Detailed information for compound 919926

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.436 | Formula: C25H21Cl2N5O4S
  • H donors: 3 H acceptors: 5 LogP: 5.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C1(C)CN(c2c1c(Cl)ccc2O)c1ccccc1NC(=O)Nc1nc2c(s1)nc(cc2)Cl
  • InChi: 1S/C25H21Cl2N5O4S/c1-3-36-22(34)25(2)12-32(20-17(33)10-8-13(26)19(20)25)16-7-5-4-6-14(16)28-23(35)31-24-29-15-9-11-18(27)30-21(15)37-24/h4-11,33H,3,12H2,1-2H3,(H2,28,29,31,35)
  • InChiKey: QBYHAJNALVUHHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor purinergic receptor P2Y, G-protein coupled, 1 373 aa 393 aa 17.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis caspase 0.0116 0.2201 0.2201
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.003 0.0294 0.0294
Echinococcus granulosus voltage gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0049
Echinococcus granulosus short transient receptor potential channel 6 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus caspase 3 0.0072 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus two pore calcium channel protein 1 0.002 0.0076 0.0076
Echinococcus multilocularis sodium leak channel non selective protein 0.002 0.0076 0.0076
Echinococcus multilocularis shaker cognate 0.002 0.0076 0.0076
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.1149 0.226
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0076 0.0076
Toxoplasma gondii exonuclease III APE 0.0019 0.0049 0.0152
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0398 0.4121
Brugia malayi photoreceptor-specific nuclear receptor 0.0145 0.2839 0.2839
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0896 0.0896
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0076 0.0076
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0116 0.2201 0.2201
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated ion channel 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.2839 0.2839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.002 0.0076 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0145 0.2839 0.2839
Echinococcus granulosus caspase 0.0116 0.2201 0.2201
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.002 0.0076 0.0076
Echinococcus multilocularis short transient receptor potential channel 6 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0077 0.133 0.133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.1149 0.1149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0049 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.002 0.0076 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.0145 0.2839 0.2839
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.002 0.0076 0.0076
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0398 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0068 0.1149 0.1149
Brugia malayi nuclear receptor NHR-88 0.0068 0.1149 0.1149
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0896 1
Plasmodium falciparum metacaspase 1 0.0044 0.0609 1
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0609 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus voltage gated potassium channel 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0145 0.2839 0.2839
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.047 1 1
Brugia malayi ecdysteroid receptor 0.0145 0.2839 0.2839
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0145 0.2839 0.2839
Leishmania major calcium channel protein, putative,ion transporter, putative 0.002 0.0076 0.0845
Schistosoma mansoni RAR-like nuclear receptor 0.0145 0.2839 0.2839
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0049 0.0049
Echinococcus multilocularis transfer RNA-Gly 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0145 0.2839 0.2839
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0077 0.133 0.133
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0145 0.2839 0.2839
Echinococcus multilocularis sodium channel protein 0.002 0.0076 0.0076
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.002 0.0076 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1816 0.1816
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0068 0.1149 0.1149
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Leishmania major metacaspase, putative 0.0044 0.0609 0.6793
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0896 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0068 0.1149 0.1149
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4826 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.002 0.0076 0.0076
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0145 0.2839 0.2839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0067 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0896 0.0896
Schistosoma mansoni inositol monophosphatase 0.0038 0.0487 0.0487
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0329
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0896 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0989 0.0989
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0076 0.0076
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.002 0.0076 0.0233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0811
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.9959 0.9959
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0145 0.2839 0.2839
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0044 0.0609 0.0609
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0144 0.2814 0.2814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0689 0.0689
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0689 0.0689
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0041 0.0542 0.0542
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0989 0.0989
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0076 0.0076
Loa Loa (eye worm) ryanodine receptor 0.002 0.0076 0.0076
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0076 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0085 0.1511 0.1511
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni ryanodine receptor related 0.002 0.0076 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Loa Loa (eye worm) nuclear receptor NHR-67 0.0068 0.1149 0.1149
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0044 0.0609 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0145 0.2839 0.2839
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0689 0.0689
Trypanosoma brucei metacaspase 5, putative 0.0044 0.0609 0.1874
Schistosoma mansoni steroid hormone receptor ad4bp 0.0145 0.2839 0.2839
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0145 0.2839 0.2839
Onchocerca volvulus 0.003 0.0294 0.0459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0294 0.0294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0145 0.2839 0.2839
Brugia malayi nuclear receptor RXR 0.0068 0.1149 0.1149
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.133 0.133
Brugia malayi nuclear receptor RXR 0.0077 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor E75 0.0068 0.1149 0.1149
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.047 1 1
Echinococcus multilocularis two pore calcium channel protein 2 0.002 0.0076 0.0076
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.0076 0.0076
Schistosoma mansoni nuclear receptor 0.0068 0.1149 0.1149
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0076 0.0055
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Echinococcus granulosus voltage dependent calcium channel 0.0164 0.3249 0.3249
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0164 0.3249 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.002 0.0076 0.0076
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0609 0.1874
Onchocerca volvulus 0.0068 0.1149 0.226
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.002 0.0076 0.0233
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0896 0.0896
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.047 1 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.002 0.0076 0.0076
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Schistosoma mansoni caspase-7 (C14 family) 0.0085 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0076 0.0076
Echinococcus multilocularis voltage dependent calcium channel 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Echinococcus multilocularis two pore calcium channel protein 1 0.002 0.0076 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0329 0.0329
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0116 0.2201 0.2201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0145 0.2839 0.2839
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0076 0.0233
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0068 0.1149 0.1149
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0989 0.0989
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0049 0.0049
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.047 1 1
Brugia malayi ecdysone receptor 0.0068 0.1149 0.1149
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.002 0.0076 0.0076
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0076 0.0076
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0076 0.0076
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.047 1 1
Echinococcus multilocularis potassium large conductance calcium activated 0.002 0.0076 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0145 0.2839 0.2839
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0076 0.0076
Brugia malayi Inositol-1 0.0038 0.0487 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0077 0.133 0.133
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.1149 0.1149
Toxoplasma gondii hypothetical protein 0.002 0.0076 0.0233
Schistosoma mansoni coup transcription factor 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.002 0.0076 0.0076
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0487 0.0916
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0076 0.0076
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.002 0.0076 0.0076
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.002 0.0076 0.0076
Loa Loa (eye worm) inositol-1 0.0038 0.0487 0.0487
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0989 0.0989
Brugia malayi Steroid receptor seven-up type 2 0.0145 0.2839 0.2839
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0294 0.0905
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0144 0.2814 0.2814
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.047 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0068 0.1149 0.1149
Schistosoma mansoni hypothetical protein 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Toxoplasma gondii transporter, cation channel family protein 0.0164 0.3249 1
Echinococcus multilocularis short transient receptor potential channel 6 0.002 0.0076 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.047 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0049 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0145 0.2839 0.2839
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0076 0.0076
Toxoplasma gondii hypothetical protein 0.0144 0.2814 0.866
Echinococcus granulosus GPCR family 2 0.0031 0.0329 0.0329
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0812 0.0812
Brugia malayi MH2 domain containing protein 0.0118 0.2237 0.2237
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0487 0.15
Onchocerca volvulus 0.0041 0.0542 0.0982
Loa Loa (eye worm) ion channel NompC 0.002 0.0076 0.0076
Schistosoma mansoni nuclear receptor 0.0068 0.1149 0.1149
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.133 0.133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1816 0.1816
Echinococcus granulosus calcium activated potassium channel 0.002 0.0076 0.0076
Echinococcus multilocularis voltage dependent calcium channel 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Schistosoma mansoni caspase-3 (C14 family) 0.0116 0.2201 0.2201
Trypanosoma brucei Metacaspase-4 0.0044 0.0609 0.1874
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0076 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0145 0.2839 0.2839
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.002 0.0076 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Brugia malayi cation channel family protein 0.002 0.0076 0.0076
Schistosoma mansoni two-pore calcium channel 0.002 0.0076 0.0076
Echinococcus granulosus nuclear receptor nhr 48 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0145 0.2839 0.2839
Brugia malayi Transient-receptor-potential like protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0145 0.2839 0.2839
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0076 0.0076
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0076 0.0076
Trypanosoma cruzi metacaspase, putative 0.0044 0.0609 0.1874
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0145 0.2839 0.2839
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0076 0.0076
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0487 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0076 0.0076
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Brugia malayi nuclear receptor NHR-67 0.0068 0.1149 0.1149
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0076 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0689 0.0689
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Echinococcus granulosus potassium large conductance calcium activated 0.002 0.0076 0.0076
Leishmania major hypothetical protein, conserved 0.002 0.0076 0.0845
Schistosoma mansoni hypothetical protein 0.0041 0.0542 0.0542
Echinococcus granulosus two pore calcium channel protein 2 0.002 0.0076 0.0076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0811
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0076 0.0076
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0076 0.0076
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.002 0.0076 0.0076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.1149 0.1149
Echinococcus multilocularis transient receptor potential gamma protein 0.002 0.0076 0.0076
Echinococcus multilocularis FTZ F1 alpha 0.0145 0.2839 0.2839
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0329 0.0329
Brugia malayi jmjC domain containing protein 0.0061 0.0989 0.0989
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.002 0.0076 0.0076
Schistosoma mansoni inositol monophosphatase 0.0038 0.0487 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Echinococcus granulosus transient receptor potential gamma protein 0.002 0.0076 0.0076
Echinococcus granulosus caspase 8 0.0044 0.0609 0.0609
Plasmodium vivax SET domain protein, putative 0.003 0.0294 0.4828
Brugia malayi Pre-SET motif family protein 0.0207 0.4197 0.4197
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.1149 0.1149
Echinococcus granulosus geminin 0.0335 0.7035 0.7035
Trypanosoma brucei metacaspase 0.0044 0.0609 0.1874
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0145 0.2839 0.2839
Schistosoma mansoni thyroid hormone receptor 0.0145 0.2839 0.2839
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0487 0.15
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0487 0.0487
Brugia malayi voltage-dependent calcium channel 0.002 0.0076 0.0076
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Brugia malayi Pre-SET motif family protein 0.003 0.0294 0.0294
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0542 0.0542
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0487 0.5169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0145 0.2839 0.2839
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0609 0.1874
Plasmodium falciparum metacaspase-like protein 0.0044 0.0609 1
Echinococcus granulosus caspase 2 0.0085 0.1511 0.1511
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.0609 0.1874
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus ecdysone induced protein 78C 0.0145 0.2839 0.2839
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.0031 0.0329 0.0329
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.133 0.133
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0068 0.1149 0.1149
Schistosoma mansoni hypothetical protein 0.0335 0.7035 0.7035
Loa Loa (eye worm) voltage-gated calcium channel 0.002 0.0076 0.0076
Echinococcus granulosus TRP transient receptor potential channel 0.002 0.0076 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.133 0.133
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.133 0.133
Brugia malayi olfactory channel protein osm-9 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.4197 0.4197
Echinococcus granulosus voltage dependent calcium channel 0.047 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0329
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0145 0.2839 0.2839
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0487 0.15
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0076 0.0076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.027 0.027
Echinococcus granulosus thyroid hormone receptor alpha 0.0068 0.1149 0.1149
Echinococcus granulosus potassium voltage gated channel subfamily C 0.002 0.0076 0.0076
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0076 0.0076
Trypanosoma cruzi metacaspase, putative 0.0044 0.0609 0.1874
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0068 0.1149 0.1149
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0076 0.0076
Brugia malayi follicle stimulating hormone receptor 0.0243 0.4991 0.4991
Onchocerca volvulus Bile acid receptor homolog 0.0145 0.2839 0.5817
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus ryanodine receptor 44f 0.002 0.0076 0.0076
Brugia malayi cation channel family protein 0.002 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Brugia malayi nuclear hormone receptor 0.0145 0.2839 0.2839
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0689 0.0689
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0329
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2237 0.2237
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0145 0.2839 0.2839
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0076 0.0076
Schistosoma mansoni transient receptor potential channel 0.002 0.0076 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2237 0.2237
Onchocerca volvulus Protein ultraspiracle homolog 0.0145 0.2839 0.5817
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.9959 0.9959
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0896 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Brugia malayi nuclear hormone receptor family member odr-7 0.0068 0.1149 0.1149
Trypanosoma cruzi metacaspase, putative 0.0044 0.0609 0.1874
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0989 0.0989
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0049
Echinococcus granulosus neuropeptide s receptor 0.0468 0.9959 0.9959
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Brugia malayi orphan nuclear receptor NR2E1 0.0068 0.1149 0.1149
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.047 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0077 0.133 0.133
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0049 0.0049
Schistosoma mansoni 60S ribosomal protein L21 0.002 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0077 0.133 0.133
Brugia malayi Cell death protein 3 precursor 0.0085 0.1511 0.1511
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0076 0.0233
Schistosoma mansoni transient receptor potential channel 4 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0294 0.0294
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0145 0.2839 0.2839
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0487 1
Leishmania major hypothetical protein, unknown function 0.002 0.0076 0.0845
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0145 0.2839 0.2839
Echinococcus multilocularis ecdysone induced protein 78C 0.0145 0.2839 0.2839
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1816 0.1816
Trypanosoma cruzi metacaspase, putative 0.0044 0.0609 0.1874
Toxoplasma gondii hypothetical protein 0.002 0.0076 0.0233
Echinococcus granulosus short transient receptor potential channel 6 0.002 0.0076 0.0076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0145 0.2839 0.5817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0145 0.2839 0.2839
Schistosoma mansoni vesicular amine transporter 0.002 0.0076 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Loa Loa (eye worm) voltage-dependent calcium channel 0.0164 0.3249 0.3249
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0329 0.0329
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Onchocerca volvulus 0.0235 0.4826 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0329 0.0329
Brugia malayi nuclear hormone receptor family member nhr-6 0.0068 0.1149 0.1149
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0076 0.0076
Schistosoma mansoni transient receptor potential channel 0.002 0.0076 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0145 0.2839 0.2839
Echinococcus multilocularis caspase 3 0.0072 0.1233 0.1233
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0294 0.0294
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.4991 0.4991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0041 0.0542 0.0542
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0049 0.0152
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0076 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0329 0.0329
Echinococcus multilocularis GPCR, family 2 0.0031 0.0329 0.0329
Loa Loa (eye worm) calcium channel 0.047 1 1
Schistosoma mansoni transient receptor potential channel 0.002 0.0076 0.0076
Echinococcus multilocularis voltage gated hydrogen channel 1 0.002 0.0076 0.0076
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.002 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0294 0.0294
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0487 0.5435
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0294 0.0294
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0329 0.0329
Schistosoma mansoni zinc finger protein 0.0068 0.1149 0.1149
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0076 0.0076
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.1149 0.1149
Echinococcus granulosus shaker cognate 0.002 0.0076 0.0076
Echinococcus multilocularis calcium activated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.133 0.133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0145 0.2839 0.2839
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0487 0.0916
Brugia malayi Nuclear hormone receptor E75 0.0068 0.1149 0.1149
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Echinococcus multilocularis caspase 2 0.0085 0.1511 0.1511
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0896 0.0896
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0609 0.1874
Brugia malayi nuclear receptor NHR-88 0.0145 0.2839 0.2839
Schistosoma mansoni inositol 145-trisphosphate receptor 0.002 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0335 0.7035 0.7035
Loa Loa (eye worm) hypothetical protein 0.0077 0.133 0.133
Trypanosoma brucei metacaspase MCA2 0.0044 0.0609 0.1874
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0609 0.1171
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0076 0.0076
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Echinococcus multilocularis ryanodine receptor 44f 0.002 0.0076 0.0076
Echinococcus multilocularis nuclear receptor nhr 48 0.0068 0.1149 0.1149
Loa Loa (eye worm) steroid hormone receptor 0.0145 0.2839 0.2839
Echinococcus granulosus potassium voltage gated channel subfamily A 0.002 0.0076 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0044 0.0609 0.0609
Brugia malayi nuclear hormone receptor 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0099 0.1816 0.1816
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1128 0.1128
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0068 0.1149 0.1149
Trypanosoma brucei metacaspase MCA3 0.0044 0.0609 0.1874
Echinococcus granulosus sodium channel protein 0.002 0.0076 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.9959 0.9959
Loa Loa (eye worm) DR-78 0.0068 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0049 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Echinococcus granulosus hypothetical protein 0.002 0.0076 0.0076
Echinococcus multilocularis geminin 0.0335 0.7035 0.7035
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0145 0.2839 0.2839
Onchocerca volvulus 0.0145 0.2839 0.5817
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0487 0.0916
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.1149 0.226
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0989 0.0989
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0989 0.0989
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0145 0.2839 0.2839
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0145 0.2839 0.2839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0689 0.0689
Onchocerca volvulus 0.0068 0.1149 0.226
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0076 0.0076
Echinococcus granulosus voltage gated hydrogen channel 1 0.002 0.0076 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0145 0.2839 0.2839
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0049 0.0049
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0294 0.0294
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0487 0.15
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0145 0.2839 0.2839
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0145 0.2839 0.2839
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0076 0.0233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0689 0.0689
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0076 0.0076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.1149 0.1149
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0329
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.002 0.0076 0.0076
Echinococcus multilocularis caspase 8 0.0044 0.0609 0.0609
Schistosoma mansoni voltage-dependent calcium channel 0.002 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Brugia malayi tailless protein 0.0068 0.1149 0.1149
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Brugia malayi conserved hypotetical protein 0.0068 0.1149 0.1149
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.002 0.0076 0.0076
Schistosoma mansoni caspase-7 (C14 family) 0.0116 0.2201 0.2201
Loa Loa (eye worm) hypothetical protein 0.0164 0.3249 0.3249
Onchocerca volvulus Cell death protein 3 homolog 0.0085 0.1511 0.3021
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0076 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0145 0.2839 0.2839
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.0609 0.1874
Plasmodium vivax metacaspase 1, putative 0.0044 0.0609 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0076
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.002 0.0076 0.0076
Brugia malayi hypothetical protein 0.0077 0.133 0.133
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0076 0.0076
Schistosoma mansoni nuclear receptor nhr-48 0.0068 0.1149 0.1149
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Brugia malayi ion channel NompC 0.002 0.0076 0.0076
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0076 0.0076
Brugia malayi jmjC domain containing protein 0.0061 0.0989 0.0989
Echinococcus granulosus FTZ F1 alpha 0.0145 0.2839 0.2839
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0076 0.0076
Echinococcus granulosus sodium leak channel non selective protein 0.002 0.0076 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0989 0.0989
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0076 0.0076
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0068 0.1149 0.1149
Schistosoma mansoni thyroid hormone receptor 0.0145 0.2839 0.2839
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.2839 0.2839
Brugia malayi steroid hormone receptor 0.0145 0.2839 0.2839
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.0609 0.1171
Schistosoma mansoni nuclear hormone receptor 0.0068 0.1149 0.1149
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0164 0.3249 1
Schistosoma mansoni voltage-gated cation channel 0.047 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0068 0.1149 0.1149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0145 0.2839 0.2839

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.05 nM Antagonist activity at P2Y1 receptor in washed human platelets assessed as 1 uM 2-methylthio-ADP-induced calcium flux by FLIPR assay ChEMBL. 24931384
IC50 (binding) = 0.61 uM Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 10 uM ADP-induced platelet aggregation preincubated for 1 min followed by ADP induction measured at 5 mins by aggregometric analysis ChEMBL. 24931384
Stabilty (ADMET) = 47 % Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 uM after 10 mins ChEMBL. 24931384
Stabilty (ADMET) = 54 % Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 uM after 10 mins ChEMBL. 24931384

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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