TDR Targets

Basic information

Technical information

TDR Targets ID: 899008
Name: 3-phenyl-2-[[4-(trifluoromethyl)phenyl]methyl sulfanyl]-6,7-dihydrothieno[2,3-e]pyrimidin-4 -one
MW: 420.471 | Formula: C20H15F3N2OS2
H donors: 0 H acceptors: 1 LogP: 5.1 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=c1c2SCCc2nc(n1c1ccccc1)SCc1ccc(cc1)C(F)(F)F
InChi: 1S/C20H15F3N2OS2/c21-20(22,23)14-8-6-13(7-9-14)12-28-19-24-16-10-11-27-17(16)18(26)25(19)15-4-2-1-3-5-15/h1-9H,10-12H2
InChiKey: GQTCFUPHWCVOPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
3-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
EU-0022223

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0082	0.1279	0.1035
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0132	0.3163	0.4706
Schistosoma mansoni	patched 1	0.0054	0.0259	0.0259
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0315	1	1
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0068	0.0747	0.0747
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0205	0.5881	0.5772
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0147	0.3716	0.3549
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0068	0.0747	0.0501
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0111	0.2357	0.174
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0747	0.0501
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0597	0.0597
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0111	0.2357	0.2154
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0132	0.3163	0.2981
Onchocerca volvulus		0.0082	0.1279	1
Giardia lamblia	Prenyltransferase	0.0111	0.2357	0.1919
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0082	0.1279	0.1035
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0068	0.0747	0.0501
Toxoplasma gondii	hypothetical protein	0.0082	0.1279	0.0857
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0597	0.0597
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0111	0.2357	0.3136
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0082	0.1279	0.1035
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0068	0.0747	0.0747
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0597	0.0347
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0111	0.2357	0.2154
Trypanosoma cruzi	hypothetical protein, conserved	0.0082	0.1279	0.1035
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0082	0.1279	0.1047
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0234	0.6948	0.6866
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0082	0.1279	0.1047
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0132	0.3163	0.3163
Echinococcus multilocularis	geminin	0.017	0.4567	0.4423
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0135	0.3269	0.309
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0597	0.0347
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0132	0.3163	0.4094
Giardia lamblia	Rab geranylgeranyltransferase	0.0082	0.1279	0.0779
Echinococcus granulosus	geminin	0.017	0.4567	0.4423
Loa Loa (eye worm)	hypothetical protein	0.0315	1	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0315	1	1
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0597	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0747	0.0501
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0082	0.1279	0.0575
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0597	0.0347
Giardia lamblia	Synaptic glycoprotein SC2	0.0068	0.0747	0.0217
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.3269	0.3269
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0082	0.1279	0.1047
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.2894	0.2706
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0054	0.0259	0.0259
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0068	0.0747	0.0501
Brugia malayi	RNA binding protein	0.0063	0.0597	0.0597
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0082	0.1279	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0159	0.4177	0.4022
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0542	0.0291
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0082	0.1279	0.1047
Trypanosoma brucei	hypothetical protein, conserved	0.0082	0.1279	0.1035
Schistosoma mansoni	hypothetical protein	0.017	0.4567	0.4567
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0315	1	1
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0082	0.1279	0.1035
Schistosoma mansoni	hypothetical protein	0.0125	0.2894	0.2894
Brugia malayi	CHE-14 protein	0.0054	0.0259	0.0259
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0111	0.2357	0.2357
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0542	0.0291
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0205	0.5881	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0315	1	1
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0205	0.5881	1
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0205	0.5881	0.5881
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0315	1	1
Brugia malayi	TAR-binding protein	0.0063	0.0597	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0747	0.0501
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0597	0.0597
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0597	0.0347
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.2894	0.2706
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0205	0.5881	0.5772
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0111	0.2357	0.2154
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0082	0.1279	0.1035
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0132	0.3163	0.2981
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0068	0.0747	0.0501
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0082	0.1279	0.1047
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0082	0.1279	0.0575
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0205	0.5881	1
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0081	0.1237	0.0529
Trypanosoma cruzi	hypothetical protein, conserved	0.0082	0.1279	0.1035
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0205	0.5881	0.5549
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0205	0.5881	0.828
Giardia lamblia	Rab geranylgeranyltransferase	0.0315	1	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0082	0.1279	0.1047
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0111	0.2357	0.2154
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0132	0.3163	0.4706
Mycobacterium ulcerans	hypothetical protein	0.0205	0.5881	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0597	0.0597
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0315	1	1
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0068	0.0747	0.0501
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0111	0.2357	0.2154
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0315	1	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0111	0.2357	0.2154
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0082	0.1279	0.1279
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0111	0.2357	0.174
Toxoplasma gondii	hypothetical protein	0.0234	0.6948	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0597	0.0597
Brugia malayi	hypoxia-induced factor 1	0.0147	0.3716	0.3716
Brugia malayi	Synaptic glycoprotein SC2	0.0068	0.0747	0.0747
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0111	0.2357	0.2154
Leishmania major	farnesyltransferase beta subunit	0.0111	0.2357	0.2344
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0315	1	1
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0111	0.2357	0.2597
Brugia malayi	hypothetical protein	0.0159	0.4177	0.4177
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0132	0.3163	0.4706
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0082	0.1279	0.0575
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0597	0.0597
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0111	0.2357	0.174
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0068	0.0747	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3163	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0205	0.5881	0.5772
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0315	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.3269	0.3269
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0111	0.2357	0.2154
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0205	0.5881	1
Schistosoma mansoni	hypothetical protein	0.017	0.4567	0.4567
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0062	0.0542	0.0291
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0082	0.1279	0.1279
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0747	0.0501
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0111	0.2357	0.3136
Echinococcus granulosus	synaptic glycoprotein sc2	0.0068	0.0747	0.0501
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0315	1	1
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0205	0.5881	0.5772
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0132	0.3163	0.3163
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0111	0.2357	0.2357
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0111	0.2357	0.3136
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0068	0.0747	0.0501
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0111	0.2357	0.2154

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 899008