TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.522 | Formula: C26H25N7O2
H donors: 4 H acceptors: 4 LogP: 3.61 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2[nH]ncc2cc1Nc1ncnc2c1c1CC(CCc1[nH]2)C(=O)NCc1ccccc1
InChi: 1S/C26H25N7O2/c1-35-22-11-20-17(13-30-33-20)10-21(22)32-25-23-18-9-16(7-8-19(18)31-24(23)28-14-29-25)26(34)27-12-15-5-3-2-4-6-15/h2-6,10-11,13-14,16H,7-9,12H2,1H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
InChiKey: ZVTOPUTUABIMNX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MAP kinase interacting serine/threonine kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	Get druggable targets OG5_131958	All targets in OG5_131958
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131958	All targets in OG5_131958

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0077	0.0967	0.0683
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0297	0.5037	0.4881
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0967	0.0452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0279	0.0102
Brugia malayi	Protein kinase domain containing protein	0.05	0.8777	0.8739
Brugia malayi	Cathepsin L-like precursor	0.0383	0.6616	0.651
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0183	0.2918	0.2789
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0515	0.9065	0.9036
Echinococcus granulosus	cathepsin l1	0.0566	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1653	0.1391
Entamoeba histolytica	cysteine proteinase, putative	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.1653	0.1391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0567	0.0453
Onchocerca volvulus		0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0118	0.1712	0.1611
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trypanosoma cruzi	major cysteine proteinase, putative	0.0115	0.1653	0.15
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Echinococcus multilocularis	cathepsin L	0.0115	0.1653	0.1177
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0383	0.6616	0.6554
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0238	0.3945	0.3835
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0101	0.1397	0.1127
Entamoeba histolytica	cysteine proteinase, putative	0.0566	1	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0056	0.0567	0.0205
Plasmodium falciparum	serine repeat antigen 1	0.0115	0.1653	0.1025
Giardia lamblia	Cathepsin B precursor	0.0238	0.3945	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0297	0.5037	0.4976
Onchocerca volvulus		0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2918	0.2789
Brugia malayi	cathepsin F-like cysteine proteinase	0.0183	0.2918	0.2696
Entamoeba histolytica	cysteine protease, putative	0.0566	1	1
Loa Loa (eye worm)	FKBP5 protein	0.0063	0.0699	0.053
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0115	0.1653	0.1391
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0082	0.1049	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0967	0.0802
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0297	0.5037	0.5037
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0566	1	1
Echinococcus multilocularis	cathepsin b	0.0515	0.9065	0.9012
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0056	0.0567	0.0271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0297	0.5037	0.4976
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0297	0.5037	0.4881
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0115	0.1653	0.1025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0177	0.0057
Trichomonas vaginalis	immunophilin, putative	0.0063	0.0699	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Brugia malayi	Cathepsin L-like precursor	0.0566	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0111	0.1587	0.1322
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.1653	0.1551
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0056	0.0567	0.003
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.1653	0.15
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0121	0.0001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1653	0.1391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0567	0.0453
Plasmodium vivax	serine-repeat antigen (SERA)	0.0115	0.1653	0.1025
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0042	0.0304	0.0128
Plasmodium vivax	vivapain-2	0.0566	1	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0063	0.0699	0.5
Onchocerca volvulus		0.0566	1	1
Plasmodium vivax	vivapain-2	0.0566	1	1
Loa Loa (eye worm)	fibroinase	0.0566	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1653	0.1391
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0063	0.0699	0.053
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0056	0.0567	0.003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.1653	0.1551
Giardia lamblia	Encystation-specific protease	0.0115	0.1653	0.4051
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0218	0.3574	0.3208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0118	0.1712	0.1611
Plasmodium vivax	serine-repeat antigen (SERA)	0.0115	0.1653	0.1025
Entamoeba histolytica	hypothetical protein	0.0094	0.128	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0383	0.6616	0.6554
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0118	0.1712	0.1611
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0056	0.0567	0.0271
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0297	0.5037	0.4946
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0063	0.0699	0.1577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0369	0.0252
Echinococcus granulosus	cathepsin L	0.0115	0.1653	0.1177
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0063	0.0699	0.0407
Schistosoma mansoni	immunophilin	0.0063	0.0699	0.0407
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0056	0.0567	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Echinococcus multilocularis	cathepsin b	0.0515	0.9065	0.9012
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0063	0.0699	0.1577
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0063	0.0699	0.0169
Brugia malayi	Papain family cysteine protease containing protein	0.0297	0.5037	0.4881
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0121	0.0001
Toxoplasma gondii	cathepsin CPL	0.0566	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0115	0.1653	0.1391
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0967	0.0452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Entamoeba histolytica	hypothetical protein	0.0115	0.1653	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Plasmodium falciparum	serine repeat antigen 7	0.0115	0.1653	0.1025
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.1653	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0539	0.0366
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0063	0.0699	0.0699
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.6616	0.651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Giardia lamblia	Cysteine protease	0.0115	0.1653	0.4051
Brugia malayi	cathepsin L precursor	0.0115	0.1653	0.1391
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.6616	0.6554
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.1653	0.1551
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0115	0.1653	0.1391
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0115	0.1653	0.4051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0121	0.0001
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Brugia malayi	Cathepsin L-like precursor	0.0566	1	1
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Schistosoma mansoni	cathepsin S (C01 family)	0.0115	0.1653	0.1391
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0082	0.1049	0.0941
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0183	0.2918	0.2696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Echinococcus granulosus	cysteine protease	0.0297	0.5037	0.4754
Brugia malayi	cathepsin L-like precursor	0.0383	0.6616	0.651
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0063	0.0699	0.0586
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0297	0.5037	0.4881
Echinococcus granulosus	cathepsin l1	0.0383	0.6616	0.6423
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0238	0.3945	0.3713
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0063	0.0699	0.0169
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0218	0.3574	0.3208
Plasmodium vivax	unspecified product	0.0297	0.5037	0.4664
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1653	0.4051
Plasmodium vivax	unspecified product	0.0115	0.1653	0.1025
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.1712	0.1452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.1653	0.1551
Brugia malayi	Cathepsin L-like precursor	0.0183	0.2918	0.2696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0369	0.0252
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0297	0.5037	0.5037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0369	0.0252
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0042	0.0304	0.0186
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1653	0.1391
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0566	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0056	0.0567	0.0395
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0063	0.0699	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0567	0.0453
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.6616	0.6575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Plasmodium falciparum	serine repeat antigen 9	0.0115	0.1653	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0115	0.1653	0.1551
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0045	0.037	0.037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0566	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0028	0.0056	0.0056
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1653	0.1391
Loa Loa (eye worm)	phosphatidylinositol 3	0.0056	0.0567	0.0395
Brugia malayi	cathepsin L-like cysteine proteinase	0.0115	0.1653	0.1391
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0297	0.5037	0.4881
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0227	0.0108
Schistosoma mansoni	cathepsin C	0.0115	0.1653	0.1391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0121	0.0001
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0063	0.0699	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0566	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0056	0.0567	0.0395
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0063	0.0699	0.053
Plasmodium falciparum	serine repeat antigen 6	0.0115	0.1653	0.1025
Echinococcus multilocularis	cathepsin L	0.0297	0.5037	0.4754
Trichomonas vaginalis	fk506-binding protein, putative	0.0063	0.0699	0.0586
Trypanosoma cruzi	cysteine proteinase, putative	0.0297	0.5037	0.4946
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0238	0.3945	0.3871
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0042	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0115	0.1653	0.1378
Giardia lamblia	Hypothetical protein	0.0115	0.1653	0.4051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0171	0.0052
Trypanosoma cruzi	cysteine peptidase, putative	0.0297	0.5037	0.4946
Echinococcus granulosus	cathepsin L cysteine protease	0.0297	0.5037	0.4754
Schistosoma mansoni	cathepsin s	0.0183	0.2918	0.2696
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0218	0.3574	0.3373
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0115	0.1653	0.1025
Giardia lamblia	Cathepsin B precursor	0.0115	0.1653	0.4051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0566	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0063	0.0699	0.053
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0566	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0115	0.1653	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.1653	0.1551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Echinococcus multilocularis	cysteine protease	0.0566	1	1
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0063	0.0699	0.053
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0115	0.1653	0.1025
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0094	0.128	0.1006
Schistosoma mansoni	cathepsin F (C01 family)	0.0566	1	1
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Giardia lamblia	Cathepsin L-like protease	0.0115	0.1653	0.4051
Brugia malayi	Papain family cysteine protease containing protein	0.0297	0.5037	0.4881
Trypanosoma cruzi	cysteine protease, putative	0.0297	0.5037	0.4946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Echinococcus granulosus	cathepsin b	0.0515	0.9065	0.9012
Echinococcus multilocularis	cysteine protease	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0566	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0515	0.9065	0.9036
Onchocerca volvulus		0.0566	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0115	0.1653	0.1025
Plasmodium falciparum	serine repeat antigen 8	0.0115	0.1653	0.1025
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Plasmodium falciparum	serine repeat antigen 5	0.0115	0.1653	0.1025
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.1712	0.1561
Brugia malayi	Cathepsin L-like precursor	0.0566	1	1
Brugia malayi	Cathepsin L-like precursor	0.0566	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0115	0.1653	0.1025
Onchocerca volvulus	Cathepsin L homolog	0.0566	1	1
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0059	0.0618	0.1365
Giardia lamblia	Cysteine protease	0.0115	0.1653	0.4051
Plasmodium falciparum	serine repeat antigen 4	0.0115	0.1653	0.1025
Brugia malayi	Cathepsin L-like precursor	0.0566	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0183	0.2918	0.2789
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.1653	0.15
Plasmodium falciparum	serine repeat antigen 3	0.0115	0.1653	0.1025
Giardia lamblia	GTOR	0.0056	0.0567	0.1235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0115	0.1653	0.1551
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0056	0.0567	0.0567
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0177	0.0057
Entamoeba histolytica	cysteine proteinase, putative	0.0297	0.5037	0.4881
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1653	0.4051
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.1653	0.1551
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0056	0.0567	0.0271
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0115	0.1653	0.1025
Brugia malayi	cathepsin B-like cysteine proteinase	0.0515	0.9065	0.9036
Onchocerca volvulus		0.0566	1	1
Onchocerca volvulus		0.0383	0.6616	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1653	0.4051
Entamoeba histolytica	cysteine proteinase 1, putative	0.0297	0.5037	0.4881
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2918	0.2789
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0115	0.1653	0.1551
Schistosoma mansoni	immunophilin	0.0054	0.0539	0.0242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.6616	0.6554
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0177	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.1653	0.1551
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1653	0.1391
Brugia malayi	cathepsin F-like cysteine proteinase	0.0115	0.1653	0.1391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.1653	0.1551
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0238	0.3945	0.3945
Loa Loa (eye worm)	cathepsin B	0.0238	0.3945	0.3835
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0515	0.9065	0.9036
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0063	0.0699	0.0407
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0056	0.0567	0.0567
Giardia lamblia	Cathepsin L-like protease	0.0115	0.1653	0.4051
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0063	0.0699	0.0407
Entamoeba histolytica	cysteine proteinase, putative	0.0297	0.5037	0.4881
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1653	0.4051
Loa Loa (eye worm)	hypothetical protein	0.0515	0.9065	0.9048
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.1653	0.1391
Toxoplasma gondii	cathepsin B	0.0238	0.3945	0.3746
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0063	0.0699	0.0169
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.1712	0.1561
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0115	0.1653	0.1025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0369	0.0252
Toxoplasma gondii	cathepsin CPC2	0.0115	0.1653	0.1378
Trypanosoma cruzi	cysteine peptidase, putative	0.0566	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0183	0.2918	0.2789
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Schistosoma mansoni	immunophilin	0.0063	0.0699	0.0407
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0566	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0042	0.0304	0.0186
Toxoplasma gondii	cathepsin CPC1	0.0115	0.1653	0.1378
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0063	0.0699	0.0407
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Brugia malayi	Cathepsin L-like precursor	0.0383	0.6616	0.651
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0115	0.1653	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1653	0.15
Loa Loa (eye worm)	phosphatidylinositol 3	0.0195	0.3143	0.3017
Trypanosoma cruzi	cysteine peptidase, putative	0.0566	1	1
Plasmodium vivax	vivapain-3	0.0297	0.5037	0.4664
Entamoeba histolytica	cysteine proteinase 2	0.0297	0.5037	0.4881
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0566	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0063	0.0699	0.0586
Leishmania major	fk506-binding protein 1-like protein	0.0063	0.0699	0.0342
Echinococcus granulosus	cathepsin b	0.0515	0.9065	0.9012
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0115	0.1653	0.1391
Schistosoma mansoni	cathepsin F (C01 family)	0.0566	1	1
Plasmodium vivax	vivapain-1	0.0297	0.5037	0.4664
Leishmania major	peptidylprolyl isomerase-like protein	0.0063	0.0699	0.0342
Loa Loa (eye worm)	cysteine protease	0.0566	1	1
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.05	0.8777	0.8755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0319	0.0201
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0056	0.0567	0.0271
Giardia lamblia	Cysteine protease	0.0115	0.1653	0.4051
Trypanosoma cruzi	cysteine peptidase, putative	0.0566	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0566	1	1
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0063	0.0699	0.0699
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0118	0.1712	0.1452
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0115	0.1653	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0566	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1653	0.4051
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0297	0.5037	0.4881
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0054	0.0535	0.0238
Entamoeba histolytica	cysteine protease, putative	0.0115	0.1653	0.1391
Trypanosoma cruzi	major cysteine proteinase, putative	0.0115	0.1653	0.15
Echinococcus multilocularis	cathepsin L cysteine protease	0.0566	1	1
Giardia lamblia	Cathepsin B precursor	0.0238	0.3945	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0369	0.0252
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.1653	0.1551
Leishmania major	cysteine peptidase A (CPA)	0.0566	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0171	0.0052
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0115	0.1653	0.1025
Giardia lamblia	Hypothetical protein	0.0115	0.1653	0.4051
Trypanosoma cruzi	target of rapamycin kinase 3	0.0045	0.037	0.0194
Echinococcus multilocularis	fk506 binding protein	0.0063	0.0699	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.6616	0.6575
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2918	0.2789
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0115	0.1653	0.15
Onchocerca volvulus		0.0566	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0115	0.1653	0.1025
Giardia lamblia	Cysteine protease	0.0115	0.1653	0.4051
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.1653	0.1391
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0425	0.0309
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0115	0.1653	0.1391
Entamoeba histolytica	cysteine protease, putative	0.0297	0.5037	0.4881
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0248	0.0129
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.6616	0.651
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0566	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0115	0.1653	0.1025
Plasmodium vivax	unspecified product	0.0183	0.2918	0.2386
Giardia lamblia	Cathepsin L precursor	0.0115	0.1653	0.4051
Brugia malayi	fibroinase precursor	0.0115	0.1653	0.1391
Leishmania major	cathepsin L-like protease	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0566	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Loa Loa (eye worm)	ctsf protein	0.0566	1	1
Giardia lamblia	Cathepsin B precursor	0.0238	0.3945	1
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1653	0.1391
Trypanosoma cruzi	cruzipain precursor, putative	0.0566	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0566	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1653	0.4051
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0566	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0515	0.9065	0.9048
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0115	0.1653	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0515	0.9065	0.9036
Onchocerca volvulus		0.0566	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.3945	0.3755
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0115	0.1653	0.1551
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1653	0.1391
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0063	0.0699	0.0407
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0566	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0115	0.1653	0.1391
Trypanosoma cruzi	cysteine proteinase, putative	0.0297	0.5037	0.4946
Giardia lamblia	Cathepsin B precursor	0.0115	0.1653	0.4051
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0383	0.6616	0.651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0115	0.1653	0.1551
Echinococcus granulosus	cathepsin L	0.0297	0.5037	0.4754
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0566	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0042	0.0304	0.0186
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0297	0.5037	0.4664
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0566	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay	ChEMBL.	25589917

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3355000

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 944703