Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0142 | 0.3132 | 0.8775 | |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0056 | 0.1132 | 0.1094 |
Echinococcus granulosus | twitchin | 0.0013 | 0.014 | 0.0274 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0017 | 0.0228 | 0.052 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.0228 | 0.0472 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0146 | 0.322 | 0.322 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 0.1132 | 0.1132 |
Echinococcus multilocularis | protein kinase shaggy | 0.0048 | 0.0945 | 0.2525 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.065 | 0.1791 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0015 | 0.0183 | 0.0394 |
Echinococcus multilocularis | aurora kinase A | 0.0056 | 0.1132 | 0.3049 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048 | 0.0945 | 0.8026 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0056 | 0.1132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0183 | 0.0183 |
Entamoeba histolytica | protein kinase, putative | 0.0048 | 0.0945 | 0.8026 |
Schistosoma mansoni | nephrin | 0.0011 | 0.0096 | 0.0157 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 0.1132 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0056 | 0.1132 | 1 |
Echinococcus multilocularis | neuroglian | 0.0011 | 0.0096 | 0.0149 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.065 | 0.4925 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0017 | 0.0228 | 0.052 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0015 | 0.0183 | 0.0142 |
Entamoeba histolytica | protein kinase, putative | 0.0056 | 0.1132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.011 |
Echinococcus granulosus | neuroglian | 0.0011 | 0.0096 | 0.0149 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0015 | 0.0183 | 0.0415 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.065 | 0.4925 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0048 | 0.0945 | 0.2525 |
Brugia malayi | Protein kinase domain | 0.0017 | 0.0228 | 0.0186 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0202 | 0.0471 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.065 | 0.4925 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0056 | 0.1132 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0056 | 0.1132 | 1 |
Brugia malayi | intracellular kinase | 0.0048 | 0.0945 | 0.0906 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0056 | 0.1132 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0017 | 0.0228 | 0.0472 |
Schistosoma mansoni | protein kinase | 0.0056 | 0.1132 | 0.3208 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0017 | 0.0228 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.0945 | 0.8026 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.0228 | 0.0472 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.3132 | 0.91 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.011 | 0.019 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0015 | 0.0183 | 0.0394 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0048 | 0.0945 | 0.0945 |
Trichomonas vaginalis | STE family protein kinase | 0.0017 | 0.0228 | 0.0472 |
Trichomonas vaginalis | STE family protein kinase | 0.0017 | 0.0228 | 0.0472 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0056 | 0.1132 | 0.3049 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0056 | 0.1132 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0146 | 0.322 | 0.3191 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.011 | 0.02 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0017 | 0.0228 | 0.052 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0439 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.065 | 0.1791 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0178 | 0.3964 | 0.3964 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0056 | 0.1132 | 1 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0178 | 0.3964 | 0.3938 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0163 | 0.3615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Giardia lamblia | Aurora kinase | 0.0056 | 0.1132 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0056 | 0.1132 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0056 | 0.1132 | 0.1094 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0017 | 0.0228 | 0.052 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0015 | 0.0183 | 0.0394 |
Onchocerca volvulus | 0.014 | 0.3087 | 0.8595 | |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0183 | 0.0415 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 0.1132 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Brugia malayi | Protein kinase domain containing protein | 0.0155 | 0.3438 | 0.341 |
Schistosoma mansoni | protein kinase | 0.0017 | 0.0228 | 0.0547 |
Trypanosoma brucei | aurora B kinase | 0.0056 | 0.1132 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0183 | 0.0415 |
Toxoplasma gondii | aurora kinase | 0.0056 | 0.1132 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0048 | 0.0945 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0142 | 0.3132 | 0.8649 |
Loa Loa (eye worm) | AUR protein kinase | 0.0056 | 0.1132 | 0.1132 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 0.1132 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 0.1132 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0155 | 0.3438 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0.0945 | 0.8026 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.0228 | 0.0472 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0056 | 0.1132 | 0.1094 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0017 | 0.0228 | 0.052 |
Schistosoma mansoni | protein kinase | 0.0017 | 0.0228 | 0.0547 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0015 | 0.0183 | 0.0142 |
Echinococcus granulosus | protein kinase shaggy | 0.0048 | 0.0945 | 0.2525 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0056 | 0.1132 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0164 | 0.0339 |
Schistosoma mansoni | protein kinase | 0.0017 | 0.0228 | 0.0547 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0155 | 0.3438 | 0.341 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0136 | 0.2997 | 0.8232 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.0228 | 0.0472 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0183 | 0.0415 |
Brugia malayi | hypothetical protein | 0.0035 | 0.065 | 0.0611 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0155 | 0.3438 | 0.3438 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0015 | 0.0183 | 0.0394 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.065 | 0.1702 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0042 | 0.0042 |
Trichomonas vaginalis | STE family protein kinase | 0.0017 | 0.0228 | 0.0472 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0164 | 0.0339 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0048 | 0.0945 | 0.2525 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0015 | 0.0183 | 0.0183 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.065 | 0.1702 |
Schistosoma mansoni | protein kinase | 0.0015 | 0.0183 | 0.0415 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1132 | 0.3208 |
Echinococcus multilocularis | rho associated protein kinase | 0.0142 | 0.3132 | 0.8649 |
Echinococcus granulosus | aurora kinase A | 0.0056 | 0.1132 | 0.3049 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.065 | 0.4925 |
Trichomonas vaginalis | STE family protein kinase | 0.0017 | 0.0228 | 0.0472 |
Leishmania major | protein kinase, putative | 0.0056 | 0.1132 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0056 | 0.1132 | 0.3049 |
Trichomonas vaginalis | STE family protein kinase | 0.0017 | 0.0228 | 0.0472 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0048 | 0.0945 | 0.0945 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0015 | 0.0183 | 0.0394 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0017 | 0.0228 | 0.052 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0155 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0164 | 0.0164 |
Trichomonas vaginalis | AGC family protein kinase | 0.0056 | 0.1132 | 1 |
Onchocerca volvulus | 0.0133 | 0.2925 | 0.7943 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048 | 0.0945 | 0.8026 |
Giardia lamblia | Kinase, CMGC GSK | 0.0048 | 0.0945 | 0.7928 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0155 | 0.3438 | 0.9504 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0155 | 0.3438 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0202 | 0.0471 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0163 | 0.3615 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0048 | 0.0945 | 0.7928 |
Brugia malayi | WH1 domain containing protein | 0.0015 | 0.0183 | 0.0142 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0155 | 0.3438 | 0.9504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.