Detailed information for compound 946471

Basic information

Technical information
  • TDR Targets ID: 946471
  • Name: 2-(4-methoxyphenyl)-1,3-oxazole
  • MW: 175.184 | Formula: C10H9NO2
  • H donors: 0 H acceptors: 1 LogP: 1.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1ncco1
  • InChi: 1S/C10H9NO2/c1-12-9-4-2-8(3-5-9)10-11-6-7-13-10/h2-7H,1H3
  • InChiKey: KQGVUFHHBWEAIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-methoxyphenyl)oxazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis leucine--tRNA ligase 0.0087 0.1014 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.8561 0.8561
Brugia malayi latrophilin 2 splice variant baaae 0.0388 0.664 0.664
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Loa Loa (eye worm) hypothetical protein 0.0567 1 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0087 0.1014 0.277
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.1935 0.1935
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0229 0.366 0.5
Brugia malayi MH2 domain containing protein 0.0033 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0388 0.664 1
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Toxoplasma gondii methionyl-tRNA synthetase 0.0229 0.366 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Brugia malayi MH2 domain containing protein 0.049 0.8561 0.8561
Echinococcus granulosus GPCR family 2 0.018 0.274 0.7487
Loa Loa (eye worm) RNA binding protein 0.0137 0.1935 0.1935
Brugia malayi MH1 domain containing protein 0.0033 0.0006 0.0006
Brugia malayi Smad1 0.0033 0.0006 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.274 0.7487
Leishmania major leucyl-tRNA synthetase, putative 0.0087 0.1014 0.277
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Schistosoma mansoni smad 0.0033 0.0006 0.0009
Toxoplasma gondii tRNA ligases class I (M) protein 0.0087 0.1014 0.277
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1014 0.277
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Brugia malayi RNA binding protein 0.0137 0.1935 0.1935
Echinococcus granulosus Smad4 0.0033 0.0006 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0567 1 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0229 0.366 1
Echinococcus multilocularis smad 0.0033 0.0006 0.0016
Echinococcus multilocularis GPCR, family 2 0.018 0.274 0.7487
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.018 0.274 0.274
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0006 0.0016
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0229 0.366 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Brugia malayi hypothetical protein 0.0051 0.0326 0.0326
Loa Loa (eye worm) latrophilin receptor protein 2 0.018 0.274 0.274
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0229 0.366 0.366
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Echinococcus granulosus smad 0.0033 0.0006 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.0891
Plasmodium falciparum methionine--tRNA ligase 0.0229 0.366 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0006 0.0006
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0229 0.366 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.664 0.664
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Brugia malayi methionyl-tRNA synthetase 0.0229 0.366 0.366
Brugia malayi MH2 domain containing protein 0.0033 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0006 0.0016
Echinococcus multilocularis Smad4 0.0033 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Echinococcus multilocularis tar DNA binding protein 0.0137 0.1935 0.5288
Brugia malayi TAR-binding protein 0.0137 0.1935 0.1935
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.0891
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.8561 0.8561
Giardia lamblia Methionyl-tRNA synthetase 0.0229 0.366 1
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0087 0.1014 0.277
Treponema pallidum leucyl-tRNA synthetase 0.0087 0.1014 0.5
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0141 0.2027 0.2027
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0006 0.0009
Chlamydia trachomatis methionine--tRNA ligase 0.0087 0.1014 0.5
Brugia malayi methionyl-tRNA synthetase 0.0087 0.1014 0.1014
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Echinococcus granulosus tar DNA binding protein 0.0137 0.1935 0.5288
Echinococcus multilocularis methionine tRNA synthetase 0.0229 0.366 1
Loa Loa (eye worm) TAR-binding protein 0.0137 0.1935 0.1935
Plasmodium vivax methionine--tRNA ligase, putative 0.0229 0.366 1
Leishmania major methionyl-tRNA synthetase, putative 0.0229 0.366 1
Schistosoma mansoni leucyl-tRNA synthetase 0.0087 0.1014 0.1527
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0006 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0567 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.274 0.7487
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0087 0.1014 0.5
Schistosoma mansoni methionine-tRNA synthetase 0.0229 0.366 0.5513
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0229 0.366 1
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0326 0.0891
Onchocerca volvulus 0.0141 0.2027 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.018 0.274 0.7487
Brugia malayi Latrophilin receptor protein 2 0.018 0.274 0.274
Plasmodium falciparum methionine--tRNA ligase, putative 0.0087 0.1014 0.277
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0326 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Echinococcus multilocularis leucyl tRNA synthetase 0.0087 0.1014 0.277
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.1935 0.1935
Treponema pallidum methionyl-tRNA synthetase 0.0087 0.1014 0.5
Brugia malayi protein ZK524.3 0.0087 0.1014 0.1014
Loa Loa (eye worm) Smad1 0.0033 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0051 0.0326 0.0891
Loa Loa (eye worm) hypothetical protein 0.018 0.274 0.274
Plasmodium vivax methionine--tRNA ligase, putative 0.0087 0.1014 0.277
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0006 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0006 0.0016
Echinococcus granulosus methionine tRNA synthetase 0.0229 0.366 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0229 0.366 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0229 0.366 0.5
Schistosoma mansoni Smad4 0.0033 0.0006 0.0009
Brugia malayi MH1 domain containing protein 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0326 0.0326
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.018 0.274 0.7487
Schistosoma mansoni methionine-tRNA synthetase 0.0087 0.1014 0.1527

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 100 uM Growth inhibition of adult Caenorhabditis elegans measured on day 3 by microscopy ChEMBL. 25488842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.