TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.431 | Formula: C23H22N2O6
H donors: 0 H acceptors: 2 LogP: 2.73 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCCn1c(nc2c(c1=O)c(=O)c1c(o2)cc(cc1)OC)c1ccc(cc1)OC
InChi: 1S/C23H22N2O6/c1-28-12-4-11-25-21(14-5-7-15(29-2)8-6-14)24-22-19(23(25)27)20(26)17-10-9-16(30-3)13-18(17)31-22/h5-10,13H,4,11-12H2,1-3H3
InChiKey: QBEVIHMZRWGOQB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0159	0.1175
Onchocerca volvulus		0.0047	0.0375	0.2674
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0088	0.0659
Onchocerca volvulus		0.0063	0.0577	0.4222
Echinococcus multilocularis	glycoprotein Antigen 5	0.0063	0.0577	0.0553
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0026	0.005
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1332	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0088	0.0659
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0063	0.0577	0.0553
Brugia malayi	hypothetical protein	0.0123	0.1332	0.4764
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.1158	0.4159
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0159	0.4043
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0242	0.1913
Toxoplasma gondii	microneme protein MIC17B	0.0019	0.0026	0.00000069154
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0242	0.1913
Onchocerca volvulus		0.0036	0.0242	0.1658
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0088	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0088	0.0274
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.1158	0.4311
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.1158	0.413
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.1158	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0088	0.0545
Brugia malayi	Trypsin family protein	0.0063	0.0577	0.2012
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Toxoplasma gondii	microneme protein MIC4	0.0019	0.0026	0.00000069154
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.1158	0.1135
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0417	0.1426
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0088	0.0225
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0159	0.4043
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.1158	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0218	0.1699
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.1158	1
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.1158	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0088	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0159	0.1175
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.1158	0.4159
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0242	0.201
Brugia malayi	Trypsin family protein	0.0063	0.0577	0.2012
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.1158	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0218	0.0748
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Mycobacterium ulcerans	lipase LipD	0.0036	0.0242	0.201
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0242	0.0903
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0242	0.079
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0088	0.0225
Toxoplasma gondii	kringle domain-containing protein	0.0047	0.0375	0.1014
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0026	0.005
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0396	0.1352
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0159	1
Onchocerca volvulus		0.0063	0.0577	0.4222
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0088	0.0545
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0047	0.0375	1
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1332	1
Brugia malayi	phosphofructokinase	0.0109	0.1158	0.413
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0026	0.005
Toxoplasma gondii	hypothetical protein	0.0019	0.0026	0.00000069154
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Echinococcus granulosus	enteropeptidase	0.0063	0.0577	0.2012
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0242	0.0903
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0417	0.1469
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0026	0.005
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.1913
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0159	0.0386
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Toxoplasma gondii	PAN domain-containing protein	0.0293	0.3469	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0242	0.1913
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0242	0.201
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0242	0.1447
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0019	0.0026	0.00000069154
Echinococcus multilocularis	enteropeptidase	0.0063	0.0577	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1332	0.4791
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0012	0.0045
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0242	0.201
Onchocerca volvulus		0.0048	0.0396	0.2837
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0026	0.00000069154
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0159	0.0386
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0026	0.0379
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0242	0.0903
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0026	0.005
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0026	0.00000069154
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0242	0.0903
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0088	0.0659
Toxoplasma gondii	microneme protein, putative	0.0019	0.0026	0.00000069154
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0026	0.5
Echinococcus multilocularis	tissue type plasminogen activator	0.0047	0.0375	0.035
Echinococcus multilocularis	Mastin	0.0063	0.0577	0.0553
Brugia malayi	Kringle domain containing protein	0.0047	0.0375	0.1274
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0242	0.0836
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0242	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.1158	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0063	0.0577	0.4871
Mycobacterium ulcerans	hypothetical protein	0.0063	0.0577	0.4933
Onchocerca volvulus		0.0024	0.0088	0.0473
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0088	0.0659
Brugia malayi	Trypsin-like protease protein 5	0.0063	0.0577	0.2012
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0088	0.0659
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0063	0.0577	0.2012
Loa Loa (eye worm)	TK/ROR protein kinase	0.0047	0.0375	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0088	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0088	0.0225
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.1158	0.4159
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1332	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0159	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.1158	1
Toxoplasma gondii	microneme protein MIC17A	0.0019	0.0026	0.00000069154
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0088	0.0659
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0242	0.0903
Brugia malayi	beta-lactamase	0.0036	0.0242	0.079
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2767	1
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0242	0.0903
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0242	0.201
Echinococcus granulosus	tissue type plasminogen activator	0.0047	0.0375	0.1274
Toxoplasma gondii	hypothetical protein	0.0019	0.0026	0.00000069154
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0242	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0903
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0242	0.079
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.1158	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.1158	1
Plasmodium falciparum	cysteine repeat modular protein 1	0.0047	0.0375	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0242	0.0629
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2767	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0159	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Onchocerca volvulus		0.0063	0.0577	0.4222
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0242	0.1913
Onchocerca volvulus		0.0063	0.0577	0.4222
Echinococcus multilocularis	transmembrane protease serine 3	0.0063	0.0577	0.0553
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0242	0.6346
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.1158	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0088	0.0326
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Brugia malayi	hypothetical protein	0.0063	0.0577	0.2012
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0088	0.0545
Toxoplasma gondii	microneme protein MIC17C	0.0019	0.0026	0.00000069154
Brugia malayi	Trypsin family protein	0.0063	0.0577	0.2012
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0242	0.1913
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0088	0.0545
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0026	0.0097
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0242	0.1913
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0159	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0242	0.1447
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.1158	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0063	0.0577	0.2012
Schistosoma mansoni	hypothetical protein	0.0047	0.0375	0.3085
Schistosoma mansoni	hypothetical protein	0.0048	0.0396	0.3274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.2686	1
Onchocerca volvulus		0.0063	0.0577	0.4222
Trichomonas vaginalis	esterase, putative	0.0036	0.0242	0.1913
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0026	0.00000069154
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2767	0.2748
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.1913
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0063	0.0577	0.2012
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0026	0.005
Toxoplasma gondii	PAN domain-containing protein	0.0293	0.3469	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Onchocerca volvulus		0.0036	0.0242	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0218	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0063	0.0577	0.2012
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.1158	1
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Schistosoma mansoni	hypothetical protein	0.0063	0.0577	0.4871
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Loa Loa (eye worm)	trypsin family protein	0.0063	0.0577	0.2052
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0088	0.0659
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Brugia malayi	hypothetical protein	0.0237	0.2767	1
Brugia malayi	Trypsin family protein	0.0063	0.0577	0.2012
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Brugia malayi	beta-lactamase family protein	0.0036	0.0242	0.079
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.1158	1
Echinococcus granulosus	transmembrane protease serine 3	0.0063	0.0577	0.2012
Loa Loa (eye worm)	hypothetical protein	0.005	0.0417	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0242	0.1913
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0577	0.4871
Onchocerca volvulus		0.0036	0.0242	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0159	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0242	0.0836
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.0375	0.3085
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0109	0.1158	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0088	0.0545
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0159	0.0386
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0026	0.012
Onchocerca volvulus		0.0063	0.0577	0.4222
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0159	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0242	0.1913
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.1158	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0242	0.1913
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0026	0.00000069154
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.005
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0026	0.0379
Brugia malayi	6-phosphofructokinase	0.0109	0.1158	0.413
Schistosoma mansoni	hypothetical protein	0.0063	0.0577	0.4871
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0375	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0088	0.0274
Echinococcus granulosus	Mastin	0.0063	0.0577	0.2012
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Leishmania major	hypothetical protein, conserved	0.0047	0.0375	0.3085
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0903
Toxoplasma gondii	subtilisin SUB12	0.0019	0.0026	0.00000069154
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0242	0.0836
Brugia malayi	PAN domain containing protein	0.0019	0.0026	0.00000086861
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0088	0.0659
Schistosoma mansoni	cercarial elastase (S01 family)	0.0063	0.0577	0.4871
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0019	0.0026	0.00000069154
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0159	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0375	0.1317
Brugia malayi	6-phosphofructokinase	0.0109	0.1158	0.413
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0242	0.0903
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0417	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0577	0.2052
Brugia malayi	beta-lactamase family protein	0.0036	0.0242	0.079
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0396	0.3274

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 886631