Detailed information for compound 897958

Basic information

Technical information
  • TDR Targets ID: 897958
  • Name: ethyl 2-[(3-methoxybenzoyl)amino]-5-[(2-metho xyphenyl)carbamoyl]-4-methylthiophene-3-carbo xylate
  • MW: 468.522 | Formula: C24H24N2O6S
  • H donors: 2 H acceptors: 3 LogP: 5.02 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(sc(c1C)C(=O)Nc1ccccc1OC)NC(=O)c1cccc(c1)OC
  • InChi: 1S/C24H24N2O6S/c1-5-32-24(29)19-14(2)20(22(28)25-17-11-6-7-12-18(17)31-4)33-23(19)26-21(27)15-9-8-10-16(13-15)30-3/h6-13H,5H2,1-4H3,(H,25,28)(H,26,27)
  • InChiKey: ZKYCULYPKOPBFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[(3-methoxybenzoyl)amino]-5-[(2-methoxyphenyl)carbamoyl]-4-methyl-thiophene-3-carboxylate
  • 5-[[(2-methoxyphenyl)amino]-oxomethyl]-2-[[(3-methoxyphenyl)-oxomethyl]amino]-4-methyl-3-thiophenecarboxylic acid ethyl ester
  • 2-[(3-methoxybenzoyl)amino]-5-[(2-methoxyphenyl)carbamoyl]-4-methyl-thiophene-3-carboxylic acid ethyl ester
  • ethyl 5-[(2-methoxyphenyl)carbamoyl]-2-[(3-methoxyphenyl)carbonylamino]-4-methyl-thiophene-3-carboxylate
  • A2386/0100991
  • Oprea1_543524
  • CBMicro_047551
  • BIM-0047563.P001
  • MixCom6_002495

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.022 0.0698 0.111
Echinococcus granulosus sodium and chloride dependent glycine 0.0103 0.026 0.0414
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.022 0.0698 0.1673
Onchocerca volvulus 0.0271 0.0888 0.4151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.022 0.0698 0.1673
Echinococcus granulosus biogenic amine 5HT receptor 0.0623 0.2203 0.3505
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.008 0.0175 0.0171
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.008 0.0175 0.0171
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0096 0.0091
Schistosoma mansoni hypothetical protein 0.022 0.0698 0.1673
Echinococcus multilocularis fmrfamide receptor 0.022 0.0698 0.1269
Onchocerca volvulus 0.022 0.0698 0.3256
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0256
Echinococcus granulosus jun protein 0.0096 0.0236 0.0375
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0138 0.0394 0.0626
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0035 0.0001
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0043 0.0037 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0103 0.026 0.0617
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Onchocerca volvulus 0.0059 0.0096 0.0427
Schistosoma mansoni myosin xvIII 0.022 0.0698 0.1673
Echinococcus granulosus 7tm_1 domain containing protein 0.022 0.0698 0.111
Echinococcus granulosus neuropeptide receptor 0.022 0.0698 0.111
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Echinococcus multilocularis sodium and chloride dependent glycine 0.0103 0.026 0.0468
Echinococcus granulosus tm gpcr rhodopsin 0.1167 0.4231 0.6731
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.0765 0.2126
Leishmania major guanosine monophosphate reductase 0.0993 0.3582 1
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0088 0.0202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Brugia malayi G protein-coupled receptor F59B2.13 0.022 0.0698 0.0693
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0059 0.0096 0.0091
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0993 0.3582 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0035 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Echinococcus granulosus sodium channel protein 0.0043 0.0037 0.0059
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi hypothetical protein 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0035 0.0084
Loa Loa (eye worm) acetylcholine receptor protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0065 0.0168
Echinococcus multilocularis orexin receptor type 2 0.022 0.0698 0.1269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Onchocerca volvulus 0.022 0.0698 0.3256
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0714
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.008 0.0175 0.0412
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.022 0.0698 0.1269
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0035 0.0001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0065 0.0084
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0394 0.0712
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.022 0.0698 0.1269
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0138 0.0394 0.0626
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0065 0.0084
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0138 0.0394 0.0626
Entamoeba histolytica hypothetical protein 0.005 0.0065 0.0137
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0065 0.0168
Echinococcus granulosus L aminoadipate semialdehyde 0.0179 0.0544 0.0865
Brugia malayi Tachykinin-like peptides receptor 99D 0.022 0.0698 0.0693
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0059 0.0096 0.0167
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus granulosus tm gpcr rhodopsin 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0103 0.026 0.0414
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0138 0.0394 0.0626
Onchocerca volvulus 0.008 0.0175 0.0802
Brugia malayi putative neuropeptide receptor 0.022 0.0698 0.0693
Schistosoma mansoni sodium/chloride dependent transporter 0.0103 0.026 0.0617
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0096 0.0152
Echinococcus multilocularis somatostatin receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0714
Brugia malayi Dopamine receptor protein 1 0.022 0.0698 0.0693
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.0394 0.0626
Echinococcus multilocularis G-protein coupled receptor, putative 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0623 0.2203 0.6147
Onchocerca volvulus 0.022 0.0698 0.3256
Schistosoma mansoni neuropeptide F-like receptor 0.022 0.0698 0.1673
Brugia malayi Dopamine receptor protein 2 0.022 0.0698 0.0693
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0103 0.026 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0138 0.0394 0.1087
Brugia malayi Dopamine receptor 0.022 0.0698 0.0693
Loa Loa (eye worm) ACC-1 protein 0.0138 0.0394 0.1087
Echinococcus granulosus G protein coupled receptor 139 0.022 0.0698 0.111
Onchocerca volvulus 0.0103 0.026 0.1201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Loa Loa (eye worm) inositol-1 0.0042 0.0035 0.0084
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Schistosoma mansoni hypothetical protein 0.0078 0.0169 0.0396
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0138 0.0394 0.0389
Brugia malayi Inositol-1 0.0042 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0059 0.0096 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0138 0.0394 0.1087
Onchocerca volvulus 0.0179 0.0544 0.2533
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0065 0.0169
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0628 0.222 1
Echinococcus multilocularis neuropeptide Y receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0363 0.1231 0.3428
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0993 0.3582 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.026 0.0617
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus multilocularis g protein coupled receptor 0.022 0.0698 0.1269
Onchocerca volvulus 0.022 0.0698 0.3256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.022 0.0698 0.1673
Schistosoma mansoni peptide (allatostatin)-like receptor 0.022 0.0698 0.1673
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0993 0.3582 0.655
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Echinococcus granulosus sex peptide receptor 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0394 0.0389
Loa Loa (eye worm) LGC-31 protein 0.0138 0.0394 0.1087
Onchocerca volvulus 0.0057 0.0088 0.0393
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0558 0.1959 0.4721
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0065 0.0084
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Onchocerca volvulus 0.0138 0.0394 0.1828
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0138 0.0394 0.1087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus multilocularis neuropeptide Y receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0138 0.0394 0.0626
Onchocerca volvulus 0.0138 0.0394 0.1828
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0096 0.0236 0.0423
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.022 0.0698 0.1269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0096 0.0091
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.022 0.0698 0.1673
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0103 0.026 0.0617
Plasmodium vivax amine transporter, putative 0.0103 0.026 0.0718
Toxoplasma gondii hypothetical protein 0.0103 0.026 0.0714
Schistosoma mansoni adenoreceptor 0.022 0.0698 0.1673
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.022 0.0698 0.1673
Echinococcus granulosus 7TM GPCR rhodopsin 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0035 0.003
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0993 0.3582 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.022 0.0698 0.111
Mycobacterium leprae conserved hypothetical protein 0.005 0.0065 0.013
Schistosoma mansoni opsin-like receptor 0.022 0.0698 0.1673
Echinococcus multilocularis jun protein 0.0096 0.0236 0.0423
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0138 0.0394 0.0712
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0988 0.3565 1
Echinococcus granulosus nAChR subunit 0.0138 0.0394 0.0626
Loa Loa (eye worm) melatonin receptor type 1A 0.022 0.0698 0.1937
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0096 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0085
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus multilocularis conserved hypothetical protein 0.1498 0.5466 1
Brugia malayi hypothetical protein 0.0139 0.0397 0.0392
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0035 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.022 0.0698 0.1673
Echinococcus granulosus hypothetical protein 0.1718 0.6286 1
Echinococcus granulosus neuropeptide s receptor 0.022 0.0698 0.111
Echinococcus multilocularis sex peptide receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Brugia malayi putative neuropeptide receptor NPR1 0.022 0.0698 0.0693
Echinococcus granulosus allatostatin A receptor 0.022 0.0698 0.111
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0394 0.0389
Brugia malayi bZIP transcription factor family protein 0.0096 0.0236 0.0231
Loa Loa (eye worm) hypothetical protein 0.0057 0.0088 0.0234
Echinococcus multilocularis neuropeptide FF receptor 2 0.022 0.0698 0.1269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Onchocerca volvulus 0.022 0.0698 0.3256
Trichomonas vaginalis set domain proteins, putative 0.0271 0.0888 0.3904
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Schistosoma mansoni jun-related protein 0.0078 0.0169 0.0396
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Echinococcus granulosus dro:myosuppressin receptor 0.022 0.0698 0.111
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0035 0.0055
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0103 0.026 0.0617
Loa Loa (eye worm) hypothetical protein 0.0693 0.2464 0.6876
Toxoplasma gondii IMP dehydrogenas 0.0993 0.3582 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.022 0.0698 0.1673
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0394 0.0712
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0558 0.1959 0.1956
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0138 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0059 0.0096 0.0254
Schistosoma mansoni neuropeptide receptor 0.022 0.0698 0.1673
Schistosoma mansoni histamine h1 receptor 0.022 0.0698 0.1673
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0138 0.0394 0.0712
Schistosoma mansoni nAChR subunit 0.0059 0.0096 0.022
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Treponema pallidum fructose-bisphosphate aldolase 0.0628 0.222 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0483 0.1679 0.4681
Loa Loa (eye worm) solute carrier family 6 member 4 0.0604 0.2133 0.595
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.022 0.0698 0.111
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.022 0.0698 0.1269
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0035 0.0056
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.008 0.0175 0.0412
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Onchocerca volvulus 0.022 0.0698 0.3256
Loa Loa (eye worm) hypothetical protein 0.0558 0.1959 0.5465
Schistosoma mansoni biogenic amine (5HT) receptor 0.0623 0.2203 0.531
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0714
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus multilocularis neuropeptide receptor 0.022 0.0698 0.1269
Onchocerca volvulus 0.0103 0.026 0.1201
Schistosoma mansoni biogenic amine receptor 0.022 0.0698 0.1673
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0059 0.0096 0.0152
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0988 0.3565 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Onchocerca volvulus 0.0059 0.0096 0.0427
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0138 0.0394 0.0939
Schistosoma mansoni biogenic amine (5HT) receptor 0.1081 0.391 0.9431
Schistosoma mansoni hypothetical protein 0.022 0.0698 0.1673
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0138 0.0394 0.1087
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0035 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.022 0.0698 0.1673
Onchocerca volvulus Putative GMP reductase 0.0437 0.1506 0.7056
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0138 0.0394 0.0712
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Loa Loa (eye worm) serotonin transporter b 0.0604 0.2133 0.595
Echinococcus multilocularis g protein coupled receptor 0.022 0.0698 0.1269
Schistosoma mansoni inositol monophosphatase 0.0042 0.0035 0.0073
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0179 0.0544 0.1302
Echinococcus multilocularis G protein coupled receptor 139 0.022 0.0698 0.1269
Echinococcus granulosus serotonin receptor 0.022 0.0698 0.111
Echinococcus granulosus biogenic amine 5HT receptor 0.1081 0.391 0.622
Schistosoma mansoni neuropeptide f receptor 76f 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0035 0.0056
Brugia malayi neuropeptide F receptor 0.022 0.0698 0.0693
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0179 0.0544 0.0539
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0043 0.0037 0.0059
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0138 0.0394 0.0389
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1081 0.391 0.715
Brugia malayi larval opioid receptor 0.022 0.0698 0.0693
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus neuropeptides capa receptor 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.0179 0.0544 0.1507
Loa Loa (eye worm) neuropeptide F receptor 0.022 0.0698 0.1937
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0005 0.0007
Loa Loa (eye worm) ACC-1 protein 0.0138 0.0394 0.1087
Schistosoma mansoni amine GPCR 0.022 0.0698 0.1673
Schistosoma mansoni amine GPCR 0.022 0.0698 0.1673
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0096 0.0236 0.0375
Echinococcus granulosus tachykinin peptides receptor 99D 0.022 0.0698 0.111
Loa Loa (eye worm) GABA receptor subunit 0.008 0.0175 0.0477
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Brugia malayi jmjC domain containing protein 0.0067 0.0128 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.026 0.0617
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus multilocularis neuropeptide s receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.022 0.0698 0.1937
Echinococcus multilocularis neuropeptide receptor A26 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0993 0.3582 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.022 0.0698 0.1269
Toxoplasma gondii hypothetical protein 0.0103 0.026 0.0714
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Schistosoma mansoni alpha-1 adrenergic receptor 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus granulosus neuropeptide Y receptor 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0138 0.0394 0.0712
Onchocerca volvulus 0.022 0.0698 0.3256
Brugia malayi hypothetical protein 0.0075 0.0159 0.0154
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0103 0.026 0.0468
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.022 0.0698 0.1269
Plasmodium vivax hypothetical protein, conserved 0.0103 0.026 0.0718
Onchocerca volvulus 0.0604 0.2133 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.022 0.0698 0.1269
Schistosoma mansoni amine GPCR 0.022 0.0698 0.1673
Brugia malayi sulfakinin receptor protein 0.022 0.0698 0.0693
Schistosoma mansoni neurotransmitter gated ion channel 0.008 0.0175 0.0412
Echinococcus granulosus geminin 0.0364 0.1236 0.1966
Echinococcus multilocularis sodium and chloride dependent glycine 0.0103 0.026 0.0468
Brugia malayi G protein-coupled receptor 0.022 0.0698 0.0693
Echinococcus multilocularis geminin 0.0364 0.1236 0.2254
Brugia malayi hypothetical protein 0.0059 0.0096 0.0091
Giardia lamblia Fructose-bisphosphate aldolase 0.0628 0.222 1
Onchocerca volvulus 0.022 0.0698 0.3256
Schistosoma mansoni sodium/chloride dependent transporter 0.0103 0.026 0.0617
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.022 0.0698 0.1673
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0138 0.0394 0.0626
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Schistosoma mansoni neuropeptide receptor 0.022 0.0698 0.1673
Schistosoma mansoni opsin-like receptor 0.022 0.0698 0.1673
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0993 0.3582 0.5698
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0993 0.3582 0.3579
Plasmodium falciparum amino acid transporter, putative 0.0103 0.026 0.0558
Loa Loa (eye worm) G-protein coupled receptor 0.022 0.0698 0.1937
Echinococcus multilocularis neuropeptides capa receptor 0.022 0.0698 0.1269
Schistosoma mansoni acetylcholine receptor-related 0.0059 0.0096 0.022
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0096 0.0167
Schistosoma mansoni amine GPCR 0.1144 0.4145 1
Brugia malayi Serotonin receptor 0.022 0.0698 0.0693
Echinococcus multilocularis neuropeptides capa receptor 0.022 0.0698 0.1269
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0394 0.0626
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0993 0.3582 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0103 0.026 0.0617
Schistosoma mansoni opsin-like receptor 0.022 0.0698 0.1673
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.022 0.0698 0.1269
Echinococcus multilocularis fmrfamide receptor 0.022 0.0698 0.1269
Schistosoma mansoni growth hormone secretagogue receptor 0.022 0.0698 0.1673
Echinococcus multilocularis dro:myosuppressin receptor 0.022 0.0698 0.1269
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0604 0.2133 0.514
Echinococcus granulosus neuropeptide FF receptor 2 0.022 0.0698 0.111
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0035 0.0056
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0138 0.0394 0.1087
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Echinococcus granulosus sodium and chloride dependent glycine 0.0103 0.026 0.0414
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0138 0.0394 0.0389
Brugia malayi AKH receptor 0.022 0.0698 0.0693
Echinococcus multilocularis nAChR subunit 0.008 0.0175 0.0312
Loa Loa (eye worm) hypothetical protein 0.0781 0.2793 0.7796
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0552 0.1936 0.538
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0138 0.0394 0.0389
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0307 0.1022 0.2783
Onchocerca volvulus 0.0138 0.0394 0.1828
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0714
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.022 0.0698 0.1673
Schistosoma mansoni sodium/chloride dependent transporter 0.0604 0.2133 0.514
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.022 0.0698 0.1269
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0993 0.3582 0.8639
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0256
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.0394 0.0712
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.022 0.0698 0.3256
Loa Loa (eye worm) hypothetical protein 0.0693 0.2464 0.6876
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0394 0.0939
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus alpha 1A adrenergic receptor 0.022 0.0698 0.111
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.022 0.0698 0.1673
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.0394 0.0712
Schistosoma mansoni neuropeptide receptor 0.022 0.0698 0.1673
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0628 0.222 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Brugia malayi follicle stimulating hormone receptor 0.0483 0.1679 0.1675
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0138 0.0394 0.0389
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Brugia malayi G-protein coupled receptor 0.022 0.0698 0.0693
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0103 0.026 0.0256
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.022 0.0698 0.0693
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.022 0.0698 0.1937
Brugia malayi hypothetical protein 0.0059 0.0096 0.0091
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.022 0.0698 0.0693
Brugia malayi Cytochrome P450 family protein 0.0064 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Brugia malayi GnHR receptor homolog 0.022 0.0698 0.0693
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0128 0.0204
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0128 0.0204
Onchocerca volvulus 0.0138 0.0394 0.1828
Brugia malayi jmjC domain containing protein 0.0067 0.0128 0.0124
Echinococcus multilocularis L aminoadipate semialdehyde 0.0179 0.0544 0.0987
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1167 0.4231 0.7739
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0138 0.0394 0.0626
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0065 0.0084
Echinococcus multilocularis serotonin receptor 0.0623 0.2203 0.4026
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Onchocerca volvulus Putative nachr subunit 0.0138 0.0394 0.1828
Leishmania major inosine-5-monophosphate dehydrogenase 0.0993 0.3582 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0138 0.0394 0.1087
Echinococcus multilocularis tachykinin peptides receptor 99D 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0103 0.026 0.0468
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0138 0.0394 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Echinococcus multilocularis nAChR subunit 0.0138 0.0394 0.0712
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0138 0.0394 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0035 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0394 0.0939
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0059 0.0096 0.0091
Echinococcus granulosus neuropeptide receptor A26 0.022 0.0698 0.111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Schistosoma mansoni hypothetical protein 0.0364 0.1236 0.2973
Loa Loa (eye worm) neuropeptide F receptor 0.022 0.0698 0.1937
Echinococcus multilocularis g protein coupled receptor 0.022 0.0698 0.1269
Echinococcus granulosus tm gpcr rhodopsin 0.022 0.0698 0.111
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi Cation transporter family protein 0.0138 0.0394 0.0389
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.008 0.0175 0.0171
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0138 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0394 0.0712
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0437 0.1506 0.1502
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0993 0.3582 1
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.0394 0.0626
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0103 0.026 0.0414
Brugia malayi Cation transporter family protein 0.0138 0.0394 0.0389
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0035 0.0073
Echinococcus granulosus peptide allatostatin:somatostatin 0.022 0.0698 0.111
Echinococcus granulosus somatostatin receptor 0.022 0.0698 0.111
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0394 0.0389
Echinococcus granulosus expressed protein 0.0427 0.147 0.2338
Brugia malayi hypothetical protein 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Onchocerca volvulus 0.0138 0.0394 0.1828
Loa Loa (eye worm) hypothetical protein 0.0604 0.2133 0.595
Echinococcus granulosus neuropeptide Y receptor 0.022 0.0698 0.111
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0103 0.026 0.0414
Echinococcus multilocularis allatostatin A receptor 0.022 0.0698 0.1269
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0394 0.0626
Schistosoma mansoni inositol monophosphatase 0.0042 0.0035 0.0073
Echinococcus multilocularis sodium channel protein 0.0043 0.0037 0.006
Brugia malayi GMP reductase 0.0437 0.1506 0.1502
Schistosoma mansoni hypothetical protein 0.0364 0.1236 0.2973
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0035 0.0001
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0103 0.026 0.0414
Onchocerca volvulus 0.008 0.0175 0.0802
Onchocerca volvulus 0.022 0.0698 0.3256
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Plasmodium falciparum transporter, putative 0.0103 0.026 0.0558
Echinococcus granulosus g-protein coupled receptor 0.022 0.0698 0.111
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Schistosoma mansoni neurotransmitter gated ion channel 0.0059 0.0096 0.022
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0394 0.0626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0103 0.026 0.0617
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0035 0.0001
Loa Loa (eye worm) hypothetical protein 0.0093 0.0226 0.0618
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0394 0.0939
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0138 0.0394 0.0939
Loa Loa (eye worm) hypothetical protein 0.0558 0.1959 0.5465
Loa Loa (eye worm) hypothetical protein 0.0103 0.026 0.0714
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0065 0.0084
Loa Loa (eye worm) norepinephrine transporter 0.0604 0.2133 0.595
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Echinococcus granulosus nAChR subunit 0.008 0.0175 0.0279
Echinococcus granulosus g protein coupled receptor 0.022 0.0698 0.111
Brugia malayi ORL1-like opioid receptor 0.022 0.0698 0.0693
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0128 0.0298
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.0394 0.0626
Loa Loa (eye worm) G-protein coupled receptor 0.022 0.0698 0.1937
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.022 0.0698 0.111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0116 0.031
Brugia malayi Melatonin receptor type 1A 0.022 0.0698 0.0693
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0714
Schistosoma mansoni biogenic amine receptor 0.022 0.0698 0.1673
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0988 0.3565 0.9952
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Onchocerca volvulus Neuropeptide F receptor homolog 0.022 0.0698 0.3256
Schistosoma mansoni nAChR subunit 0.0059 0.0096 0.022
Echinococcus granulosus neuropeptide receptor 0.022 0.0698 0.111
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.0394 0.0712
Onchocerca volvulus 0.0138 0.0394 0.1828
Onchocerca volvulus 0.022 0.0698 0.3256
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0138 0.0394 0.0712
Schistosoma mansoni amine GPCR 0.022 0.0698 0.1673
Echinococcus granulosus g protein coupled receptor 0.022 0.0698 0.111
Loa Loa (eye worm) GMP reductase 0.0437 0.1506 0.4198
Onchocerca volvulus 0.022 0.0698 0.3256
Brugia malayi G-protein coupled receptor 0.022 0.0698 0.0693
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0437 0.1506 0.1502
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0307 0.1022 0.2816
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Echinococcus granulosus serotonin transporter 0.0604 0.2133 0.3393
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0035 0.0056
Echinococcus granulosus thyrotropin releasing hormone receptor 0.022 0.0698 0.111
Loa Loa (eye worm) IMP dehydrogenase 1 0.0993 0.3582 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.022 0.0698 0.1269
Echinococcus multilocularis g-protein coupled receptor 0.022 0.0698 0.1269
Echinococcus granulosus g protein coupled receptor 0.022 0.0698 0.111
Schistosoma mansoni hypothetical protein 0.022 0.0698 0.1673
Brugia malayi hypothetical protein 0.0059 0.0096 0.0091
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus multilocularis expressed protein 0.0427 0.147 0.2683
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0441 0.1523 0.4224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Schistosoma mansoni neurotransmitter gated ion channel 0.0059 0.0096 0.022
Schistosoma mansoni acetylcholine receptor subunit beta 0.0059 0.0096 0.022
Loa Loa (eye worm) hypothetical protein 0.0138 0.0394 0.1087
Echinococcus granulosus fmrfamide receptor 0.022 0.0698 0.111
Brugia malayi hypothetical protein 0.0103 0.026 0.0256
Schistosoma mansoni sodium-dependent amino acid transporter 0.0103 0.026 0.0617
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0103 0.026 0.0256
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.022 0.0698 0.111
Echinococcus multilocularis serotonin transporter 0.0604 0.2133 0.3897
Schistosoma mansoni neuropeptide receptor 0.022 0.0698 0.1673
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0065 0.013
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0035 0.0001
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0128 0.0226
Trypanosoma brucei GMP reductase 0.0993 0.3582 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.022 0.0698 0.0693
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0128 0.0345
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0128 0.0226
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0035 0.0001
Treponema pallidum sodium- and chloride- dependent transporter 0.0604 0.2133 0.9594
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Schistosoma mansoni hypothetical protein 0.022 0.0698 0.1673
Brugia malayi RE15519p 0.022 0.0698 0.0693
Echinococcus granulosus orexin receptor type 2 0.022 0.0698 0.111
Echinococcus multilocularis neuropeptide receptor 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Onchocerca volvulus 0.0059 0.0096 0.0427
Trypanosoma cruzi GMP reductase 0.0993 0.3582 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.022 0.0698 0.1269
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Brugia malayi excitatory GABA receptor EXP-1A 0.0138 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.0254
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0604 0.2133 0.2129
Onchocerca volvulus 0.0075 0.0159 0.0724
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Echinococcus granulosus rhodopsin orphan GPCR 0.022 0.0698 0.111
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0993 0.3582 1
Entamoeba histolytica hypothetical protein 0.008 0.0175 0.0642
Loa Loa (eye worm) hypothetical protein 0.0604 0.2133 0.595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.022 0.0698 0.1673
Brugia malayi Cation transporter family protein 0.0138 0.0394 0.0389
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0128 0.0298
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0993 0.3582 1
Onchocerca volvulus 0.0103 0.026 0.1201
Schistosoma mansoni nAChR subunit 0.0138 0.0394 0.0939
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0628 0.222 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.022 0.0698 0.0693
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.008 0.0175 0.0477
Loa Loa (eye worm) TYRA-2 protein 0.022 0.0698 0.1937
Echinococcus multilocularis tumor protein p63 0.0386 0.1319 0.2407
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0103 0.026 0.0468
Echinococcus multilocularis serotonin receptor 0.0623 0.2203 0.4026
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Brugia malayi Pre-SET motif family protein 0.0238 0.0765 0.0761
Loa Loa (eye worm) hypothetical protein 0.022 0.0698 0.1937
Loa Loa (eye worm) hypothetical protein 0.0604 0.2133 0.595
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0128 0.0298
Loa Loa (eye worm) hypothetical protein 0.0623 0.2203 0.6147
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.022 0.0698 0.1673
Echinococcus granulosus tumor protein p63 0.0386 0.1319 0.2098
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0307 0.1022 0.2816
Trypanosoma cruzi GMP reductase 0.0993 0.3582 1
Onchocerca volvulus 0.022 0.0698 0.3256
Brugia malayi hypothetical protein 0.022 0.0698 0.0693
Brugia malayi neuropeptide F receptor 0.022 0.0698 0.0693
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0552 0.1936 0.538
Schistosoma mansoni biogenic amine receptor 0.022 0.0698 0.1673
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0035 0.0056
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0441 0.1523 0.4197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0394 0.0389
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.026 0.0617
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.008 0.0175 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.022 0.0698 0.111

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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