Detailed information for compound 884703

Basic information

Technical information
  • TDR Targets ID: 884703
  • Name: 6-(2-diethylaminoethyl)-4,7-dimethyl-2-(2-phe nylethyl)purino[7,8-a]imidazole-1,3-dione
  • MW: 422.523 | Formula: C23H30N6O2
  • H donors: 0 H acceptors: 3 LogP: 3.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCn1c(C)cn2c1nc1c2c(=O)n(c(=O)n1C)CCc1ccccc1)CC
  • InChi: 1S/C23H30N6O2/c1-5-26(6-2)14-15-27-17(3)16-29-19-20(24-22(27)29)25(4)23(31)28(21(19)30)13-12-18-10-8-7-9-11-18/h7-11,16H,5-6,12-15H2,1-4H3
  • InChiKey: NXIVRENFYDOQGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2-diethylaminoethyl)-4,7-dimethyl-2-(2-phenylethyl)purino[7,8-a]imidazole-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0031 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.1126 0.1157
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2434 0.5597 1
Trypanosoma cruzi cysteine proteinase, putative 0.108 0.245 0.1493
Echinococcus multilocularis cathepsin L cysteine protease 0.1916 0.4393 0.4516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.1126 0.1157
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Loa Loa (eye worm) hypothetical protein 0.005 0.0054 0.0038
Schistosoma mansoni bromodomain containing protein 0.0074 0.011 0.0113
Giardia lamblia Cysteine protease 0.051 0.1126 0.1985
Echinococcus granulosus cathepsin L 0.051 0.1126 0.1157
Echinococcus granulosus cathepsin l1 0.1346 0.3068 0.3154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1126 0.1386
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0049 0.005
Loa Loa (eye worm) cysteine protease 0.1916 0.4393 0.4506
Brugia malayi PHD-finger family protein 0.0034 0.0018 0.0012
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.1916 0.4393 0.4516
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.051 0.1126 0.1386
Schistosoma mansoni cathepsin S (C01 family) 0.051 0.1126 0.1157
Giardia lamblia Dipeptidyl-peptidase I precursor 0.051 0.1126 0.1985
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.051 0.1126 0.2532
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.1126 0.1157
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.004 0.0041
Brugia malayi cathepsin L-like cysteine proteinase 0.051 0.1126 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1126 0.1386
Toxoplasma gondii cathepsin CPC1 0.051 0.1126 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.051 0.1126 0.1157
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.108 0.245 0.2519
Schistosoma mansoni cathepsin s 0.057 0.1264 0.1299
Echinococcus granulosus peregrin 0.0037 0.0024 0.0025
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.057 0.1264 0.1293
Brugia malayi cathepsin L-like precursor 0.1346 0.3068 0.315
Entamoeba histolytica cysteine proteinase, putative 0.108 0.245 0.4054
Leishmania major cathepsin L-like protease 0.4327 1 1
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Loa Loa (eye worm) hypothetical protein 0.1346 0.3068 0.3142
Plasmodium falciparum serine repeat antigen 3 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.108 0.245 0.3937
Plasmodium falciparum serine repeat antigen 7 0.051 0.1126 0.2532
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0035 0.0035
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0018 0.0018
Brugia malayi cathepsin B-like cysteine proteinase 0.421 0.9727 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0074 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.108 0.245 0.1493
Giardia lamblia Cathepsin L-like protease 0.051 0.1126 0.1985
Brugia malayi cathepsin F-like cysteine proteinase 0.051 0.1126 0.1151
Onchocerca volvulus 0.1916 0.4393 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Plasmodium vivax unspecified product 0.051 0.1126 0.2532
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.421 0.9727 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1126 0.1386
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Echinococcus granulosus cathepsin l1 0.1916 0.4393 0.4516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Entamoeba histolytica cysteine proteinase, putative 0.1346 0.3068 0.5946
Onchocerca volvulus Cathepsin L homolog 0.1916 0.4393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Plasmodium falciparum serine repeat antigen 2 0.051 0.1126 0.2532
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Trypanosoma cruzi cysteine protease, putative 0.108 0.245 0.1493
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.051 0.1126 0.2532
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.051 0.1126 0.2532
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1126 0.1386
Echinococcus multilocularis cathepsin b 0.421 0.9727 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.051 0.1126 0.1141
Leishmania major cathepsin L-like protease 0.4327 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1346 0.3068 0.5128
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Giardia lamblia Cathepsin B precursor 0.2434 0.5597 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Echinococcus multilocularis cathepsin b 0.421 0.9727 1
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Plasmodium vivax serine-repeat antigen (SERA) 0.051 0.1126 0.2532
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.1346 0.3068 0.3154
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1126 0.1386
Onchocerca volvulus 0.1916 0.4393 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.421 0.9727 0.9693
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.051 0.1126 0.1157
Entamoeba histolytica cysteine proteinase, putative 0.108 0.245 0.4054
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0031 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.4327 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1916 0.4393 0.4516
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.108 0.245 0.2519
Brugia malayi Cathepsin L-like precursor 0.1346 0.3068 0.315
Brugia malayi Bromodomain containing protein 0.0037 0.0024 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0036 0.0037
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Onchocerca volvulus 0.1916 0.4393 1
Plasmodium vivax vivapain-2 0.1916 0.4393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1126 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1126 0.1151
Brugia malayi Papain family cysteine protease containing protein 0.108 0.245 0.2514
Loa Loa (eye worm) hypothetical protein 0.057 0.1264 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Giardia lamblia Cathepsin B precursor 0.2434 0.5597 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.004 0.0041
Loa Loa (eye worm) hypothetical protein 0.057 0.1264 0.1283
Onchocerca volvulus 0.1346 0.3068 0.6972
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0101 0.0103
Echinococcus multilocularis cysteine protease 0.1916 0.4393 0.4516
Schistosoma mansoni cathepsin C 0.051 0.1126 0.1157
Loa Loa (eye worm) cathepsin B 0.2434 0.5597 0.5746
Giardia lamblia Hypothetical protein 0.051 0.1126 0.1985
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0207 0.0419 0.0425
Giardia lamblia Cysteine protease 0.051 0.1126 0.1985
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.004 0.0041
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.421 0.9727 1
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Brugia malayi Bromodomain containing protein 0.0045 0.0043 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.051 0.1126 0.1386
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Plasmodium vivax vivapain-1 0.108 0.245 0.5559
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1916 0.4393 1
Schistosoma mansoni cathepsin B (C01 family) 0.051 0.1126 0.1157
Plasmodium vivax vivapain-3 0.108 0.245 0.5559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Toxoplasma gondii cathepsin CPC2 0.051 0.1126 0.1985
Plasmodium falciparum serine repeat antigen 5 0.051 0.1126 0.2532
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.1346 0.3068 0.3142
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.051 0.1126 0.2532
Echinococcus granulosus cathepsin b 0.421 0.9727 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1916 0.4393 0.768
Echinococcus granulosus neuropeptide receptor A26 0.0539 0.1191 0.1224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0074 0.0069
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Entamoeba histolytica cysteine proteinase, putative 0.1916 0.4393 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Onchocerca volvulus 0.1916 0.4393 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2434 0.5597 0.5039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.108 0.245 0.2514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Echinococcus granulosus neuropeptide s receptor 0.0539 0.1191 0.1224
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.051 0.1126 0.1157
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0102 0.0087
Loa Loa (eye worm) hypothetical protein 0.1346 0.3068 0.3142
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.1126 0.1157
Plasmodium vivax vivapain-2 0.1916 0.4393 1
Echinococcus granulosus cathepsin b 0.421 0.9727 1
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Schistosoma mansoni cathepsin F (C01 family) 0.1916 0.4393 0.4516
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1126 0.1386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Brugia malayi cathepsin F-like cysteine proteinase 0.057 0.1264 0.1293
Giardia lamblia Cysteine protease 0.051 0.1126 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.004 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.108 0.245 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.051 0.1126 0.2532
Plasmodium falciparum cysteine proteinase falcipain 1 0.108 0.245 0.5559
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0049 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.1916 0.4393 0.4516
Giardia lamblia Cathepsin B precursor 0.051 0.1126 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Loa Loa (eye worm) hypothetical protein 0.057 0.1264 0.1283
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.051 0.1126 0.1985
Giardia lamblia Dipeptidyl-peptidase I precursor 0.051 0.1126 0.1985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Loa Loa (eye worm) hypothetical protein 0.0047 0.0049 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Brugia malayi fibroinase precursor 0.051 0.1126 0.1151
Toxoplasma gondii preprocathepsin c precursor, putative 0.051 0.1126 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.051 0.1126 0.1386
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Schistosoma mansoni jumonji domain containing protein 0.0088 0.0144 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1916 0.4393 0.4506
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Echinococcus multilocularis peregrin 0.0037 0.0024 0.0025
Plasmodium vivax unspecified product 0.108 0.245 0.5559
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.3758 0.8675 0.8507
Onchocerca volvulus 0.051 0.1126 0.2532
Plasmodium falciparum cysteine proteinase falcipain 3 0.1916 0.4393 1
Brugia malayi Cathepsin L-like precursor 0.057 0.1264 0.1293
Onchocerca volvulus 0.1916 0.4393 1
Trypanosoma cruzi cysteine peptidase, putative 0.4327 1 1
Loa Loa (eye worm) hypothetical protein 0.421 0.9727 1
Onchocerca volvulus Cathepsin L homolog 0.051 0.1126 0.2532
Trypanosoma cruzi cysteine peptidase, putative 0.1916 0.4393 0.3682
Loa Loa (eye worm) hypothetical protein 0.0207 0.0419 0.0413
Echinococcus multilocularis neuropeptide receptor A26 0.0539 0.1191 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Giardia lamblia Hypothetical protein 0.051 0.1126 0.1985
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1916 0.4393 0.4506
Plasmodium vivax serine-repeat antigen (SERA), putative 0.051 0.1126 0.2532
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Plasmodium falciparum serine repeat antigen 9 0.051 0.1126 0.2532
Brugia malayi Papain family cysteine protease containing protein 0.1916 0.4393 0.4512
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0101 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Giardia lamblia Cathepsin B precursor 0.051 0.1126 0.1985
Brugia malayi Papain family cysteine protease containing protein 0.051 0.1126 0.1151
Echinococcus multilocularis neuropeptide s receptor 0.0539 0.1191 0.1224
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0018 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0074 0.0058
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Trypanosoma cruzi cysteine peptidase, putative 0.4327 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.108 0.245 0.1493
Schistosoma mansoni cathepsin F (C01 family) 0.1916 0.4393 0.4516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.108 0.245 0.3937
Plasmodium falciparum serine repeat antigen 1 0.051 0.1126 0.2532
Brugia malayi Cathepsin L-like precursor 0.1346 0.3068 0.315
Brugia malayi jmjC domain containing protein 0.0111 0.0198 0.0197
Trypanosoma cruzi cysteine proteinase, putative 0.108 0.245 0.1493
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.1126 0.1157
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1916 0.4393 1
Giardia lamblia Cathepsin B precursor 0.051 0.1126 0.1985
Entamoeba histolytica cysteine proteinase, putative 0.1916 0.4393 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trypanosoma cruzi cruzipain precursor, putative 0.057 0.1264 0.0156
Echinococcus granulosus cathepsin l cysteine peptidase 0.1916 0.4393 0.4516
Brugia malayi Papain family cysteine protease containing protein 0.051 0.1126 0.1151
Onchocerca volvulus Cathepsin F homolog 0.1916 0.4393 1
Giardia lamblia Cathepsin B precursor 0.2434 0.5597 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.0198 0.0203
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2434 0.5597 0.5754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.051 0.1126 0.2532
Loa Loa (eye worm) papain family cysteine protease containing protein 0.051 0.1126 0.1141
Trypanosoma cruzi cruzipain precursor, putative 0.4327 1 1
Echinococcus multilocularis cysteine protease 0.1916 0.4393 0.4516
Loa Loa (eye worm) ctsf protein 0.1916 0.4393 0.4506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.013 0.0116
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.051 0.1126 0.1985
Plasmodium vivax unspecified product 0.057 0.1264 0.2847
Brugia malayi Papain family cysteine protease containing protein 0.051 0.1126 0.1151
Entamoeba histolytica cysteine proteinase, putative 0.108 0.245 0.4054
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1126 0.1386
Giardia lamblia Cysteine protease 0.051 0.1126 0.1985
Plasmodium vivax serine-repeat antigen (SERA), putative 0.051 0.1126 0.2532
Trypanosoma cruzi cysteine peptidase, putative 0.057 0.1264 0.0156
Echinococcus granulosus cysteine protease 0.108 0.245 0.2519
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Giardia lamblia Cathepsin L precursor 0.051 0.1126 0.1985
Echinococcus granulosus cathepsin L 0.108 0.245 0.2519
Echinococcus multilocularis cathepsin L 0.108 0.245 0.2519
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.051 0.1126 0.2532
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.421 0.9727 1
Entamoeba histolytica cysteine proteinase, putative 0.108 0.245 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.421 0.9727 1
Brugia malayi jmjC domain containing protein 0.0043 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1916 0.4393 0.4516
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1916 0.4393 0.768
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Onchocerca volvulus 0.1916 0.4393 1
Giardia lamblia Cathepsin B precursor 0.051 0.1126 0.1985
Giardia lamblia Cathepsin B precursor 0.051 0.1126 0.1985
Brugia malayi Cathepsin L-like precursor 0.1916 0.4393 0.4512
Echinococcus granulosus cathepsin L cysteine protease 0.108 0.245 0.2519
Brugia malayi Bromodomain containing protein 0.0087 0.0142 0.014
Brugia malayi Cathepsin L-like cysteine proteinase 0.1346 0.3068 0.315
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.051 0.1126 0.1141
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1126 0.1151
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.051 0.1126 0.2532
Brugia malayi cathepsin L precursor 0.051 0.1126 0.1151
Trypanosoma cruzi major cysteine proteinase, putative 0.2922 0.6733 0.6318
Giardia lamblia Encystation-specific protease 0.051 0.1126 0.1985
Loa Loa (eye worm) hypothetical protein 0.0045 0.0043 0.0026
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0058
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.051 0.1126 0.1157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trypanosoma brucei cysteine peptidase C (CPC) 0.2434 0.5597 0.4168
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2434 0.5597 0.2148
Giardia lamblia Cathepsin L-like protease 0.051 0.1126 0.1985
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.1126 0.1386
Loa Loa (eye worm) hypothetical protein 0.1916 0.4393 0.4506
Echinococcus multilocularis cathepsin L 0.051 0.1126 0.1157
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Loa Loa (eye worm) fibroinase 0.1916 0.4393 0.4506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1916 0.4393 0.768
Onchocerca volvulus Cathepsin L homolog 0.1916 0.4393 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.057 0.1264 0.1283
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.108 0.245 0.2519
Brugia malayi cahepsin L-like non-peptiedase homolog 0.051 0.1126 0.1151
Plasmodium falciparum serine repeat antigen 4 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.051 0.1126 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1126 0.1386
Plasmodium falciparum serine repeat antigen 8 0.051 0.1126 0.2532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1346 0.3068 0.5128
Toxoplasma gondii cathepsin CPL 0.1916 0.4393 0.7841
Loa Loa (eye worm) hypothetical protein 0.051 0.1126 0.1141
Plasmodium falciparum serine repeat antigen 6 0.051 0.1126 0.2532
Entamoeba histolytica cysteine protease, putative 0.108 0.245 0.4054
Entamoeba histolytica cysteine proteinase 2 0.108 0.245 0.4054
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.0198 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1916 0.4393 0.768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4327 1 1
Toxoplasma gondii cathepsin B 0.2434 0.5597 1
Onchocerca volvulus 0.1916 0.4393 1
Entamoeba histolytica cysteine protease, putative 0.1916 0.4393 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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