Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1751 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0039 | 0.1461 | 1 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Schistosoma mansoni | plexin | 0.0011 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | plexin A | 0.0013 | 0.035 | 0.035 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1461 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0039 | 0.1461 | 0.1751 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0039 | 0.1461 | 0.1461 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0004 | 0.0000072064 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Brugia malayi | PXA domain containing protein | 0.0039 | 0.1461 | 0.1461 |
Loa Loa (eye worm) | RGS-3 protein | 0.0039 | 0.1461 | 0.1461 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0199 | 0.8347 | 0.8347 |
Onchocerca volvulus | 0.0011 | 0.0267 | 1 | |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0004 | 0.0000072064 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0039 | 0.1461 | 0.1751 |
Trypanosoma brucei | NEK family Serine/threonine-protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0004 | 0.0000072064 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1461 |
Schistosoma mansoni | plexin | 0.0006 | 0.0075 | 0.0075 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0039 | 0.1461 | 0.1461 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1751 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0199 | 0.8347 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0238 | 1 | 1 |
Schistosoma mansoni | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | plexin a4 | 0.0013 | 0.035 | 0.042 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0004 | 0.0000072064 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0238 | 1 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1751 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Echinococcus granulosus | expressed protein | 0.0039 | 0.1461 | 0.1751 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1461 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0182 | 0.762 | 0.762 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0004 | 0.0000072064 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0004 | 0.0000072064 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0039 | 0.1461 | 0.1751 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0039 | 0.1461 | 0.1751 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0039 | 0.1461 | 0.1461 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0004 | 0.0000072064 | 0.0000086331 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0199 | 0.8347 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0199 | 0.8347 | 0.8347 |
Trypanosoma cruzi | Protein kinase B | 0.0004 | 0.0000072064 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0199 | 0.8347 | 0.8347 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0182 | 0.762 | 0.9129 |
Trypanosoma brucei | serine/threonine-protein kinase NrkA | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0039 | 0.1461 | 0.1751 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0039 | 0.1461 | 0.1751 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1751 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0004 | 0.0000072064 | 0.0000072064 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0039 | 0.1461 | 0.1751 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0182 | 0.762 | 0.762 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0039 | 0.1461 | 0.1751 |
Schistosoma mansoni | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1461 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0004 | 0.0000072064 | 0.0000072064 |
Schistosoma mansoni | hypothetical protein | 0.0006 | 0.0075 | 0.0075 |
Trypanosoma brucei | protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0039 | 0.1461 | 0.1751 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1461 |
Trypanosoma brucei | serine/threonine-protein kinase NRKB, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0039 | 0.1461 | 0.1751 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0039 | 0.1461 | 0.1461 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0039 | 0.1461 | 0.1461 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0182 | 0.762 | 0.762 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0004 | 0.0000072064 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0039 | 0.1461 | 0.1751 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0039 | 0.1461 | 0.1461 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Echinococcus multilocularis | expressed protein | 0.0039 | 0.1461 | 0.1751 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.0144 | 0.5968 | 0.7149 |
Leishmania major | folate/biopterin transporter, putative | 0.0004 | 0.0000072064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0075 | 0.0075 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1461 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1461 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0004 | 0.0000072064 | 0.0000072064 |
Brugia malayi | Plexin repeat family protein | 0.0011 | 0.0267 | 0.0267 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0182 | 0.762 | 0.9129 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0004 | 0.0000072064 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0039 | 0.1461 | 0.1461 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.1461 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0039 | 0.1461 | 0.1751 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Leishmania major | protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0004 | 0.0000072064 | 0.5 |
Echinococcus granulosus | plexin a4 | 0.0013 | 0.035 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0004 | 0.0000072064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0039 | 0.1461 | 0.1751 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.0144 | 0.5968 | 0.7149 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK21, putative | 0.0004 | 0.0000072064 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0039 | 0.1461 | 0.1461 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0039 | 0.1461 | 0.1461 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0004 | 0.0000072064 | 0.0000086331 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.1461 | 0.1461 |
Brugia malayi | PXA domain containing protein | 0.0039 | 0.1461 | 0.1461 |
Trypanosoma cruzi | serine/threonine-protein kinase NRKB, putative | 0.0004 | 0.0000072064 | 0.5 |
Brugia malayi | plexin A | 0.0013 | 0.035 | 0.035 |
Brugia malayi | Protein kinase domain containing protein | 0.0004 | 0.0000072064 | 0.0000072064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.