Detailed information for compound 883900

Basic information

Technical information
  • TDR Targets ID: 883900
  • Name: 3-[[4-chloro-2,5-dioxo-1-(phenylmethyl)pyrrol -3-yl]amino]-N-(4-fluorophenyl)-4-methylbenza mide
  • MW: 463.888 | Formula: C25H19ClFN3O3
  • H donors: 2 H acceptors: 3 LogP: 4.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)c1ccc(c(c1)NC1=C(Cl)C(=O)N(C1=O)Cc1ccccc1)C
  • InChi: 1S/C25H19ClFN3O3/c1-15-7-8-17(23(31)28-19-11-9-18(27)10-12-19)13-20(15)29-22-21(26)24(32)30(25(22)33)14-16-5-3-2-4-6-16/h2-13,29H,14H2,1H3,(H,28,31)
  • InChiKey: DIQHFTXXFHSMQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[4-chloro-2,5-dioxo-1-(phenylmethyl)pyrrol-3-yl]amino]-N-(4-fluorophenyl)-4-methyl-benzamide
  • 3-[[4-chloro-2,5-dioxo-1-(phenylmethyl)-3-pyrrolyl]amino]-N-(4-fluorophenyl)-4-methylbenzamide
  • 3-[[1-(benzyl)-4-chloro-2,5-diketo-3-pyrrolin-3-yl]amino]-N-(4-fluorophenyl)-4-methyl-benzamide
  • ST5207317

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0915
Brugia malayi beta-lactamase family protein 0.0038 0.0532 0.0692
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0271 0.0465
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0046 0.0802
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0472 0.0404
Loa Loa (eye worm) hypothetical protein 0.003 0.038 0.0564
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Brugia malayi Pre-SET motif family protein 0.0218 0.4365 0.6441
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0071 0.1227
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.3673 1
Onchocerca volvulus 0.0016 0.0071 0.0105
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0071 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Entamoeba histolytica protein kinase, putative 0.0035 0.0471 1
Schistosoma mansoni hypothetical protein 0.0114 0.215 0.3407
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0532 0.0965
Schistosoma mansoni hypothetical protein 0.0303 0.6175 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.215 0.5853
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0071 0.0122
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0271 0.395
Schistosoma mansoni hypothetical protein 0.003 0.038 0.0506
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0472 0.0617
Onchocerca volvulus 0.0016 0.0071 0.0105
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0532 0.0692
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0532 0.0465
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Schistosoma mansoni jumonji domain containing protein 0.0079 0.142 0.221
Echinococcus multilocularis polycomb protein SCMH1 0.0127 0.2442 0.6647
Leishmania major hypothetical protein, conserved 0.0016 0.0071 0.1227
Brugia malayi beta-lactamase family protein 0.0038 0.0532 0.0692
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0046 0.0802
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0532 0.0965
Mycobacterium ulcerans beta-lactamase 0.0038 0.0532 0.0803
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0634 0.1726
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0071 0.0122
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0184 0.364 0.5495
Echinococcus granulosus solute carrier family 22 0.0016 0.0071 0.0193
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0046 0.0802
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0532 0.0803
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0532 0.1449
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0071 0.0193
Schistosoma mansoni sex comb on midleg homolog 0.0127 0.2442 0.3884
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0456 0.0784
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0494 0.8574
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0395 0.1076
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0481 0.8339
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0271 0.5083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0472 0.0404
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0498 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0071 0.0122
Schistosoma mansoni sex comb on midleg homolog 0.0127 0.2442 0.3884
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0395 0.1076
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0204 0.0351
Plasmodium vivax hypothetical protein, conserved 0.003 0.038 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1071 0.159
Brugia malayi beta-lactamase 0.0038 0.0532 0.0692
Loa Loa (eye worm) glutaminase 0.0286 0.5818 0.8635
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Mycobacterium ulcerans glutaminase 0.0286 0.5818 1
Brugia malayi mbt repeat family protein 0.0329 0.6738 1
Plasmodium falciparum hexose transporter 0.0114 0.215 0.2094
Schistosoma mansoni glucose transport protein 0.0114 0.215 0.3407
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.215 0.3696
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0271 0.03
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0071 0.1227
Schistosoma mansoni single-minded 0.0049 0.0767 0.1141
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.4365 0.6479
Brugia malayi glutaminase DH11.1 0.0286 0.5818 0.862
Onchocerca volvulus 0.0016 0.0071 0.0105
Leishmania major glucose transporter, lmgt2 0.0035 0.0481 0.8339
Echinococcus granulosus SAM and MBT domain containing protein 0.0117 0.2232 0.6076
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0271 0.0327
Echinococcus multilocularis solute carrier family 22 0.0016 0.0071 0.0193
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0456 0.0677
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0481 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0471 0.081
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.038 0.1034
Plasmodium vivax SET domain protein, putative 0.0031 0.0395 0.0327
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0767 0.1141
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0577 1
Onchocerca volvulus 0.0248 0.5006 0.7429
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Leishmania major protein kinase, putative 0.0015 0.0046 0.0802
Echinococcus granulosus General substrate transporter 0.0098 0.181 0.4927
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0532 0.0965
Brugia malayi PHD-finger family protein 0.003 0.038 0.0463
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0471 0.1283
Trichomonas vaginalis set domain proteins, putative 0.0248 0.5006 0.8603
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0494 0.8374
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0516 0.0766
Leishmania major protein kinase, putative 0.0035 0.0471 0.8174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0395 0.0532
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0634 0.1726
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0532 0.0965
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0472 0.0404
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0071 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0532 0.0756
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0028 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0532 0.0915
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0494 0.0734
Brugia malayi Augmenter of liver regeneration 0.0036 0.0494 0.0636
Onchocerca volvulus 0.0016 0.0071 0.0105
Echinococcus multilocularis solute carrier family 22 0.0016 0.0071 0.0193
Brugia malayi Cytochrome P450 family protein 0.003 0.0364 0.0439
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.0965
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0456 0.8575
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0498 0.1356
Mycobacterium tuberculosis Conserved protein 0.0038 0.0532 0.0965
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0456 0.1243
Schistosoma mansoni protein kinase 0.0035 0.0471 0.0656
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0532 0.0803
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0402
Loa Loa (eye worm) hypothetical protein 0.0028 0.032 0.0475
Loa Loa (eye worm) hypothetical protein 0.0052 0.0844 0.1252
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0481 0.0827
Echinococcus granulosus peregrin 0.003 0.038 0.1034
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.215 0.3201
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0472 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0395 0.0532
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0481 0.8339
Mycobacterium ulcerans lipase LipD 0.0038 0.0532 0.0803
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0532 0.079
Brugia malayi follicle stimulating hormone receptor 0.0242 0.4888 0.7226
Onchocerca volvulus 0.0016 0.0071 0.0105
Onchocerca volvulus 0.0016 0.0071 0.0105
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0532 0.0965
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0481 0.8107
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0494 0.8574
Onchocerca volvulus 0.0031 0.0395 0.0587
Onchocerca volvulus 0.0036 0.0498 0.0739
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0532 0.923
Echinococcus multilocularis General substrate transporter 0.0098 0.181 0.4927
Plasmodium falciparum proline--tRNA ligase 0.004 0.0577 0.051
Trypanosoma brucei glucose transporter 2A 0.0035 0.0481 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.038 0.0506
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0532 0.0965
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0189 0.0248
Echinococcus multilocularis peregrin 0.003 0.038 0.1034
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0271 0.0308
Echinococcus multilocularis SAM and MBT domain containing protein 0.0117 0.2232 0.6076
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0456 0.1243
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Onchocerca volvulus 0.0016 0.0071 0.0105
Brugia malayi jmjC domain containing protein 0.0037 0.0516 0.0668
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0271 0.0348
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0532 0.1449
Onchocerca volvulus 0.0016 0.0071 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Brugia malayi Bromodomain containing protein 0.003 0.038 0.0463
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0516 0.073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0271 0.0348
Plasmodium falciparum phd finger protein, putative 0.003 0.038 0.0311
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0364 0.0539
Plasmodium vivax hexose transporter 0.0114 0.215 0.2094
Brugia malayi Pre-SET motif family protein 0.0031 0.0395 0.0487
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0271 1
Onchocerca volvulus 0.0016 0.0071 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0471 0.0656
Echinococcus granulosus solute carrier family 22 0.0016 0.0071 0.0193
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0184 0.364 0.3595
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0472 0.0404
Schistosoma mansoni glucose transport protein 0.0114 0.215 0.3407
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0532 0.923
Echinococcus multilocularis solute carrier family 22 0.0016 0.0071 0.0193
Loa Loa (eye worm) sugar transporter 0.0114 0.215 0.3191
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0471 0.0601
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0481 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0481 0.0827
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0271 0.4692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0471 0.07
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0494 0.1346
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0395 0.1076
Loa Loa (eye worm) beta-lactamase 0.0038 0.0532 0.079
Echinococcus granulosus single minded 2 0.0036 0.0498 0.1356
Giardia lamblia PHD finger protein 15 0.003 0.038 0.8012
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0577 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0046 0.0802
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0071 0.0122
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0329 0.6738 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Brugia malayi Sugar transporter family protein 0.0114 0.215 0.3119
Onchocerca volvulus 0.0038 0.0532 0.079
Schistosoma mansoni protein kinase 0.0035 0.0471 0.0656
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0189 0.3554
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.4853 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0071 0.0105
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0498 0.0743
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0141 0.244
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0271 0.0737
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0456 0.0578
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0577 0.051
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0516 0.073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0117 0.2232 0.3541
Brugia malayi jmjC domain containing protein 0.01 0.1857 0.2679
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0071 0.1227
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0494 0.1346
Brugia malayi mbt repeat family protein 0.0117 0.2232 0.3241
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0481 0.0827
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0456 0.9253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Onchocerca volvulus 0.0038 0.0532 0.079
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0271 0.0201
Echinococcus granulosus polycomb protein SCMH1 0.0127 0.2442 0.6647
Echinococcus granulosus solute carrier family 22 0.0016 0.0071 0.0193
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0516 0.1406
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0471 0.07
Onchocerca volvulus 0.0016 0.0071 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0532 0.0965
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0494 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trypanosoma brucei glucose transporter 1E 0.0035 0.0481 0.8107
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.3673 1
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0071 0.0122
Onchocerca volvulus 0.0016 0.0071 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0456 0.0632
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0577 0.0779
Onchocerca volvulus 0.0016 0.0071 0.0105
Onchocerca volvulus 0.0127 0.2442 0.3624
Toxoplasma gondii protein kinase, putative 0.0321 0.6567 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0532 0.0803
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0271 0.4692
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0471 0.7919
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0471 0.07
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Entamoeba histolytica protein kinase, putative 0.0035 0.0471 1
Brugia malayi hypothetical protein 0.0163 0.3209 0.4707
Schistosoma mansoni glutaminase 0.0286 0.5818 0.9416
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0481 0.8339
Loa Loa (eye worm) mbt repeat family protein 0.0117 0.2232 0.3312
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0494 0.0427
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.038 0.0476
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0481 0.8107
Loa Loa (eye worm) hypothetical protein 0.0329 0.6738 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Onchocerca volvulus 0.0016 0.0071 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Leishmania major protein kinase, putative 0.0015 0.0046 0.0802
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0271 0.0327
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0577 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0915
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0456 0.0632
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0472 0.0617
Onchocerca volvulus 0.0016 0.0071 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0532 0.079
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0532 0.0915
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0456 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.3209 0.4763
Echinococcus granulosus solute carrier family 22 0.0016 0.0071 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Leishmania major glucose transporter, lmgt3 0.0035 0.0481 0.8339
Trichomonas vaginalis esterase, putative 0.0038 0.0532 0.0915
Leishmania major hypothetical protein, conserved 0.0038 0.0532 0.923
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0472 0.0404
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0271 0.0201
Loa Loa (eye worm) PHD-finger family protein 0.003 0.038 0.0564
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.294 0.4363
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0494 0.8574
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Leishmania major hypothetical protein, conserved 0.0036 0.0494 0.8574
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1857 0.5055
Echinococcus multilocularis solute carrier family 22 0.0016 0.0071 0.0193
Leishmania major glucose transporter, lmgt1 0.0035 0.0481 0.8339
Trypanosoma cruzi hexose transporter 0.0035 0.0481 0.8339
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Onchocerca volvulus 0.0016 0.0071 0.0105
Schistosoma mansoni glucose transport protein 0.0114 0.215 0.3407
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0494 0.0652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0472 0.0404
Mycobacterium leprae Probable lipase LipE 0.0038 0.0532 1
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0071 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0395 0.0587
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0532 0.0756
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0532 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0071 0.1227
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0426 0.1159
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0481 0.8339
Brugia malayi Cam kinase protein 1 0.0035 0.0471 0.0601
Toxoplasma gondii ABC1 family protein 0.0038 0.0532 0.0711
Brugia malayi PAS domain containing protein 0.0049 0.0767 0.1045
Brugia malayi hypoxia-induced factor 1 0.0151 0.294 0.4303
Schistosoma mansoni protein kinase 0.0035 0.0471 0.0656
Loa Loa (eye worm) hypothetical protein 0.0034 0.0456 0.0677
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0472 0.0617
Plasmodium vivax CDK-related protein kinase 6, putative 0.0482 1 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0071 0.0193
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0395 0.05
Trichomonas vaginalis glutaminase, putative 0.0286 0.5818 1
Onchocerca volvulus Alhambra homolog 0.003 0.038 0.0564
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0481 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.215 0.5853
Plasmodium falciparum mitogen-activated protein kinase 2 0.0184 0.364 0.3595
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.038 0.0476
Loa Loa (eye worm) sugar transporter 0.0016 0.0071 0.0105
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0271 0.5182
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0271 0.0737
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.038 0.1034
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0471 0.1283
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0071 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Loa Loa (eye worm) glutaminase 2 0.0286 0.5818 0.8635
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0532 0.9122
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0516 0.1406
Onchocerca volvulus Putative transporter 0.0016 0.0071 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0481 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0481 0.0827
Trypanosoma brucei glucose transporter, putative 0.0035 0.0481 0.8107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0395 0.0532
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0456 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0071 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0494 0.0652
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Plasmodium falciparum protein kinase 7 0.0321 0.6567 0.6542
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0426 0.1159
Onchocerca volvulus 0.0038 0.0532 0.079
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0189 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0532 0.0915
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1857 0.5055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0371 0.101
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0472 0.0404
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0071 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0577 1
Onchocerca volvulus 0.0016 0.0071 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0395 0.0532
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0105
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0472 0.0404
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.4888 0.7255
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0071 0.0122

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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