Detailed information for compound 897821

Basic information

Technical information
  • TDR Targets ID: 897821
  • Name: 4-methyl-3-(4-methylpiperidin-1-yl)sulfonylbe nzoic acid
  • MW: 297.37 | Formula: C14H19NO4S
  • H donors: 1 H acceptors: 4 LogP: 2.24 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)S(=O)(=O)c1cc(ccc1C)C(=O)O
  • InChi: 1S/C14H19NO4S/c1-10-5-7-15(8-6-10)20(18,19)13-9-12(14(16)17)4-3-11(13)2/h3-4,9-10H,5-8H2,1-2H3,(H,16,17)
  • InChiKey: JUSRWKCHOORZQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-3-[(4-methyl-1-piperidyl)sulfonyl]benzoic acid
  • 4-methyl-3-[(4-methyl-1-piperidinyl)sulfonyl]benzoic acid
  • 4-methyl-3-(4-methylpiperidin-1-yl)sulfonyl-benzoic acid
  • Oprea1_756718
  • BIM-0025084.P001
  • CBMicro_025094

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis importin subunit beta 1 0.003 0.049 0.0572
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0112 0.2245 0.3265
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0759 1
Onchocerca volvulus 0.0016 0.0191 0.0147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.6635 1
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0691 0.051
Brugia malayi Importin beta-1 subunit 0.003 0.049 0.0741
Brugia malayi Pax transcription factor protein 2 0.0249 0.5156 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0572 0.0698
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0587 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0174 0.0087
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0596 0.2252
Loa Loa (eye worm) hypothetical protein 0.0027 0.0438 0.0493
Schistosoma mansoni protein kinase 0.0034 0.0587 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0587 0.0721
Brugia malayi major facilitator superfamily protein 0.0016 0.0191 0.0147
Onchocerca volvulus 0.0016 0.0191 0.0147
Loa Loa (eye worm) hypothetical protein 0.0013 0.013 0.0021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0388 0.4303
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0572 0.0698
Schistosoma mansoni glucose transport protein 0.0112 0.2245 0.3265
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0027 0.0437 0.0492
Echinococcus granulosus solute carrier family 22 0.0016 0.0191 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Schistosoma mansoni sugar transporter 0.0016 0.0191 0.0114
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0039 0.0695 1
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0191 0.0348
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0572 1
Onchocerca volvulus 0.0016 0.0191 0.0147
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0319 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0587 0.0404
Echinococcus multilocularis lamin 0.0028 0.0449 0.0509
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.1405 0.1977
Schistosoma mansoni hypothetical protein 0.0319 0.6635 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0191 0.0147
Toxoplasma gondii sugar transporter ST2 0.0016 0.0191 0.0141
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0039 0.0695 0.0887
Loa Loa (eye worm) hypothetical protein 0.0034 0.0572 0.0698
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0191 0.0147
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Onchocerca volvulus 0.0016 0.0191 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0388 0.0539
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0039 0.0695 0.2717
Echinococcus granulosus solute carrier family 22 0.0016 0.0191 0.0114
Onchocerca volvulus 0.0016 0.0191 0.0147
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0191 0.1271
Brugia malayi hypothetical protein 0.0016 0.0191 0.0147
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0039 0.0695 0.0887
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0572 0.0903
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0308 0.9654
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0388 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.1405 0.1977
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0691 0.9917
Echinococcus granulosus acetylcholinesterase 0.0073 0.1405 0.1977
Schistosoma mansoni sugar transporter 0.0016 0.0191 0.0114
Echinococcus multilocularis snurportin 1 0.0319 0.6635 1
Leishmania major protein kinase, putative 0.0034 0.0587 0.7922
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0587 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0388 0.0201
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0191 0.0331
Mycobacterium ulcerans sugar transporter 0.0016 0.0191 0.1271
Brugia malayi Sugar transporter family protein 0.0112 0.2245 0.4223
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0691 0.8828
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0191 0.0348
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0174 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0596 0.7213
Schistosoma mansoni protein kinase 0.0034 0.0587 0.0721
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0191 0.1271
Brugia malayi RNA, U transporter 1 0.0085 0.1661 0.3064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0572 0.0698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0759 1
Echinococcus multilocularis General substrate transporter 0.0097 0.1909 0.2749
Echinococcus granulosus solute carrier family 22 0.0016 0.0191 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0181 0.3717 0.5559
Onchocerca volvulus 0.0016 0.0191 0.0147
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0322 0.0315
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0191 0.0114
Entamoeba histolytica Ran family GTPase 0.0022 0.0322 0.285
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0191 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0388 0.0417
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0174 0.0087
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Echinococcus multilocularis solute carrier family 22 0.0016 0.0191 0.0114
Plasmodium falciparum mitogen-activated protein kinase 2 0.0181 0.3717 0.3595
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0319 0.2787
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0319 0.4038
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0388 0.3046
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0174 0.0113
Entamoeba histolytica hypothetical protein 0.0025 0.0388 0.4117
Plasmodium falciparum hexose transporter 0.0112 0.2245 0.2094
Plasmodium vivax CDK-related protein kinase 6, putative 0.0477 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0541 0.0652
Echinococcus granulosus dna polymerase kappa 0.0043 0.0759 0.0986
Plasmodium vivax hexose transporter 0.0112 0.2245 0.2094
Schistosoma mansoni DNA polymerase eta 0.0015 0.0174 0.0087
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0449 0.0509
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0587 0.075
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0039 0.0695 0.1148
Onchocerca volvulus Putative transporter 0.0016 0.0191 0.0147
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0191 0.5984
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0039 0.0695 0.1148
Echinococcus granulosus solute carrier family 22 0.0016 0.0191 0.0114
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0191 0.1271
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0039 0.0695 0.913
Loa Loa (eye worm) hypothetical protein 0.0013 0.013 0.0021
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0322 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0191 0.0295
Plasmodium falciparum importin beta, putative 0.003 0.049 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Schistosoma mansoni hypothetical protein 0.0175 0.3587 0.5324
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0322 0.0967
Loa Loa (eye worm) hypothetical protein 0.0013 0.0141 0.0038
Leishmania major importin beta-1 subunit, putative 0.0024 0.037 0.3763
Schistosoma mansoni sugar transporter 0.0016 0.0191 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0388 0.0444
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0587 0.0933
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0587 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0191 0.0348
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0449 0.0509
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0191 0.5
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0388 0.0417
Toxoplasma gondii protein kinase, putative 0.0317 0.6608 1
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0572 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0039 0.0695 0.2717
Plasmodium vivax importin-beta 2, putative 0.003 0.049 0.0305
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0587 0.075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0322 0.0408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0191 0.0114
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0388 0.5182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0449 0.0509
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0039 0.0695 0.0887
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Schistosoma mansoni hypothetical protein 0.0112 0.2245 0.3265
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0587 0.0721
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0039 0.0695 0.0887
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0388 0.4117
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0596 0.2252
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0691 0.9071
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0039 0.0695 0.0514
Onchocerca volvulus 0.0016 0.0191 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0539 0.7024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0141 0.0038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0173 0.0086
Leishmania major hypothetical protein, conserved 0.0016 0.0191 0.0331
Leishmania major glucose transporter, lmgt1 0.0035 0.0596 0.8102
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0039 0.0695 0.8903
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Trypanosoma brucei unspecified product 0.001 0.0075 0.0732
Echinococcus multilocularis lamin dm0 0.0028 0.0449 0.0509
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0587 0.075
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0388 0.0417
Onchocerca volvulus 0.0016 0.0191 0.0147
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.1405 0.1977
Schistosoma mansoni protein kinase 0.0034 0.0587 0.0721
Loa Loa (eye worm) carboxylesterase 0.0073 0.1405 0.1977
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0759 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.049 0.6353
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0587 0.2208
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0191 0.0348
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0191 0.0114
Echinococcus multilocularis musashi 0.0028 0.0449 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Leishmania major GTP-binding protein, putative 0.0022 0.0322 0.285
Brugia malayi hypothetical protein 0.0016 0.0191 0.0147
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0449 0.0659
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0596 0.7213
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0174 0.0087
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0191 0.0147
Brugia malayi hypothetical protein 0.0016 0.0191 0.0147
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.1405 0.1977
Echinococcus granulosus snurportin 1 0.0319 0.6635 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0249 0.5156 0.7731
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0191 0.0114
Loa Loa (eye worm) hypothetical protein 0.0073 0.1405 0.1977
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Schistosoma mansoni lamin 0.0028 0.0449 0.0509
Schistosoma mansoni glucose transporter 0.0016 0.0191 0.0114
Echinococcus granulosus lamin 0.0028 0.0449 0.0509
Toxoplasma gondii facilitative glucose transporter GT1 0.0112 0.2245 0.3297
Onchocerca volvulus 0.0249 0.5156 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.1405 0.1977
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Echinococcus granulosus General substrate transporter 0.0097 0.1909 0.2749
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.022 0.2699
Echinococcus granulosus intermediate filament protein 0.0028 0.0449 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0191 0.0114
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0191 0.0295
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0191 0.0141
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0587 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.037 0.1189
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0572
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0191 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0181 0.3717 0.3595
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0174 0.0113
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0322 0.0315
Leishmania major DNA polymerase kappa, putative 0.0022 0.0319 0.2787
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0174 0.0087
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0587 0.7663
Loa Loa (eye worm) hypothetical protein 0.0015 0.0174 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trypanosoma brucei unspecified product 0.0036 0.0614 0.8033
Echinococcus multilocularis dna polymerase eta 0.0015 0.0174 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Echinococcus granulosus lamin dm0 0.0028 0.0449 0.0509
Entamoeba histolytica hypothetical protein 0.0024 0.037 0.3763
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Echinococcus multilocularis geminin 0.0175 0.3587 0.5324
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0572 0.7638
Trichomonas vaginalis importin beta-1, putative 0.0024 0.037 0.1189
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0322 0.0343
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0587 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0596 0.7213
Onchocerca volvulus 0.0016 0.0191 0.0147
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0039 0.0695 0.0887
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0117 0.3659
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0388 0.3666
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Echinococcus granulosus geminin 0.0175 0.3587 0.5324
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0691 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.022 0.2699
Echinococcus granulosus carboxylesterase 5A 0.0073 0.1405 0.1977
Plasmodium falciparum protein kinase 7 0.0317 0.6608 0.6542
Trypanosoma brucei glucose transporter 1E 0.0035 0.0596 0.779
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Echinococcus multilocularis solute carrier family 22 0.0016 0.0191 0.0114
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0117 0.3659
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0322 0.2538
Loa Loa (eye worm) hypothetical protein 0.0032 0.0539 0.0648
Schistosoma mansoni sugar transporter 0.0016 0.0191 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Echinococcus granulosus importin subunit beta 1 0.003 0.049 0.0572
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0322 0.0134
Leishmania major glucose transporter, lmgt3 0.0035 0.0596 0.8102
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trypanosoma cruzi hexose transporter 0.0035 0.0596 0.7213
Echinococcus granulosus acetylcholinesterase 0.0073 0.1405 0.1977
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0587 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0191 0.2305
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0039 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Toxoplasma gondii sugar transporter ST3 0.0016 0.0191 0.0141
Trypanosoma brucei unspecified product 0.001 0.0075 0.0732
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0039 0.0695 0.8903
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.2245 1
Brugia malayi major facilitator superfamily protein 0.0016 0.0191 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0759 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0149 0.005
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Entamoeba histolytica protein kinase, putative 0.0034 0.0587 0.7922
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.049 0.0601
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0322 0.2538
Schistosoma mansoni glucose transport protein 0.0112 0.2245 0.3265
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0388 0.0417
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Echinococcus multilocularis solute carrier family 22 0.0016 0.0191 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0191 0.0348
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0596 0.779
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0691 0.051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0596 0.779
Schistosoma mansoni glucose transport protein 0.0112 0.2245 0.3265
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0759 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0596 0.779
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0614 0.8033
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0112 0.2245 0.3265
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0388 0.4303
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0191 0.0295
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0596 0.2252
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0596 0.2252
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0759 1
Schistosoma mansoni lamin 0.0028 0.0449 0.0509
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0759 0.0986
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0596 0.8102
Onchocerca volvulus 0.0016 0.0191 0.0147
Schistosoma mansoni ran 0.0022 0.0322 0.0315
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0174 0.2071
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0322 0.3448
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Schistosoma mansoni intermediate filament proteins 0.0028 0.0449 0.0509
Brugia malayi intermediate filament protein 0.0028 0.0449 0.0659
Brugia malayi Carboxylesterase family protein 0.0073 0.1405 0.2557
Leishmania major glucose transporter, lmgt2 0.0035 0.0596 0.8102
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0759 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.049 0.6353
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0759 0.3019
Onchocerca volvulus 0.0016 0.0191 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0596 0.2252
Loa Loa (eye worm) hypothetical protein 0.0073 0.1405 0.1977
Loa Loa (eye worm) sugar transporter 0.0112 0.2245 0.3265
Trypanosoma brucei sugar transporter, putative 0.0016 0.0191 0.2305
Onchocerca volvulus 0.0016 0.0191 0.0147
Brugia malayi Cam kinase protein 1 0.0034 0.0587 0.0933
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0572 0.0903
Toxoplasma gondii sugar transporter ST1 0.0016 0.0191 0.0141
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.037 0.335
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0039 0.0695 0.0916
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0587 0.0721
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0388 0.4978
Trypanosoma cruzi hexose transporter, putative 0.0019 0.026 0.1475
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0759 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0308 0.9654
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0587 0.0721
Schistosoma mansoni ran 0.0022 0.0322 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0539 0.7024
Onchocerca volvulus 0.0016 0.0191 0.0147
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0108 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Echinococcus multilocularis solute carrier family 22 0.0016 0.0191 0.0114
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0388 0.0417
Loa Loa (eye worm) sugar transporter 0.0016 0.0191 0.0114
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0322 0.0134
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0759 0.3019
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0541 0.0652
Giardia lamblia DINP protein human, muc B family 0.0022 0.0319 0.3361
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0388 0.0201
Trypanosoma brucei glucose transporter 2A 0.0035 0.0596 0.779
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0572 0.0698
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Onchocerca volvulus 0.0016 0.0191 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0572 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0596 0.2252
Echinococcus granulosus dna polymerase eta 0.0015 0.0174 0.0087
Brugia malayi Sugar transporter family protein 0.0016 0.0191 0.0147
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0191 0.5984
Brugia malayi Sugar transporter family protein 0.0016 0.0191 0.0147
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0691 0.8828
Brugia malayi polk-prov protein 0.0032 0.0539 0.0839
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0141 0.0038
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.0117 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0596 0.2252
Entamoeba histolytica protein kinase, putative 0.0034 0.0587 0.7922
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0173 0.0112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0191 0.0114
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0587 0.0404
Trichomonas vaginalis ran, putative 0.0022 0.0322 0.0966
Schistosoma mansoni hypothetical protein 0.0175 0.3587 0.5324
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0039 0.0695 0.0514
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0691 0.9917
Schistosoma mansoni importin beta-1 0.003 0.049 0.0572
Onchocerca volvulus 0.0028 0.0449 0.0659
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0572 0.2139
Loa Loa (eye worm) hypothetical protein 0.0034 0.0587 0.0721
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.037 0.1189
Onchocerca volvulus 0.0016 0.0191 0.0147
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Trypanosoma brucei glucose transporter, putative 0.0035 0.0596 0.779
Onchocerca volvulus 0.0016 0.0191 0.0147
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0388 0.1276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0174 0.5442
Onchocerca volvulus 0.0028 0.0449 0.0659
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0322 0.4083
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0587 0.0404
Brugia malayi Carboxylesterase family protein 0.0073 0.1405 0.2557
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0759 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0117 0.3659
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.022 0.2699
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0587 0.0721
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0191 0.0348

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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