Detailed information for compound 929755

Basic information

Technical information
  • TDR Targets ID: 929755
  • Name: propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-5- (3-furan-2-ylphenyl)-3-hydroxypent-1-enyl]-3, 5-dihydroxycyclopentyl]hept-5-enoate
  • MW: 496.635 | Formula: C30H40O6
  • H donors: 3 H acceptors: 4 LogP: 4.55 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@@H](CCc1cccc(c1)c1ccco1)O)O)C
  • InChi: 1S/C30H40O6/c1-21(2)36-30(34)13-6-4-3-5-11-25-26(28(33)20-27(25)32)17-16-24(31)15-14-22-9-7-10-23(19-22)29-12-8-18-35-29/h3,5,7-10,12,16-19,21,24-28,31-33H,4,6,11,13-15,20H2,1-2H3/b5-3-,17-16+/t24-,25-,26-,27+,28-/m1/s1
  • InChiKey: MOUSQDSBOBLWHW-LXFWEKMUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-5-[3-(2-furyl)phenyl]-3-hydroxy-pent-1-enyl]-3,5-dihydroxy-cyclopentyl]hept-5-enoate
  • (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-5-[3-(2-furyl)phenyl]-3-hydroxypent-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid isopropyl ester
  • (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-5-[3-(2-furyl)phenyl]-3-hydroxy-pent-1-enyl]-3,5-dihydroxy-cyclopentyl]hept-5-enoic acid isopropyl ester
  • propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-5-(3-furan-2-ylphenyl)-3-hydroxy-pent-1-enyl]-3,5-dihydroxy-cyclopentyl]hept-5-enoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0055 0.0054
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0055 0.0049
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0254 0.0248
Toxoplasma gondii hypothetical protein 0.0055 0.0076 0.228
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.1077 0.2392 0.2391
Schistosoma mansoni tar DNA-binding protein 0.0061 0.009 0.0089
Echinococcus multilocularis fibrillin 1 0.0029 0.0016 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0286 0.1591
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0286 0.1591
Echinococcus granulosus tissue type plasminogen activator 0.0032 0.0023 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0278 0.0276
Brugia malayi hypothetical protein 0.0108 0.0196 0.0194
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0096 0.0091
Schistosoma mansoni survival motor neuron protein 0.0242 0.05 0.0499
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0286 0.028
Brugia malayi beta-lactamase family protein 0.0148 0.0286 0.0285
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0286 0.1368
Onchocerca volvulus 0.0168 0.0332 0.0317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.003 0.0019 0.0017
Plasmodium vivax glutathione reductase, putative 0.0046 0.0055 0.0049
Brugia malayi Fibulin-1 precursor 0.0029 0.0016 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0188 0.603
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0215 0.1027
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Loa Loa (eye worm) hypothetical protein 0.1077 0.2392 0.2391
Mycobacterium tuberculosis Probable reductase 0.0105 0.0188 0.09
Onchocerca volvulus 0.1878 0.4209 0.42
Schistosoma mansoni tar DNA-binding protein 0.0061 0.009 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0286 0.1368
Loa Loa (eye worm) hypothetical protein 0.1077 0.2392 0.2391
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0242 0.05 0.0499
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0188 0.09
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.4432 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.009 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0188 0.09
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0944 0.2091 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.1878 0.4209 0.4209
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Brugia malayi beta-lactamase 0.0148 0.0286 0.0285
Echinococcus multilocularis microtubule associated protein 2 0.4171 0.9408 0.9408
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0286 0.1591
Brugia malayi hypothetical protein 0.4432 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0019 0.0013
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.1077 0.2392 0.2391
Brugia malayi TAR-binding protein 0.0061 0.009 0.0089
Echinococcus multilocularis peptidase Clp (S14 family) 0.0104 0.0188 0.0182
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0096 0.0095
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0096 0.3229
Trichomonas vaginalis esterase, putative 0.0148 0.0286 0.1591
Onchocerca volvulus 0.1878 0.4209 0.42
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0286 0.1591
Mycobacterium ulcerans beta-lactamase 0.0148 0.0286 0.915
Entamoeba histolytica hypothetical protein 0.0108 0.0196 1
Onchocerca volvulus 0.014 0.0269 0.0253
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0096 0.3229
Brugia malayi beta-lactamase family protein 0.0148 0.0286 0.0285
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0215 0.0214
Brugia malayi Kringle domain containing protein 0.0032 0.0023 0.0021
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Loa Loa (eye worm) hypothetical protein 0.4432 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0104 0.0188 0.0898
Onchocerca volvulus 0.0148 0.0286 0.027
Loa Loa (eye worm) doublecortin family protein 0.4432 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0096 0.3229
Brugia malayi hypothetical protein 0.1187 0.2642 0.2641
Entamoeba histolytica hypothetical protein 0.0108 0.0196 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0007 0.0032
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0061 0.009 0.0089
Plasmodium falciparum thioredoxin reductase 0.0046 0.0055 0.0049
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0096 0.0095
Schistosoma mansoni microtubule-associated protein tau 0.4171 0.9408 0.9408
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0096 0.3229
Schistosoma mansoni hypothetical protein 0.0108 0.0196 0.0194
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0196 0.019
Brugia malayi Thioredoxin reductase 0.0046 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.1077 0.2392 0.2391
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.0297 0.0295
Loa Loa (eye worm) inositol-1 0.0024 0.0006 0.0004
Echinococcus granulosus lipoxygenase domain containing protein 0.4432 1 1
Onchocerca volvulus 0.0032 0.0023 0.0006
Echinococcus granulosus tar DNA binding protein 0.0061 0.009 0.0085
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0286 0.9165
Echinococcus multilocularis lipoxygenase domain containing protein 0.4432 1 1
Onchocerca volvulus 0.4432 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0286 0.0285
Onchocerca volvulus 0.1077 0.2392 0.238
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0188 0.09
Echinococcus multilocularis tumor protein p63 0.1041 0.2312 0.2308
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0029 0.0016 0.0015
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0801 0.1768 0.1767
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0286 0.1368
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0096 0.0091
Loa Loa (eye worm) beta-lactamase 0.0148 0.0286 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0005
Schistosoma mansoni inositol monophosphatase 0.0024 0.0006 0.0004
Loa Loa (eye worm) glutathione reductase 0.0046 0.0055 0.0054
Entamoeba histolytica hypothetical protein 0.0108 0.0196 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0055 0.1612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0123 0.023 0.0229
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0286 0.0285
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0286 0.915
Brugia malayi Inositol-1 0.0024 0.0006 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0215 0.1027
Mycobacterium ulcerans lipase LipD 0.0148 0.0286 0.915
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0023 0.0608
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.1733 0.1728
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0159 0.0312 0.0307
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0032 0.0023 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0286 0.1368
Plasmodium falciparum cysteine repeat modular protein 1 0.0032 0.0023 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0061 0.009 0.0089
Echinococcus multilocularis survival motor neuron protein 1 0.1187 0.2642 0.2638
Brugia malayi RNA binding protein 0.0061 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0168 0.0332 0.0331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0159 0.0312 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0286 1
Brugia malayi hypothetical protein 0.4432 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0215 0.0214
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0029 0.0016 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.4432 1 1
Echinococcus multilocularis Tolloid protein 1 0.0029 0.0016 0.0011
Trypanosoma brucei trypanothione reductase 0.0046 0.0055 0.1762
Schistosoma mansoni inositol monophosphatase 0.0024 0.0006 0.0004
Echinococcus multilocularis tissue type plasminogen activator 0.0032 0.0023 0.0017
Echinococcus multilocularis RUN 0.4432 1 1
Loa Loa (eye worm) hypothetical protein 0.0801 0.1768 0.1767
Loa Loa (eye worm) hypothetical protein 0.1077 0.2392 0.2391
Loa Loa (eye worm) hypothetical protein 0.0801 0.1768 0.1767
Brugia malayi glutathione reductase 0.0046 0.0055 0.0054
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0286 0.1368
Onchocerca volvulus 0.0148 0.0286 0.027
Echinococcus granulosus peptidase Clp S14 family 0.0104 0.0188 0.0182
Brugia malayi MH2 domain containing protein 0.0117 0.0215 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0286 0.0281
Mycobacterium tuberculosis Conserved protein 0.0148 0.0286 0.1368
Toxoplasma gondii calcium binding egf domain-containing protein 0.0029 0.0016 0.0346
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.1878 0.4209 0.4209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.0025 0.0023
Brugia malayi Protein kinase domain containing protein 0.0032 0.0023 0.0021
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.1077 0.2392 0.2391
Onchocerca volvulus 0.0242 0.05 0.0484
Schistosoma mansoni hypothetical protein 0.4432 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0055 0.0264
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.009 0.0089
Schistosoma mansoni rab6-interacting 0.4432 1 1
Plasmodium falciparum glutathione reductase 0.0046 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.1077 0.2392 0.2391
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0104 0.0188 0.6016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0133 0.0254 0.0252
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0159 0.0312 1
Mycobacterium tuberculosis Conserved protein 0.0148 0.0286 0.1368
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.1187 0.2642 0.2641
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Mycobacterium leprae Probable lipase LipE 0.0148 0.0286 0.9165
Schistosoma mansoni hypothetical protein 0.0242 0.05 0.0499
Onchocerca volvulus 0.0148 0.0286 0.027
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Brugia malayi Probable ClpP-like protease 0.0159 0.0312 0.0311
Onchocerca volvulus 0.1878 0.4209 0.42
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0286 0.1368
Schistosoma mansoni rab6-interacting 0.4432 1 1
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0061 0.009 0.0085
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0278 0.0272
Onchocerca volvulus 0.0152 0.0297 0.0281
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.0312 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0019 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0076 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0286 0.0285
Brugia malayi hypothetical protein 0.0168 0.0332 0.0331
Trichomonas vaginalis set domain proteins, putative 0.014 0.0269 0.1493
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0076 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0278 0.0276
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0104 0.0188 0.0898
Schistosoma mansoni egf-like domain protein 0.0029 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0023 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0286 0.0285
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0254 0.0248
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.1878 0.4209 0.4209
Schistosoma mansoni peptidase Clp (S14 family) 0.0159 0.0312 0.0311
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0055 0.1762
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.1077 0.2392 0.2391
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.009 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0286 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0286 0.0281
Leishmania major hypothetical protein, conserved 0.0032 0.0023 0.0608
Loa Loa (eye worm) hypothetical protein 0.0152 0.0297 0.0295
Loa Loa (eye worm) hypothetical protein 0.0159 0.0312 0.0311
Brugia malayi hypothetical protein 0.0024 0.0007 0.0005
Echinococcus granulosus laminin 0.0029 0.0016 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0055 0.0049
Mycobacterium ulcerans hypothetical protein 0.0148 0.0286 0.915
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0188 0.09
Loa Loa (eye worm) hypothetical protein 0.0148 0.0286 0.0285
Loa Loa (eye worm) TK/ROR protein kinase 0.0032 0.0023 0.0021
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0029 0.0016 0.0015
Loa Loa (eye worm) RNA binding protein 0.0061 0.009 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0061 0.009 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0019 0.0017
Onchocerca volvulus 0.1878 0.4209 0.42
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0215 0.6877
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 0.0306
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.0312 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0029 0.0016 0.0015
Onchocerca volvulus 0.1878 0.4209 0.42
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0215 0.1027
Brugia malayi hypothetical protein 0.1077 0.2392 0.2391
Echinococcus granulosus microtubule associated protein 2 0.4171 0.9408 0.9408
Onchocerca volvulus 0.1878 0.4209 0.42
Echinococcus multilocularis lipoxygenase domain containing protein 0.4432 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0159 0.0312 0.0306
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.1077 0.2392 0.2391
Schistosoma mansoni loxhd1 0.4432 1 1
Onchocerca volvulus 0.1878 0.4209 0.42
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0019 0.0013
Echinococcus granulosus RUN 0.4432 1 1
Leishmania major hypothetical protein, conserved 0.0148 0.0286 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0019 0.0013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0286 0.1368
Echinococcus granulosus lipoxygenase domain containing protein 0.4432 1 1
Entamoeba histolytica hypothetical protein 0.0108 0.0196 1
Brugia malayi LBP/BPI 0.0801 0.1768 0.1767
Echinococcus multilocularis Polycystic kidney disease protein 0.4432 1 1
Echinococcus granulosus Tolloid protein 1 0.0029 0.0016 0.0011
Schistosoma mansoni polycystin 1-related 0.4432 1 1
Echinococcus multilocularis laminin 0.0029 0.0016 0.0011
Echinococcus granulosus Polycystic kidney disease protein 0.4432 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0007 0.0029
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0076 0.2421
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0007 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0286 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0029 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.1878 0.4209 0.4209
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0035 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0019 0.0017
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0096 0.4765
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0286 0.1591
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0035 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0188 0.09
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.1878 0.4209 0.4209
Echinococcus granulosus tumor protein p63 0.1041 0.2312 0.2308
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0007 0.0032
Leishmania major trypanothione reductase 0.0046 0.0055 0.1762
Echinococcus granulosus survival motor neuron protein 1 0.1187 0.2642 0.2638
Plasmodium falciparum LCCL domain-containing protein 0.4432 1 1
Mycobacterium tuberculosis Conserved protein 0.0148 0.0286 0.1368
Loa Loa (eye worm) hypothetical protein 0.0801 0.1768 0.1767
Onchocerca volvulus 0.1878 0.4209 0.42
Onchocerca volvulus 0.0801 0.1768 0.1755
Brugia malayi Pre-SET motif family protein 0.0123 0.023 0.0229
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0055 0.0049
Onchocerca volvulus 0.4432 1 1
Brugia malayi hypothetical protein 0.1077 0.2392 0.2391
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0196 0.0194
Toxoplasma gondii calcium binding egf domain-containing protein 0.0029 0.0016 0.0346
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0286 0.915
Onchocerca volvulus 0.1077 0.2392 0.238
Trichomonas vaginalis conserved hypothetical protein 0.0801 0.1768 1
Brugia malayi hypothetical protein 0.0801 0.1768 0.1767
Schistosoma mansoni lipoxygenase 0.4432 1 1
Toxoplasma gondii kringle domain-containing protein 0.0032 0.0023 0.0557
Toxoplasma gondii ABC1 family protein 0.0148 0.0286 0.915
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.003 0.0019 0.0017

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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