TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.409 | Formula: C21H20N4O3
H donors: 3 H acceptors: 3 LogP: 2.92 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)Nc1ncc(c(c1)Oc1ccccc1)C(=O)Nc1ccccc1
InChi: 1S/C21H20N4O3/c1-2-22-21(27)25-19-13-18(28-16-11-7-4-8-12-16)17(14-23-19)20(26)24-15-9-5-3-6-10-15/h3-14H,2H2,1H3,(H,24,26)(H2,22,23,25,27)
InChiKey: UYNXGJLIGHDSLP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	DNA gyrase, subunit B		References
Escherichia coli	DNA gyrase (type II topoisomerase), subunit A		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	Get druggable targets OG5_128755	All targets in OG5_128755
Plasmodium falciparum	DNA gyrase subunit B	Get druggable targets OG5_128755	All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	Get druggable targets OG5_129568	All targets in OG5_129568
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	Get druggable targets OG5_129568	All targets in OG5_129568
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Plasmodium yoelii	DNA topoisomerase II, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	Get druggable targets OG5_128755	All targets in OG5_128755
Leishmania braziliensis	mitochondrial DNA topoisomerase II	Get druggable targets OG5_128755	All targets in OG5_128755
Leishmania major	mitochondrial DNA topoisomerase II	Get druggable targets OG5_128755	All targets in OG5_128755
Chlamydia trachomatis	DNA gyrase subunit B	Get druggable targets OG5_128755	All targets in OG5_128755
Chlamydia trachomatis	DNA gyrase subunit A	Get druggable targets OG5_129568	All targets in OG5_129568
Babesia bovis	DNA gyrase subunit B, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Plasmodium falciparum	DNA gyrase subunit A	Get druggable targets OG5_129568	All targets in OG5_129568
Plasmodium vivax	DNA gyrase subunit A, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Leishmania infantum	mitochondrial DNA topoisomerase II	Get druggable targets OG5_128755	All targets in OG5_128755
Babesia bovis	DNA gyrase A subunit, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	Get druggable targets OG5_128755	All targets in OG5_128755
Treponema pallidum	DNA gyrase, subunit A (gyrA)	Get druggable targets OG5_129568	All targets in OG5_129568
Trypanosoma brucei	DNA topoisomerase ii	Get druggable targets OG5_128755	All targets in OG5_128755
Plasmodium yoelii	DNA gyrase subunit a-related	Get druggable targets OG5_129568	All targets in OG5_129568
Plasmodium knowlesi	DNA gyrase subunit B, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Mycobacterium ulcerans	DNA gyrase subunit B	Get druggable targets OG5_128755	All targets in OG5_128755
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	Get druggable targets OG5_129568	All targets in OG5_129568
Leishmania donovani	mitochondrial DNA topoisomerase II	Get druggable targets OG5_128755	All targets in OG5_128755
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Theileria parva	DNA gyrase subunit B, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Leishmania mexicana	mitochondrial DNA topoisomerase II	Get druggable targets OG5_128755	All targets in OG5_128755
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	Get druggable targets OG5_128755	All targets in OG5_128755
Mycobacterium ulcerans	DNA gyrase subunit A	Get druggable targets OG5_129568	All targets in OG5_129568
Trypanosoma congolense	DNA topoisomerase II, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Treponema pallidum	DNA gyrase, subunit B (gyrB)	Get druggable targets OG5_128755	All targets in OG5_128755
Trypanosoma brucei gambiense	DNA topoisomerase II, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Theileria parva	DNA gyrase subunit A, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Plasmodium berghei	DNA gyrase subunit A, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Neospora caninum	hypothetical protein	Get druggable targets OG5_128755	All targets in OG5_128755
Plasmodium knowlesi	DNA gyrase subunit A, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Plasmodium berghei	DNA gyrase subunit B, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Neospora caninum	DNA gyrase subunit A, putative	Get druggable targets OG5_129568	All targets in OG5_129568
Plasmodium vivax	DNA gyrase subunit B, putative	Get druggable targets OG5_128755	All targets in OG5_128755
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	Get druggable targets OG5_129568	All targets in OG5_129568

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0843	0.0819
Plasmodium falciparum	DNA gyrase subunit B	0.0153	0.0477	0.2735
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Echinococcus multilocularis	cathepsin b	0.1928	1	1
Echinococcus multilocularis	cathepsin L	0.0115	0.0275	0.025
Entamoeba histolytica	cysteine protease, putative	0.0376	0.1676	1
Echinococcus multilocularis	cysteine protease	0.0376	0.1676	0.1654
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1928	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.0843	0.4952
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0115	0.0275	0.151
Giardia lamblia	Cysteine protease	0.0115	0.0275	0.0837
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.0275	0.025
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0843	0.0819
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.1108	0.3322
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0115	0.0275	0.151
Brugia malayi	Cathepsin L-like cysteine proteinase	0.027	0.1108	0.1085
Giardia lamblia	Cathepsin B precursor	0.0676	0.3283	1
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.0843	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0115	0.0275	0.151
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0115	0.0275	0.025
Onchocerca volvulus		0.0376	0.1676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0376	0.1676	0.5066
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.0275	0.0765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Giardia lamblia	Cathepsin B precursor	0.0115	0.0275	0.0837
Giardia lamblia	Cysteine protease	0.0115	0.0275	0.0837
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.0275	0.0837
Onchocerca volvulus	Cathepsin L homolog	0.0115	0.0275	0.151
Plasmodium vivax	unspecified product	0.0106	0.0225	0.1208
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.0275	0.0765
Chlamydia trachomatis	DNA gyrase subunit B	0.0153	0.0477	0.2419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Entamoeba histolytica	cysteine proteinase, putative	0.027	0.1108	0.6558
Plasmodium vivax	DNA gyrase subunit A, putative	0.0318	0.1362	0.8098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Plasmodium falciparum	serine repeat antigen 7	0.0115	0.0275	0.151
Onchocerca volvulus		0.0376	0.1676	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.0275	0.0837
Leishmania major	cathepsin L-like protease	0.0376	0.1676	0.4598
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Onchocerca volvulus		0.0376	0.1676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Entamoeba histolytica	cysteine proteinase, putative	0.0376	0.1676	1
Onchocerca volvulus		0.0115	0.0275	0.151
Trypanosoma cruzi	cysteine peptidase, putative	0.0376	0.1676	0.1484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0376	0.1676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0115	0.0275	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Toxoplasma gondii	cathepsin CPC2	0.0115	0.0275	0.0765
Giardia lamblia	Hypothetical protein	0.0115	0.0275	0.0837
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.0275	0.025
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.0275	0.025
Onchocerca volvulus		0.0376	0.1676	1
Brugia malayi	Papain family cysteine protease containing protein	0.0221	0.0843	0.0819
Trypanosoma cruzi	cysteine proteinase, putative	0.0221	0.0843	0.0632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Loa Loa (eye worm)	cysteine protease	0.0376	0.1676	0.1654
Plasmodium vivax	vivapain-2	0.0376	0.1676	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Giardia lamblia	Cathepsin B precursor	0.0676	0.3283	1
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0152	0.047	0.5
Plasmodium falciparum	serine repeat antigen 6	0.0115	0.0275	0.151
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0115	0.0275	0.151
Brugia malayi	cathepsin L-like precursor	0.027	0.1108	0.1085
Echinococcus granulosus	cathepsin l1	0.027	0.1108	0.1085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.0275	0.0765
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0376	0.1676	0.1654
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0115	0.0275	0.0837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.0843	0.1798
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.1923	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Plasmodium falciparum	serine repeat antigen 8	0.0115	0.0275	0.151
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0318	0.1362	1
Echinococcus granulosus	cathepsin L	0.0221	0.0843	0.0819
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1928	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.027	0.1108	0.3322
Schistosoma mansoni	cathepsin F (C01 family)	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.0843	0.2509
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0221	0.0843	0.0632
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.0275	0.025
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0225	0.02
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0225	0.02
Onchocerca volvulus		0.0376	0.1676	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.1108	0.1085
Echinococcus multilocularis	cathepsin b	0.1928	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0115	0.0275	0.025
Plasmodium vivax	DNA gyrase subunit B, putative	0.0153	0.0477	0.2735
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1928	1	1
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0115	0.0275	0.0765
Giardia lamblia	Cathepsin B precursor	0.0115	0.0275	0.0837
Schistosoma mansoni	cathepsin F (C01 family)	0.0376	0.1676	0.1654
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Trypanosoma cruzi	major cysteine proteinase, putative	0.0115	0.0275	0.0051
Toxoplasma gondii	cathepsin B	0.0676	0.3283	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.0275	0.025
Brugia malayi	cathepsin F-like cysteine proteinase	0.0115	0.0275	0.025
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0115	0.0275	0.151
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0106	0.0225	0.02
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0843	0.0819
Leishmania major	cathepsin L-like protease	0.0376	0.1676	0.4598
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.0275	0.0837
Plasmodium falciparum	serine repeat antigen 3	0.0115	0.0275	0.151
Onchocerca volvulus	Cathepsin L homolog	0.0376	0.1676	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Entamoeba histolytica	cysteine proteinase 1, putative	0.0221	0.0843	0.4952
Echinococcus granulosus	cathepsin b	0.1928	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.0275	0.025
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0376	0.1676	1
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0376	0.1676	0.5066
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0221	0.0843	0.4952
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0115	0.0275	0.151
Toxoplasma gondii	cathepsin CPL	0.0376	0.1676	0.5066
Echinococcus multilocularis	cathepsin L cysteine protease	0.0376	0.1676	0.1654
Plasmodium falciparum	serine repeat antigen 2	0.0115	0.0275	0.151
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.1923	0.1737
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0115	0.0275	0.151
Brugia malayi	Papain family cysteine protease containing protein	0.0221	0.0843	0.0819
Leishmania major	cathepsin L-like protease	0.0376	0.1676	0.4598
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0676	0.3283	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.0275	0.025
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Brugia malayi	fibroinase precursor	0.0115	0.0275	0.025
Plasmodium vivax	vivapain-2	0.0376	0.1676	1
Loa Loa (eye worm)	fibroinase	0.0376	0.1676	0.1654
Plasmodium vivax	vivapain-1	0.0221	0.0843	0.4952
Giardia lamblia	Cathepsin L-like protease	0.0115	0.0275	0.0837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Plasmodium falciparum	serine repeat antigen 1	0.0115	0.0275	0.151
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0376	0.1676	0.1654
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0115	0.0275	0.025
Loa Loa (eye worm)	hypothetical protein	0.027	0.1108	0.1085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.0275	0.025
Giardia lamblia	Encystation-specific protease	0.0115	0.0275	0.0837
Echinococcus granulosus	cathepsin L cysteine protease	0.0221	0.0843	0.0819
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0318	0.1362	0.4103
Plasmodium falciparum	serine repeat antigen 9	0.0115	0.0275	0.151
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Loa Loa (eye worm)	cathepsin B	0.0676	0.3283	0.3265
Brugia malayi	Cathepsin L-like precursor	0.027	0.1108	0.1085
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0376	0.1676	0.1654
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1928	1	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0115	0.0275	0.151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0115	0.0275	0.151
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0115	0.0275	0.151
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Plasmodium vivax	unspecified product	0.0115	0.0275	0.151
Entamoeba histolytica	cysteine proteinase 2	0.0221	0.0843	0.4952
Onchocerca volvulus	Cathepsin L homolog	0.0376	0.1676	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0115	0.0275	0.151
Entamoeba histolytica	cysteine proteinase, putative	0.0376	0.1676	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0317	0.1355	0.1156
Plasmodium falciparum	serine repeat antigen 4	0.0115	0.0275	0.151
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0676	0.3283	0.3128
Leishmania major	cathepsin L-like protease	0.0422	0.1923	0.5428
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.0843	0.2509
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0115	0.0275	0.0765
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0115	0.0275	0.025
Loa Loa (eye worm)	hypothetical protein	0.1928	1	1
Entamoeba histolytica	hypothetical protein	0.0115	0.0275	0.151
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1928	1	1
Echinococcus multilocularis	cathepsin L	0.0221	0.0843	0.0819
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0676	0.3283	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0376	0.1676	0.1654
Onchocerca volvulus		0.0376	0.1676	1
Brugia malayi	Papain family cysteine protease containing protein	0.0376	0.1676	0.1654
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.1923	0.1737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.0275	0.0765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0318	0.1362	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0121	0.0308	0.0085
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Echinococcus granulosus	cathepsin l1	0.0376	0.1676	0.1654
Toxoplasma gondii	cathepsin CPC1	0.0115	0.0275	0.0765
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.0275	0.0765
Onchocerca volvulus	Cathepsin F homolog	0.0376	0.1676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0318	0.1362	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0376	0.1676	0.1654
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0115	0.0275	0.151
Giardia lamblia	Cysteine protease	0.0115	0.0275	0.0837
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0376	0.1676	1
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1676	0.1654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Trypanosoma cruzi	cysteine protease, putative	0.0221	0.0843	0.0632
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0088	0.0131	0.0323
Echinococcus granulosus	cysteine protease	0.0221	0.0843	0.0819
Plasmodium vivax	vivapain-3	0.0221	0.0843	0.4952
Loa Loa (eye worm)	hypothetical protein	0.027	0.1108	0.1085
Leishmania major	cathepsin L-like protease	0.0422	0.1923	0.5428
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.0275	0.0765
Brugia malayi	cathepsin F-like cysteine proteinase	0.0106	0.0225	0.02
Plasmodium vivax	serine-repeat antigen (SERA)	0.0115	0.0275	0.151
Giardia lamblia	Hypothetical protein	0.0115	0.0275	0.0837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Giardia lamblia	Cathepsin B precursor	0.0115	0.0275	0.0837
Plasmodium vivax	unspecified product	0.0221	0.0843	0.4952
Onchocerca volvulus		0.0376	0.1676	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0115	0.0275	0.151
Brugia malayi	Cathepsin L-like precursor	0.027	0.1108	0.1085
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0106	0.0225	0.02
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Chlamydia trachomatis	DNA gyrase subunit A	0.0318	0.1362	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.0275	0.0765
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0676	0.3283	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0115	0.0275	0.151
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.0275	0.025
Giardia lamblia	Cysteine protease	0.0115	0.0275	0.0837
Trypanosoma cruzi	cysteine proteinase, putative	0.0221	0.0843	0.0632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Echinococcus granulosus	cathepsin L	0.0115	0.0275	0.025
Leishmania major	cysteine peptidase A (CPA)	0.0376	0.1676	0.4598
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0275	0.025
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Giardia lamblia	Cathepsin L-like protease	0.0115	0.0275	0.0837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.0275	0.0837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.1923	0.5428
Echinococcus granulosus	cathepsin b	0.1928	1	1
Leishmania major	cathepsin L-like protease	0.0376	0.1676	0.4598
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.0843	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Loa Loa (eye worm)	ctsf protein	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0225	0.02
Schistosoma mansoni	cathepsin C	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Giardia lamblia	Cathepsin B precursor	0.0115	0.0275	0.0837
Schistosoma mansoni	cathepsin S (C01 family)	0.0115	0.0275	0.025
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0225	0.02
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.0275	0.025
Schistosoma mansoni	cathepsin s	0.0106	0.0225	0.02
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.0275	0.0765
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0115	0.0275	0.0765
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0115	0.0275	0.151
Mycobacterium ulcerans	DNA gyrase subunit A	0.0318	0.1362	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0221	0.0843	0.0632
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.0843	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0275	0.0765
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Brugia malayi	cathepsin L precursor	0.0115	0.0275	0.025
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.0275	0.0765
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0121	0.0308	0.0085
Trypanosoma cruzi	major cysteine proteinase, putative	0.0161	0.0522	0.0304
Plasmodium falciparum	DNA gyrase subunit A	0.0318	0.1362	0.8098
Leishmania major	cathepsin L-like protease	0.0376	0.1676	0.4598
Schistosoma mansoni	cathepsin F (C01 family)	0.027	0.1108	0.1085
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0115	0.0275	0.025
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Giardia lamblia	Cathepsin B precursor	0.0676	0.3283	1
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0376	0.1676	0.5066
Brugia malayi	Cathepsin L-like precursor	0.0376	0.1676	0.1654
Echinococcus multilocularis	cathepsin L cysteine protease	0.0376	0.1676	0.1654
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0676	0.3283	0.3265
Onchocerca volvulus		0.027	0.1108	0.6558
Schistosoma mansoni	cathepsin B (C01 family)	0.0115	0.0275	0.025
Giardia lamblia	Cathepsin L precursor	0.0115	0.0275	0.0837
Leishmania major	cathepsin L-like protease	0.0422	0.1923	0.5428
Entamoeba histolytica	cysteine protease, putative	0.0115	0.0275	0.151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.0843	0.1798
Plasmodium falciparum	serine repeat antigen 5	0.0115	0.0275	0.151
Trypanosoma cruzi	cruzipain precursor, putative	0.0422	0.1923	0.1737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0115	0.0275	0.0765
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Entamoeba histolytica	cysteine protease, putative	0.0221	0.0843	0.4952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.1676	0.5066
Plasmodium vivax	serine-repeat antigen (SERA)	0.0115	0.0275	0.151
Echinococcus multilocularis	cysteine protease	0.0376	0.1676	0.1654

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.9 uM	Inhibition of Escherichia coli GyrB A2B2 subunits assessed reduction in DNA supercoiling activity by malachite green dye based by spectrophotometry	ChEMBL.	25137573

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329315

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 927181