Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | mbt repeat family protein | 0.0268 | 0.3004 | 0.58 |
Echinococcus multilocularis | chromobox protein 2 | 0.0191 | 0.2047 | 0.3441 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0374 | 0.4308 | 0.7239 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1109 | 0.2142 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0124 | 0.1218 | 0.5 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0258 | 0.2874 | 0.483 |
Plasmodium vivax | JmjC domain containing protein | 0.0028 | 0.0025 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0093 | 0.0828 | 0.16 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1109 | 0.2142 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0133 | 0.1324 | 0.2556 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0093 | 0.0828 | 0.1392 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.2517 | 0.4229 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.5179 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0268 | 0.3004 | 0.58 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0111 | 0.1049 | 0.1762 |
Echinococcus granulosus | chromobox protein 2 | 0.0191 | 0.2047 | 0.3441 |
Onchocerca volvulus | 0.0293 | 0.3307 | 0.62 | |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0111 | 0.1049 | 0.1762 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0444 | 0.5179 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0318 | 0.3615 | 0.6074 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0028 | 0.0025 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.009 | 0.0795 | 0.1336 |
Echinococcus granulosus | neuropeptide s receptor | 0.0455 | 0.5321 | 0.8941 |
Brugia malayi | mbt repeat family protein | 0.0444 | 0.5179 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0093 | 0.0828 | 0.16 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0506 | 0.5951 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0124 | 0.1218 | 0.2047 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0455 | 0.5321 | 0.8941 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0124 | 0.1218 | 0.2352 |
Brugia malayi | hypothetical protein | 0.0229 | 0.2517 | 0.486 |
Onchocerca volvulus | 0.0146 | 0.1491 | 0.2511 | |
Schistosoma mansoni | phd finger protein | 0.004 | 0.0165 | 0.0165 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0093 | 0.0828 | 0.1392 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0124 | 0.1218 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0075 | 0.0608 | 0.1022 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0455 | 0.5321 | 0.8941 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0124 | 0.1218 | 0.2047 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0124 | 0.1218 | 0.2047 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0093 | 0.0828 | 0.1392 |
Brugia malayi | P38 map kinase family protein 2 | 0.0124 | 0.1218 | 0.2352 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1491 | 0.2879 |
Brugia malayi | jmjC domain containing protein | 0.0133 | 0.1324 | 0.2556 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.009 | 0.0795 | 0.0795 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0374 | 0.4308 | 0.4308 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0318 | 0.3615 | 0.6074 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.2517 | 0.4229 |
Echinococcus multilocularis | histone acetyltransferase myst3 | 0.004 | 0.0165 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1491 | 0.2879 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0828 | 0.16 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0124 | 0.1218 | 0.2047 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0254 | 0.0254 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.009 | 0.0795 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.3615 | 0.3615 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0254 | 0.0254 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0455 | 0.5321 | 0.8941 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0258 | 0.2874 | 0.2874 |
Schistosoma mansoni | chromobox protein | 0.0191 | 0.2047 | 0.2047 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0258 | 0.2874 | 0.2874 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0124 | 0.1218 | 0.2047 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0124 | 0.1218 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0093 | 0.0828 | 0.1392 |
Toxoplasma gondii | PLU-1 family protein | 0.0043 | 0.0204 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0506 | 0.5951 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0124 | 0.1218 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0093 | 0.0828 | 0.0828 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0124 | 0.1218 | 0.2047 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0258 | 0.2874 | 0.483 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0374 | 0.4308 | 0.7239 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1109 | 0.2142 |
Echinococcus granulosus | histone acetyltransferase myst3 | 0.004 | 0.0165 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.2517 | 0.486 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0254 | 0.0491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.