain containing protein 0.0194 0.073 0.1397
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0059 0.0113
Brugia malayi cyclin fold protein 1 variant b 0.0194 0.073 0.073
Schistosoma mansoni tyrosine kinase 0.0059 0.0115 0.0115
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0134 0.0459 0.0445
Trichomonas vaginalis cyclin B, putative 0.0194 0.073 0.1397
Schistosoma mansoni cyclin G 0.0194 0.073 0.073
Echinococcus multilocularis cyclin A3 4 0.0194 0.073 0.0717
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0058 0.0044
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.1499 0.6674 0.6669
Giardia lamblia G2/mitotic-specific cyclin B 0.1182 0.5229 1
Plasmodium falciparum cyclin 0.0804 0.3508 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.01 0.0304 0.0582
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0049 0.0071 0.0063
Echinococcus multilocularis cyclin G2 0.0194 0.073 0.0717
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0071 0.0071
Trichomonas vaginalis cyclin B3, putative 0.0194 0.073 0.1397
Giardia lamblia Cyclin A 0.0804 0.3508 0.667
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0194 0.073 0.0717
Loa Loa (eye worm) TK/ABL protein kinase 0.0228 0.0885 0.0877
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0049 0.0071 0.0071
Echinococcus multilocularis cyclin G2 0.0194 0.073 0.0717
Schistosoma mansoni hypothetical protein 0.0049 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.073 0.1397
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0184 0.0683 0.0676
Schistosoma mansoni nephrin 0.0064 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.073 0.1397
Brugia malayi Fibronectin type III domain containing protein 0.0049 0.0071 0.0071
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0059 0.0113
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Echinococcus granulosus twitchin 0.0066 0.0149 0.0135
Loa Loa (eye worm) cyclin domain-containing protein 0.1499 0.6674 0.6671
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0027 0.0012
Echinococcus granulosus cyclin y 0.0194 0.073 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0092 0.0092
Echinococcus granulosus tyrosine protein kinase Lyn 0.0056 0.0102 0.0087
Brugia malayi Cyclin, N-terminal domain containing protein 0.1182 0.5229 0.5229
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0402 0.1676 0.1664
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0059 0.0051
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0047 0.0059 0.0051
Loa Loa (eye worm) TK protein kinase 0.0416 0.1741 0.1734
Echinococcus multilocularis cyclin dependent kinase 0.0047 0.0059 0.0045
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0434 0.1822 0.181
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0054 0.0092 0.0177
Schistosoma mansoni vesicular amine transporter 0.0049 0.0071 0.0071
Echinococcus granulosus cyclin y 0.0194 0.073 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.01 0.0304 0.0296
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0047 0.0059 0.0045
Echinococcus granulosus cyclins 0.0804 0.3508 0.3498
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0145 0.0145
Echinococcus multilocularis Cyclin L1 0.0194 0.073 0.0717
Trypanosoma cruzi cyclin 9, putative 0.0194 0.073 0.1397
Entamoeba histolytica protein kinase, putative 0.0039 0.0027 0.0051
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0402 0.1676 0.1664
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.0089 0.0074
Echinococcus multilocularis cyclin y 0.0194 0.073 0.0717
Plasmodium falciparum cyclin 1 0.0194 0.073 0.1946
Brugia malayi Tyrosine-protein kinase abl-1 0.0104 0.0321 0.0321
Brugia malayi Cyclin, N-terminal domain containing protein 0.1499 0.6674 0.6674
Schistosoma mansoni protein kinase 0.0052 0.0084 0.0084
Loa Loa (eye worm) TK protein kinase 0.0039 0.0027 0.0019
Echinococcus multilocularis cyclin y 0.0194 0.073 0.0717
Loa Loa (eye worm) hypothetical protein 0.1182 0.5229 0.5225
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0103 0.0317 0.0302
Trichomonas vaginalis cyclins, putative 0.0194 0.073 0.1397
Loa Loa (eye worm) hypothetical protein 0.0065 0.0143 0.0135
Echinococcus multilocularis cyclin t1 0.0194 0.073 0.0717
Trichomonas vaginalis cyclin B, putative 0.1182 0.5229 1
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0194 0.073 0.0717
Entamoeba histolytica protein kinase, putative 0.0052 0.0084 0.0161
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0089 0.0074
Echinococcus granulosus cyclin dependent kinase 5 0.0047 0.0059 0.0045
Echinococcus multilocularis cyclin B3 1 0.0804 0.3508 0.3498
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Trypanosoma cruzi p21-activated kinase 3, putative 0.0054 0.0092 0.0177
Echinococcus multilocularis tyrosine protein kinase Abl 0.0104 0.0321 0.0307
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0058 0.0044
Entamoeba histolytica hypothetical protein 0.008 0.0211 0.0403
Brugia malayi WH1 domain containing protein 0.0049 0.0071 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0416 0.1741 0.1741
Toxoplasma gondii hypothetical protein 0.0194 0.073 0.2617
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0059 0.0059
Echinococcus granulosus cyclin t1 0.0194 0.073 0.0717
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Leishmania major mitotic cyclin, putative 0.0194 0.073 0.1298
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0089 0.0074
Schistosoma mansoni hypothetical protein 0.0194 0.073 0.073
Schistosoma mansoni g1/s-specific cyclin C 0.0194 0.073 0.073
Trichomonas vaginalis STE family protein kinase 0.0052 0.0084 0.0161
Trypanosoma cruzi cyclin, putative 0.1182 0.5229 1
Entamoeba histolytica cyclin, putative 0.0804 0.3508 0.6708
Brugia malayi Cyclin C 0.0194 0.073 0.073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.0143 0.0143
Trypanosoma brucei cyclin 9 0.0194 0.073 0.1397
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Trypanosoma brucei cdc2-related kinase 3 0.0047 0.0059 0.0113
Trichomonas vaginalis cyclin B3, putative 0.0194 0.073 0.1397
Schistosoma mansoni tyrosine kinase 0.0221 0.0853 0.0853
Brugia malayi cell division control protein 2 homolog 0.0047 0.0059 0.0059
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0054 0.0092 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01 0.0304 0.0304
Schistosoma mansoni cyclins 0.0804 0.3508 0.3508
Toxoplasma gondii hypothetical protein 0.061 0.2624 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.01 0.0304 0.0582
Schistosoma mansoni protein kinase 0.0103 0.0317 0.0317
Trichomonas vaginalis cyclins, putative 0.1182 0.5229 1
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0103 0.0317 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.073 0.1397
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Entamoeba histolytica protein kinase, putative 0.0052 0.0084 0.0161
Trichomonas vaginalis STE family protein kinase 0.0103 0.0317 0.0605
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.0089 0.0074
Entamoeba histolytica cyclin, putative 0.1182 0.5229 1
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.073 0.1397
Loa Loa (eye worm) hypothetical protein 0.009 0.0259 0.0251
Brugia malayi Protein kinase domain containing protein 0.0047 0.0059 0.0059
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0059 0.0045
Trichomonas vaginalis cyclin A, putative 0.0194 0.073 0.1397
Brugia malayi Cyclin, N-terminal domain containing protein 0.0451 0.19 0.19
Schistosoma mansoni tyrosine kinase 0.0402 0.1676 0.1676
Schistosoma mansoni cell adhesion molecule 0.0056 0.0103 0.0103
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0147 0.0147
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0088 0.025 0.025
Echinococcus granulosus PAK box P21 Rho binding 0.0049 0.0071 0.0056
Echinococcus multilocularis cyclin B 0.1182 0.5229 0.5222
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0069 0.0161 0.0308
Echinococcus multilocularis G1:S specific cyclin D1 0.223 1 1
Entamoeba histolytica hypothetical protein 0.0049 0.0071 0.0136
Schistosoma mansoni cyclin G2 0.0194 0.073 0.073
Giardia lamblia Kinase, STE STE20 0.0103 0.0317 0.0497
Leishmania major cyclin 0.1182 0.5229 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0058 0.0044
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.1182 0.5229 1
Trichomonas vaginalis cyclin B, putative 0.1182 0.5229 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0189 0.0707 0.0693
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.0089 0.0074
Brugia malayi hypothetical protein 0.0194 0.073 0.073
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0194 0.073 0.0717
Echinococcus granulosus roundabout 2 0.007 0.0168 0.0154
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0501 0.213 0.2123
Echinococcus multilocularis roundabout 2 0.007 0.0168 0.0154
Trichomonas vaginalis cyclin D, putative 0.0194 0.073 0.1397
Echinococcus granulosus cyclin B3 1 0.0804 0.3508 0.3498
Plasmodium vivax cyclin 4, putative 0.0194 0.073 1
Echinococcus multilocularis neuroglian 0.0064 0.0136 0.0122
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0059 0.0045
Echinococcus granulosus cyclin dependent kinase 1 0.0047 0.0059 0.0045
Schistosoma mansoni tyrosine kinase 0.0053 0.0089 0.0089
Echinococcus multilocularis Immunoglobulin 0.0049 0.0071 0.0057
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.073 0.0723
Entamoeba histolytica p21-activated kinase 0.0103 0.0317 0.0605
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0056 0.0103 0.0089
Schistosoma mansoni Cyclin fold protein 0.0194 0.073 0.073
Brugia malayi Protein kinase domain 0.0103 0.0317 0.0317
Echinococcus granulosus tyrosine kinase 0.0046 0.0058 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Echinococcus multilocularis PAK box P21 Rho binding 0.0052 0.0084 0.0069
Brugia malayi P21-Rho-binding domain containing protein 0.0049 0.0071 0.0071
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0194 0.073 0.2617
Trichomonas vaginalis cyclins, putative 0.1182 0.5229 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0228 0.0885 0.0871
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.0089 0.0074
Echinococcus multilocularis cyclin k 0.0194 0.073 0.0717
Echinococcus granulosus cyclin A3 4 0.0194 0.073 0.0717
Entamoeba histolytica protein kinase, putative 0.0103 0.0317 0.0605
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.073 0.073
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Loa Loa (eye worm) SRC-1 0.0053 0.0089 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0059 0.0113
Schistosoma mansoni hypothetical protein 0.0194 0.073 0.073
Trichomonas vaginalis cyclin D, putative 0.0804 0.3508 0.6708
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.073 0.0723
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.008 0.0211 0.0403
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0194 0.073 0.1397
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.073 0.073
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0194 0.073 1
Echinococcus granulosus cyclins 0.0804 0.3508 0.3498
Plasmodium vivax cyclin homologue, putative 0.0194 0.073 1
Trypanosoma brucei mitotic cyclin 0.0194 0.073 0.1397
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0189 0.0707 0.0707
Echinococcus granulosus G2:mitotic specific cyclin B3 0.1499 0.6674 0.6669
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Loa Loa (eye worm) hypothetical protein 0.223 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0194 0.073 0.1946
Echinococcus multilocularis Immunoglobulin 0.0049 0.0071 0.0057
Trypanosoma cruzi CYC2-like cyclin, putative 0.1182 0.5229 1
Schistosoma mansoni tyrosine kinase 0.0053 0.0089 0.0089
Giardia lamblia Cyclin fold protein 1, putative 0.0194 0.073 0.1298
Echinococcus granulosus cyclin dependent kinase 6 0.0174 0.0639 0.0625
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.0089 0.0074
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0049 0.0071 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0103 0.0095
Trypanosoma cruzi cyclin 6, putative 0.1182 0.5229 1
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0194 0.073 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0304 0.058
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0049 0.0071 0.0056
Echinococcus granulosus neuroglian 0.0064 0.0136 0.0122
Echinococcus granulosus cyclins 0.0194 0.073 0.0717
Schistosoma mansoni protein kinase 0.0103 0.0317 0.0317
Echinococcus granulosus cyclins 0.0804 0.3508 0.3498
Entamoeba histolytica cyclin family protein 0.0804 0.3508 0.6708
Giardia lamblia Hypothetical protein 0.0194 0.073 0.1298
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0103 0.0317 0.0302
Trypanosoma cruzi mitotic cyclin, putative 0.0194 0.073 0.1397
Toxoplasma gondii cyclin dependent kinase binding protein 0.0194 0.073 0.2617
Trypanosoma brucei cyclin 3 0.0194 0.073 0.1397
Loa Loa (eye worm) cyclin C 0.0194 0.073 0.0723
Onchocerca volvulus 0.1182 0.5229 1
Echinococcus multilocularis cyclins 0.0804 0.3508 0.3498
Schistosoma mansoni hypothetical protein 0.0049 0.0071 0.0071
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0194 0.073 0.0723
Echinococcus granulosus cyclins 0.0804 0.3508 0.3498
Trichomonas vaginalis STE family protein kinase 0.0103 0.0317 0.0605
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Schistosoma mansoni cyclin B3 0.1499 0.6674 0.6674
Toxoplasma gondii cyclin 4, putative 0.0194 0.073 0.2617
Brugia malayi protein-tyrosine kinase 0.0046 0.0058 0.0058
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0054 0.0092 0.0084
Trichomonas vaginalis STE family protein kinase 0.0103 0.0317 0.0605
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Brugia malayi SRC-1 0.0053 0.0089 0.0089
Leishmania major cyclin 9, putative 0.0194 0.073 0.1298
Loa Loa (eye worm) phosphatidylinositol 3 0.0168 0.0613 0.0606
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0103 0.0317 0.0302
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0103 0.0317 0.0302
Trichomonas vaginalis STE family protein kinase 0.0103 0.0317 0.0605
Entamoeba histolytica cyclin family protein 0.0804 0.3508 0.6708
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0189 0.0707 0.0693
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0058 0.0044
Echinococcus multilocularis cyclin b3 0.0804 0.3508 0.3498
Plasmodium vivax hypothetical protein, conserved 0.0194 0.073 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0049 0.0071 0.0057
Loa Loa (eye worm) hypothetical protein 0.007 0.0168 0.016
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0049 0.0071 0.0056
Echinococcus granulosus cyclin k 0.0194 0.073 0.0717
Trypanosoma brucei mitotic cyclin 6 0.1182 0.5229 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0049 0.0071 0.0071
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.0143 0.0128
Trichomonas vaginalis cyclins, putative 0.0194 0.073 0.1397
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0049 0.0071 0.0071
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0065 0.0143 0.0128
Trypanosoma cruzi mitotic cyclin, putative 0.0194 0.073 0.1397
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0059 0.0051
Entamoeba histolytica hypothetical protein 0.0049 0.0071 0.0136
Trichomonas vaginalis cyclin B, putative 0.0194 0.073 0.1397
Loa Loa (eye worm) TK protein kinase 0.0046 0.0058 0.005
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0068 0.0016
Trichomonas vaginalis cyclins, putative 0.1182 0.5229 1
Brugia malayi P21-Rho-binding domain containing protein 0.0049 0.0071 0.0071
Schistosoma mansoni protein kinase 0.0049 0.0071 0.0071
Trichomonas vaginalis cyclin B, putative 0.1182 0.5229 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0058 0.0044
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.01 0.0304 0.0582
Echinococcus granulosus cyclin G2 0.0194 0.073 0.0717
Trypanosoma brucei cdc2-related kinase 1 0.0047 0.0059 0.0113
Trichomonas vaginalis cyclins, putative 0.1182 0.5229 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.01 0.0304 0.0582
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0027 0.0012
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0059 0.0113
Echinococcus granulosus fibroblast growth factor receptor 4 0.0402 0.1676 0.1664
Loa Loa (eye worm) hypothetical protein 0.0194 0.073 0.0723
Leishmania major mitotic cyclin, putative 0.0194 0.073 0.1298
Echinococcus granulosus cyclin dependent kinase 0.0047 0.0059 0.0045
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0059 0.0113
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0054 0.0092 0.0092
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.0089 0.0074
Entamoeba histolytica cyclin C, putative 0.0194 0.073 0.1397
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0194 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0049 0.0071 0.0071
Brugia malayi serine/threonine-protein kinase PAK 7 0.0184 0.0683 0.0683
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0228 0.0885 0.0871
Giardia lamblia Hypothetical protein 0.0194 0.073 0.1298
Trichomonas vaginalis cyclins, putative 0.0804 0.3508 0.6708
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.073 0.1397
Trichomonas vaginalis cyclin D, putative 0.0804 0.3508 0.6708
Echinococcus granulosus Cyclin L1 0.0194 0.073 0.0717
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0063
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Schistosoma mansoni cyclin B 0.1182 0.5229 0.5229
Brugia malayi hypothetical protein 0.0194 0.073 0.073
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0059 0.0113
Giardia lamblia Hypothetical protein 0.0804 0.3508 0.667
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.01 0.0304 0.0582
Echinococcus granulosus defective proboscis extension response 0.0049 0.0071 0.0057
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0402 0.1676 0.1664
Loa Loa (eye worm) hypothetical protein 0.1182 0.5229 0.5225
Schistosoma mansoni cyclin k 0.0194 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0044 0.0046 0.0038
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.0442 0.0442
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.073 0.0723
Echinococcus granulosus cyclin B 0.1182 0.5229 0.5222
Brugia malayi Cyclin, N-terminal domain containing protein 0.1182 0.5229 0.5229
Loa Loa (eye worm) cyclin domain-containing protein 0.0451 0.19 0.1893
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0054 0.0092 0.0177
Trichomonas vaginalis cyclin A, putative 0.1182 0.5229 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.073 0.073
Entamoeba histolytica protein kinase, putative 0.0052 0.0084 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0059 0.0113
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0103 0.0317 0.0302
Echinococcus granulosus cyclin b3 0.0804 0.3508 0.3498
Loa Loa (eye worm) CYL-1 protein 0.0194 0.073 0.0723
Echinococcus granulosus G1:S specific cyclin D1 0.223 1 1
Trichomonas vaginalis cyclins, putative 0.0572 0.2452 0.4689
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.0089 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0804 0.3508 0.6708
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0089 0.0074
Loa Loa (eye worm) hypothetical protein 0.0378 0.1569 0.1562
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.073 0.0723
Loa Loa (eye worm) hypothetical protein 0.007 0.0168 0.016
Giardia lamblia Cyclin B-like protein 0.0194 0.073 0.1298
Echinococcus granulosus cyclin G2 0.0194 0.073 0.0717
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.0089 0.0074
Loa Loa (eye worm) hypothetical protein 0.2036 0.9117 0.9116
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0194 0.073 0.0717
Echinococcus granulosus cyclin 0.0194 0.073 0.0717
Entamoeba histolytica cyclin, domain containing protein 0.0194 0.073 0.1397
Entamoeba histolytica hypothetical protein 0.0194 0.073 0.1397
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0059 0.0113
Echinococcus multilocularis PAK box P21 Rho binding 0.0049 0.0071 0.0056
Echinococcus multilocularis cyclin dependent kinase 5 0.0047 0.0059 0.0045
Echinococcus multilocularis cyclin dependent kinase 6 0.0174 0.0639 0.0625
Trichomonas vaginalis cyclin B, putative 0.0804 0.3508 0.6708
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.073 0.073
Trypanosoma cruzi cyclin, putative 0.1182 0.5229 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.073 0.0723
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.005 0.0095
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0069 0.0161 0.0308
Echinococcus granulosus cyclins 0.0804 0.3508 0.3498
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0066 0.0147 0.0139
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.073 0.073
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0134 0.0459 0.0445
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0194 0.073 0.2617
Schistosoma mansoni cyclin l 0.0194 0.073 0.073

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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