Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Delta5 fatty acid desaturase | 0.0247 | 0.0758 | 0.0826 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0113 | 0.0776 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0247 | 0.0758 | 0.0726 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0247 | 0.0758 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2782 | 0.918 | 0.9177 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0247 | 0.0758 | 1 |
Leishmania major | delta-6 fatty acid desaturase | 0.0247 | 0.0758 | 0.0726 |
Brugia malayi | acyl-CoA desaturase | 0.2782 | 0.918 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0247 | 0.0758 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0247 | 0.0758 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0247 | 0.0758 | 0.0791 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0113 | 0.0086 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0247 | 0.0758 | 0.0726 |
Leishmania major | fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0034 | 0.0037 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0113 | 0.0776 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0115 | 0.0319 | 0.0347 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0247 | 0.0758 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0247 | 0.0758 | 0.5 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0247 | 0.0758 | 0.0726 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0058 | 0.0027 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Leishmania major | fatty-acid desaturase, putative | 0.3029 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Leishmania major | delta-4 fatty acid desaturase | 0.0247 | 0.0758 | 0.0726 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0198 | 0.2001 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0247 | 0.0758 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2782 | 0.918 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0247 | 0.0758 | 0.0826 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0247 | 0.0758 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0247 | 0.0758 | 0.5 |
Onchocerca volvulus | 0.3029 | 1 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2782 | 0.918 | 0.9177 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.3029 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0115 | 0.0319 | 0.0347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0113 | 0.0776 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.0758 | 0.0791 |
Brugia malayi | Fatty acid desaturase family protein | 0.0247 | 0.0758 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0319 | 0.0311 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0113 | 0.0123 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0247 | 0.0758 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0058 | 0.0064 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0247 | 0.0758 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0247 | 0.0758 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0113 | 0.0776 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0058 | 0.0064 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.0394 | 0.0394 |
Mycobacterium ulcerans | hypothetical protein | 0.0247 | 0.0758 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.0394 | 0.0394 |
Onchocerca volvulus | 0.3029 | 1 | 1 | |
Leishmania major | delta-5 fatty acid desaturase | 0.0247 | 0.0758 | 0.0726 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0113 | 0.0776 |
Leishmania major | delta-12 fatty acid desaturase | 0.0247 | 0.0758 | 0.0726 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0247 | 0.0758 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0247 | 0.0758 | 0.0791 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0058 | 0.0027 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0247 | 0.0758 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.0198 | 0.0216 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0247 | 0.0758 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0113 | 0.0776 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2782 | 0.918 | 1 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Schistosoma mansoni | fatty acid desaturase | 0.0247 | 0.0758 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0113 | 0.0776 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0247 | 0.0758 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0198 | 0.018 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0115 | 0.0319 | 0.0311 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0247 | 0.0758 | 0.0726 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.0394 | 0.0429 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2782 | 0.918 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 300 uM | Antimicrobial activity against Escherichia coli MTCC 739 incubated for 24 hrs by well diffusion method | ChEMBL. | 25304897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.