Detailed information for compound 937210

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.912 | Formula: C27H26ClNO5Se
  • H donors: 2 H acceptors: 3 LogP: 4.38 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc2c(c1)[se]c(c2c1ccc(cc1)O)C(=O)c1ccc(cc1)OCCN1CCOCC1.Cl
  • InChi: 1S/C27H25NO5Se.ClH/c29-20-5-1-18(2-6-20)25-23-10-7-21(30)17-24(23)34-27(25)26(31)19-3-8-22(9-4-19)33-16-13-28-11-14-32-15-12-28;/h1-10,17,29-30H,11-16H2;1H
  • InChiKey: LDORCSGRVYCZMS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0564 0.1824
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0084 0.0485
Plasmodium vivax CDK-related protein kinase 6, putative 0.0908 1 1
Schistosoma mansoni sugar transporter 0.003 0.0167 0.054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0417 0.1349
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0167 0.0964
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0327 0.3491 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.0862
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0541 0.1549
Plasmodium falciparum DNA topoisomerase 2 0.0291 0.3092 0.3092
Entamoeba histolytica hypothetical protein 0.0048 0.0365 0.093
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0365 0.1045
Trichomonas vaginalis glucose transporter, putative 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0328 0.1059
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0228 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0564 0.1824
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0167 0.0964
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0063 0.0532 0.0805
Loa Loa (eye worm) hypothetical protein 0.0054 0.0439 0.1421
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0573 0.1642
Giardia lamblia Hexose transporter 0.003 0.0167 0.0426
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0137 0.0348
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0284 0.1642
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1513 0.4334
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0016 0.0052
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0365 0.1045
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0052 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.3386 0.97
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0228 0.0737
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0989 0.2522
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Loa Loa (eye worm) DNA topoisomerase III 0.0016 0.0006 0.002
Schistosoma mansoni hypothetical protein 0.0038 0.0254 0.0821
Entamoeba histolytica hypothetical protein 0.0104 0.0995 0.2535
Leishmania major DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.054
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0063 0.0532 0.3069
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.1001
Loa Loa (eye worm) hypothetical protein 0.0064 0.0549 0.1776
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0564 0.1824
Brugia malayi hypothetical protein 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi glucose transporter, putative 0.003 0.0167 0.0478
Echinococcus granulosus dna polymerase kappa 0.0063 0.0541 0.1749
Onchocerca volvulus 0.003 0.0167 0.0794
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0549 0.1776
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Schistosoma mansoni glucose transport protein 0.0214 0.2226 0.7201
Entamoeba histolytica protein kinase, putative 0.0065 0.0564 0.1437
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0564 0.0564
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0052 0.0414 0.134
Leishmania major DNA polymerase eta, putative 0.0035 0.0228 0.0652
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0518 0.1677
Schistosoma mansoni protein kinase 0.0065 0.0564 0.1824
Plasmodium falciparum DNA gyrase subunit B 0.017 0.1732 0.1732
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0573 0.1642
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0541 0.1749
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0167 0.0478
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0748
Toxoplasma gondii DNA topoisomerase family protein 0.0016 0.0006 0.0009
Onchocerca volvulus 0.003 0.0167 0.0794
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0541 0.3123
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0052
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0167 0.0478
Entamoeba histolytica hypothetical protein 0.0038 0.0254 0.0647
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0051
Schistosoma mansoni transient receptor potential channel 4 0.0102 0.0973 0.3147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0254 0.0821
Giardia lamblia DNA repair protein RAD52 0.0365 0.3923 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0549 0.1776
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0327 0.3491 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0016 0.0006 0.002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0016 0.0016
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0127 0.0363
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1236 0.3997
Onchocerca volvulus 0.003 0.0167 0.0794
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Brugia malayi hypothetical protein 0.0026 0.0127 0.041
Mycobacterium ulcerans DNA topoisomerase I 0.0016 0.0006 0.0035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0016 0.0016
Onchocerca volvulus 0.003 0.0167 0.0794
Plasmodium falciparum flap endonuclease 1 0.0027 0.0137 0.0137
Onchocerca volvulus 0.0159 0.1609 0.7905
Onchocerca volvulus 0.003 0.0167 0.0794
Loa Loa (eye worm) hypothetical protein 0.0048 0.0365 0.118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0573 0.1854
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0564 0.1824
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0159 0.1609 0.5205
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0365 0.3923 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0214 0.2226 0.3373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0016 0.0051
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0063 0.0532 0.3069
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0167 0.054
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0016 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.054
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0284 0.1642
Leishmania major hypothetical protein, conserved 0.0026 0.0127 0.0363
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Giardia lamblia DINP protein human, muc B family 0.0042 0.0305 0.0778
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1513 0.4334
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0564 0.0564
Toxoplasma gondii sugar transporter ST3 0.003 0.0167 0.0253
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0052 0.0052
Echinococcus granulosus geminin 0.0178 0.1825 0.5904
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0006 0.0017
Brugia malayi Sugar transporter family protein 0.0214 0.2226 0.7201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0167 0.054
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.054
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Onchocerca volvulus 0.003 0.0167 0.0794
Trypanosoma cruzi DNA topoisomerase II, putative 0.0275 0.2916 0.8352
Echinococcus multilocularis protein patched 0.0044 0.0328 0.1059
Chlamydia trachomatis DNA gyrase subunit A 0.0063 0.0532 0.3069
Schistosoma mansoni hypothetical protein 0.0178 0.1825 0.5904
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0564 0.0564
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0063 0.0532 0.3069
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0016 0.0006 0.002
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0016 0.0006 0.0009
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma brucei unspecified product 0.0024 0.0104 0.0299
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0305 0.0875
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0016 0.0006 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0052 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0328 0.1059
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.054
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0254 0.0821
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0328 0.1059
Schistosoma mansoni flap endonuclease-1 0.0025 0.0107 0.0347
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0365 0.0365
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0564 0.0564
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.033 0.0946
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0046
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0255 0.0825
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0541 0.1549
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0267 0.0764
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0137 0.0442
Brugia malayi Sugar transporter family protein 0.003 0.0167 0.054
Trypanosoma brucei DNA topoisomerase IA, putative 0.0016 0.0006 0.0017
Plasmodium vivax hexose transporter 0.0214 0.2226 0.2226
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0586 0.1895
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0748
Loa Loa (eye worm) hypothetical protein 0.0197 0.2037 0.659
Loa Loa (eye worm) hypothetical protein 0.0064 0.0548 0.1772
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0564 0.0564
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0137 0.0348
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0167 0.0964
Loa Loa (eye worm) hypothetical protein 0.0102 0.0973 0.3147
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.054
Brugia malayi DNA topoisomerase III beta-1 0.0016 0.0006 0.002
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0573 0.1642
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0668 0.1914
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0052 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0573 0.1854
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0076 0.0678 1
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0016 0.0006 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Schistosoma mansoni sugar transporter 0.003 0.0167 0.054
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0573 0.1854
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0167 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0052 0.0167
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0051
Schistosoma mansoni ap endonuclease 0.002 0.0052 0.0167
Brugia malayi hypothetical protein 0.003 0.0167 0.054
Onchocerca volvulus 0.003 0.0167 0.0794
Schistosoma mansoni sugar transporter 0.003 0.0167 0.054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Loa Loa (eye worm) hypothetical protein 0.0118 0.1157 0.3741
Loa Loa (eye worm) hypothetical protein 0.0052 0.0417 0.1349
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0016 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0052
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0016 0.0006 0.002
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0016 0.0006 0.002
Echinococcus granulosus expressed conserved protein 0.0097 0.0919 0.2972
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0254 0.0821
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Trypanosoma brucei unspecified product 0.0057 0.0463 0.1327
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0549 0.1399
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0328 0.1059
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0549 0.1776
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0052 0.0167
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0463 0.1327
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0305 0.1763
Leishmania major DNA topoisomerase 1A 0.0016 0.0006 0.0017
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Trypanosoma cruzi DNA topoisomerase II, putative 0.0275 0.2916 0.8352
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0365 0.2107
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0167 0.054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.3386 0.97
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Chlamydia trachomatis DNA topoisomerase I 0.0016 0.0006 0.0035
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0541 0.3123
Schistosoma mansoni sugar transporter 0.003 0.0167 0.054
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0167 0.0964
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0137 0.0137
Onchocerca volvulus 0.003 0.0167 0.0794
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0137 0.0392
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.0702
Plasmodium vivax DNA gyrase subunit B, putative 0.017 0.1732 0.1732
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0035 0.0228 0.0737
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Trypanosoma brucei DNA topoisomerase ii 0.0327 0.3491 1
Loa Loa (eye worm) TOPoisomerase family member 0.0291 0.3092 1
Trypanosoma brucei glucose transporter 2A 0.0066 0.0573 0.1642
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0167 0.0964
Brugia malayi hypothetical protein 0.0038 0.0254 0.0821
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0586 0.1895
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0417 0.1349
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.3386 0.97
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.017 0.1732 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0016 0.0052
Echinococcus granulosus transient receptor potential gamma protein 0.0102 0.0973 0.3147
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0016 0.0051
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0167 0.054
Schistosoma mansoni hypothetical protein 0.0178 0.1825 0.5904
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0365 0.5386
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0573 0.1854
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.3386 0.97
Schistosoma mansoni glucose transporter 0.003 0.0167 0.054
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0564 0.0855
Plasmodium falciparum DNA topoisomerase 3, putative 0.0016 0.0006 0.0006
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0668 0.1914
Loa Loa (eye worm) sugar transporter 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.004 0.0278 0.09
Toxoplasma gondii DNA topoisomerase 2, putative 0.0291 0.3092 0.4684
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0291 0.3092 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0016 0.0052
Echinococcus granulosus transient receptor potential ion channel A 0.0099 0.0935 0.3024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.033 0.0946
Brugia malayi Cam kinase protein 1 0.0065 0.0564 0.1824
Brugia malayi Sugar transporter family protein 0.003 0.0167 0.054
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0284 0.4196
Echinococcus granulosus GPCR family 2 0.0017 0.0016 0.0051
Echinococcus multilocularis transient receptor potential ion channel A 0.0099 0.0935 0.3024
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1513 0.4334
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0024
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0668 0.1914
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Brugia malayi major facilitator superfamily protein 0.003 0.0167 0.054
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0989 0.32
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0051
Brugia malayi polk-prov protein 0.0039 0.0267 0.0862
Mycobacterium ulcerans DNA gyrase subunit A 0.0063 0.0532 0.3069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0549 0.1776
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0084 0.0485
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Giardia lamblia DNA topoisomerase II 0.0276 0.2922 0.7447
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0365 0.118
Schistosoma mansoni ap endonuclease 0.002 0.0052 0.0167
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0197 0.2034 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0127 0.0192
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0328 0.1059
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Leishmania major mitochondrial DNA topoisomerase II 0.0327 0.3491 1
Onchocerca volvulus 0.003 0.0167 0.0794
Leishmania major DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0668 0.1012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Echinococcus granulosus flap endonuclease 1 0.0027 0.0137 0.0442
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Echinococcus multilocularis rho GTPase activating protein 20 0.0016 0.0006 0.002
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0541 0.1749
Trypanosoma cruzi hexose transporter 0.0066 0.0573 0.1642
Onchocerca volvulus Putative transporter 0.003 0.0167 0.0794
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.054
Echinococcus multilocularis GPCR, family 2 0.0017 0.0016 0.0051
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0346 0.3702 0.3702
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0518 0.1677
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Onchocerca volvulus 0.003 0.0167 0.0794
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.054
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0365 0.118
Trypanosoma brucei sugar transporter, putative 0.003 0.0167 0.0478
Brugia malayi DNA topoisomerase III 0.0016 0.0006 0.002
Echinococcus granulosus General substrate transporter 0.0184 0.1889 0.6111
Loa Loa (eye worm) hypothetical protein 0.0103 0.0989 0.32
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.1487 0.4809
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0035 0.0228 0.0737
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0236 0.0677
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0564 0.1615
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0051
Schistosoma mansoni DNA polymerase eta 0.0035 0.0228 0.0737
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0052 0.0148
Trypanosoma cruzi sugar transporter, putative 0.003 0.0167 0.0478
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0006 0.0017
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.1007 0.3258
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0668 0.0668
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0549 0.1776
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0989 0.32
Trichomonas vaginalis DNA topoisomerase II, putative 0.0291 0.3092 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0278 0.09
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0365 0.118
Brugia malayi MH2 domain containing protein 0.0125 0.1236 0.3997
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.054
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0564 0.0855
Schistosoma mansoni DNA topoisomerase II 0.0291 0.3092 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0267 0.0764
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0016 0.0052
Echinococcus multilocularis General substrate transporter 0.0184 0.1889 0.6111
Schistosoma mansoni glucose transport protein 0.0214 0.2226 0.7201
Entamoeba histolytica hypothetical protein 0.0038 0.0254 0.0647
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Onchocerca volvulus 0.003 0.0167 0.0794
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0541 0.1749
Schistosoma mansoni transient receptor potential channel 0.0067 0.0586 0.1895
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.0995 0.2535
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0668 0.1914
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0255 0.0825
Leishmania major hypothetical protein, conserved 0.003 0.0167 0.0478
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0016 0.0051
Chlamydia trachomatis DNA gyrase subunit A 0.0063 0.0532 0.3069
Brugia malayi hypothetical protein 0.003 0.0167 0.054
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0046
Toxoplasma gondii sugar transporter ST1 0.003 0.0167 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0573 0.1854
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0573 0.1642
Brugia malayi Flap endonuclease-1 0.0027 0.0137 0.0442
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0564 0.0564
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.054
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0006 0.002
Entamoeba histolytica DNA topoisomerase II, putative 0.0291 0.3092 0.788
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0573 0.1642
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Mycobacterium ulcerans sugar transporter 0.003 0.0167 0.0964
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0275 0.2916 0.8352
Mycobacterium ulcerans hypothetical protein 0.0167 0.1703 0.9833
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.1001
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0006 0.002
Brugia malayi Probable DNA topoisomerase II 0.0291 0.3092 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0052 0.0297
Schistosoma mansoni terminal deoxycytidyl transferase 0.0035 0.0228 0.0737
Leishmania major glucose transporter, lmgt3 0.0066 0.0573 0.1642
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0549 0.1776
Giardia lamblia Sugar-proton symporter 0.003 0.0167 0.0426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0016 0.0046
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0006 0.0015
Schistosoma mansoni glucose transport protein 0.0214 0.2226 0.7201
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0549 0.8102
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0365 0.093
Plasmodium falciparum protein kinase 7 0.0604 0.66 0.66
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0052 0.0148
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0228 0.0737
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.1001
Loa Loa (eye worm) hypothetical protein 0.0065 0.0564 0.1824
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0052 0.0167
Giardia lamblia DNA topoisomerase III 0.0016 0.0006 0.0015
Brugia malayi GRF zinc finger family protein 0.0016 0.0006 0.002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1236 0.3997
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.2226 0.7201
Leishmania major DNA polymerase kappa, putative 0.0042 0.0305 0.0875
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0291 0.3092 1
Leishmania major glucose transporter, lmgt2 0.0066 0.0573 0.1642
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0137 0.0442
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Plasmodium falciparum DNA gyrase subunit A 0.0063 0.0532 0.0532
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma brucei unspecified product 0.0024 0.0104 0.0299
Schistosoma mansoni hypothetical protein 0.0214 0.2226 0.7201
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0573 0.1854
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0255 0.0825
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0016 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0016 0.0051
Onchocerca volvulus 0.003 0.0167 0.0794
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0989 0.32
Loa Loa (eye worm) hypothetical protein 0.004 0.0278 0.09
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0016 0.0051
Schistosoma mansoni transient receptor potential channel 0.0067 0.0586 0.1895
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.017 0.1732 0.2624
Plasmodium falciparum hexose transporter 0.0214 0.2226 0.2226
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0549 0.1399
Onchocerca volvulus 0.003 0.0167 0.0794
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0365 0.2107
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0365 0.118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0031 0.0047
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0564 0.0564
Echinococcus multilocularis dna polymerase eta 0.0035 0.0228 0.0737
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0573 0.1854
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0127 0.0127
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0299 0.0967
Schistosoma mansoni protein kinase 0.0065 0.0564 0.1824
Giardia lamblia DNA topoisomerase III 0.0016 0.0006 0.0015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0016 0.0052
Loa Loa (eye worm) hypothetical protein 0.0197 0.2037 0.659
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0365 0.2107
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0564 0.1824
Echinococcus multilocularis protein dispatched 1 0.0051 0.0398 0.1287
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0197 0.2034 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0052 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0305 0.0875
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0167 0.054
Plasmodium vivax DNA topoisomerase II, putative 0.0291 0.3092 0.3092
Loa Loa (eye worm) sugar transporter 0.0214 0.2226 0.7201
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0137 0.0207
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0439 0.1259
Chlamydia trachomatis DNA gyrase subunit B 0.0134 0.1333 0.7695
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0167 0.0964
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0564 0.1824
Schistosoma mansoni patched 1 0.0044 0.0328 0.1059
Schistosoma mansoni protein kinase 0.0065 0.0564 0.1824
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0255 0.0825
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0668 0.1914
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi hexose transporter, putative 0.003 0.0167 0.0478
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0052 0.0148
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0231 0.0748
Plasmodium vivax sugar transporter, putative 0.003 0.0167 0.0167
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0035 0.0228 0.0737
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0365 0.118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0016 0.0051
Onchocerca volvulus 0.003 0.0167 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0052 0.0167
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Brugia malayi CHE-14 protein 0.0044 0.0328 0.1059
Echinococcus multilocularis expressed conserved protein 0.0097 0.0919 0.2972
Loa Loa (eye worm) hypothetical protein 0.0035 0.0228 0.0737
Trypanosoma brucei glucose transporter 1E 0.0066 0.0573 0.1642
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.033 0.0946
Mycobacterium ulcerans DNA gyrase subunit B 0.017 0.1732 1
Leishmania major protein kinase, putative 0.0065 0.0564 0.1615
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0365 0.0365
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0127 0.0363
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.1487 0.4809
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0291 0.3092 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0564 0.1824
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.054
Entamoeba histolytica hypothetical protein 0.0038 0.0254 0.0647
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0052 0.0131
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0125 0.0405
Plasmodium vivax DNA gyrase subunit A, putative 0.0063 0.0532 0.0532
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0228 0.0652
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0084 0.0485
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0016 0.0051
Trypanosoma brucei glucose transporter, putative 0.0066 0.0573 0.1642
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.041
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0668 0.0668
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.017 0.1732 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0197 0.2034 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0137 0.0442
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0346 0.3702 0.5609
Toxoplasma gondii protein kinase, putative 0.0604 0.66 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0214 0.2226 0.7201
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0328 0.1059
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0167 0.054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.033 0.0946
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0549 0.1776
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0541 0.1549
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0016 0.0046
Brugia malayi hypothetical protein 0.0159 0.1609 0.5205
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0052 0.0052
Leishmania major glucose transporter, lmgt1 0.0066 0.0573 0.1642
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0365 0.0553
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1703 0.9833
Treponema pallidum DNA topoisomerase I (topA) 0.0016 0.0006 0.0035
Brugia malayi major facilitator superfamily protein 0.003 0.0167 0.054
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0573 0.1642
Brugia malayi hypothetical protein 0.0017 0.0022 0.007
Toxoplasma gondii sugar transporter ST2 0.003 0.0167 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0127 0.0363
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0006 0.0015
Toxoplasma gondii exonuclease III APE 0.002 0.0052 0.0078
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0564 0.0855
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0549 0.1776
Chlamydia trachomatis DNA gyrase subunit B 0.017 0.1732 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0417 0.1349
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0365 0.1045
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0167 0.0253
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.1001
Entamoeba histolytica protein kinase, putative 0.0065 0.0564 0.1437
Echinococcus granulosus dna polymerase eta 0.0035 0.0228 0.0737
Entamoeba histolytica hypothetical protein 0.0038 0.0254 0.0647
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0006 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0228 0.1315
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0573 0.1642
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0586 0.1895
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0035 0.0228 0.0737
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0052 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.054
Plasmodium falciparum mitogen-activated protein kinase 2 0.0346 0.3702 0.3702
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2226 0.7201
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0052 0.0167
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0365 0.118
Echinococcus multilocularis geminin 0.0178 0.1825 0.5904
Leishmania major DNA topoisomerase ii 0.0275 0.2916 0.8352
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0586 0.1895
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Entamoeba histolytica deoxycytidyl transferase, putative 0.0035 0.0228 0.058
Onchocerca volvulus 0.003 0.0167 0.0794
Schistosoma mansoni transient receptor potential channel 0.0102 0.0973 0.3147
Echinococcus multilocularis transient receptor potential gamma protein 0.0102 0.0973 0.3147
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0016 0.0006 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0182 0.0521
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.017 0.1732 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0291 0.3092 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.054
Plasmodium vivax DNA topoisomerase 3, putative 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0118 0.1157 0.3741
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0275 0.2916 0.8352
Toxoplasma gondii hypothetical protein 0.0051 0.0404 0.0612
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0564 0.0564
Onchocerca volvulus 0.003 0.0167 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.054

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.2 uM Cytotoxicity against mouse MG-22A cells after 72 hrs by MTT assay ChEMBL. 25282270
IC50 (functional) = 31 uM Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay ChEMBL. 25282270

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 25282270

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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