Detailed information for compound 886638

Basic information

Technical information
  • TDR Targets ID: 886638
  • Name: 5-(3,4-diethoxyphenyl)-1-(3-dimethylaminoprop yl)-4-(furan-2-carbonyl)-3-hydroxy-5H-pyrrol- 2-one
  • MW: 442.505 | Formula: C24H30N2O6
  • H donors: 1 H acceptors: 3 LogP: 3.46 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1OCC)C1N(CCCN(C)C)C(=O)C(=C1C(=O)c1ccco1)O
  • InChi: 1S/C24H30N2O6/c1-5-30-17-11-10-16(15-19(17)31-6-2)21-20(22(27)18-9-7-14-32-18)23(28)24(29)26(21)13-8-12-25(3)4/h7,9-11,14-15,21,28H,5-6,8,12-13H2,1-4H3
  • InChiKey: ZBFSBCITBMLVTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(3,4-diethoxyphenyl)-1-(3-dimethylaminopropyl)-4-(2-furyl-oxomethyl)-3-hydroxy-5H-pyrrol-2-one
  • 5-(3,4-diethoxyphenyl)-1-(3-dimethylaminopropyl)-4-(furan-2-carbonyl)-3-hydroxy-3-pyrrolin-2-one
  • 5-(3,4-diethoxyphenyl)-1-(3-dimethylaminopropyl)-4-furan-2-ylcarbonyl-3-hydroxy-5H-pyrrol-2-one
  • STOCK3S-93626

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0064 0.0575 0.055
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0659
Onchocerca volvulus Huntingtin homolog 0.0125 0.1332 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.0051
Echinococcus multilocularis glycoprotein Antigen 5 0.0064 0.0575 0.055
Onchocerca volvulus 0.0064 0.0575 0.4201
Mycobacterium ulcerans hypothetical protein 0.0024 0.0088 0.0659
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0159 0.1175
Onchocerca volvulus 0.0048 0.0376 0.2677
Onchocerca volvulus 0.0037 0.0242 0.1657
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0026 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0242 0.1913
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0242 0.1913
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0159 0.4037
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1158 0.4159
Brugia malayi hypothetical protein 0.0125 0.1332 0.4764
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1158 0.4311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0088 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0225
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1158 0.1135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0417 0.1426
Toxoplasma gondii microneme protein MIC4 0.0019 0.0026 0.0001
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Brugia malayi Trypsin family protein 0.0064 0.0575 0.2002
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1158 1
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1158 0.413
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0088 0.0545
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.0545
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1158 1
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1158 1
Schistosoma mansoni hypothetical protein 0.0035 0.0218 0.1699
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1158 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0159 0.4037
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0225
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0242 0.079
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0242 0.0903
Mycobacterium ulcerans lipase LipD 0.0037 0.0242 0.201
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1158 1
Brugia malayi Trypsin family protein 0.0064 0.0575 0.2002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0218 0.0748
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1158 0.4159
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0159 0.1175
Mycobacterium ulcerans beta-lactamase 0.0037 0.0242 0.201
Onchocerca volvulus 0.0064 0.0575 0.4201
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0545
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0048 0.0376 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0396 0.1352
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0159 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.0051
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Toxoplasma gondii kringle domain-containing protein 0.0048 0.0376 0.1015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Toxoplasma gondii hypothetical protein 0.0019 0.0026 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.005
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.055
Brugia malayi phosphofructokinase 0.0111 0.1158 0.413
Onchocerca volvulus Huntingtin homolog 0.0125 0.1332 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.1913
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0159 0.0386
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0417 0.1469
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0242 0.0903
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Echinococcus granulosus enteropeptidase 0.0064 0.0575 0.2002
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0242 0.201
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0242 0.1447
Leishmania major hypothetical protein, conserved 0.0037 0.0242 0.1913
Toxoplasma gondii PAN domain-containing protein 0.0298 0.3472 1
Onchocerca volvulus 0.0049 0.0396 0.2836
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0242 0.201
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Loa Loa (eye worm) hypothetical protein 0.0125 0.1332 0.4791
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0012 0.0045
Echinococcus multilocularis enteropeptidase 0.0064 0.0575 0.055
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0026 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0378
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0159 0.0386
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0001
Echinococcus multilocularis Mastin 0.0064 0.0575 0.055
Toxoplasma gondii microneme protein, putative 0.0019 0.0026 0.0001
Echinococcus multilocularis tissue type plasminogen activator 0.0048 0.0376 0.0351
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0242 0.0903
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0088 0.0659
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.0051
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0242 0.0903
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1158 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0064 0.0575 0.4848
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0242 0.0903
Loa Loa (eye worm) beta-lactamase 0.0037 0.0242 0.0836
Brugia malayi Kringle domain containing protein 0.0048 0.0376 0.1276
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0064 0.0575 0.2002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0088 0.0659
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Brugia malayi Trypsin-like protease protein 5 0.0064 0.0575 0.2002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0088 0.0659
Onchocerca volvulus 0.0024 0.0088 0.0471
Mycobacterium ulcerans hypothetical protein 0.0064 0.0575 0.491
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Loa Loa (eye worm) hypothetical protein 0.0125 0.1332 0.4791
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1158 0.4159
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0274
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0376 0.1319
Mycobacterium ulcerans hypothetical protein 0.0037 0.0242 0.201
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0242 0.0903
Loa Loa (eye worm) hypothetical protein 0.0241 0.2767 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0242 0.0903
Brugia malayi beta-lactamase 0.0037 0.0242 0.079
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0659
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0026 0.0001
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1158 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0242 0.079
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1158 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0903
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0242 0.0217
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Echinococcus granulosus tissue type plasminogen activator 0.0048 0.0376 0.1276
Toxoplasma gondii hypothetical protein 0.0019 0.0026 0.0001
Onchocerca volvulus 0.0064 0.0575 0.4201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0242 0.1913
Onchocerca volvulus 0.0064 0.0575 0.4201
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0159 0.4037
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2767 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Toxoplasma gondii ABC1 family protein 0.0037 0.0242 0.0628
Plasmodium falciparum cysteine repeat modular protein 1 0.0048 0.0376 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1158 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0545
Brugia malayi hypothetical protein 0.0064 0.0575 0.2002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0088 0.0326
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1158 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0242 0.6337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Echinococcus multilocularis transmembrane protease serine 3 0.0064 0.0575 0.055
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0545
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0242 0.1913
Brugia malayi Trypsin family protein 0.0064 0.0575 0.2002
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0026 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.0396 0.3274
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1158 1
Schistosoma mansoni hypothetical protein 0.0048 0.0376 0.3089
Echinococcus granulosus glycoprotein Antigen 5 0.0064 0.0575 0.2002
Mycobacterium leprae Probable lipase LipE 0.0037 0.0242 0.1447
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0159 0.1175
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0242 0.1913
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0097
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0001
Trichomonas vaginalis esterase, putative 0.0037 0.0242 0.1913
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Onchocerca volvulus 0.0064 0.0575 0.4201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2686 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.1913
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2767 0.2748
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0218 0.0702
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Onchocerca volvulus 0.0037 0.0242 0.1657
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Toxoplasma gondii PAN domain-containing protein 0.0298 0.3472 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.0051
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0064 0.0575 0.2002
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Loa Loa (eye worm) trypsin family protein 0.0064 0.0575 0.2042
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.4848
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1158 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0064 0.0575 0.2002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1158 1
Echinococcus granulosus transmembrane protease serine 3 0.0064 0.0575 0.2002
Brugia malayi beta-lactamase family protein 0.0037 0.0242 0.079
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Brugia malayi Trypsin family protein 0.0064 0.0575 0.2002
Brugia malayi hypothetical protein 0.0241 0.2767 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0088 0.0659
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0159 0.4037
Onchocerca volvulus 0.0037 0.0242 0.1657
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0064 0.0575 0.4848
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0242 0.1913
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Loa Loa (eye worm) hypothetical protein 0.0051 0.0417 0.1469
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0159 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Onchocerca volvulus 0.0064 0.0575 0.4201
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.0545
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0159 0.0386
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.012
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1158 1
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0376 0.3089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0836
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Brugia malayi Protein kinase domain containing protein 0.0048 0.0376 0.1276
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0274
Schistosoma mansoni hypothetical protein 0.0064 0.0575 0.4848
Brugia malayi 6-phosphofructokinase 0.0111 0.1158 0.413
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0378
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.1913
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1158 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0051
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0242 0.1913
Schistosoma mansoni cercarial elastase (S01 family) 0.0064 0.0575 0.4848
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0659
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0026 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0159 0.1175
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0242 0.0836
Toxoplasma gondii subtilisin SUB12 0.0019 0.0026 0.0001
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0903
Leishmania major hypothetical protein, conserved 0.0048 0.0376 0.3089
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.0001
Echinococcus granulosus Mastin 0.0064 0.0575 0.2002
Schistosoma mansoni survival motor neuron protein 0.0049 0.0396 0.3274
Brugia malayi beta-lactamase family protein 0.0037 0.0242 0.079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0417 0.1426
Loa Loa (eye worm) hypothetical protein 0.0064 0.0575 0.2042
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0903
Brugia malayi 6-phosphofructokinase 0.0111 0.1158 0.413
Loa Loa (eye worm) hypothetical protein 0.0048 0.0376 0.1319

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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