TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.479 | Formula: C23H29NO6
H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCOC(=C1C(=NC2=C(C1c1ccc(c(c1OC)OC)OC)C(=O)CCC2)C)O
InChi: 1S/C23H29NO6/c1-6-12-30-23(26)18-13(2)24-15-8-7-9-16(25)20(15)19(18)14-10-11-17(27-3)22(29-5)21(14)28-4/h10-11,19,26H,6-9,12H2,1-5H3
InChiKey: PJWYWKTZYHDEIN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0047	0.0743	0.0829
Schistosoma mansoni	hypothetical protein	0.0033	0.0308	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0743	0.0743
Brugia malayi	cathepsin B-like cysteine proteinase	0.0165	0.4498	0.7719
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1524	0.2615
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.1354	0.2325
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0201	0.0201
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.3812	0.3812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0302	0.0448
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0075	0.0168
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.0743	0.3362
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1153	0.5219
Echinococcus multilocularis	snurportin 1	0.0339	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.1354	0.1354
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0266	0.1202
Schistosoma mansoni	hypothetical protein	0.0339	1	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0092	0.0092
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0743	0.0743
Toxoplasma gondii	cathepsin CPL	0.0047	0.0743	0.5389
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0743	0.0743
Trypanosoma cruzi	cysteine protease, putative	0.0026	0.0096	0.0214
Entamoeba histolytica	hypothetical protein	0.0026	0.0075	0.1015
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0266	0.0266
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0201	0.1462
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0075	0.0112
Plasmodium vivax	vivapain-2	0.0047	0.0743	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Echinococcus granulosus	lamin	0.0054	0.0984	0.0984
Echinococcus multilocularis	cathepsin b	0.0165	0.4498	0.4498
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.2572	0.4414
Brugia malayi	RNA, U transporter 1	0.009	0.2121	0.3639
Onchocerca volvulus		0.0054	0.0984	0.1198
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.1378	0.6238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Onchocerca volvulus		0.0033	0.0302	0.0154
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0026	0.0096	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0743	0.1103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0096	0.0096
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0743	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0266	0.0266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.3812	0.3812
Leishmania major	cathepsin L-like protease	0.0047	0.0743	0.3362
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0096	0.0143
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0266	0.3576
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.1378	0.1378
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0096	0.1295
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.1354	0.1354
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0201	0.0201
Trypanosoma cruzi	cysteine proteinase, putative	0.0026	0.0096	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0984	0.0984
Brugia malayi	Importin beta-1 subunit	0.0032	0.0266	0.0456
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0743	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.1354	0.1354
Brugia malayi	intermediate filament protein	0.0054	0.0984	0.1689
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0308	0.0308
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1378	0.1378
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0096	0.0165
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0984	0.1689
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1354	0.1354
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0302	0.0302
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0096	0.1295
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.2209	0.4912
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.2209	0.4912
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0302	0.0518
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1153	0.2564
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1378	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0167	0.0167
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.0743	0.0743
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Brugia malayi	Pre-SET motif family protein	0.003	0.0201	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0302	0.0448
Echinococcus multilocularis	cathepsin b	0.0165	0.4498	0.4498
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0308	0.0308
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0096	0.0214
Brugia malayi	RNA binding protein	0.0066	0.1354	0.2325
Brugia malayi	TAR-binding protein	0.0066	0.1354	0.2325
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.3812	0.3812
Echinococcus granulosus	lamin dm0	0.0054	0.0984	0.0984
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0266	0.1202
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0079	0.1768	0.3932
Echinococcus multilocularis	lamin dm0	0.0054	0.0984	0.0984
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1354	0.1354
Brugia malayi	Pre-SET motif family protein	0.0207	0.5827	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0201	0.0201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.4498	0.4498
Loa Loa (eye worm)	cysteine protease	0.0047	0.0743	0.0743
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.1378	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1378	0.1378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0201	0.0201
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.0743	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.5827	0.5827
Loa Loa (eye worm)	ctsf protein	0.0047	0.0743	0.0743
Schistosoma mansoni	hypothetical protein	0.0187	0.5172	0.5172
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0984	0.0984
Echinococcus granulosus	cathepsin L cysteine protease	0.0026	0.0096	0.0096
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0743	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1524	0.1524
Echinococcus multilocularis	cathepsin L	0.0026	0.0096	0.0096
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Schistosoma mansoni	hypothetical protein	0.0033	0.0308	0.0308
Echinococcus granulosus	cathepsin l1	0.0047	0.0743	0.0743
Leishmania major	cathepsin L-like protease	0.0047	0.0743	0.3362
Echinococcus granulosus	geminin	0.0187	0.5172	0.5172
Plasmodium vivax	SET domain protein, putative	0.003	0.0201	0.2713
Onchocerca volvulus		0.0047	0.0743	0.0829
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0743	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0025	0.006	0.006
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.1378	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0165	0.4498	1
Echinococcus multilocularis	cysteine protease	0.0047	0.0743	0.0743
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0308	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0025	0.006	0.006
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.2209	0.4912
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.2572	0.2572
Plasmodium vivax	vivapain-1	0.0026	0.0096	0.1295
Echinococcus multilocularis	geminin	0.0187	0.5172	0.5172
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0183	0.0315
Echinococcus granulosus	intermediate filament protein	0.0054	0.0984	0.0984
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0743	0.0743
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0096	0.0096
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1378	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1153	0.5219
Onchocerca volvulus		0.0054	0.0984	0.1198
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0308	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0096	0.1295
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.0743	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4498	0.4498
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1153	0.1712
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.0743	0.0743
Plasmodium vivax	unspecified product	0.0026	0.0096	0.1295
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.4498	0.4498
Schistosoma mansoni	importin beta-1	0.0032	0.0266	0.0266
Loa Loa (eye worm)	cathepsin B	0.006	0.1153	0.1153
Plasmodium vivax	vivapain-2	0.0047	0.0743	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0953	0.0953
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0183	0.0183
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1354	0.1354
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0201	0.0201
Trypanosoma cruzi	cysteine proteinase, putative	0.0026	0.0096	0.0214
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0984	0.0984
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1354	0.1354
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0308	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.1122	0.2494
Plasmodium vivax	vivapain-3	0.0026	0.0096	0.1295
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0743	0.1651
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1378	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0308	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Giardia lamblia	Cathepsin B precursor	0.006	0.1153	1
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0743	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Toxoplasma gondii	cathepsin B	0.006	0.1153	0.8366
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0743	0.1275
Leishmania major	cathepsin L-like protease	0.0047	0.0743	0.3362
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.0743	0.0743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0096	0.0143
Trypanosoma cruzi	cruzipain precursor, putative	0.0093	0.2209	0.4912
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.4498	0.4498
Plasmodium falciparum	importin beta, putative	0.0032	0.0266	0.3576
Onchocerca volvulus		0.0047	0.0743	0.0829
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0075	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0302	0.0518
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0201	0.0201
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0308	0.0308
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.3812	0.3812
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0339	1	1
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0075	0.0341
Loa Loa (eye worm)	fibroinase	0.0047	0.0743	0.0743
Onchocerca volvulus		0.0236	0.6734	1
Onchocerca volvulus		0.0047	0.0743	0.0829
Onchocerca volvulus		0.0047	0.0743	0.0829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0092	0.0092
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.3812	0.3812
Schistosoma mansoni	lamin	0.0054	0.0984	0.0984
Echinococcus multilocularis	musashi	0.0054	0.0984	0.0984
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0165	0.4498	0.4498
Echinococcus granulosus	cathepsin b	0.0165	0.4498	0.4498
Schistosoma mansoni	hypothetical protein	0.0033	0.0308	0.0308
Leishmania major	cathepsin L-like protease	0.0093	0.2209	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0266	0.1927
Onchocerca volvulus		0.0047	0.0743	0.0829
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0096	0.1295
Schistosoma mansoni	hypothetical protein	0.0033	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0302	0.0302
Giardia lamblia	Cathepsin B precursor	0.006	0.1153	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Echinococcus granulosus	tar DNA binding protein	0.0066	0.1354	0.1354
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.3812	0.3812
Schistosoma mansoni	hypothetical protein	0.0072	0.1524	0.1524
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.0743	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0201	0.0201
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0308	0.0528
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0144	0.3812	0.6542
Onchocerca volvulus		0.0047	0.0743	0.0829
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.2572	0.4414
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0096	0.0165
Echinococcus granulosus	cysteine protease	0.0026	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus granulosus	GPCR family 2	0.0033	0.0308	0.0308
Schistosoma mansoni	lamin	0.0054	0.0984	0.0984
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0984	0.0984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Loa Loa (eye worm)	RNA binding protein	0.0066	0.1354	0.1354
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0302	0.4065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Entamoeba histolytica	cysteine proteinase 2	0.0026	0.0096	0.1295
Leishmania major	cathepsin L-like protease	0.0093	0.2209	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0026	0.0096	0.1295
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0033	0.0302	0.0518
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0308	0.0308
Entamoeba histolytica	cysteine proteinase 1, putative	0.0026	0.0096	0.1295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0096	0.0435
Brugia malayi	cathepsin L-like precursor	0.0033	0.0302	0.0518
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Loa Loa (eye worm)	hypothetical protein	0.0105	0.2572	0.2572
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.6734	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus multilocularis	lamin	0.0054	0.0984	0.0984
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.3812	0.3812
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0096	0.1295
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0743	0.0829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0096	0.0435
Giardia lamblia	Cathepsin B precursor	0.006	0.1153	1
Schistosoma mansoni	hypothetical protein	0.0187	0.5172	0.5172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Leishmania major	cathepsin L-like protease	0.0093	0.2209	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.2209	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0144	0.3812	0.3812
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0266	0.0266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0092	0.0092
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.0743	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1153	0.1153
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.1378	0.1378
Echinococcus granulosus	cathepsin l1	0.0033	0.0302	0.0302
Echinococcus granulosus	cathepsin L	0.0026	0.0096	0.0096
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0743	0.0743
Echinococcus multilocularis	cysteine protease	0.0047	0.0743	0.0743
Leishmania major	cathepsin L-like protease	0.0047	0.0743	0.3362
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0743	0.0743
Leishmania major	cathepsin L-like protease	0.0047	0.0743	0.3362
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0302	0.0302
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0075	0.0112
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0743	0.1275
Echinococcus granulosus	cathepsin b	0.0165	0.4498	0.4498
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0743	0.0743
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0201	0.0201
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1354	0.1354
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0743	0.1103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906791