TDR Targets

Basic information

Technical information

TDR Targets ID: 888469
Name: N-[4-methoxy-3-(trifluoromethyl)phenyl]-3-met hylbenzenesulfonamide
MW: 345.337 | Formula: C15H14F3NO3S
H donors: 1 H acceptors: 2 LogP: 3.67 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1C(F)(F)F)NS(=O)(=O)c1cccc(c1)C
InChi: 1S/C15H14F3NO3S/c1-10-4-3-5-12(8-10)23(20,21)19-11-6-7-14(22-2)13(9-11)15(16,17)18/h3-9,19H,1-2H3
InChiKey: PJOPHHUNGZJDJT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-methoxy-3-(trifluoromethyl)phenyl]-3-methyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ABC1 family protein	0.0042	0.0915	0.5661
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0345	1
Brugia malayi	beta-lactamase	0.0042	0.0915	0.0915
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0915	0.0877
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0915	0.4788
Onchocerca volvulus		0.0042	0.0915	0.033
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0167	0.4605	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0915	0.4788
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0678	0.4196
Echinococcus granulosus	lysine specific demethylase 5A	0.011	0.2923	0.5604
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0702	0.1624
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.0303	0.0068
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0345	0.2134
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0345	0.0345
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0029	0.0538	0.3328
Brugia malayi	beta-lactamase family protein	0.0042	0.0915	0.0915
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0915	0.2116
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0271	0.0271
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0345	0.2134
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0702	0.4345
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0538	0.0538
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.2134
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0345	0.0078
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0915	0.1361
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0303	0.0034
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0066	0.1616	0.2844
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0167	0.4605	0.5897
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.0171
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0915	0.5661
Brugia malayi	jmjC domain containing protein	0.0029	0.0538	0.0538
Schistosoma mansoni	phd/f-box containing protein	0.0029	0.0538	0.1244
Giardia lamblia	PHD finger protein 15	0.0034	0.0678	0.0419
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.1751	0.1751
Schistosoma mansoni	phosphatidylserine receptor	0.0029	0.0538	0.1244
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0702	0.1624
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0341	0.9771	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0678	0.4196
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0702	0.1624
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0678	0.0678
Leishmania major	hypothetical protein, conserved	0.0029	0.0538	0.1986
Onchocerca volvulus		0.0035	0.0702	0.0034
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0345	0.0552
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0345	0.2134
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0023	0.0345	0.0101
Leishmania major	hypothetical protein, conserved	0.0042	0.0915	0.4788
Leishmania major	trypanothione reductase	0.0066	0.1616	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.2134
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0303	0.0303
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Echinococcus multilocularis	peregrin	0.0034	0.0678	0.0861
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0345	1
Plasmodium vivax	SET domain protein, putative	0.0035	0.0702	0.4345
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0915	0.0877
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.1073	0.1695
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0915	0.1361
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0345	0.2134
Echinococcus granulosus	thioredoxin glutathione reductase	0.0066	0.1616	0.2844
Schistosoma mansoni	ap endonuclease	0.002	0.0271	0.0626
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0345	0.0078
Brugia malayi	jmjC domain containing protein	0.0029	0.0538	0.0538
Loa Loa (eye worm)	jmjC domain-containing protein	0.011	0.2923	0.2923
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0166	0.0166
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0915	0.0877
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0303	0.0034
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0303	0.0068
Echinococcus multilocularis	lysine specific demethylase 6a	0.0029	0.0538	0.0565
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0702	0.1624
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0303	0.1874
Plasmodium vivax	glutathione reductase, putative	0.0066	0.1616	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0345	0.2134
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0303	0.0303
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0029	0.0538	0.1244
Onchocerca volvulus		0.0276	0.7857	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0345	0.0076
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0915	0.0915
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0303	0.0034
Mycobacterium ulcerans	lipase LipD	0.0042	0.0915	0.1487
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0303	0.1874
Giardia lamblia	Fructose-bisphosphate aldolase	0.0341	0.9771	0.9765
Brugia malayi	beta-lactamase family protein	0.0042	0.0915	0.0915
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0702	0.0912
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0915	0.0877
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0029	0.0538	0.3328
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0538	0.0538
Schistosoma mansoni	protein phosphatase 2C	0.0029	0.0538	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0345	0.0552
Brugia malayi	glutathione reductase	0.0066	0.1616	0.1616
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0303	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0702	0.0912
Brugia malayi	jmjC domain containing protein	0.0029	0.0538	0.0538
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0345	0.0101
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0915	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0538	0.0538
Schistosoma mansoni	hypothetical protein	0.0034	0.0678	0.1568
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Echinococcus multilocularis	phd:f box containing protein	0.0029	0.0538	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0077	0.194	0.194
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0915	0.0877
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0702	0.0912
Plasmodium falciparum	glutathione reductase	0.0023	0.0345	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3253	0.3253
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0345	0.2134
Brugia malayi	Pre-SET motif family protein	0.0035	0.0702	0.0702
Trypanosoma cruzi	trypanothione reductase, putative	0.0066	0.1616	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0029	0.0538	0.3328
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0345	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Brugia malayi	jmjC domain containing protein	0.0029	0.0538	0.0538
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.1073	0.1695
Schistosoma mansoni	jumonji/arid domain-containing protein	0.011	0.2923	0.6758
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0915	0.1487
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0678	0.0861
Treponema pallidum	NADH oxidase	0.0023	0.0345	0.0078
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0303	0.0303
Brugia malayi	PHD-finger family protein	0.0034	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0915	0.0678
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0303	0.0303
Toxoplasma gondii	exonuclease III APE	0.002	0.0271	0.1674
Brugia malayi	Bromodomain containing protein	0.0034	0.0678	0.0678
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0538	0.1986
Onchocerca volvulus		0.0042	0.0915	0.033
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0915	0.2116
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0345	0.0101
Plasmodium vivax	thioredoxin reductase, putative	0.0066	0.1616	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0702	0.0702
Brugia malayi	Protein kinase domain containing protein	0.0121	0.3253	0.3253
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0915	0.0877
Schistosoma mansoni	DNA helicase recq1	0.0021	0.0303	0.07
Echinococcus granulosus	peregrin	0.0034	0.0678	0.0861
Schistosoma mansoni	DNA helicase recq5	0.0021	0.0303	0.07
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0303	0.0303
Loa Loa (eye worm)	glutathione reductase	0.0066	0.1616	0.1616
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0915	0.0915
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.018	0.5003	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.6863	0.6863
Loa Loa (eye worm)	thioredoxin reductase	0.0066	0.1616	0.1616
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.0303	0.0033
Echinococcus multilocularis	JmjC domain containing protein 4	0.0029	0.0538	0.0565
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0915	0.0877
Echinococcus granulosus	phd:f box containing protein	0.0029	0.0538	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0349	1	1
Brugia malayi	jmjC domain containing protein	0.018	0.5003	0.5003
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Plasmodium falciparum	thioredoxin reductase	0.0066	0.1616	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0023	0.0345	0.0101
Plasmodium falciparum	glutathione reductase	0.0066	0.1616	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.762	1
Schistosoma mansoni	jumonji domain containing protein	0.0029	0.0538	0.1244
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.0303	0.0068
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0303	0.1874
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0915	0.0678
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0915	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0915	0.0915
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0021	0.0303	0.1874
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0915	0.1338
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0678	0.4196
Trichomonas vaginalis	esterase, putative	0.0042	0.0915	0.0678
Echinococcus granulosus	lysine specific demethylase 6a	0.0029	0.0538	0.0565
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0038	0.0088
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0345	0.2134
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0029	0.0538	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0538	0.0538
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0678	0.1568
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0271	0.1674
Treponema pallidum	fructose-bisphosphate aldolase	0.0341	0.9771	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0345	0.0552
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0664	0.0832
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0678	0.4196
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0303	0.1874
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0303	0.024
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.0798
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0915	0.1487
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0345	0.0552
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.0157
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0271	0.1674
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0066	0.1616	0.1831
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.0303	0.0068
Plasmodium vivax	JmjC domain containing protein	0.0029	0.0538	0.3328
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0538	0.1986
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0345	0.2134
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0167	0.4605	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0271	0.1674
Trichomonas vaginalis	set domain proteins, putative	0.0276	0.7857	0.7985
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0345	0.0157
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0029	0.0538	0.3328
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0345	0.0552
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Schistosoma mansoni	ap endonuclease	0.002	0.0271	0.0626
Schistosoma mansoni	jumonji domain containing protein	0.0157	0.4325	1
Toxoplasma gondii	thioredoxin reductase	0.0066	0.1616	1
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0915	0.1487
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0538	0.0538
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0915	0.0877
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0029	0.0538	0.0565
Brugia malayi	Pre-SET motif family protein	0.0243	0.6863	0.6863
Brugia malayi	Fibroblast growth factor family protein	0.0349	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.018	0.5003	1
Brugia malayi	jmjC domain containing protein	0.011	0.2923	0.2923
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0915	0.0877
Brugia malayi	Thioredoxin reductase	0.0066	0.1616	0.1616
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0915	0.1338
Echinococcus granulosus	jumonji domain containing 1A	0.0029	0.0538	0.0565
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0345	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.011	0.2923	0.5604
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0915	0.0877
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0345	0.2134
Onchocerca volvulus		0.0042	0.0915	0.033
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0303	0.024
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0915	0.0678
Trypanosoma brucei	trypanothione reductase	0.0066	0.1616	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.011	0.2923	0.6758
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0341	0.9771	1
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0915	0.1487
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0345	0.0171
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0303	0.0068
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0678	0.0861
Echinococcus multilocularis	jumonji domain containing 1A	0.0029	0.0538	0.0565
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0038	0.0038
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0915	0.0915
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.0303	0.0303
Echinococcus granulosus	JmjC domain containing protein 4	0.0029	0.0538	0.0565
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0678	0.0678
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0341	0.9771	1
Loa Loa (eye worm)	hypothetical protein	0.0349	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0915	0.5661
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0345	0.0171
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.0303	0.0068
Giardia lamblia	Hypothetical protein	0.0349	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 888469