TDR Targets

Basic information

Technical information

TDR Targets ID: 887223
Name: 2,3,4,5,6-pentamethyl-N-(4-methylsulfanylphen yl)benzenesulfonamide
MW: 349.511 | Formula: C18H23NO2S2
H donors: 1 H acceptors: 2 LogP: 4.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccc(cc1)NS(=O)(=O)c1c(C)c(C)c(c(c1C)C)C
InChi: 1S/C18H23NO2S2/c1-11-12(2)14(4)18(15(5)13(11)3)23(20,21)19-16-7-9-17(22-6)10-8-16/h7-10,19H,1-6H3
InChiKey: XKOZFROFEPBGHZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,3,4,5,6-pentamethyl-N-[4-(methylthio)phenyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0524	0.0905
Leishmania major	glucose transporter, lmgt2	0.0036	0.0541	0.8107
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0133	0.0291
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0541	0.8107
Leishmania major	hypothetical protein, conserved	0.0035	0.0524	0.7778
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0541	0.1973
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0036	0.0532	0.0404
Leishmania major	glucose transporter, lmgt3	0.0036	0.0541	0.8107
Onchocerca volvulus		0.0016	0.0133	0.1728
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0541	0.8107
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0133	0.0291
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0524	0.0905
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0524	0.7778
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1078	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Toxoplasma gondii	TIM10 family protein, putative	0.0047	0.0762	0.0974
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0524	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0036	0.0532	0.0404
Echinococcus granulosus	solute carrier family 22	0.0016	0.0133	0.0291
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0332	0.5942
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0486	0.106
Brugia malayi	beta-lactamase	0.0035	0.0524	0.1144
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0524	0.1144
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0524	0.1144
Onchocerca volvulus		0.0016	0.0133	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0485	0.1059
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0356
Leishmania major	glucose transporter, lmgt1	0.0036	0.0541	0.8107
Echinococcus granulosus	GPCR family 2	0.0015	0.0115	0.025
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0133	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Plasmodium falciparum	hexose transporter	0.0116	0.22	0.2094
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0133	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0133	0.5
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1078	0.2352
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0381	0.0832
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0517	0.1127
Echinococcus multilocularis	expressed protein	0.0047	0.0762	0.1663
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0041	0.0636	0.0779
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0486	0.106
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0036	0.0532	0.0404
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0133	0.0291
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.025
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0036	0.0532	0.0617
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0133	0.0291
Echinococcus granulosus	General substrate transporter	0.01	0.1862	0.4061
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0203	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0332	0.395
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0115	0.025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0047	0.0762	0.0637
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0524	1
Onchocerca volvulus		0.0016	0.0133	0.1728
Onchocerca volvulus		0.0047	0.0772	1
Schistosoma mansoni	sugar transporter	0.0016	0.0133	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Brugia malayi	Sugar transporter family protein	0.0016	0.0133	0.0291
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0036	0.0532	0.0404
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0524	0.0905
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0133	0.0413
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0524	1
Trichomonas vaginalis	esterase, putative	0.0035	0.0524	0.1893
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0133	0.0291
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0036	0.0532	0.116
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0524	0.1144
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0133	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0532	0.116
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0332	0.0201
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0524	0.0905
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0805	0.1756
Leishmania major	protein kinase, putative	0.0036	0.0532	0.7919
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0091	0.0199
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0772	0.2393
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1078	0.3341
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0805	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0036	0.0532	0.7919
Brugia malayi	Sugar transporter family protein	0.0116	0.22	0.4798
Brugia malayi	hypothetical protein	0.0016	0.0133	0.0291
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0115	0.025
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Echinococcus granulosus	solute carrier family 22	0.0016	0.0133	0.0291
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0524	0.0396
Onchocerca volvulus	Putative transporter	0.0016	0.0133	0.1728
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0541	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Onchocerca volvulus		0.0016	0.0133	0.1728
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0517	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Brugia malayi	hypothetical protein	0.0232	0.4584	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1078	0.3341
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0036	0.0532	0.116
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0541	0.1973
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0541	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0036	0.0532	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Entamoeba histolytica	protein kinase, putative	0.0036	0.0532	1
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0047	0.0762	0.1663
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Onchocerca volvulus		0.0035	0.0524	0.6793
Onchocerca volvulus		0.0016	0.0133	0.1728
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0524	0.0905
Mycobacterium ulcerans	sugar transporter	0.0016	0.0133	0.1756
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0332	0.1029
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Schistosoma mansoni	protein kinase	0.0036	0.0532	0.1647
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Plasmodium vivax	proline--tRNA ligase, putative	0.0041	0.0636	0.051
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0772	0.1684
Trypanosoma cruzi	hexose transporter	0.0036	0.0541	0.8107
Schistosoma mansoni	hypothetical protein	0.0166	0.3227	1
Brugia malayi	major facilitator superfamily protein	0.0016	0.0133	0.0291
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0524	0.0905
Echinococcus multilocularis	General substrate transporter	0.01	0.1862	0.4061
Brugia malayi	major facilitator superfamily protein	0.0016	0.0133	0.0291
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0133	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0524	0.0905
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1078	0.3341
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0636	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0116	0.22	0.4798
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0188	0.3681	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1078	0.2352
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0524	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Toxoplasma gondii	protein kinase, putative	0.0329	0.6588	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.4454	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1078	0.2352
Schistosoma mansoni	hypothetical protein	0.0047	0.0772	0.2393
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1078	0.2352
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0332	0.0724
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0332	0.2959
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0636	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0636	1
Schistosoma mansoni	hypothetical protein	0.0166	0.3227	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0524	0.1893
Onchocerca volvulus		0.0016	0.0133	0.1728
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0133	0.0291
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0541	0.8107
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0036	0.0532	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Mycobacterium ulcerans	lipase LipD	0.0035	0.0524	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0332	0.1029
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0532	0.1647
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0524	0.1625
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0636	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Echinococcus granulosus	geminin	0.0166	0.3227	0.7039
Onchocerca volvulus		0.0035	0.0524	0.6793
Echinococcus granulosus	solute carrier family 22	0.0016	0.0133	0.0291
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0524	1
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0047	0.0762	0.2362
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0532	0.116
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0541	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0035	0.0517	0.9714
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.025
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0332	0.0961
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0541	0.1973
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0517	0.1127
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0524	0.7778
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0532	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Onchocerca volvulus		0.0016	0.0133	0.1728
Schistosoma mansoni	glucose transporter	0.0016	0.0133	0.0413
Schistosoma mansoni	glucose transport protein	0.0116	0.22	0.6816
Chlamydia trachomatis	lysine--tRNA ligase	0.0026	0.0332	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0524	0.1144
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0485	0.1059
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0036	0.0532	0.0404
Onchocerca volvulus		0.0016	0.0133	0.1728
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0524	0.0905
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0524	0.7778
Brugia malayi	TAR-binding protein	0.0062	0.1078	0.2352
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.025
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0805	0.1756
Brugia malayi	beta-lactamase family protein	0.0035	0.0524	0.1144
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0047	0.0762	0.1663
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0035	0.0517	0.9253
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0517	0.1601
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0133	0.0291
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0036	0.0532	0.0617
Plasmodium falciparum	proline--tRNA ligase	0.0041	0.0636	0.051
Onchocerca volvulus		0.0016	0.0133	0.1728
Schistosoma mansoni	hypothetical protein	0.0033	0.0485	0.1504
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0524	0.1625
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0115	0.025
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0036	0.0541	0.8107
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0332	0.0308
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0047	0.0762	0.0974
Toxoplasma gondii	facilitative glucose transporter GT1	0.0116	0.22	0.3201
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0133	0.0291
Onchocerca volvulus		0.0016	0.0133	0.1728
Onchocerca volvulus		0.0016	0.0133	0.1728
Echinococcus multilocularis	geminin	0.0166	0.3227	0.7039
Loa Loa (eye worm)	sugar transporter	0.0116	0.22	0.4798
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0332	0.395
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0266	0.0641
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0524	0.0905
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0494	1	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0036	0.0532	0.0617
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0541	0.8107
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0188	0.3681	0.3595
Onchocerca volvulus		0.0016	0.0133	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0133	0.0291
Onchocerca volvulus		0.0016	0.0133	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0332	0.0724
Echinococcus granulosus	solute carrier family 22	0.0016	0.0133	0.0291
Brugia malayi	hypothetical protein	0.0016	0.0133	0.0291
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.4584	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0517	0.1127
Onchocerca volvulus		0.0016	0.0133	0.1728
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0332	0.0724
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0517	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0332	0.5942
Toxoplasma gondii	ABC1 family protein	0.0035	0.0524	0.0606
Schistosoma mansoni	glucose transport protein	0.0116	0.22	0.6816
Onchocerca volvulus		0.0016	0.0133	0.1728
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0524	0.1893
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0115	0.025
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0541	0.8107
Trypanosoma brucei	glucose transporter 2A	0.0036	0.0541	0.8107
Brugia malayi	Sugar transporter family protein	0.0016	0.0133	0.0291
Entamoeba histolytica	protein kinase, putative	0.0036	0.0532	1
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0047	0.0762	0.0637
Onchocerca volvulus		0.0016	0.0133	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0805	0.1756
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1078	0.3341
Trypanosoma brucei	glucose transporter 1E	0.0036	0.0541	0.8107
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0332	0.5182
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.4584	1
Schistosoma mansoni	protein kinase	0.0036	0.0532	0.1647
Brugia malayi	beta-lactamase family protein	0.0035	0.0524	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Schistosoma mansoni	sugar transporter	0.0016	0.0133	0.0413
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0251	0.0272
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0036	0.0532	0.116
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0133	0.1756
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0133	0.1756
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0524	0.1893
Brugia malayi	hypothetical protein	0.0016	0.0133	0.0291
Plasmodium vivax	hexose transporter	0.0116	0.22	0.2094
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.025
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0036	0.0532	0.116
Brugia malayi	RNA binding protein	0.0062	0.1078	0.2352
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1078	0.2352
Echinococcus granulosus	expressed protein	0.0047	0.0762	0.1663
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0036	0.0532	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0133	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.22	1
Loa Loa (eye worm)	sugar transporter	0.0016	0.0133	0.0291
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0541	0.8107
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0524	0.1893
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0332	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0524	0.1144
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0115	0.025
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0251	0.0272
Onchocerca volvulus		0.0035	0.0524	0.6793
Schistosoma mansoni	glucose transport protein	0.0116	0.22	0.6816
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0332	0.0724
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0356
Brugia malayi	Cam kinase protein 1	0.0036	0.0532	0.116
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0332	0.395
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0036	0.0532	0.0404
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0524	0.1893
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0524	0.0905
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0188	0.3681	0.3595
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0524	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0035	0.0517	0.1855
Schistosoma mansoni	hypothetical protein	0.0116	0.22	0.6816
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0035	0.0517	0.1127
Schistosoma mansoni	sugar transporter	0.0016	0.0133	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0232	0.4584	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0356
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0636	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.22	0.4798
Schistosoma mansoni	protein kinase	0.0036	0.0532	0.1647
Plasmodium falciparum	protein kinase 7	0.0329	0.6588	0.6542
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0541	0.1973
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0133	0.0291
Giardia lamblia	Prolyl-tRNA synthetase	0.0035	0.0517	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0035	0.0517	0.1127
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1078	0.3341
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0541	0.1973
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0524	1
Schistosoma mansoni	sugar transporter	0.0016	0.0133	0.0413

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 887223