Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0829 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3719 | 0.4609 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.7878 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0168 | 0.0006 | 0.0006 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0168 | 0.0006 | 0.0006 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0168 | 0.0006 | 0.0006 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3719 | 0.4609 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3719 | 0.4609 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.7878 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3719 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.1901 | 0.2252 | 0.2252 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.3719 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | serotonin transporter b | 0.0168 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0829 | 0.0862 | 0.0862 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0168 | 0.0006 | 0.0006 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0168 | 0.0006 | 0.0006 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0829 | 0.0862 | 0.0862 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0168 | 0.0006 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0168 | 0.0006 | 0.0006 |
Echinococcus granulosus | serotonin transporter | 0.0168 | 0.0006 | 0.0006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman method based spectrophotometry | ChEMBL. | 25036795 |
IC50 (binding) | = 1500 nM | Inhibition of equine serum BuChE using butyrylthiocholine iodide substrate by Ellman method based spectrophotometry | ChEMBL. | 25036795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.