Detailed information for compound 928788

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.518 | Formula: C24H28N6O2
  • H donors: 0 H acceptors: 4 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1cncc(c1)c1nnc2n1c1cc(ccc1nc2C)CN1CCOCC1
  • InChi: 1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
  • InChiKey: JJQZDOKXARNTKH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma Starlite/ChEMBL References
Homo sapiens phosphodiesterase 1A, calmodulin-dependent Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens phosphodiesterase 6A, cGMP-specific, rod, alpha References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 6G, cGMP-specific, rod, gamma Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 2A, cGMP-stimulated Starlite/ChEMBL References
Homo sapiens phosphodiesterase 11A Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 7A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 9A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 6D, cGMP-specific, rod, delta References
Homo sapiens phosphodiesterase 6B, cGMP-specific, rod, beta Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 6C, cGMP-specific, cone, alpha prime References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase Get druggable targets OG5_135549 All targets in OG5_135549
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium knowlesi 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Plasmodium yoelii asparagine-rich protein Get druggable targets OG5_130344 All targets in OG5_130344
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_132370 All targets in OG5_132370
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum cGMP-dependent 3',5'-cyclic phosphodiesterase, putative Get druggable targets OG5_135549 All targets in OG5_135549
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Babesia bovis 3'5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132370 All targets in OG5_132370
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase Get druggable targets OG5_132370 All targets in OG5_132370
Schistosoma japonicum cGMP-dependent 3',5'-cyclic phosphodiesterase, putative Get druggable targets OG5_135549 All targets in OG5_135549
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135549 All targets in OG5_135549
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_130344 All targets in OG5_130344
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, putative Get druggable targets OG5_130344 All targets in OG5_130344
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_135549 All targets in OG5_135549
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative Get druggable targets OG5_132370 All targets in OG5_132370
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum ko:K06927 endoribonuclease, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_135549 All targets in OG5_135549
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi hypothetical protein Get druggable targets OG5_132370 All targets in OG5_132370
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium yoelii cGMP phosphodiesterase A4, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative Get druggable targets OG5_135363 All targets in OG5_135363
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 668 aa 24.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Trypanosoma congolense cAMP-specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 656 aa 30.9 %
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 693 aa 25.3 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase phosphodiesterase 2A, cGMP-stimulated 934 aa 748 aa 27.1 %
Drosophila melanogaster Phosphodiesterase 6 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 684 aa 32.2 %
Leishmania infantum cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 671 aa 30.4 %
Trypanosoma brucei cAMP-specific phosphodiesterase phosphodiesterase 6B, cGMP-specific, rod, beta 854 aa 805 aa 25.7 %
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 666 aa 30.5 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 653 aa 23.0 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 686 aa 24.1 %
Trypanosoma brucei cAMP-specific phosphodiesterase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 661 aa 30.3 %
Leishmania mexicana cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 672 aa 30.2 %
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 689 aa 22.8 %
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 665 aa 23.5 %
Trypanosoma cruzi cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 665 aa 30.5 %
Leishmania donovani cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 671 aa 30.6 %
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 661 aa 30.3 %
Trypanosoma brucei cAMP-specific phosphodiesterase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 666 aa 30.5 %
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 686 aa 29.0 %
Leishmania braziliensis cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 674 aa 29.1 %
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 661 aa 22.7 %
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 666 aa 29.1 %
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 683 aa 27.5 %
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 682 aa 23.5 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 711 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania infantum cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 671 aa 30.6 %
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 655 aa 24.1 %
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 688 aa 29.1 %
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 671 aa 26.5 %
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 668 aa 25.7 %
Trypanosoma brucei Ras-related protein RAB2B, putative phosphodiesterase 6D, cGMP-specific, rod, delta 93 aa 81 aa 28.4 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 679 aa 26.7 %
Trypanosoma cruzi cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 668 aa 30.5 %
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 716 aa 26.0 %
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein phosphodiesterase 11A 489 aa 471 aa 34.4 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 699 aa 25.5 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 689 aa 22.8 %
Trypanosoma brucei cAMP-specific phosphodiesterase phosphodiesterase 6C, cGMP-specific, cone, alpha prime 858 aa 763 aa 27.4 %
Leishmania braziliensis cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 674 aa 29.2 %
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 712 aa 25.0 %
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 682 aa 28.9 %
Trypanosoma brucei cAMP-specific phosphodiesterase phosphodiesterase 6A, cGMP-specific, rod, alpha 860 aa 777 aa 25.9 %
Leishmania mexicana cAMP specific phosphodiesterase, putative cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A   794 aa 671 aa 30.8 %
Toxoplasma gondii FATC domain-containing protein phosphodiesterase 6G, cGMP-specific, rod, gamma 87 aa 71 aa 35.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0256 0.2622 1
Loa Loa (eye worm) hypothetical protein 0.0387 0.5252 0.5252
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0365 0.4815 0.4448
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0346 0.4419 0.8414
Echinococcus multilocularis fatty acid amide hydrolase 1 0.02 0.1505 0.015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0283 0.3169 0.5524
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.2324 0.4051
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0223 0.1961 0.0743
Mycobacterium leprae conserved hypothetical protein 0.0158 0.0678 0.5
Schistosoma mansoni fatty-acid amide hydrolase 0.02 0.1505 0.2865
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Loa Loa (eye worm) PDE1B protein 0.0346 0.4419 0.4419
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0229 0.2088 0.7962
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0539 0.8297 0.897
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0539 0.8297 0.897
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0194 0.1389 0.2884
Plasmodium falciparum GAF domain-related protein, putative 0.0158 0.0678 0.2586
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0365 0.4815 0.9168
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0223 0.1961 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0194 0.1389 0.5297
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.0342 0.4358 0.8297
Loa Loa (eye worm) hypothetical protein 0.0625 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Loa Loa (eye worm) hypothetical protein 0.05 0.7509 0.7509
Echinococcus granulosus fatty acid amide hydrolase 1 0.02 0.1505 0.015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0346 0.4419 0.3934
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0365 0.4815 1
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.2324 0.4051
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Plasmodium vivax hypothetical protein, conserved 0.0158 0.0678 0.4882
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0223 0.1961 0.0743
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0207 0.1646 0.2869
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0365 0.4815 1
Toxoplasma gondii hypothetical protein 0.0241 0.2324 0.8864
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0539 0.8297 0.8297
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0205 0.16 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0387 0.5252 0.5252
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Loa Loa (eye worm) hypothetical protein 0.0342 0.4358 0.4358
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0194 0.1389 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0365 0.4815 0.4448
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0207 0.1646 0.3419
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0346 0.4419 0.3934
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.0921 0.1606
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0131 0.0127 0.0484
Loa Loa (eye worm) hypothetical protein 0.0223 0.1961 0.1961
Echinococcus granulosus fatty acid amide hydrolase 1 0.02 0.1505 0.015
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0387 0.5252 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0223 0.1961 0.3733
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0194 0.1389 0.2884
Brugia malayi hypothetical protein 0.0342 0.4358 0.4358
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.0342 0.4358 0.7596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0256 0.2622 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0223 0.1961 0.0743
Loa Loa (eye worm) hypothetical protein 0.0256 0.2637 0.2637
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0411 0.5737 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.0921 0.1606
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Toxoplasma gondii GAF domain-containing protein 0.0158 0.0678 0.2586
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0256 0.2622 0.4992
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0194 0.1389 0.5297
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Loa Loa (eye worm) hypothetical protein 0.0415 0.5806 0.5806
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0205 0.16 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0411 0.5737 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0194 0.1389 0.2884
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0365 0.4815 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0579 0.9091 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0256 0.2622 0.1601
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0283 0.3169 0.5524
Toxoplasma gondii hypothetical protein 0.0158 0.0678 0.2586
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0365 0.4815 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0194 0.1389 0.2884
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Toxoplasma gondii hypothetical protein 0.0158 0.0678 0.2586
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0223 0.1961 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0678 0.1182
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0346 0.4419 0.4419
Brugia malayi amidase 0.02 0.1505 0.1505
Echinococcus multilocularis fatty acid amide hydrolase 1 0.02 0.1505 0.015
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0579 0.9091 1
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.5737 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0411 0.5737 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0365 0.4815 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Schistosoma mansoni amidase 0.02 0.1505 0.2865
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.2324 0.4051
Loa Loa (eye worm) hypothetical protein 0.02 0.1505 0.1505
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0256 0.2622 0.1601
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0207 0.1646 0.2869
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0283 0.3169 0.5524
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0365 0.4815 0.8394
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0365 0.4815 0.8394

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10.1 nM Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting method ChEMBL. 25221665
IC50 (binding) = 2138 nM Inhibition of human PDE11A4 expressed in Sf9 cells by scintillation counting method ChEMBL. 25221665
IC50 (binding) = 4823 nM Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE9A1 expressed in Sf9 cells by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE7A1 expressed in Sf9 cells by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE6AB expressed in Sf9 cells by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE5A3 expressed in Sf9 cells by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE4D by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE3B by scintillation counting method ChEMBL. 25221665
IC50 (binding) > 10000 nM Inhibition of human PDE1A by scintillation counting method ChEMBL. 25221665
IC50 (ADMET) > 10 uM Inhibition of CYP3A4 in human liver microsomes ChEMBL. 25221665
IC50 (ADMET) > 10 uM Inhibition of CYP2C19 in human liver microsomes ChEMBL. 25221665
IC50 (ADMET) > 10 uM Inhibition of CYP2D6 in human liver microsomes ChEMBL. 25221665
IC50 (ADMET) > 10 uM Inhibition of CYP2C9 in human liver microsomes ChEMBL. 25221665
IC50 (ADMET) > 10 uM Inhibition of CYP1A2 in human liver microsomes ChEMBL. 25221665
Stabilty (ADMET) = 0 % Stability in human liver microsomes assessed as parent compound remaining after 15 mins ChEMBL. 25221665

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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